PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10535753-1 1999 A phenylalanine substitution for serine in the reduced folate carrier at residue 309 (RFC1-S309F) was identified in a methotrexate (MTX)-resistant cell line selected with 5-formyltetrahydrofolate (5-CHO-THF) as the sole folate source. Leucovorin 171-195 replication factor C (activator 1) 1 Mus musculus 86-90 23904512-7 2013 In COCs, transport of MTX and the reduced folate leucovorin was inhibited by the anion transport inhibitor SITS that blocks RFC1 but was insensitive to dynasore, a specific dynamin inhibitor that instead inhibits folate receptor-receptor mediated endocytosis, whereas the opposite was found in 2-cell embryos and blastocysts. Leucovorin 49-59 replication factor C (activator 1) 1 Mus musculus 124-128 23904512-8 2013 The inhibitor profile and transport properties of MTX and leucovorin in COCs correspond to established transport characteristics of RFC1 (SLC19A1), whereas those in 2-cell embryos and blastocysts correspond with those of FOLR1, consistent with the mRNA expression patterns. Leucovorin 58-68 replication factor C (activator 1) 1 Mus musculus 132-136