PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18445470-6 2008 In the final step, the ammonia is then converted to NAD by NAD synthetase (EC 6.3.1.5). NAD 52-55 NAD synthetase 1 Homo sapiens 59-73 25890336-6 2015 Following initial validation, pathways that include NAD synthetase 1 (NADSYN1) and protein kinase B (AKT2) were hypothesized and experimentally tested to provide a mechanistic basis for AMPK regulation of cell migration and maintenance of cellular NAD(+) concentrations during catabolic processes. NAD 248-254 NAD synthetase 1 Homo sapiens 52-68 25890336-6 2015 Following initial validation, pathways that include NAD synthetase 1 (NADSYN1) and protein kinase B (AKT2) were hypothesized and experimentally tested to provide a mechanistic basis for AMPK regulation of cell migration and maintenance of cellular NAD(+) concentrations during catabolic processes. NAD 248-254 NAD synthetase 1 Homo sapiens 70-77 22720044-2 2012 The last step of NAD synthesis is the ATP-dependent amidation of deamido-NAD by NAD synthetase (NADS). NAD 17-20 NAD synthetase 1 Homo sapiens 80-94 22720044-2 2012 The last step of NAD synthesis is the ATP-dependent amidation of deamido-NAD by NAD synthetase (NADS). NAD 17-20 NAD synthetase 1 Homo sapiens 96-100 17395143-3 2007 In this system, NAADP is first converted into nicotinic acid adenine dinucleotide (NAAD) by alkaline phosphatase, after which the NAAD is converted to NAD, AMP, and PPi by NAD synthetase (NADS) in the presence of ATP and ammonia. NAD 151-154 NAD synthetase 1 Homo sapiens 172-186 10403507-3 1999 Raised activities of two enzymes catalysing NAD synthesis from nicotinic acid (nicotinic acid phosphoribosyltransferase: NAPRT, and NAD synthetase: NADs) was found in erythrocyte lysates from all patients. NAD 44-47 NAD synthetase 1 Homo sapiens 132-146 16305310-1 2005 NAD synthetase is responsible for the conversion of nicotinic acid adenine dinucleotide to nicotinamide adenine dinucleotide. NAD 91-124 NAD synthetase 1 Homo sapiens 0-14 12547821-5 2003 Consistent with the domain structures, biochemical assays indicated (i) that both NADsyn1 and NADsyn2 have NAD synthetase activity, (ii) that NADsyn1 uses glutamine as well as ammonia as an amide donor, whereas NADsyn2 catalyzes only ammonia-dependent NAD synthesis, and (iii) that mutant NADsyn1 in which Cys-175 corresponding to the catalytic cysteine residue in nitrilases was replaced with Ser does not use glutamine. NAD 82-85 NAD synthetase 1 Homo sapiens 107-121 12547821-5 2003 Consistent with the domain structures, biochemical assays indicated (i) that both NADsyn1 and NADsyn2 have NAD synthetase activity, (ii) that NADsyn1 uses glutamine as well as ammonia as an amide donor, whereas NADsyn2 catalyzes only ammonia-dependent NAD synthesis, and (iii) that mutant NADsyn1 in which Cys-175 corresponding to the catalytic cysteine residue in nitrilases was replaced with Ser does not use glutamine. NAD 82-85 NAD synthetase 1 Homo sapiens 142-149 12547821-5 2003 Consistent with the domain structures, biochemical assays indicated (i) that both NADsyn1 and NADsyn2 have NAD synthetase activity, (ii) that NADsyn1 uses glutamine as well as ammonia as an amide donor, whereas NADsyn2 catalyzes only ammonia-dependent NAD synthesis, and (iii) that mutant NADsyn1 in which Cys-175 corresponding to the catalytic cysteine residue in nitrilases was replaced with Ser does not use glutamine. NAD 82-85 NAD synthetase 1 Homo sapiens 142-149 31883644-2 2020 Here we present five individuals from four unrelated families, individuals who share similar phenotypes with disease-causal bi-allelic variants in NADSYN1, encoding NAD synthetase 1, the final enzyme of the nicotinamide adenine dinucleotide (NAD) de novo synthesis pathway. NAD 207-240 NAD synthetase 1 Homo sapiens 147-154 35491967-1 2022 Congenital nicotinamide adenine dinucleotide (NAD) deficiency disorders are associated with pathogenic variants in the genes NADSYN1, HAAO, and KYNU. NAD 11-44 NAD synthetase 1 Homo sapiens 125-132 32179648-2 2020 The prokaryotic NAD synthetase enzyme NadE catalyzes the last step of NAD+ biosynthesis, converting nicotinic acid adenine dinucleotide (NaAD) to NAD+ Some members of the NadE family use l-glutamine as a nitrogen donor and are named NadEGln Previous gene neighborhood analysis has indicated that the bacterial nadE gene is frequently clustered with the gene encoding the regulatory signal transduction protein PII, suggesting a functional relationship between these proteins in response to the nutritional status and the carbon/nitrogen ratio of the bacterial cell. NAD 70-74 NAD synthetase 1 Homo sapiens 16-30 32179648-2 2020 The prokaryotic NAD synthetase enzyme NadE catalyzes the last step of NAD+ biosynthesis, converting nicotinic acid adenine dinucleotide (NaAD) to NAD+ Some members of the NadE family use l-glutamine as a nitrogen donor and are named NadEGln Previous gene neighborhood analysis has indicated that the bacterial nadE gene is frequently clustered with the gene encoding the regulatory signal transduction protein PII, suggesting a functional relationship between these proteins in response to the nutritional status and the carbon/nitrogen ratio of the bacterial cell. NAD 146-150 NAD synthetase 1 Homo sapiens 16-30 31883644-2 2020 Here we present five individuals from four unrelated families, individuals who share similar phenotypes with disease-causal bi-allelic variants in NADSYN1, encoding NAD synthetase 1, the final enzyme of the nicotinamide adenine dinucleotide (NAD) de novo synthesis pathway. NAD 207-240 NAD synthetase 1 Homo sapiens 165-181 31883644-2 2020 Here we present five individuals from four unrelated families, individuals who share similar phenotypes with disease-causal bi-allelic variants in NADSYN1, encoding NAD synthetase 1, the final enzyme of the nicotinamide adenine dinucleotide (NAD) de novo synthesis pathway. NAD 147-150 NAD synthetase 1 Homo sapiens 165-181 31883644-7 2020 Thus, NADSYN1 represents an additional gene required for NAD synthesis during embryogenesis, and NADSYN1 has bi-allelic missense variants that cause NAD deficiency-dependent malformations. NAD 57-60 NAD synthetase 1 Homo sapiens 6-13