PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32308644-8	2020	Sirtuins, a family of adenine dinucleotide (NAD+)-dependent histone deacetylases, have been demonstrated to regulate a series of physiological processes and affect diseases such as obesity, insulin resistance, type 2 diabetes (T2DM), heart disease, cancer, and aging.	NAD	44-47	insulin	Homo sapiens	190-197	
26574954-8	2016	CONCLUSIONS: Our data highlight a strong relationship of reduced NAD(+)/SIRT pathway expression with acquired obesity, inflammation, insulin resistance, and impaired mitochondrial protein homeostasis in SAT.	NAD	65-71	insulin	Homo sapiens	133-140	
30707625-1	2019	The nicotinamide adenine dinucleotide-dependent deacetylase, sirtuin (SIRT)1, in skeletal muscle is reduced in insulin-resistant states.	NAD	4-37	insulin	Homo sapiens	111-118	
30576653-2	2018	(2018) describe a mechanism by which insulin signaling represses the NAD+-dependent SIRT1 deacetylase by promoting PACS-2 binding and provide structural clues to understanding how SIRT1 activating compounds (STACs) work.	NAD	69-73	insulin	Homo sapiens	37-44	
28973648-0	2017	The NAD+-dependent deacetylase SIRT2 attenuates oxidative stress and mitochondrial dysfunction and improves insulin sensitivity in hepatocytes.	NAD	4-8	insulin	Homo sapiens	108-115	
26568959-2	2015	While pyruvate and NADH metabolic pathways are known to be involved in regulating insulin secretion in response to glucose stimulation, the roles of many other components along the metabolic pathways remain poorly understood.	NAD	19-23	insulin	Homo sapiens	82-89	
25536389-0	2015	Effect of NAD on PARP-mediated insulin sensitivity in oleic acid treated hepatocytes.	NAD	10-13	insulin	Homo sapiens	31-38	
25536389-4	2015	Furthermore, treatment with PJ34 reversed the oleic acid-induced decrease in intracellular NAD concentration, while exogenous NAD protected cells against oleic acid-induced insulin insensitivity.	NAD	126-129	insulin	Homo sapiens	173-180	
25536389-7	2015	Taken together, these data suggest that NAD depletion by PARP1 activation is essential for the modulation of insulin sensitivity in oleic acid-induced lipotoxicity.	NAD	40-43	insulin	Homo sapiens	109-116	
23813101-0	2013	Insulin resistance and dysregulation of tryptophan-kynurenine and kynurenine-nicotinamide adenine dinucleotide metabolic pathways.	NAD	77-110	insulin	Homo sapiens	0-7	
21484571-2	2011	First identified in humans as a cytokine cytokine pre-B-cell colony enhancing factor pre-B cell colony enhancing factor (PBEF PBEF ) and subsequently described as an insulin-mimetic hormone visfatin visfatin , Nampt has recently excited the scientific interest of researchers from diverse fields, including NAD biology, metabolic regulation, and inflammation.	NAD	307-310	insulin	Homo sapiens	166-173	
22332087-6	2011	Based on this synthesis, a model is proposed that links the FFA-rich environment of obesity/insulin resistance and T2DM with diminution of BCAA catabolic enzyme activity, changes in methionine oxidation and cysteine/cystine generation, and tissue redox balance (NADH/NAD+).	NAD	262-266	insulin	Homo sapiens	92-99	
22332087-6	2011	Based on this synthesis, a model is proposed that links the FFA-rich environment of obesity/insulin resistance and T2DM with diminution of BCAA catabolic enzyme activity, changes in methionine oxidation and cysteine/cystine generation, and tissue redox balance (NADH/NAD+).	NAD	267-271	insulin	Homo sapiens	92-99	
21149440-1	2011	Forkhead transcription factor FoxO1 and the NAD(+)-dependent histone deacetylase SIRT1 are evolutionarily conserved regulators of the development of aging, oxidative stress resistance, insulin resistance, and metabolism in species ranging from invertebrates to mammals.	NAD	44-50	insulin	Homo sapiens	185-192	
19344310-0	2009	Overexpression of the malate-aspartate NADH shuttle member Aralar1 in the clonal beta-cell line BRIN-BD11 enhances amino-acid-stimulated insulin secretion and cell metabolism.	NAD	39-43	insulin	Homo sapiens	137-144	
20638297-5	2010	These studies suggest that insulin signaling underpins mitochondrial electron transport chain integrity and activity by suppressing FOXO1/HMOX1 and maintaining the NAD(+)/NADH ratio, the mediator of the SIRT1/PGC1alpha pathway for mitochondrial biogenesis and function.	NAD	164-170	insulin	Homo sapiens	27-34	
20638297-5	2010	These studies suggest that insulin signaling underpins mitochondrial electron transport chain integrity and activity by suppressing FOXO1/HMOX1 and maintaining the NAD(+)/NADH ratio, the mediator of the SIRT1/PGC1alpha pathway for mitochondrial biogenesis and function.	NAD	171-175	insulin	Homo sapiens	27-34	
19273250-2	2009	For the past several years, studies on the mammalian NAD-dependent protein deacetylase SIRT1 and systemic NAD biosynthesis mediated by nicotinamide phosphoribosyltransferase (NAMPT) have demonstrated that these two regulatory components together play a critical role in the regulation of glucose homeostasis, particularly in the regulation of glucose-stimulated insulin secretion in pancreatic beta cells.	NAD	53-56	insulin	Homo sapiens	362-369	
19273250-2	2009	For the past several years, studies on the mammalian NAD-dependent protein deacetylase SIRT1 and systemic NAD biosynthesis mediated by nicotinamide phosphoribosyltransferase (NAMPT) have demonstrated that these two regulatory components together play a critical role in the regulation of glucose homeostasis, particularly in the regulation of glucose-stimulated insulin secretion in pancreatic beta cells.	NAD	106-109	insulin	Homo sapiens	362-369	
12909186-2	2003	HYPOTHESIS: We hypothesised that this was due to the following effects of alcohol: (1) alcohol metabolism increases NADH, leading to a reduction in hepatic gluconeogenesis; (2) increased glycogen phosphorylase activity depletes hepatic glycogen stores; (3) after the alcohol is metabolised, hepatic insulin sensitivity is increased, leading to the restoration of glycogen stores and reduction in blood glucose levels; and (4) consequently, after several hours, glycogen stores and insulin sensitivity return to normal.	NAD	116-120	insulin	Homo sapiens	299-306	
12238047-0	2002	[Role of NADH shuttle system in glucose-stimulated insulin secretion].	NAD	9-13	insulin	Homo sapiens	51-58	
8511877-1	1993	Insulin-stimulated synthesis of plasma membraneous "signal" ATP (psATP) from ADP and P(i) in oxidation coupled with that of NADH was detected in a preparation of plasma membranes from human erythrocytes; psATP was formed at concentrations of 10(-8)-10(-9) M. Effect of medicinal plasmapheresis on ability of erythrocyte membranes to produce psATP was studied.	NAD	124-128	insulin	Homo sapiens	0-7	
34718610-7	2022	In transfected HepG2 cells, both variants significantly increased MDH2 enzymatic activity, thereby decreasing the NAD+/NADH ratio - a change known to affect insulin signaling and secretion.	NAD	114-118	insulin	Homo sapiens	157-164	
34718610-7	2022	In transfected HepG2 cells, both variants significantly increased MDH2 enzymatic activity, thereby decreasing the NAD+/NADH ratio - a change known to affect insulin signaling and secretion.	NAD	119-123	insulin	Homo sapiens	157-164	
34629354-2	2021	The diabetogenic agents, alloxan and streptozotocin, caused DNA strand breaks, which in turn activated poly(ADP-ribose) polymerase/synthetase (PARP) to deplete NAD+, thereby inhibiting islet beta-cell functions such as proinsulin synthesis and ultimately leading to beta-cell necrosis.	NAD	160-164	insulin	Homo sapiens	219-229	
34180254-2	2022	As the metabolic and redox hub, mitochondria provide numerous links to the plasma membrane channels, insulin granule vesicles (IGVs), cell redox, NADH, NADPH, and Ca2+-homeostasis, all affecting insulin secretion.	NAD	146-150	insulin	Homo sapiens	195-202	
34233170-3	2021	(2021) now provide the clinical evidence that an NAD+ booster increases muscle insulin sensitivity in postmenopausal prediabetic women, validating the therapeutic promises of NAD+ boosters in humans.	NAD	49-53	insulin	Homo sapiens	79-86	
35134563-6	2022	ATP and NADH, derivatives of adenosine, inhibit insulin signaling inside cells by downregulation of activities of AMPK and SIRT1, respectively.	NAD	8-12	insulin	Homo sapiens	48-55	
35134563-8	2022	Current evidence suggests that ATP, NADH, cGAMP and uridine are potential biomarkers of insulin resistance.	NAD	36-40	insulin	Homo sapiens	88-95	
2988200-1	1985	In the particles enriched with plasmatic membranes of target cells (human erythrocytes, skeletal muscles and adipocytes of rats) ATP was steadily formed within 1 min of incubation of the particles with insulin (4 microgram/ml) in the medium containing Tris-HCl buffer, pH 7.5, ADP, Mg2+, inorganic phosphate, NaF, during NADH oxidation in presence of cytochrome c and oxygen (30 degrees).	NAD	321-325	insulin	Homo sapiens	202-209	
35173682-6	2021	NAD+-increasing interventions improved capacity to exercise, decreased blood pressure, increased the anti-inflammatory profile and insulin-stimulated glucose disposal, and reduced the fat-free mass.	NAD	0-4	insulin	Homo sapiens	131-138	
36318-7	1979	Our data suggest that the insulin-releasing action of leucine depends on the islets" NADPH and reduced glutathione (GSH); in addition, leucine may contribute to insulin secretion by increasing the islet NADPH:NADP ratio and the NADH:NAD ratio.	NAD	228-232	insulin	Homo sapiens	26-33	
6292673-0	1982	Does an increase in the ratio of cytoplasmic NADPH to NADP+ accompanied by a decrease in the ratio of cytoplasmic NADH to NAD+ mediate the actions of insulin?	NAD	114-118	insulin	Homo sapiens	150-157	
6292673-0	1982	Does an increase in the ratio of cytoplasmic NADPH to NADP+ accompanied by a decrease in the ratio of cytoplasmic NADH to NAD+ mediate the actions of insulin?	NAD	122-126	insulin	Homo sapiens	150-157	
36318-7	1979	Our data suggest that the insulin-releasing action of leucine depends on the islets" NADPH and reduced glutathione (GSH); in addition, leucine may contribute to insulin secretion by increasing the islet NADPH:NADP ratio and the NADH:NAD ratio.	NAD	85-88	insulin	Homo sapiens	26-33	
33606677-5	2021	Further, additional results suggest that NAD+ conversion to a second messenger, cyclic ADP ribose (cADPR), via ADP ribosyl cyclase/cADPR hydrolase (CD38) is required for imeglimin"s effects in islets, thus representing a potential link between increased NAD+ and enhanced glucose-induced Ca2+ mobilization which-in turn-is known to drive insulin granule exocytosis.	NAD	41-45	insulin	Homo sapiens	338-345	
33543238-2	2021	The major purpose of the present study was to test the hypothesis that NAD+ in white adipose tissue (WAT) is a regulator of whole-body metabolic flexibility in response to changes in insulin sensitivity and with respect to substrate availability and use during feeding and fasting conditions.	NAD	71-75	insulin	Homo sapiens	183-190	
33442387-1	2020	Sirtuins, NAD + dependent proteins belonging to class III histone deacetylases, are involved in regulating numerous cellular processes including cellular stress, insulin resistance, inflammation, mitochondrial biogenesis, chromatin silencing, cell cycle regulation, transcription, and apoptosis.	NAD	10-13	insulin	Homo sapiens	162-169	
32305451-0	2020	Interplay between NADH oxidation by complex I, glutathione redox state and sirtuin-3, and its role in the development of insulin resistance.	NAD	18-22	insulin	Homo sapiens	121-128	
32305451-4	2020	We propose that maintenance of proper NADH/NAD+ and GSH/GSSG ratios are central to ameliorate insulin resistance, as alterations in these redox couples lead to complex I dysfunction, disruption of SIRT-3 activity, ROS production and impaired beta-oxidation, the latter two being key effectors of insulin resistance.	NAD	38-42	insulin	Homo sapiens	94-101