PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8983929-1 1995 bolus of calcium folinate: pharmacokinetic drug interaction with preadministered interferon-alpha-2b. Leucovorin 9-25 interferon alpha 2 Homo sapiens 81-100 8708718-2 1996 PURPOSE: To determine the effects of interferon alpha-2a (IFN alpha) on the efficacy and toxicity of fluorouracil (FUra) and leucovorin (LV) in patients with advanced colorectal cancer. Leucovorin 125-135 interferon alpha 2 Homo sapiens 37-56 8708718-2 1996 PURPOSE: To determine the effects of interferon alpha-2a (IFN alpha) on the efficacy and toxicity of fluorouracil (FUra) and leucovorin (LV) in patients with advanced colorectal cancer. Leucovorin 125-135 interferon alpha 2 Homo sapiens 58-67 8708718-2 1996 PURPOSE: To determine the effects of interferon alpha-2a (IFN alpha) on the efficacy and toxicity of fluorouracil (FUra) and leucovorin (LV) in patients with advanced colorectal cancer. Leucovorin 137-139 interferon alpha 2 Homo sapiens 37-56 8708718-2 1996 PURPOSE: To determine the effects of interferon alpha-2a (IFN alpha) on the efficacy and toxicity of fluorouracil (FUra) and leucovorin (LV) in patients with advanced colorectal cancer. Leucovorin 137-139 interferon alpha 2 Homo sapiens 58-67 9815884-0 1995 Potentiation of 5-fluorouracil-leucovorin activity by alpha2a-interferon in colon adenocarcinoma xenografts. Leucovorin 31-41 interferon alpha 2 Homo sapiens 54-72 8374869-9 1993 The addition of IFN-alpha produced more 5-FU-related toxicity compared with a previous study in which the same dosage and schedule of 5-FU plus LV was used. Leucovorin 144-146 interferon alpha 2 Homo sapiens 16-25 8398300-1 1993 Pharmacokinetic interaction of alpha-2a interferon and leucovorin. Leucovorin 55-65 interferon alpha 2 Homo sapiens 31-50 1867955-1 1991 Recombinant human interferon-alpha 2a (rIFN-alpha 2a; 500 or 5,000 IU/mL) or [6RS] leucovorin ([6RS]LV; 1 microM) each potentiated the cytotoxic activity of 5-fluorouracil (FUra) by 2.6- to 3.2-fold during 72 hr exposures in two human colon adenocarcinoma cell lines (GC3/c1; VRC5/c1). Leucovorin 100-102 interferon alpha 2 Homo sapiens 18-37 8398300-14 1993 Pharmacokinetics of oral LV was performed in patients treated with and without alpha-IF: significantly higher serum levels of LV and 5-methyltetrahydrofolate were found after alpha-IF addition. Leucovorin 25-27 interferon alpha 2 Homo sapiens 79-87 8398300-14 1993 Pharmacokinetics of oral LV was performed in patients treated with and without alpha-IF: significantly higher serum levels of LV and 5-methyltetrahydrofolate were found after alpha-IF addition. Leucovorin 25-27 interferon alpha 2 Homo sapiens 175-183 12598341-1 2003 BACKGROUND: The aim of this study was to determine whether the efficacy of the combination of 5-fluorouracil (5-FU), leucovorin (LV) and radiation therapy (RT) could be improved by the addition of interferon-alpha2b (IFN-alpha) in patients who have had a "curative" resection, for rectal adenocarcinoma (Dukes" B2/C; T3 N0, T4 N0, N1-3). Leucovorin 129-131 interferon alpha 2 Homo sapiens 197-215 12598341-1 2003 BACKGROUND: The aim of this study was to determine whether the efficacy of the combination of 5-fluorouracil (5-FU), leucovorin (LV) and radiation therapy (RT) could be improved by the addition of interferon-alpha2b (IFN-alpha) in patients who have had a "curative" resection, for rectal adenocarcinoma (Dukes" B2/C; T3 N0, T4 N0, N1-3). Leucovorin 129-131 interferon alpha 2 Homo sapiens 217-226 9726437-3 1998 pretreatment with interferon (IFN)-alpha2b in patients with advanced colorectal carcinoma refractory to previous therapy with 5-FU modulated by methotrexate (MTX) or leucovorin (LV) or both. Leucovorin 166-176 interferon alpha 2 Homo sapiens 18-42