PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19998502-11 2009 LDH release from HepG2 cells was analyzed at 24, 48, 72 and 96 h after infection with LV-NT4(Si)-p53(N15)-Ant and LV-EGFP, which showed that LDH release was significantly higher in LV-NT4(Si)-p53(N15)-Ant treatment group (682 IU/L) than in control group (45 IU/L, P < 0.01). Leucovorin 86-88 tumor protein p53 Homo sapiens 97-100 15342418-1 2004 We have demonstrated previously that interferon (IFN)-gamma sensitizes human colon carcinoma cell lines to the cytotoxic effects of 5-fluorouracil combined with leucovorin and to the thymidylate synthase inhibitor, ZD9331, dependent on thymineless stress-induced DNA damage, independent of p53. Leucovorin 161-171 tumor protein p53 Homo sapiens 290-293 16528528-10 2006 FDXR gene expression, which is regulated at least in part by p53, is associated with both response and survival when metastatic colorectal cancer is treated with 5-FU plus LV. Leucovorin 172-174 tumor protein p53 Homo sapiens 61-64 15611505-0 2004 Prediction of TP53 status for primary cisplatin, fluorouracil, and leucovorin chemotherapy in ethmoid sinus intestinal-type adenocarcinoma. Leucovorin 67-77 tumor protein p53 Homo sapiens 14-18 12171874-1 2002 Potentiation of 5-fluorouracil/leucovorin (FUra/LV) cytotoxicity by IFN-gamma in colon carcinoma cells is dependent on FUra-induced DNA damage, the Fas death receptor, and independent of p53 and RNA-mediated FUra toxicity, which occurs in normal gastrointestinal tissues. Leucovorin 31-41 tumor protein p53 Homo sapiens 187-190 14695155-2 2003 Importantly, the cytotoxic effects of thymidine deprivation induced by 5-fluorouracil (FUra) combined with leucovorin (LV) was enhanced by IFN-gamma, and the synergism was shown to be dependent on Fas, FUra-induced DNA damage, and independent of p53. Leucovorin 107-117 tumor protein p53 Homo sapiens 246-249 14695155-2 2003 Importantly, the cytotoxic effects of thymidine deprivation induced by 5-fluorouracil (FUra) combined with leucovorin (LV) was enhanced by IFN-gamma, and the synergism was shown to be dependent on Fas, FUra-induced DNA damage, and independent of p53. Leucovorin 119-121 tumor protein p53 Homo sapiens 246-249 12171874-1 2002 Potentiation of 5-fluorouracil/leucovorin (FUra/LV) cytotoxicity by IFN-gamma in colon carcinoma cells is dependent on FUra-induced DNA damage, the Fas death receptor, and independent of p53 and RNA-mediated FUra toxicity, which occurs in normal gastrointestinal tissues. Leucovorin 48-50 tumor protein p53 Homo sapiens 187-190 11038045-1 2000 BACKGROUND: We assessed the hypothesis that a compromised p53 function could account for the non response of colon cancer patients with low thymidylate synthase (TS) expression receiving a bolus 5-fluorouracil (5-FU) leucovorin (LV) combination. Leucovorin 217-227 tumor protein p53 Homo sapiens 58-61 11802206-0 2002 P53 overexpression predicts poor chemosensitivity to high-dose 5-fluorouracil plus leucovorin chemotherapy for stage IV colorectal cancers after palliative bowel resection. Leucovorin 83-93 tumor protein p53 Homo sapiens 0-3 11038045-1 2000 BACKGROUND: We assessed the hypothesis that a compromised p53 function could account for the non response of colon cancer patients with low thymidylate synthase (TS) expression receiving a bolus 5-fluorouracil (5-FU) leucovorin (LV) combination. Leucovorin 229-231 tumor protein p53 Homo sapiens 58-61 21541641-4 1996 Increased p53 protein levels have previously been shown to correlate with disease progression in a series of colorectal carcinoma patients treated with 5-FU/folinic acid biomodulated chemotherapy. Leucovorin 157-169 tumor protein p53 Homo sapiens 10-13 32731241-5 2020 Intestinal-type adenocarcinoma carrying a functional p53 protein may be treated with preoperative cisplatin, 5-fluorouracil, and leucovorin. Leucovorin 129-139 tumor protein p53 Homo sapiens 53-56 31897925-10 2020 Neoadjuvant chemotherapy with cisplatin, 5-fluorouracil and leucovorin may offer high response rates and long-term control in a subgroup of patients affected by intestinal-type adenocarcinoma, and in particular in those whose tumors harbor a functional p53 protein. Leucovorin 60-70 tumor protein p53 Homo sapiens 253-256