PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21380490-2	2011	Given that LV effects are attributable to increased levels of reduced folate in cancer cells, we attempted here to show the in vivo role of folylpolyglutamate synthetase (FPGS), which stabilizes intracellular reduced folate, in the anticancer activities of oral fluoropyrimidines, UFT or S-1, combined with LV.	Leucovorin	11-13	folylpolyglutamate synthase	Homo sapiens	140-169	
3756000-7	1986	5-Formyltetrahydrofolate, which is used as a rescue agent in high-dose methotrexate-rescue chemotherapy, is a better alternate substrate of FPGS than is methotrexate and therefore is a potent competitive inhibitor of the glutamylation of methotrexate.	Leucovorin	0-24	folylpolyglutamate synthase	Homo sapiens	140-144	
3873989-8	1985	Folinic acid, often used as the rescue agent in high-dose MTX therapy, has a low Km with mammalian FPGS (7 microM).	Leucovorin	0-12	folylpolyglutamate synthase	Homo sapiens	99-103	
3873989-11	1985	This inhibition is competitive, presumably because folinic acid and MTX are competing substrates for FPGS.	Leucovorin	51-63	folylpolyglutamate synthase	Homo sapiens	101-105	
21380490-5	2011	FPGS shRNA HCT-15 tumors expressed a significantly lower level of FPGS at protein and mRNA levels than parental HCT-15 cells, and the levels of reduced folate in FPGS shRNA HCT-15 tumors became 57% of those in parent after a single administration of 10 mg/kg of LV.	Leucovorin	262-264	folylpolyglutamate synthase	Homo sapiens	0-4	
21380490-9	2011	In conclusion, the present results provide in vivo evidence that intratumor FPGS plays an important role in the efficacy of oral fluoropyrimidine plus LV therapy for colorectal cancer.	Leucovorin	151-153	folylpolyglutamate synthase	Homo sapiens	76-80	
21380490-2	2011	Given that LV effects are attributable to increased levels of reduced folate in cancer cells, we attempted here to show the in vivo role of folylpolyglutamate synthetase (FPGS), which stabilizes intracellular reduced folate, in the anticancer activities of oral fluoropyrimidines, UFT or S-1, combined with LV.	Leucovorin	11-13	folylpolyglutamate synthase	Homo sapiens	171-175	
18035049-0	2008	Folylpolyglutamate synthase and gamma-glutamyl hydrolase regulate leucovorin-enhanced 5-fluorouracil anticancer activity.	Leucovorin	66-76	folylpolyglutamate synthase	Homo sapiens	0-27	
18035049-2	2008	We investigated the roles of folylpolyglutamate synthase (FPGS) and gamma-glutamyl hydrolase (GGH), which are the main enzymes involved in folate metabolism, in the effect of LV.	Leucovorin	175-177	folylpolyglutamate synthase	Homo sapiens	29-56	
18035049-2	2008	We investigated the roles of folylpolyglutamate synthase (FPGS) and gamma-glutamyl hydrolase (GGH), which are the main enzymes involved in folate metabolism, in the effect of LV.	Leucovorin	175-177	folylpolyglutamate synthase	Homo sapiens	58-62	
18035049-4	2008	Small-interfering RNA (siRNA) transfected into DLD-1 cells to downregulate FPGS reduced the basal level of reduced folate, the folate level after LV treatment, and the enhancement of 5-fluoro-2"-deoxyuridine (FdUrd)-induced cytotoxicity elicited by LV.	Leucovorin	146-148	folylpolyglutamate synthase	Homo sapiens	75-79	
18035049-4	2008	Small-interfering RNA (siRNA) transfected into DLD-1 cells to downregulate FPGS reduced the basal level of reduced folate, the folate level after LV treatment, and the enhancement of 5-fluoro-2"-deoxyuridine (FdUrd)-induced cytotoxicity elicited by LV.	Leucovorin	249-251	folylpolyglutamate synthase	Homo sapiens	75-79	
18035049-6	2008	These results suggest that FPGS and GGH expression levels in tumors are determinants of the efficacy of LV in enhancing the antitumor activity of 5-FU.	Leucovorin	104-106	folylpolyglutamate synthase	Homo sapiens	27-31	
19636555-10	2010	CONCLUSIONS: The expression level of FPGS, GGH and ABCC1 in CRC tissues could predict the reduced folate level after LV administration, and these factors may determine the efficacy of LV treatment.	Leucovorin	117-119	folylpolyglutamate synthase	Homo sapiens	37-41	
19636555-10	2010	CONCLUSIONS: The expression level of FPGS, GGH and ABCC1 in CRC tissues could predict the reduced folate level after LV administration, and these factors may determine the efficacy of LV treatment.	Leucovorin	184-186	folylpolyglutamate synthase	Homo sapiens	37-41