PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34129218-11 2022 AST activated the NRF-2/HO-1 pathway that could remarkably restrain BU-induced apoptosis in SSCs. Busulfan 68-70 NFE2 like bZIP transcription factor 2 Homo sapiens 18-23 33384597-0 2020 NRF2 -617 C/A Polymorphism Impacts Proinflammatory Cytokine Levels, Survival, and Transplant-Related Mortality After Hematopoietic Stem Cell Transplantation in Adult Patients Receiving Busulfan-Based Conditioning Regimens. Busulfan 185-193 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 33384597-5 2020 In this study, we evaluated the influence of NRF2 polymorphisms on BU exposure, proinflammatory cytokine levels, and clinical outcomes in HSCT patients. Busulfan 67-69 NFE2 like bZIP transcription factor 2 Homo sapiens 45-49 33384597-12 2020 Thus, NRF2 -617 CA/AA genotyping combined with TDM would further optimize personalized BU dosing for sufficient efficacy and safety endpoint. Busulfan 87-89 NFE2 like bZIP transcription factor 2 Homo sapiens 6-10