PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35616339-8	2022	The circadian metabolite, NAD+ , serves as a crucial link connecting clock genes to sirtuin activity.	NAD	26-30	clock circadian regulator	Homo sapiens	69-74	
35616339-9	2022	This is because, NAMPT which is a rate limiting enzyme in NAD+ biosynthesis is transcriptionally regulated by the clock genes and NAD+ in turn is a cofactor regulating the deacetylation activity of sirtuins.	NAD	58-62	clock circadian regulator	Homo sapiens	114-119	
35616339-9	2022	This is because, NAMPT which is a rate limiting enzyme in NAD+ biosynthesis is transcriptionally regulated by the clock genes and NAD+ in turn is a cofactor regulating the deacetylation activity of sirtuins.	NAD	130-134	clock circadian regulator	Homo sapiens	114-119	
35616339-11	2022	Thus, the Clock-NAD+-Sirtuin connection represents a novel "feedback loop" circuit that regulates the metabolic machinery.	NAD	16-20	clock circadian regulator	Homo sapiens	10-15	
35616339-12	2022	The current review underpins the importance of NAD+ on the sirtuin and clock connection in preventing fatty liver disorder.	NAD	47-51	clock circadian regulator	Homo sapiens	71-76	
18662537-4	2008	(2008) now demonstrate that the NAD(+)-dependent enzyme SIRT1 functions as a histone deacetylase that counteracts the activity of CLOCK.	NAD	32-38	clock circadian regulator	Homo sapiens	130-135	
21048160-6	2010	A search for the histone deacetylase (HDAC) that counterbalances CLOCK activity revealed that SIRT1, a nicotinamide adenin dinucleotide (NAD(+))-dependent HDAC, functions in a circadian manner.	NAD	137-144	clock circadian regulator	Homo sapiens	65-70	
19299583-0	2009	Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis.	NAD	54-58	clock circadian regulator	Homo sapiens	10-15	
19299583-2	2009	Here we report that both the rate-limiting enzyme in mammalian nicotinamide adenine dinucleotide (NAD+) biosynthesis, nicotinamide phosphoribosyltransferase (NAMPT), and levels of NAD+ display circadian oscillations that are regulated by the core clock machinery in mice.	NAD	63-96	clock circadian regulator	Homo sapiens	247-252	
19299583-2	2009	Here we report that both the rate-limiting enzyme in mammalian nicotinamide adenine dinucleotide (NAD+) biosynthesis, nicotinamide phosphoribosyltransferase (NAMPT), and levels of NAD+ display circadian oscillations that are regulated by the core clock machinery in mice.	NAD	98-102	clock circadian regulator	Homo sapiens	247-252	
19299583-4	2009	In turn, the circadian transcription factor CLOCK binds to and up-regulates Nampt, thus completing a feedback loop involving NAMPT/NAD+ and SIRT1/CLOCK:BMAL1.	NAD	131-135	clock circadian regulator	Homo sapiens	44-49	
33388853-2	2021	Sirtuins (SIRTs) are nuclear, cytoplasmic and mitochondrial histone deacetylases that influence the circadian clock with clock-controlled oscillatory protein, NAMPT, and its metabolite NAD+.	NAD	185-189	clock circadian regulator	Homo sapiens	110-115	
33388853-4	2021	This review focuses on SIRT1, an NAD+-dependent class III histone deacetylase which counterbalances the intrinsic histone acetyltransferase activity of one of the clock genes, CLOCK.	NAD	33-36	clock circadian regulator	Homo sapiens	163-168	
33388853-4	2021	This review focuses on SIRT1, an NAD+-dependent class III histone deacetylase which counterbalances the intrinsic histone acetyltransferase activity of one of the clock genes, CLOCK.	NAD	33-36	clock circadian regulator	Homo sapiens	176-181	
33038659-5	2020	SIRT1 that is an NAD+-dependent deacetylase positively regulates circadian clock and telomere homeostasis.	NAD	17-20	clock circadian regulator	Homo sapiens	75-80	
22179986-6	2011	A search for the histone deacetylase (HDAC) that counterbalanced CLOCK activity revealed that SIRT1, a nicotinamide adenine dinucleotide (NAD(+))-dependent HDAC, functions in a circadian manner.	NAD	103-136	clock circadian regulator	Homo sapiens	65-70	
22179986-6	2011	A search for the histone deacetylase (HDAC) that counterbalanced CLOCK activity revealed that SIRT1, a nicotinamide adenine dinucleotide (NAD(+))-dependent HDAC, functions in a circadian manner.	NAD	138-145	clock circadian regulator	Homo sapiens	65-70