PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20647221-1 2011 BACKGROUND: To assess the predictive value of polymorphism in nine genes, primarily thymidylate synthase (TS) and orotate phosphoribosyltransferase (OPRT), which relates to 5-fluorouracil (5-FU) metabolism, for toxicity in patients treated with oral uracil/tegafur (UFT) plus leucovorin (LV). Leucovorin 276-286 uridine monophosphate synthetase Homo sapiens 114-147 20647221-1 2011 BACKGROUND: To assess the predictive value of polymorphism in nine genes, primarily thymidylate synthase (TS) and orotate phosphoribosyltransferase (OPRT), which relates to 5-fluorouracil (5-FU) metabolism, for toxicity in patients treated with oral uracil/tegafur (UFT) plus leucovorin (LV). Leucovorin 276-286 uridine monophosphate synthetase Homo sapiens 149-153 20647221-1 2011 BACKGROUND: To assess the predictive value of polymorphism in nine genes, primarily thymidylate synthase (TS) and orotate phosphoribosyltransferase (OPRT), which relates to 5-fluorouracil (5-FU) metabolism, for toxicity in patients treated with oral uracil/tegafur (UFT) plus leucovorin (LV). Leucovorin 288-290 uridine monophosphate synthetase Homo sapiens 114-147 20647221-1 2011 BACKGROUND: To assess the predictive value of polymorphism in nine genes, primarily thymidylate synthase (TS) and orotate phosphoribosyltransferase (OPRT), which relates to 5-fluorouracil (5-FU) metabolism, for toxicity in patients treated with oral uracil/tegafur (UFT) plus leucovorin (LV). Leucovorin 288-290 uridine monophosphate synthetase Homo sapiens 149-153 20647221-8 2011 CONCLUSIONS: OPRT polymorphism predicts toxicity, especially grade 3 or greater diarrhea to oral UFT + LV adjuvant chemotherapy, whereas TS does not, in our study cohort. Leucovorin 103-105 uridine monophosphate synthetase Homo sapiens 13-17 28347333-10 2017 The UMPS 638 CC genotype might be a candidate biomarker predicting toxicity in patients receiving tegafur-uracil/leucovorin-based preoperative chemoradiation for locally advanced rectal cancer. Leucovorin 113-123 uridine monophosphate synthetase Homo sapiens 4-8