PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31865244-0 2020 Naltrexone (NTX) relieves inflammation in the collagen-induced- arthritis (CIA) rat models through regulating TLR4/NFkappaB signaling pathway. Naltrexone 0-10 toll-like receptor 4 Rattus norvegicus 110-114 32905811-0 2021 Experimental autoimmune encephalopathy (EAE)-induced hippocampal neuroinflammation and memory deficits are prevented with the non-opioid TLR2/TLR4 antagonist (+)-naltrexone. Naltrexone 162-172 toll-like receptor 4 Rattus norvegicus 142-146 32905811-3 2021 Previously, we have shown that toll-like receptor 4 (TLR4) antagonists, such as (+)-naltrexone [(+)-NTX], block neuropathic pain and associated spinal inflammation in rats. Naltrexone 84-94 toll-like receptor 4 Rattus norvegicus 31-51 32905811-3 2021 Previously, we have shown that toll-like receptor 4 (TLR4) antagonists, such as (+)-naltrexone [(+)-NTX], block neuropathic pain and associated spinal inflammation in rats. Naltrexone 84-94 toll-like receptor 4 Rattus norvegicus 53-57 33127584-11 2021 Demonstrating a casual role for such neuroinflammatory signaling, allodynia was reversed by treatment with either minocycline, the TLR4 inhibitor (+)-naltrexone, or IL-10 plasmid DNA. Naltrexone 150-160 toll-like receptor 4 Rattus norvegicus 131-135 30741729-1 2020 The Toll-like receptor 4 (TLR4) antagonists, (+)-naloxone and (+)-naltrexone, have been reported to decrease self-administration of opioids in rats and to reduce other preclinical indicators of abuse potential. Naltrexone 66-76 toll-like receptor 4 Rattus norvegicus 4-24 30741729-1 2020 The Toll-like receptor 4 (TLR4) antagonists, (+)-naloxone and (+)-naltrexone, have been reported to decrease self-administration of opioids in rats and to reduce other preclinical indicators of abuse potential. Naltrexone 66-76 toll-like receptor 4 Rattus norvegicus 26-30 30741729-4 2020 The TLR4 antagonist (+)-naltrexone decreased responding in rats trained to self-administer the micro-opioid receptor agonist remifentanil, but with a potency that was not significantly different from that observed in another group of subjects in which responding was maintained by food reinforcement. Naltrexone 24-34 toll-like receptor 4 Rattus norvegicus 4-8 31865244-0 2020 Naltrexone (NTX) relieves inflammation in the collagen-induced- arthritis (CIA) rat models through regulating TLR4/NFkappaB signaling pathway. Naltrexone 12-15 toll-like receptor 4 Rattus norvegicus 110-114 31865244-10 2020 The expression of TLR4, NF-kappaB and RANKL was reduced in the spleen and synovium in the NTX group. Naltrexone 90-93 toll-like receptor 4 Rattus norvegicus 18-22 28322750-11 2017 Lastly, the toll-like receptor 4 (TLR4) antagonist (+)-naltrexone likewise blocked development of facial allodynia after supradural inflammatory soup. Naltrexone 51-65 toll-like receptor 4 Rattus norvegicus 12-32 28322750-11 2017 Lastly, the toll-like receptor 4 (TLR4) antagonist (+)-naltrexone likewise blocked development of facial allodynia after supradural inflammatory soup. Naltrexone 51-65 toll-like receptor 4 Rattus norvegicus 34-38 27519154-6 2016 Co-administering the non-opioid toll-like receptor 4 (TLR4) antagonist (+)-naltrexone throughout the morphine regimen prevented morphine-induced amplification of SNAP. Naltrexone 71-85 toll-like receptor 4 Rattus norvegicus 32-52 27519154-6 2016 Co-administering the non-opioid toll-like receptor 4 (TLR4) antagonist (+)-naltrexone throughout the morphine regimen prevented morphine-induced amplification of SNAP. Naltrexone 71-85 toll-like receptor 4 Rattus norvegicus 54-58 26603732-0 2016 Pharmacological characterization of the opioid inactive isomers (+)-naltrexone and (+)-naloxone as antagonists of toll-like receptor 4. Naltrexone 64-78 toll-like receptor 4 Rattus norvegicus 114-134 27296151-2 2016 Recently, the (+)-enantiomers of naloxone and naltrexone, TLR4 antagonists, have been reported to attenuate preclinical indicators of both opioid and stimulant abuse. Naltrexone 46-56 toll-like receptor 4 Rattus norvegicus 58-62 26603732-2 2016 The opioid inactive isomers (+)-naltrexone and (+)-naloxone act as TLR4 antagonists, reversing neuropathic pain and reducing opioid and cocaine reward and reinforcement. Naltrexone 28-42 toll-like receptor 4 Rattus norvegicus 67-71 26603732-4 2016 Here, we have elucidated the molecular mechanism of (+)-naltrexone and (+)-naloxone on TLR4 signalling. Naltrexone 52-66 toll-like receptor 4 Rattus norvegicus 87-91 26603732-6 2016 Effects were measured using Western blotting, luciferase reporter assays, fluorescence microscopy and ELISA KEY RESULTS: (+)-Naltrexone and (+)-naloxone were equi-potent inhibitors of the LPS-induced TLR4 downstream signalling and induction of the pro-inflammatory factors NO and TNF-alpha. Naltrexone 121-135 toll-like receptor 4 Rattus norvegicus 200-204 26603732-12 2016 CONCLUSIONS AND IMPLICATIONS: (+)-Naltrexone and (+)-naloxone were TRIF-IFN regulatory factor 3 axis-biased TLR4 antagonists. Naltrexone 30-44 toll-like receptor 4 Rattus norvegicus 108-112 23384483-0 2013 Effect of chronic delivery of the Toll-like receptor 4 antagonist (+)-naltrexone on incubation of heroin craving. Naltrexone 66-80 toll-like receptor 4 Rattus norvegicus 34-54 26010811-0 2015 Structure-Activity Relationships of (+)-Naltrexone-Inspired Toll-like Receptor 4 (TLR4) Antagonists. Naltrexone 36-50 toll-like receptor 4 Rattus norvegicus 60-80 26010811-0 2015 Structure-Activity Relationships of (+)-Naltrexone-Inspired Toll-like Receptor 4 (TLR4) Antagonists. Naltrexone 36-50 toll-like receptor 4 Rattus norvegicus 82-86 26010811-2 2015 (+)-Naltrexone acts as a Toll-like receptor 4 (TLR4) antagonist and has been shown to reverse neuropathic pain in rat studies. Naltrexone 0-14 toll-like receptor 4 Rattus norvegicus 25-45 26010811-2 2015 (+)-Naltrexone acts as a Toll-like receptor 4 (TLR4) antagonist and has been shown to reverse neuropathic pain in rat studies. Naltrexone 0-14 toll-like receptor 4 Rattus norvegicus 47-51 24412802-6 2014 Indeed, the phosphodiesterase inhibitor propentofylline, the macrophage migration inhibitory factor inhibitor ibudilast, and the toll-like receptor 4 antagonist (+)-naltrexone each reversed below-level allodynia bilaterally. Naltrexone 161-175 toll-like receptor 4 Rattus norvegicus 129-149 23384483-2 2013 Here, we determined the effect of the TLR4 antagonist (+)-naltrexone (a mu-opioid receptor inactive isomer) on the time-dependent increases in cue-induced heroin seeking after withdrawal (incubation of heroin craving). Naltrexone 54-68 toll-like receptor 4 Rattus norvegicus 38-42