PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10995219-5	2000	The cSHMT SUTR-luciferase mRNA binds to the cSHMT.glycine.5-formyltetrahydrofolate ternary complex with an apparent K(d) of 10 microM.	Leucovorin	58-82	serine hydroxymethyltransferase 1	Homo sapiens	4-9	
10995219-5	2000	The cSHMT SUTR-luciferase mRNA binds to the cSHMT.glycine.5-formyltetrahydrofolate ternary complex with an apparent K(d) of 10 microM.	Leucovorin	58-82	serine hydroxymethyltransferase 1	Homo sapiens	44-49	
30867454-1	2019	In folate-mediated one-carbon metabolism (FOCM), 5-formyltetrahydrofolate (5fTHF), a one-carbon substituted tetrahydrofolate (THF) vitamer, acts as an intracellular storage form of folate and as an inhibitor of the folate-dependent enzymes phosphoribosylaminoimidazolecarboxamide formyltransferase (AICARFT) and serine hydroxymethyltransferase (SHMT).	Leucovorin	49-73	serine hydroxymethyltransferase 1	Homo sapiens	312-343	
30867454-1	2019	In folate-mediated one-carbon metabolism (FOCM), 5-formyltetrahydrofolate (5fTHF), a one-carbon substituted tetrahydrofolate (THF) vitamer, acts as an intracellular storage form of folate and as an inhibitor of the folate-dependent enzymes phosphoribosylaminoimidazolecarboxamide formyltransferase (AICARFT) and serine hydroxymethyltransferase (SHMT).	Leucovorin	49-73	serine hydroxymethyltransferase 1	Homo sapiens	345-349	
30867454-1	2019	In folate-mediated one-carbon metabolism (FOCM), 5-formyltetrahydrofolate (5fTHF), a one-carbon substituted tetrahydrofolate (THF) vitamer, acts as an intracellular storage form of folate and as an inhibitor of the folate-dependent enzymes phosphoribosylaminoimidazolecarboxamide formyltransferase (AICARFT) and serine hydroxymethyltransferase (SHMT).	Leucovorin	75-80	serine hydroxymethyltransferase 1	Homo sapiens	312-343	
30867454-1	2019	In folate-mediated one-carbon metabolism (FOCM), 5-formyltetrahydrofolate (5fTHF), a one-carbon substituted tetrahydrofolate (THF) vitamer, acts as an intracellular storage form of folate and as an inhibitor of the folate-dependent enzymes phosphoribosylaminoimidazolecarboxamide formyltransferase (AICARFT) and serine hydroxymethyltransferase (SHMT).	Leucovorin	75-80	serine hydroxymethyltransferase 1	Homo sapiens	345-349	
30867454-2	2019	Cellular levels of 5fTHF are regulated by a futile cycle comprising the enzymes SHMT and 5,10-methenyltetrahydrofolate synthetase (MTHFS).	Leucovorin	19-24	serine hydroxymethyltransferase 1	Homo sapiens	80-129	
15170323-2	2004	SHMT also catalyzes the folate-independent retroaldol cleavage of allothreonine and 3-phenylserine and the irreversible conversion of 5,10-methenyltetrahydrofolate to 5-formyltetrahydrofolate.	Leucovorin	167-191	serine hydroxymethyltransferase 1	Homo sapiens	0-4	
15170323-6	2004	Glu75 of SHMT is clearly involved in the reaction mechanism; it is within hydrogen bonding distance of the hydroxyl group of serine and the formyl group of 5-formyltetrahydrofolate in complexes of these species with SHMT.	Leucovorin	156-180	serine hydroxymethyltransferase 1	Homo sapiens	9-13	
15170323-6	2004	Glu75 of SHMT is clearly involved in the reaction mechanism; it is within hydrogen bonding distance of the hydroxyl group of serine and the formyl group of 5-formyltetrahydrofolate in complexes of these species with SHMT.	Leucovorin	156-180	serine hydroxymethyltransferase 1	Homo sapiens	216-220