PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11037109-10	2000	Except for AKR1C4, the enzymes had a strong preference for NADPH over NADH, and the highest activities were measured with an NADPH-regenerating system.	NAD	70-74	aldo-keto reductase family 1 member C4	Homo sapiens	11-17	
12416991-7	2002	Two-substrate kinetic analysis and dead-end inhibition studies for 5alpha-DHP reduction and allopregnanolone oxidation indicated that 3alpha-HSD type III utilized a ternary complex (sequential) kinetic mechanism, with nicotinamide adenine dinucleotide cofactor binding before steroid substrate and leaving after steroid product.	NAD	218-251	aldo-keto reductase family 1 member C4	Homo sapiens	134-144	
15383625-12	2004	Using NAD+, the 3-hydroxymetabolites were efficiently oxidized by homogeneous recombinant AKR1C2 and AKR1C4.	NAD	6-10	aldo-keto reductase family 1 member C4	Homo sapiens	101-107	
30794798-2	2019	3alpha-HSD/CR uses remote binding interactions to accelerate the reaction of androsterone with NAD+.	NAD	95-99	aldo-keto reductase family 1 member C4	Homo sapiens	0-10	
2559189-5	1989	Reduced nicotinamideadenine dinucleotide was produced on the immobilized 3 alpha-HSD column and then determined fluorometrically.	NAD	8-40	aldo-keto reductase family 1 member C4	Homo sapiens	73-84	
30794798-3	2019	Here, we examine the enthalpic and entropic components of the remote binding energy in the 3alpha-HSD/CR-catalyzed reaction of NAD+ with androsterone versus the substrate analogs, 2-decalol and cyclohexanol, by analyzing the temperature-dependent kinetic parameters through steady-state kinetics.	NAD	127-131	aldo-keto reductase family 1 member C4	Homo sapiens	91-101	
28137513-1	2017	3alpha-Hydroxysteroid dehydrogenase/carbonyl reductase (3alpha-HSD/CR) catalyzes the oxidation of androsterone with NAD+ to form androstanedione and NADH with the rate limiting step being the release of NADH.	NAD	116-120	aldo-keto reductase family 1 member C4	Homo sapiens	56-66	
28137513-1	2017	3alpha-Hydroxysteroid dehydrogenase/carbonyl reductase (3alpha-HSD/CR) catalyzes the oxidation of androsterone with NAD+ to form androstanedione and NADH with the rate limiting step being the release of NADH.	NAD	149-153	aldo-keto reductase family 1 member C4	Homo sapiens	56-66	
28137513-1	2017	3alpha-Hydroxysteroid dehydrogenase/carbonyl reductase (3alpha-HSD/CR) catalyzes the oxidation of androsterone with NAD+ to form androstanedione and NADH with the rate limiting step being the release of NADH.	NAD	203-207	aldo-keto reductase family 1 member C4	Homo sapiens	56-66	
28137513-5	2017	The rate limiting step is hydride transfer for 3alpha-HSD/CR catalyzing the reaction of cyclohexanol with NAD+ based on the observed rapid equilibrium ordered mechanism and equal deuterium isotope effects of 3.9 on V and V/K for cyclohexanol.	NAD	106-110	aldo-keto reductase family 1 member C4	Homo sapiens	47-57