PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22725682-9	2013	The high-activity rats with elevated enkephalin, but not high-TG rats, were also unusually sensitive to naltrexone, which significantly reduced their alcohol intake.	Naltrexone	104-114	proenkephalin	Rattus norvegicus	37-47	
15806307-8	2005	Naltrexone-induced blockade of all met-Enk receptor subtypes decreased proliferative activity in immature adrenal and raised it in regenerating glands.	Naltrexone	0-10	proenkephalin	Rattus norvegicus	39-42	
19951300-19	2010	Naltrexone therapy for alcoholism may act, in part, by blocking the enkephalin-triggered positive feedback cycle.	Naltrexone	0-10	proenkephalin	Rattus norvegicus	68-78	
15806307-10	2005	In contrast, met-Enk exerted a marked antiproliferogenic effect that was reversed by naltrexone.	Naltrexone	85-95	proenkephalin	Rattus norvegicus	17-20	
14519525-7	2003	In another experiment, virally mediated ENK gene transfer into the OT of intact rats decreased footshock-induced freezing, and this effect was reversed by naltrexone administration.	Naltrexone	155-165	proenkephalin	Rattus norvegicus	40-43	
1687763-3	1991	Naltrexone significantly blocked the EEG effects of morphine and the enkephalin analog, but methyl naltrexone failed to do so.	Naltrexone	0-10	proenkephalin	Rattus norvegicus	69-79	
10965231-5	2000	Met-Enk-induced immunopotentiation was antagonized by anti-Met-Enk antibodies (anti-Met-Enk-Ig) and quaternary naltrexone (qNtx).	Naltrexone	111-121	proenkephalin	Rattus norvegicus	4-7	
9443794-6	1998	Analysis by fast atom bombardment mass spectrometry suggested that the recovered fragment was met-enk Administration of met-enk inhibits osteoblast cell growth in culture, which is reversible by naltrexone.	Naltrexone	195-205	proenkephalin	Rattus norvegicus	98-101	
9443794-6	1998	Analysis by fast atom bombardment mass spectrometry suggested that the recovered fragment was met-enk Administration of met-enk inhibits osteoblast cell growth in culture, which is reversible by naltrexone.	Naltrexone	195-205	proenkephalin	Rattus norvegicus	124-127	
8836576-4	1996	Morphine and D-Ala2,D-Leu5-enkephalin (DADLE) had a comparable inhibitory potency with a maximal effect at 1 mM concentration, while both naltrexone and naltrindole antagonized their effect at only 10 nM.	Naltrexone	138-148	proenkephalin	Rattus norvegicus	27-37	
1662276-8	1991	Infusion into AT (10 min before) of naltrexone (2-4 ng), ICI 154, 129 (1-10 ng) and WIN 44,441-3 (2-20 ng) antagonized the antinociception evoked by locally applied morphine (25 ng), [D-Pen2,D-Pen5]enkephalin (50 ng) and U 50,488 (100 ng), respectively.	Naltrexone	36-46	proenkephalin	Rattus norvegicus	198-208	
9639282-7	1998	[3H]D-Ala2,N-Me-Phe4,Gly-ol5-enkephalin binding to mu opioid receptors was significantly higher in the globus pallidus, amygdala, thalamus, hypothalamus, hippocampus, substantia nigra, ventral tegmental area, central gray, and interpeduncular nucleus of the naltrexone-treated rats.	Naltrexone	258-268	proenkephalin	Rattus norvegicus	29-39	
9374199-7	1997	In both saline and NTX-treated lactating subjects, ARC mRNA levels of proDYN, POMC and proENK were significantly decreased compared with the saline or NTX-treated post-lactating subjects (P < 0.01).	Naltrexone	19-22	proenkephalin	Rattus norvegicus	87-93	
2173759-6	1990	Evidence for a peripheral site of action of enkephalin-like peptides in this model was provided by the antagonism of the actions of thiorphan/bestatin by quaternary naltrexone (10-20 mg kg-1 s.c.).	Naltrexone	165-175	proenkephalin	Rattus norvegicus	44-54	
2540993-0	1989	Chronic administration of morphine and naltrexone up-regulate mu-opioid binding sites labeled by [3H][D-Ala2,MePhe4,Gly-ol5]enkephalin: further evidence for two mu-binding sites.	Naltrexone	39-49	proenkephalin	Rattus norvegicus	124-134	
2847072-0	1988	Chronic administration of morphine and naltrexone up-regulate[3H][D-Ala2,D-leu5]enkephalin binding sites by different mechanisms.	Naltrexone	39-49	proenkephalin	Rattus norvegicus	80-90	
2847072-4	1988	The experiments reported in this paper tested the hypothesis that chronic administration of morphine and naltrexone up-regulated the binding sites for [3H][D-ala2,D-leu5]enkephalin by different mechanisms.	Naltrexone	105-115	proenkephalin	Rattus norvegicus	170-180	
2847072-6	1988	Chronic administration of morphine up-regulated the lower affinity site, while chronic administration of naltrexone up-regulated both the higher and lower affinity binding sites for [3H][D-ala2,D-leu5]enkephalin.	Naltrexone	105-115	proenkephalin	Rattus norvegicus	201-211	
2847072-8	1988	These data suggest that chronic administration of morphine and naltrexone up-regulate binding sites for [3H][D-ala2,D-leu5]enkephalin through different mechanisms, and that the lower affinity binding sites for [3H][D-ala2, D-leu5]enkephalin which are up-regulated by chronic administration of morphine and naltrexone might differ biochemically from the lower affinity binding sites present in membranes treated with placebo.	Naltrexone	63-73	proenkephalin	Rattus norvegicus	123-133	
2847072-8	1988	These data suggest that chronic administration of morphine and naltrexone up-regulate binding sites for [3H][D-ala2,D-leu5]enkephalin through different mechanisms, and that the lower affinity binding sites for [3H][D-ala2, D-leu5]enkephalin which are up-regulated by chronic administration of morphine and naltrexone might differ biochemically from the lower affinity binding sites present in membranes treated with placebo.	Naltrexone	63-73	proenkephalin	Rattus norvegicus	230-240	
2847072-8	1988	These data suggest that chronic administration of morphine and naltrexone up-regulate binding sites for [3H][D-ala2,D-leu5]enkephalin through different mechanisms, and that the lower affinity binding sites for [3H][D-ala2, D-leu5]enkephalin which are up-regulated by chronic administration of morphine and naltrexone might differ biochemically from the lower affinity binding sites present in membranes treated with placebo.	Naltrexone	306-316	proenkephalin	Rattus norvegicus	123-133	
2998381-1	1985	Naltrexone was administered to rats for 7 days by osmotic minipump (5 mg/kg/day) and thereupon, forebrain mu opioid receptor levels in subcellular fractions were monitored by homologous displacement of [3H]D-ala2-mePhe4-gly-ol5 enkephalin binding.	Naltrexone	0-10	proenkephalin	Rattus norvegicus	228-238	
6328530-8	1984	Receptor density changes are paralleled by increases in methionine-enkephalin content in the striatum, nucleus accumbens, periaqueductal gray, and hypothalamic areas of chronic naltrexone-treated rats relative to control rats.	Naltrexone	177-187	proenkephalin	Rattus norvegicus	67-77	
193169-3	1977	Opiate agonists, morphine, dihydromorphine and l-methadone and opiate antagonists, naltrexone and naloxone are less effective inhibitors of 3H-enkephalin than in 3H-dihydromorphine and 3H-naloxone binding.	Naltrexone	83-93	proenkephalin	Rattus norvegicus	143-153	
3018230-7	1986	The discriminative effects of D-Ala2-NMePhe4-Gly5(ol)enkephalin, D-Ala2-D-Leu5enkephalin and beta-endorphin were antagonized by low doses of s.c. naltrexone (0.01-1.0 mg/kg).	Naltrexone	146-156	proenkephalin	Rattus norvegicus	53-63