PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22848014-4	2012	We postulate that phenobarbitone in combination with MTHFR deficiency may have caused her rash to deteriorate and subsequent folinic acid was helpful in treating the rash and preventing further acute neurological decline as commonly associated with this condition.	Leucovorin	125-137	methylenetetrahydrofolate reductase	Homo sapiens	53-58	
29317847-4	2018	We present the case of a patient with reduced COMT and MTHFR expression treated with leucovorin 10 mg daily for the management of chronic pain.	Leucovorin	85-95	methylenetetrahydrofolate reductase	Homo sapiens	55-60	
34214447-6	2021	The resulting atlas of MTHFR variant effects reveals many complex dependencies on both folinate and p.Ala222Val.	Leucovorin	87-95	methylenetetrahydrofolate reductase	Homo sapiens	23-28	
30867454-8	2019	Finally, the model simulations indicate that the 5fTHF futile cycle dampens the stochastic noise in FOCM that results from both folate deficiency and a common variant in the methylenetetrahydrofolate reductase (MTHFR) gene.	Leucovorin	49-54	methylenetetrahydrofolate reductase	Homo sapiens	174-209	
30867454-8	2019	Finally, the model simulations indicate that the 5fTHF futile cycle dampens the stochastic noise in FOCM that results from both folate deficiency and a common variant in the methylenetetrahydrofolate reductase (MTHFR) gene.	Leucovorin	49-54	methylenetetrahydrofolate reductase	Homo sapiens	211-216	
26898294-6	2016	We report three patients with severe MTHFR deficiency (enzyme activity <=1% of controls) who had undetectable levels of CSF 5-MTHF at diagnosis and while on treatment with either folic acid or calcium folinate.	Leucovorin	196-212	methylenetetrahydrofolate reductase	Homo sapiens	37-42	
21044746-0	2010	Methylenetetrahydrofolate reductase polymorphism (677 C>T) predicts long time to progression in metastatic colon cancer treated with 5-fluorouracil and folinic acid.	Leucovorin	155-167	methylenetetrahydrofolate reductase	Homo sapiens	0-35	
21920473-0	2012	The effect of folinic acid on methylenetetrahydrofolate reductase polymorphisms in methotrexate-treated allogeneic hematopoietic stem cell transplants.	Leucovorin	14-26	methylenetetrahydrofolate reductase	Homo sapiens	30-65	
11710708-2	2001	METHODS: Genotype analysis of the MTHFR gene was done in 236 patients who started MTX treatment with (n = 157) or without (n = 79) folic or folinic acid supplementation.	Leucovorin	140-152	methylenetetrahydrofolate reductase	Homo sapiens	34-39	
11299748-17	2001	The MTHFR genotype might be considered in the design of 5-FU-based chemotherapy, especially in patient-specific strategies with leucovorin supplementation.	Leucovorin	128-138	methylenetetrahydrofolate reductase	Homo sapiens	4-9	
10958818-3	2000	This study was undertaken to determine the capacity of homozygotes for the MTHFR C677T transition to convert 5-formyltetrahydrofolic acid (5-HCO-H(4) folic acid) to 5-CH(3)-H(4) folic acid, a process that requires the action of MTHFR.	Leucovorin	109-137	methylenetetrahydrofolate reductase	Homo sapiens	75-80	
10958818-3	2000	This study was undertaken to determine the capacity of homozygotes for the MTHFR C677T transition to convert 5-formyltetrahydrofolic acid (5-HCO-H(4) folic acid) to 5-CH(3)-H(4) folic acid, a process that requires the action of MTHFR.	Leucovorin	109-137	methylenetetrahydrofolate reductase	Homo sapiens	228-233	
10462625-2	1999	The metabolism of leucovorin is mediated through the enzyme methylenetetrahydrofolate reductase (MTHFR).	Leucovorin	18-28	methylenetetrahydrofolate reductase	Homo sapiens	60-95	
10462625-2	1999	The metabolism of leucovorin is mediated through the enzyme methylenetetrahydrofolate reductase (MTHFR).	Leucovorin	18-28	methylenetetrahydrofolate reductase	Homo sapiens	97-102