PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25774718-1	2015	To test the hypothesis that a fall in cellular ATP following stimulation of endothelial cells with thrombin is secondary to a decrease in NAD levels caused by poly(ADP-Ribose)polymerase (PARP), we measured the levels of NAD and ATP in endothelial cells after treatment with thrombin, the Ca(++)-ionophore A23187, or hydrogen peroxide (H2O2), and compared the effects of inhibitors of PARP, NAD synthesis, and ADP-ribose breakdown on these responses.	NAD	138-141	coagulation factor II, thrombin	Homo sapiens	99-107	
29537672-9	2018	Interestingly, the NADH-stimulated oxygen consumption and ATP synthesis increased in the presence of the physiological platelets agonists, thrombin or collagen.	NAD	19-23	coagulation factor II, thrombin	Homo sapiens	139-147	
25774718-1	2015	To test the hypothesis that a fall in cellular ATP following stimulation of endothelial cells with thrombin is secondary to a decrease in NAD levels caused by poly(ADP-Ribose)polymerase (PARP), we measured the levels of NAD and ATP in endothelial cells after treatment with thrombin, the Ca(++)-ionophore A23187, or hydrogen peroxide (H2O2), and compared the effects of inhibitors of PARP, NAD synthesis, and ADP-ribose breakdown on these responses.	NAD	220-223	coagulation factor II, thrombin	Homo sapiens	99-107	
25774718-1	2015	To test the hypothesis that a fall in cellular ATP following stimulation of endothelial cells with thrombin is secondary to a decrease in NAD levels caused by poly(ADP-Ribose)polymerase (PARP), we measured the levels of NAD and ATP in endothelial cells after treatment with thrombin, the Ca(++)-ionophore A23187, or hydrogen peroxide (H2O2), and compared the effects of inhibitors of PARP, NAD synthesis, and ADP-ribose breakdown on these responses.	NAD	220-223	coagulation factor II, thrombin	Homo sapiens	99-107	
23850783-2	2013	Herein, the AuNCs prepared by using polyamidoamine dendrimer as template were constructed not only as nanocarriers for anchoring the large amounts of secondary thrombin aptamers but also as nanocatalysts to catalyze the oxidation of NADH efficiently.	NAD	233-237	coagulation factor II, thrombin	Homo sapiens	160-168	
23146393-2	2012	The hemin/G-quadruplex formed by intercalating hemin into thrombin binding aptamer (TBA), firstly acted as a NADH oxidase, assisting the oxidation of NADH to NAD(+) accompanying with the generation of H(2)O(2) in the presence of dissolved O(2).	NAD	109-113	coagulation factor II, thrombin	Homo sapiens	58-66	
23146393-2	2012	The hemin/G-quadruplex formed by intercalating hemin into thrombin binding aptamer (TBA), firstly acted as a NADH oxidase, assisting the oxidation of NADH to NAD(+) accompanying with the generation of H(2)O(2) in the presence of dissolved O(2).	NAD	158-164	coagulation factor II, thrombin	Homo sapiens	58-66	
20054824-6	2010	Importantly, beta-NAD significantly attenuated thrombin-induced EC permeability as well as the barrier-compromising effects of Gram-negative and Gram-positive bacterial toxins representing the barrier-protective function of beta-NAD.	NAD	13-21	coagulation factor II, thrombin	Homo sapiens	47-55	
10391925-5	1999	This effect of thrombin was accompanied by increased O-2 and H2O2 generation and NADH/NADPH consumption.	NAD	81-85	coagulation factor II, thrombin	Homo sapiens	15-23