PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35369299-4 2022 Sirtuin 3 (SIRT3) is one of the seven mammalian sirtuins (SIRT1 to SIRT7), with NAD+ dependent deacetylase activity. NAD 80-83 sirtuin 7 Homo sapiens 67-72 34128977-5 2021 SIRT7, as a NAD+-dependent histone desuccinylase, could bind to cccDNA through interaction with HBV core protein where it catalysed histone H3K122 desuccinylation. NAD 12-15 sirtuin 7 Homo sapiens 0-5 34604215-2 2021 SIRT7 is a NAD+-dependent protein deacetylase. NAD 11-14 sirtuin 7 Homo sapiens 0-5 35616339-6 2022 Sirtuins (SIRT1-SIRT7) are a highly conserved family of nicotinamide adenine dinucleotide (NAD+)-dependent deacetylases, protecting cells from metabolic stress by deacetylating vital proteins associated with lipid metabolism. NAD 56-89 sirtuin 7 Homo sapiens 16-21 35616339-6 2022 Sirtuins (SIRT1-SIRT7) are a highly conserved family of nicotinamide adenine dinucleotide (NAD+)-dependent deacetylases, protecting cells from metabolic stress by deacetylating vital proteins associated with lipid metabolism. NAD 91-95 sirtuin 7 Homo sapiens 16-21 33749979-5 2021 Moreover, SIRT7 interacts with KCC4 in a NAD+ -dependent manner and increases its stability and activity in HEK293 cells. NAD 41-45 sirtuin 7 Homo sapiens 10-15 32861997-1 2020 SIRT7 is a member of the mammalian sirtuins and functions as an NAD+-dependent deacylase. NAD 64-67 sirtuin 7 Homo sapiens 0-5 33738675-4 2021 In mammals, sirtuin family comprises seven members (SIRT1-SIRT7), and they all possess a conserved NAD+ binding catalytic domain, termed the sirtuin core domain which is imperative for their activity. NAD 99-103 sirtuin 7 Homo sapiens 58-63 33440786-4 2021 In this review, we provide an overview of the current knowledge of NAD+ metabolism, highlighting the functional liaison with mono(ADP-ribosyl)ating enzymes, such as the well-known ARTD10 (also named PARP10), SIRT6, and SIRT7. NAD 67-71 sirtuin 7 Homo sapiens 219-224 32403131-1 2021 CONTEXT: The sirtuins (SIRT1 to SIRT7) constitute a family of highly conserved nicotinamide adenine dinucleotide-dependent proteins. NAD 79-112 sirtuin 7 Homo sapiens 32-37 31970414-1 2020 NAD+-dependent SIRT7 deacylase plays essential roles in ribosome biogenesis, stress response, genome integrity, metabolism and aging, while how it is transcriptionally regulated is still largely unclear. NAD 0-3 sirtuin 7 Homo sapiens 15-20 32586688-1 2020 Sirtuin 7 (SIRT7) is a NAD+ (nicotinamide adenine dinucleotide) dependent deacetylase that is reported to contribute to tumour growth and invasion by selectively acting on histone H3K18. NAD 23-26 sirtuin 7 Homo sapiens 0-9 32586688-1 2020 Sirtuin 7 (SIRT7) is a NAD+ (nicotinamide adenine dinucleotide) dependent deacetylase that is reported to contribute to tumour growth and invasion by selectively acting on histone H3K18. NAD 23-26 sirtuin 7 Homo sapiens 11-16 32586688-1 2020 Sirtuin 7 (SIRT7) is a NAD+ (nicotinamide adenine dinucleotide) dependent deacetylase that is reported to contribute to tumour growth and invasion by selectively acting on histone H3K18. NAD 29-62 sirtuin 7 Homo sapiens 0-9 32586688-1 2020 Sirtuin 7 (SIRT7) is a NAD+ (nicotinamide adenine dinucleotide) dependent deacetylase that is reported to contribute to tumour growth and invasion by selectively acting on histone H3K18. NAD 29-62 sirtuin 7 Homo sapiens 11-16 32519817-4 2020 We further demonstrated that the NAD-dependent protein deacetylase, SIRT7, and the FOXO4 transcription factor acted as endogenous brakes for GLS1 expression, which are inhibited by TGF-beta. NAD 33-36 sirtuin 7 Homo sapiens 68-73 31843644-7 2020 In this study, we also find that the SIRT7 enzyme can specifically transfer a single moiety of ADP ribose on other nuclear proteins, with a preference for NAD+. NAD 155-158 sirtuin 7 Homo sapiens 37-42 31025603-1 2020 The sirtuin family comprises seven NAD+-dependent histone deacetylases named SIRT1 to SIRT7. NAD 35-39 sirtuin 7 Homo sapiens 86-91 31025603-9 2020 Preferred orientations of NAD+ and acetyl-lysine inside SIRT7 were found, with all components forming a stable complex. NAD 26-30 sirtuin 7 Homo sapiens 56-61 29879377-1 2018 SIRT7, a member of the sirtuin family, with coenzyme NAD catalyzes protein deacetylation and has been implicated in multiple biologic processes; however, its function in mammalian oocytes remains to be explored. NAD 53-56 sirtuin 7 Homo sapiens 0-5 30453040-3 2019 As a family of NAD+ dependent protein modifying enzymes, sirtuins (SIRT1-SIRT7) have multiple catalytic functions such as deacetylase, desuccinylase, demalonylase, demyristoylase, depalmitoylase, and/or mono-ADP-ribosyltransferase. NAD 15-18 sirtuin 7 Homo sapiens 73-78 31075303-1 2019 Sirtuin 7 (SIRT7) is an NAD+-dependent lysine deacetylase that regulates diverse biological processes. NAD 24-27 sirtuin 7 Homo sapiens 0-9 31075303-1 2019 Sirtuin 7 (SIRT7) is an NAD+-dependent lysine deacetylase that regulates diverse biological processes. NAD 24-27 sirtuin 7 Homo sapiens 11-16 31206100-7 2019 H2AQ104 methylation and chromatin dynamics are regulated by fibrillarin (FBL) and the NAD+-dependent nucleolar deacetylase sirtuin 7 (SIRT7). NAD 86-90 sirtuin 7 Homo sapiens 123-132 31206100-7 2019 H2AQ104 methylation and chromatin dynamics are regulated by fibrillarin (FBL) and the NAD+-dependent nucleolar deacetylase sirtuin 7 (SIRT7). NAD 86-90 sirtuin 7 Homo sapiens 134-139 30655851-1 2019 Sirtuin-7 is an evolutionarily conserved NAD-dependent deacetylase, which serves an important role in carcinogenesis. NAD 41-44 sirtuin 7 Homo sapiens 0-9 30090057-1 2018 Sirtuin enzymes are a family of highly seven conserved protein deacetylases, namely SIRT1 through SIRT7, whose enzymatic activities require the cofactor nicotinamide adenine dinucleotide (NAD+). NAD 153-186 sirtuin 7 Homo sapiens 98-103 30090057-1 2018 Sirtuin enzymes are a family of highly seven conserved protein deacetylases, namely SIRT1 through SIRT7, whose enzymatic activities require the cofactor nicotinamide adenine dinucleotide (NAD+). NAD 188-192 sirtuin 7 Homo sapiens 98-103 28655758-1 2017 Sirtuin 7 (SIRT7), a member of the NAD+-dependent class III histone deacetylases, is involved in the regulation of various cellular processes and in resisting various stresses, such as hypoxia, low glucose levels, and DNA damage. NAD 35-39 sirtuin 7 Homo sapiens 0-9 28655758-1 2017 Sirtuin 7 (SIRT7), a member of the NAD+-dependent class III histone deacetylases, is involved in the regulation of various cellular processes and in resisting various stresses, such as hypoxia, low glucose levels, and DNA damage. NAD 35-39 sirtuin 7 Homo sapiens 11-16 27882448-1 2017 Sirtuins (SIRT1-SIRT7) are unique histone deacetylases (HDACs) whose activity depends on NAD+ levels and thus on the cellular metabolic status. NAD 89-93 sirtuin 7 Homo sapiens 16-21 26704979-3 2016 Here we showed that the human Dicer protein interacts with SIRT7, an NAD(+)-dependent H3K18Ac (acetylated lysine 18 of histone H3) deacetylase, and holds a proportion of SIRT7 in the cytoplasm. NAD 69-75 sirtuin 7 Homo sapiens 59-64 27498548-1 2016 BACKGROUND: SIRT7 is one of the histone deacetylases and is NAD-dependent. NAD 60-63 sirtuin 7 Homo sapiens 12-17 26704979-3 2016 Here we showed that the human Dicer protein interacts with SIRT7, an NAD(+)-dependent H3K18Ac (acetylated lysine 18 of histone H3) deacetylase, and holds a proportion of SIRT7 in the cytoplasm. NAD 69-75 sirtuin 7 Homo sapiens 170-175 25970806-1 2015 SIRT7 with coenzyme NAD catalyzes protein de-acetylation. NAD 20-23 sirtuin 7 Homo sapiens 0-5 26112889-1 2015 Sirtuins (Sirt1-Sirt7) comprise a family of nicotinamide adenine dinucleotide (NAD(+))-dependent enzymes. NAD 44-77 sirtuin 7 Homo sapiens 16-21 26112889-1 2015 Sirtuins (Sirt1-Sirt7) comprise a family of nicotinamide adenine dinucleotide (NAD(+))-dependent enzymes. NAD 79-85 sirtuin 7 Homo sapiens 16-21 25921180-1 2015 BACKGROUND: Sirtuin7 (SIRT7) is a type of nicotinamide adenine dinucleotide oxidized form (NAD+)-dependent deacetylase and the least understood member of the sirtuins family; it is implicated in various processes, such as aging, DNA damage repair and cell signaling transduction. NAD 42-75 sirtuin 7 Homo sapiens 12-20 25860861-4 2015 Here we report that Sirt7, a NAD(+)-dependent class III histone deacetylase, is over-expressed in human gastric cancer tissues. NAD 29-35 sirtuin 7 Homo sapiens 20-25 25921180-1 2015 BACKGROUND: Sirtuin7 (SIRT7) is a type of nicotinamide adenine dinucleotide oxidized form (NAD+)-dependent deacetylase and the least understood member of the sirtuins family; it is implicated in various processes, such as aging, DNA damage repair and cell signaling transduction. NAD 42-75 sirtuin 7 Homo sapiens 22-27 22722849-3 2012 Here we show that SIRT7 is an NAD(+)-dependent H3K18Ac (acetylated lysine 18 of histone H3) deacetylase that stabilizes the transformed state of cancer cells. NAD 30-36 sirtuin 7 Homo sapiens 18-23 24536059-1 2014 SIRT7 belongs to the Sirtuin family of NAD-dependent enzymes, the members of which play diverse roles in aging, metabolism, and disease biology. NAD 39-42 sirtuin 7 Homo sapiens 0-5 23680022-1 2013 Sirtuins belong to a class of NAD-dependent deacetylases, and include seven distinct isoforms, of which SIRT7 is the least studied member. NAD 30-33 sirtuin 7 Homo sapiens 104-109