PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19913571-5 2010 Exercise training induced SIRT1 activity due to the positive effect of exercise on the activity of nicotinamide phosphoribosyltransferase (NAMPT) and thereby the production of sirtuin-fueling NAD(+). NAD 192-198 sirtuin 1 Rattus norvegicus 26-31 20429690-2 2010 Resveratrol is a natural polyphenol that activates SIRT1, a novel cardioprotective and longevity factor having NAD(+)-dependent histone deacetylase activity. NAD 111-117 sirtuin 1 Rattus norvegicus 51-56 20617556-2 2010 The anti-inflammatory function of Sirtuin 1 (SIRT1), a NAD-dependent class III histone/protein deacetylase, has been well documented, but how SIRT1 is regulated under inflammatory conditions is largely unknown. NAD 55-58 sirtuin 1 Rattus norvegicus 34-43 20617556-2 2010 The anti-inflammatory function of Sirtuin 1 (SIRT1), a NAD-dependent class III histone/protein deacetylase, has been well documented, but how SIRT1 is regulated under inflammatory conditions is largely unknown. NAD 55-58 sirtuin 1 Rattus norvegicus 45-50 19913571-9 2010 Regular exercise decelerates the deleterious effects of the aging process via SIRT1-dependent pathways through the stimulation of NAD(+) biosynthesis by NAMPT. NAD 130-136 sirtuin 1 Rattus norvegicus 78-83 34530866-0 2021 NAD+ improves cognitive function and reduces neuroinflammation by ameliorating mitochondrial damage and decreasing ROS production in chronic cerebral hypoperfusion models through Sirt1/PGC-1alpha pathway. NAD 0-4 sirtuin 1 Rattus norvegicus 179-184 18555842-2 2008 Although the oxidized form of nicotinamide adenine dinucloetide (NAD(+))-dependent histone deacetylase SIRT1 has been shown to mediate PGC-1alpha-induced metabolic adaptation, the effect of endurance exercise on the SIRT1 protein remains to be elucidated. NAD 65-72 sirtuin 1 Rattus norvegicus 103-108 18555842-2 2008 Although the oxidized form of nicotinamide adenine dinucloetide (NAD(+))-dependent histone deacetylase SIRT1 has been shown to mediate PGC-1alpha-induced metabolic adaptation, the effect of endurance exercise on the SIRT1 protein remains to be elucidated. NAD 65-72 sirtuin 1 Rattus norvegicus 216-221 34666848-1 2022 OBJECTIVE: Since the NAD+-dependent histone deacetylases sirtuin-1 (SIRT1) and sirtuin-2 (SIRT2) are critically involved in epigenetics, endocrinology and immunology and affect the longevity in model organisms, we investigated their expression in brains of 3 month old and 14-15 month old rat model of depression Flinders Sensitive Line (FSL) and control Flinders Resistant Line (FRL) rats. NAD 21-24 sirtuin 1 Rattus norvegicus 57-66 19299582-2 2009 Sirtuin 1 (SIRT1) is an NAD(+)-dependent class III protein deacetylase that is known to be involved in regulating production of proinflammatory cytokines including TNF-alpha. NAD 24-30 sirtuin 1 Rattus norvegicus 0-9 19299582-2 2009 Sirtuin 1 (SIRT1) is an NAD(+)-dependent class III protein deacetylase that is known to be involved in regulating production of proinflammatory cytokines including TNF-alpha. NAD 24-30 sirtuin 1 Rattus norvegicus 11-16 19071213-1 2009 Resveratrol increases longevity through SirT1, which is activated with NAD(+) supplied by an anti-aging enzyme PBEF. NAD 71-77 sirtuin 1 Rattus norvegicus 40-45 15716268-4 2005 In PC12 cells, increased expression of the NAD-dependent deacetylase SIRT1 reduces cellular oxygen consumption by approximately 25%. NAD 43-46 sirtuin 1 Rattus norvegicus 69-74 34861210-3 2022 In this study, we found that the expression of Sirtuin 1 (SIRT1), a nicotinamide adenine dinucleotide (NAD+)-dependent histone deacetylase, was downregulated significantly in the hippocampus of streptozotocin (STZ)-induced diabetic cognitive impairment rats. NAD 68-101 sirtuin 1 Rattus norvegicus 47-56 34861210-3 2022 In this study, we found that the expression of Sirtuin 1 (SIRT1), a nicotinamide adenine dinucleotide (NAD+)-dependent histone deacetylase, was downregulated significantly in the hippocampus of streptozotocin (STZ)-induced diabetic cognitive impairment rats. NAD 68-101 sirtuin 1 Rattus norvegicus 58-63 34861210-3 2022 In this study, we found that the expression of Sirtuin 1 (SIRT1), a nicotinamide adenine dinucleotide (NAD+)-dependent histone deacetylase, was downregulated significantly in the hippocampus of streptozotocin (STZ)-induced diabetic cognitive impairment rats. NAD 103-107 sirtuin 1 Rattus norvegicus 47-56 34861210-3 2022 In this study, we found that the expression of Sirtuin 1 (SIRT1), a nicotinamide adenine dinucleotide (NAD+)-dependent histone deacetylase, was downregulated significantly in the hippocampus of streptozotocin (STZ)-induced diabetic cognitive impairment rats. NAD 103-107 sirtuin 1 Rattus norvegicus 58-63 34530866-10 2021 Results of mechanistic pathway analysis indicated that the detrimental effects of CCH might be associated with decreased gene expression of PPAR-gamma co-activator1alpha (PGC-1alpha) and its upstream transcription factor Sirt1, while NAD+ treatment markedly reversed their decrease. NAD 234-238 sirtuin 1 Rattus norvegicus 221-226 34530866-11 2021 In vitro study confirmed that NAD+ administration had protective effects on hypoxia-induced neuroinflammation and mitochondrial damage, as well as ROS production in BV2 microglia via Sirt1/PGC-1alpha pathway. NAD 30-34 sirtuin 1 Rattus norvegicus 183-188 34530866-12 2021 Sirt1 overexpression mimicked the protective effects of NAD+ treatment in BV2 microglia. NAD 56-60 sirtuin 1 Rattus norvegicus 0-5 34530866-13 2021 CONCLUSIONS: NAD+ ameliorated cognitive impairment and dampened neuroinflammation in CCH models in vivo and in vitro, and these beneficial effects were associated with mitochondrial protection and ROS inhibition via activating Sirt1/PGC-1alpha pathway. NAD 13-17 sirtuin 1 Rattus norvegicus 227-232 35250263-9 2022 MG can significantly inhibit the activity of AChE and increase the level of NAD+, thereby further up-regulated the expression levels of alpha7nAChR and SIRT1. NAD 76-80 sirtuin 1 Rattus norvegicus 152-157 34265417-2 2021 Sirtuin 1(SIRT1) is an NAD+-dependent histone deacetylase and transcriptional enhancer of GR. NAD 23-26 sirtuin 1 Rattus norvegicus 0-9 34265417-2 2021 Sirtuin 1(SIRT1) is an NAD+-dependent histone deacetylase and transcriptional enhancer of GR. NAD 23-26 sirtuin 1 Rattus norvegicus 10-15 32087266-6 2020 Meanwhile, NAD+ booster nicotinamide mononucleotide also counteracted the deleterious effects of ethanol by increasing SIRT1, suggesting the regulation of SIRT1-UCP2 axis may be associated with cellular NAD+/NADH ratio. NAD 11-15 sirtuin 1 Rattus norvegicus 119-124 35207470-13 2022 Cytosolic NAD+ concentration is diminished by PA-induced ER stress, leading to decreased Sirt1 activity. NAD 10-14 sirtuin 1 Rattus norvegicus 89-94 32228195-3 2020 Nicotinamide adenine dinucleotide-dependent deacetylase sirtuin-1 (SIRT1)/forkhead box O3 (FOXO3a) signaling is critical for maintaining neuronal function and regulation of the apoptotic pathway. NAD 0-33 sirtuin 1 Rattus norvegicus 56-65 32228195-3 2020 Nicotinamide adenine dinucleotide-dependent deacetylase sirtuin-1 (SIRT1)/forkhead box O3 (FOXO3a) signaling is critical for maintaining neuronal function and regulation of the apoptotic pathway. NAD 0-33 sirtuin 1 Rattus norvegicus 67-72 32848753-15 2020 Moreover, our study found that TMZ upregulated Sirt1 expression by increasing the expression of nicotinamide phosphoribosyl transferase (Nampt), which is a rate limiting enzyme for nicotinamide adenine dinucleotide (NAD+) generation by salvage pathway. NAD 181-214 sirtuin 1 Rattus norvegicus 47-52 32848753-15 2020 Moreover, our study found that TMZ upregulated Sirt1 expression by increasing the expression of nicotinamide phosphoribosyl transferase (Nampt), which is a rate limiting enzyme for nicotinamide adenine dinucleotide (NAD+) generation by salvage pathway. NAD 216-220 sirtuin 1 Rattus norvegicus 47-52 32848753-16 2020 And the increased NAD+ promoted Sirt1 expression. NAD 18-22 sirtuin 1 Rattus norvegicus 32-37 32087266-6 2020 Meanwhile, NAD+ booster nicotinamide mononucleotide also counteracted the deleterious effects of ethanol by increasing SIRT1, suggesting the regulation of SIRT1-UCP2 axis may be associated with cellular NAD+/NADH ratio. NAD 11-15 sirtuin 1 Rattus norvegicus 155-160 32087266-6 2020 Meanwhile, NAD+ booster nicotinamide mononucleotide also counteracted the deleterious effects of ethanol by increasing SIRT1, suggesting the regulation of SIRT1-UCP2 axis may be associated with cellular NAD+/NADH ratio. NAD 203-207 sirtuin 1 Rattus norvegicus 155-160 32087266-6 2020 Meanwhile, NAD+ booster nicotinamide mononucleotide also counteracted the deleterious effects of ethanol by increasing SIRT1, suggesting the regulation of SIRT1-UCP2 axis may be associated with cellular NAD+/NADH ratio. NAD 208-212 sirtuin 1 Rattus norvegicus 119-124 32087266-6 2020 Meanwhile, NAD+ booster nicotinamide mononucleotide also counteracted the deleterious effects of ethanol by increasing SIRT1, suggesting the regulation of SIRT1-UCP2 axis may be associated with cellular NAD+/NADH ratio. NAD 208-212 sirtuin 1 Rattus norvegicus 155-160 32360040-2 2020 Collective evidence suggested that the activation of pulmonary nicotinamide adenine dinucleotide-dependent deacetylase sirtuin-1 (SIRT1) plays a critical role in inhibiting the production of reactive oxygen species (ROS) and tumor necrosis factor (TNF)-alpha, as well as the protection against ALI. NAD 63-96 sirtuin 1 Rattus norvegicus 119-128 32360040-2 2020 Collective evidence suggested that the activation of pulmonary nicotinamide adenine dinucleotide-dependent deacetylase sirtuin-1 (SIRT1) plays a critical role in inhibiting the production of reactive oxygen species (ROS) and tumor necrosis factor (TNF)-alpha, as well as the protection against ALI. NAD 63-96 sirtuin 1 Rattus norvegicus 130-135 29253500-5 2018 Importantly, the suppression of COL1A2 transcription following CA treatment depended on the reduction of Smad3 acetylation via the activation of Sirtuin 1 (SIRT1), a nicotinamide adenine dinucleotide+ (NAD+)-dependent deacetylase. NAD 166-199 sirtuin 1 Rattus norvegicus 145-154 31551807-12 2019 Taken together, our results demonstrated that CD38 knockdown alleviated D-gal induced cell senescence and oxidative stress via NAD+/Sirt1 signaling pathway. NAD 127-130 sirtuin 1 Rattus norvegicus 132-137 31938369-2 2018 The aim of this study was to determine whether sirtuin type 1 (SIRT1), an NAD+ dependent deacetylase, affected allodynia and hyperalgesia in neuropathic pain. NAD 74-77 sirtuin 1 Rattus norvegicus 47-61 31938369-2 2018 The aim of this study was to determine whether sirtuin type 1 (SIRT1), an NAD+ dependent deacetylase, affected allodynia and hyperalgesia in neuropathic pain. NAD 74-77 sirtuin 1 Rattus norvegicus 63-68 31583043-5 2019 Sirt1 is an NAD+-dependent deacetylase, and we showed that the expression of Sirt1 was decreased in NP tissues, while hyperglycaemia could suppress the expression and activity of Sirt1 in NP cells. NAD 12-15 sirtuin 1 Rattus norvegicus 0-5 31583043-5 2019 Sirt1 is an NAD+-dependent deacetylase, and we showed that the expression of Sirt1 was decreased in NP tissues, while hyperglycaemia could suppress the expression and activity of Sirt1 in NP cells. NAD 12-15 sirtuin 1 Rattus norvegicus 77-82 31583043-5 2019 Sirt1 is an NAD+-dependent deacetylase, and we showed that the expression of Sirt1 was decreased in NP tissues, while hyperglycaemia could suppress the expression and activity of Sirt1 in NP cells. NAD 12-15 sirtuin 1 Rattus norvegicus 77-82 31175267-0 2019 Nicotinamide phosphoribosyltransferase postpones rat bone marrow mesenchymal stem cell senescence by mediating NAD+-Sirt1 signaling. NAD 111-115 sirtuin 1 Rattus norvegicus 116-121 31175267-9 2019 Thus, Nampt suppresses MSC senescence via mediating NAD+-Sirt1 signaling. NAD 52-56 sirtuin 1 Rattus norvegicus 57-62 30649099-2 2019 Our previous results demonstrated that sirtuin 1 (SIRT1), a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, alleviates neuropathic pain in type 2 diabetes mellitus rats. NAD 60-93 sirtuin 1 Rattus norvegicus 39-48 30649099-2 2019 Our previous results demonstrated that sirtuin 1 (SIRT1), a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, alleviates neuropathic pain in type 2 diabetes mellitus rats. NAD 60-93 sirtuin 1 Rattus norvegicus 50-55 30625381-3 2019 SIRT1 is an NAD+ dependent protein deacetylase and increased availability of NAD+ has been shown to augment SIRT1 activity. NAD 12-15 sirtuin 1 Rattus norvegicus 0-5 30625381-3 2019 SIRT1 is an NAD+ dependent protein deacetylase and increased availability of NAD+ has been shown to augment SIRT1 activity. NAD 12-16 sirtuin 1 Rattus norvegicus 0-5 29253500-5 2018 Importantly, the suppression of COL1A2 transcription following CA treatment depended on the reduction of Smad3 acetylation via the activation of Sirtuin 1 (SIRT1), a nicotinamide adenine dinucleotide+ (NAD+)-dependent deacetylase. NAD 166-199 sirtuin 1 Rattus norvegicus 156-161 28688179-1 2017 SCOPE: Resveratrol has been shown to improve insulin resistance via activating the NAD+ -dependent deacetylase SIRT1, but the effects of resveratrol on ethanol-induced insulin resistance remain unclear. NAD 83-86 sirtuin 1 Rattus norvegicus 111-116 28688179-6 2017 CONCLUSION: Resveratrol exhibits benefits against ethanol-induced insulin resistance via improving the ratio of NAD+ /NADH to regulate SIRT1, which is associated with the modulation of ethanol metabolism enzymes. NAD 112-116 sirtuin 1 Rattus norvegicus 135-140 28688179-6 2017 CONCLUSION: Resveratrol exhibits benefits against ethanol-induced insulin resistance via improving the ratio of NAD+ /NADH to regulate SIRT1, which is associated with the modulation of ethanol metabolism enzymes. NAD 118-122 sirtuin 1 Rattus norvegicus 135-140 28751004-3 2017 The energy homeostasis is regulated by a network consisting of "fuel gauze" called AMP-activated protein kinase (AMPK), the NAD+ dependent type III deacetylase (SIRT1) and peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) which is disrupted in T2D. NAD 124-128 sirtuin 1 Rattus norvegicus 161-166 28017962-4 2017 Silent information regulator family protein 1 (SIRT1), a member of the NAD+-dependent protein deacetylases, has been shown to exhibit neuroprotective activities in animal models of various pathologies, including ischemic brain injury, subarachnoid hemorrhage and several neurodegenerative diseases. NAD 71-74 sirtuin 1 Rattus norvegicus 0-45 28427145-6 2017 These results indicated that COP rats have an increased capacity to maintain NAD+-dependent SIRT1 activity under genotoxic stress. NAD 77-81 sirtuin 1 Rattus norvegicus 92-97 28017962-4 2017 Silent information regulator family protein 1 (SIRT1), a member of the NAD+-dependent protein deacetylases, has been shown to exhibit neuroprotective activities in animal models of various pathologies, including ischemic brain injury, subarachnoid hemorrhage and several neurodegenerative diseases. NAD 71-74 sirtuin 1 Rattus norvegicus 47-52 27357440-1 2016 Sirt1 is a highly conserved nicotinamide adenine dinucleotide (NAD(+)) dependent histone deacetylase which plays an important role in heart diseases. NAD 28-61 sirtuin 1 Rattus norvegicus 0-5 27614022-4 2016 Because of its dependence on NAD+, Sirt1 also functions as a nutrient/redox sensor, and new novel data show a function of this enzyme in the maturation of hypothalamic peptide hormones controlling energy balance either through regulation of specific nuclear transcription factors or by regulating specific pro-hormone convertases (PCs) involved in the post-translational processing of pro-hormones. NAD 29-33 sirtuin 1 Rattus norvegicus 35-40 27357440-1 2016 Sirt1 is a highly conserved nicotinamide adenine dinucleotide (NAD(+)) dependent histone deacetylase which plays an important role in heart diseases. NAD 63-69 sirtuin 1 Rattus norvegicus 0-5 27035562-2 2016 Nicotinamide phosphoribosyltransferase (NAMPT) catalyzes the first rate-limiting step in the nicotinamide adenine dinucleotide (NAD+) biosynthetic pathway in mammals, is a substrate for NAD+-dependent enzymes, such as sirtuin 1 (SIRT1), and contributes to cell fate decisions. NAD 93-126 sirtuin 1 Rattus norvegicus 218-227 27061137-2 2016 SIRT1, one of the NAD+-dependent class III histone deacetylases, controls cellular processes and is regulated by hypoxia and inflammatory cytokines in a cell-type-dependent manner. NAD 18-22 sirtuin 1 Rattus norvegicus 0-5 27035562-2 2016 Nicotinamide phosphoribosyltransferase (NAMPT) catalyzes the first rate-limiting step in the nicotinamide adenine dinucleotide (NAD+) biosynthetic pathway in mammals, is a substrate for NAD+-dependent enzymes, such as sirtuin 1 (SIRT1), and contributes to cell fate decisions. NAD 93-126 sirtuin 1 Rattus norvegicus 229-234 27035562-2 2016 Nicotinamide phosphoribosyltransferase (NAMPT) catalyzes the first rate-limiting step in the nicotinamide adenine dinucleotide (NAD+) biosynthetic pathway in mammals, is a substrate for NAD+-dependent enzymes, such as sirtuin 1 (SIRT1), and contributes to cell fate decisions. NAD 128-132 sirtuin 1 Rattus norvegicus 218-227 27035562-2 2016 Nicotinamide phosphoribosyltransferase (NAMPT) catalyzes the first rate-limiting step in the nicotinamide adenine dinucleotide (NAD+) biosynthetic pathway in mammals, is a substrate for NAD+-dependent enzymes, such as sirtuin 1 (SIRT1), and contributes to cell fate decisions. NAD 128-132 sirtuin 1 Rattus norvegicus 229-234 27035562-2 2016 Nicotinamide phosphoribosyltransferase (NAMPT) catalyzes the first rate-limiting step in the nicotinamide adenine dinucleotide (NAD+) biosynthetic pathway in mammals, is a substrate for NAD+-dependent enzymes, such as sirtuin 1 (SIRT1), and contributes to cell fate decisions. NAD 186-190 sirtuin 1 Rattus norvegicus 218-227 27035562-2 2016 Nicotinamide phosphoribosyltransferase (NAMPT) catalyzes the first rate-limiting step in the nicotinamide adenine dinucleotide (NAD+) biosynthetic pathway in mammals, is a substrate for NAD+-dependent enzymes, such as sirtuin 1 (SIRT1), and contributes to cell fate decisions. NAD 186-190 sirtuin 1 Rattus norvegicus 229-234 27102823-6 2016 The increase in both the NAD(+) availability and Sirt1 mRNA levels, in turn, resulted in the hepatic activation of SIRT1, which was significantly associated with improved protection against hepatic triglyceride accumulation. NAD 25-31 sirtuin 1 Rattus norvegicus 115-120 27102823-7 2016 Our data clearly indicates that PAC consumption could be a valid tool to enhance hepatic SIRT1 activity through the modulation of NAD(+) levels. NAD 130-136 sirtuin 1 Rattus norvegicus 89-94 26544624-0 2015 Enhancement of NAD+-dependent SIRT1 deacetylase activity by methylselenocysteine resets the circadian clock in carcinogen-treated mammary epithelial cells. NAD 15-19 sirtuin 1 Rattus norvegicus 30-35 26124049-1 2015 BACKGROUND: The energy status of the cell is regulated by the energy sensing network constituted by AMP-activated protein kinase (AMPK), the NAD+-dependent type III deacetylase silence information regulator T1 (SIRT1) and peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha). NAD 141-145 sirtuin 1 Rattus norvegicus 177-209 26124049-1 2015 BACKGROUND: The energy status of the cell is regulated by the energy sensing network constituted by AMP-activated protein kinase (AMPK), the NAD+-dependent type III deacetylase silence information regulator T1 (SIRT1) and peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha). NAD 141-145 sirtuin 1 Rattus norvegicus 211-216 26544624-8 2015 Together with our previous findings, these results suggest that enhancement of NAD+-dependent SIRT1 activity contributes to the chemopreventive efficacy of MSC by restoring epigenetic regulation of circadian gene expression at early stages of mammary tumorigenesis. NAD 79-83 sirtuin 1 Rattus norvegicus 94-99 26544624-4 2015 Moreover, NMU inhibited intracellular NAD+/NADH ratio and reduced NAD+-dependent SIRT1 activity in a dose-dependent manner, while MSC restored NAD+/NADH and SIRT1 activity in the NMU-treated cells, indicating that the NAD+-SIRT1 pathway was targeted by NMU and MSC. NAD 66-70 sirtuin 1 Rattus norvegicus 81-86 26544624-4 2015 Moreover, NMU inhibited intracellular NAD+/NADH ratio and reduced NAD+-dependent SIRT1 activity in a dose-dependent manner, while MSC restored NAD+/NADH and SIRT1 activity in the NMU-treated cells, indicating that the NAD+-SIRT1 pathway was targeted by NMU and MSC. NAD 66-70 sirtuin 1 Rattus norvegicus 81-86 26544624-4 2015 Moreover, NMU inhibited intracellular NAD+/NADH ratio and reduced NAD+-dependent SIRT1 activity in a dose-dependent manner, while MSC restored NAD+/NADH and SIRT1 activity in the NMU-treated cells, indicating that the NAD+-SIRT1 pathway was targeted by NMU and MSC. NAD 66-70 sirtuin 1 Rattus norvegicus 81-86 25798922-1 2015 SIRT1 is a NAD+-dependent deacetylase thought to regulate cellular metabolic pathways in response to alterations in nutrient flux. NAD 11-15 sirtuin 1 Rattus norvegicus 0-5 25965594-2 2015 Sirtuin 1 (SIRT1), a nicotinamide adenine dinucleotide NAD(+)-dependent deacetylase, is known to play a role in diabetes-related complications as well as ER-stress. NAD 21-54 sirtuin 1 Rattus norvegicus 0-9 25965594-2 2015 Sirtuin 1 (SIRT1), a nicotinamide adenine dinucleotide NAD(+)-dependent deacetylase, is known to play a role in diabetes-related complications as well as ER-stress. NAD 21-54 sirtuin 1 Rattus norvegicus 11-16 26221253-2 2015 SIRT1 (Sir2) is a NAD-dependent deacetylase and is reported to regulate a wide variety of cellular processes including inflammation, aging and lifespan extension. NAD 18-21 sirtuin 1 Rattus norvegicus 0-5 26221253-2 2015 SIRT1 (Sir2) is a NAD-dependent deacetylase and is reported to regulate a wide variety of cellular processes including inflammation, aging and lifespan extension. NAD 18-21 sirtuin 1 Rattus norvegicus 7-11 25849131-2 2015 One process that is considered a key feature of resveratrol action is the activation of the nicotinamide adenine dinucleotide (NAD(+))-dependent deacetylase sirtuin 1 (SIRT1) in various tissues. NAD 92-125 sirtuin 1 Rattus norvegicus 168-173 25849131-2 2015 One process that is considered a key feature of resveratrol action is the activation of the nicotinamide adenine dinucleotide (NAD(+))-dependent deacetylase sirtuin 1 (SIRT1) in various tissues. NAD 127-134 sirtuin 1 Rattus norvegicus 168-173 25925963-7 2015 Moreover, we found that OSC-related decrease in NAD(+) amounts among middle-aged rats is associated to increased NADPH levels and SIRT1 activity. NAD 48-54 sirtuin 1 Rattus norvegicus 130-135 25925963-8 2015 In contrast, we associated OSC-related decrease in NAD(+) amounts among young rats to decreased NADPH levels and increased SIRT1 activity. NAD 51-57 sirtuin 1 Rattus norvegicus 123-128 26185373-10 2015 This was concomitant with increased levels of NAD(+) (0.87 +- 0.22 vs 1.195 +- 0.144, P < 0.05) the co-factor necessary for SIRT1 activity, as well as with decreases in ac-FoxO1 expression. NAD 46-52 sirtuin 1 Rattus norvegicus 127-132 25863291-0 2015 NAD(+)-dependent SIRT1 deactivation has a key role on ischemia-reperfusion-induced apoptosis. NAD 0-6 sirtuin 1 Rattus norvegicus 17-22 25684941-11 2015 The elevated SIRT1 activity in presence of TMZ can be attributed to the enhanced NAMPT protein and NAD(+)/NADH levels. NAD 99-105 sirtuin 1 Rattus norvegicus 13-18 25684941-11 2015 The elevated SIRT1 activity in presence of TMZ can be attributed to the enhanced NAMPT protein and NAD(+)/NADH levels. NAD 106-110 sirtuin 1 Rattus norvegicus 13-18 25411384-8 2015 Sirt-1 activity could be reestablished by treatment with NAD(+), silencing NOX4, and poly (ADP-ribose) polymerase-1 (PARP-1) blockade, or with theobromine. NAD 57-63 sirtuin 1 Rattus norvegicus 0-6 25411384-12 2015 These results suggest that in diabetes mellitus, Sirt-1 activity is reduced by PARP-1 activation and NAD(+) depletion due to low AMPK, which increases NOX4 expression, leading to ECM accumulation mediated by transforming growth factor (TGF)-beta1 signaling. NAD 101-107 sirtuin 1 Rattus norvegicus 49-55 25339333-7 2014 CONCLUSION: High dose of Vitamin B3 may play an important role in increasing absolute neutrophil count in healthy rat under steady state, and the mechanism may be dependent on NAMPT-NAD+-SIRT1 signaling pathways. NAD 182-186 sirtuin 1 Rattus norvegicus 187-192 25314136-4 2014 Resveratrol increases intracellular Ca2+ (Cai) and AMP kinase (AMPK) and NAD-dependent deacetylase sirtuin1 (SIRT1) activities, all of which could activate NO production. NAD 73-76 sirtuin 1 Rattus norvegicus 99-107 25314136-4 2014 Resveratrol increases intracellular Ca2+ (Cai) and AMP kinase (AMPK) and NAD-dependent deacetylase sirtuin1 (SIRT1) activities, all of which could activate NO production. NAD 73-76 sirtuin 1 Rattus norvegicus 109-114 25766524-1 2015 BACKGROUND: SIRT1, which belongs to the Sirtuin family of NAD-dependent enzymes, plays diverse roles in aging, metabolism, and disease biology. NAD 58-61 sirtuin 1 Rattus norvegicus 12-17 24239904-1 2014 The NAD(+) depending enzyme SIRT1 regulates the mitochondrial biogenesis, fat and glucose metabolism through catalyzing the deacetylation of several metabolism-related protein-substrates. NAD 4-10 sirtuin 1 Rattus norvegicus 28-33 24296261-1 2014 Sirtuin1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD(+))-dependent deacetylase functioning in the regulation of metabolism, cell survival and organismal lifespan. NAD 22-55 sirtuin 1 Rattus norvegicus 0-8 24296261-1 2014 Sirtuin1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD(+))-dependent deacetylase functioning in the regulation of metabolism, cell survival and organismal lifespan. NAD 22-55 sirtuin 1 Rattus norvegicus 10-15 24296261-1 2014 Sirtuin1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD(+))-dependent deacetylase functioning in the regulation of metabolism, cell survival and organismal lifespan. NAD 57-64 sirtuin 1 Rattus norvegicus 0-8 24296261-1 2014 Sirtuin1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD(+))-dependent deacetylase functioning in the regulation of metabolism, cell survival and organismal lifespan. NAD 57-64 sirtuin 1 Rattus norvegicus 10-15 23384296-0 2014 Exogenous NAD(+) supplementation protects H9c2 cardiac myoblasts against hypoxia/reoxygenation injury via Sirt1-p53 pathway. NAD 10-16 sirtuin 1 Rattus norvegicus 106-111 23384296-1 2014 Nicotinamide adenine dinucleotide (NAD(+) ) not only transfers electrons in mitochondrial respiration, but also acts as an indispensable cosubstrate for Sirt1, the class III histone/nonhistone deacetylase. NAD 0-33 sirtuin 1 Rattus norvegicus 153-158 23384296-1 2014 Nicotinamide adenine dinucleotide (NAD(+) ) not only transfers electrons in mitochondrial respiration, but also acts as an indispensable cosubstrate for Sirt1, the class III histone/nonhistone deacetylase. NAD 35-41 sirtuin 1 Rattus norvegicus 153-158 23384296-9 2014 NAD(+) replenishment restored Sirt1 activity, reduced the acetylation level of p53 (Lys373 & 382), and attenuated cell apoptosis in HR-stressed H9c2 cells, whereas inhibition of Sirt1 activity alleviated the effects of NAD(+) replenishment. NAD 0-6 sirtuin 1 Rattus norvegicus 30-35 23384296-9 2014 NAD(+) replenishment restored Sirt1 activity, reduced the acetylation level of p53 (Lys373 & 382), and attenuated cell apoptosis in HR-stressed H9c2 cells, whereas inhibition of Sirt1 activity alleviated the effects of NAD(+) replenishment. NAD 0-6 sirtuin 1 Rattus norvegicus 182-187 23384296-10 2014 These results indicated that exogenous NAD(+) supplementation attenuated HR-induced cell apoptosis, which was at least partly mediated by restoring Sirt1 activity and subsequently inhibiting p53 activity via deacetylating p53 at lysine 373 and 382. NAD 39-45 sirtuin 1 Rattus norvegicus 148-153 24586272-1 2014 Poly(ADP-ribose)polymerase and sirtuin 1 are both NAD(+)-dependent enzymes. NAD 50-56 sirtuin 1 Rattus norvegicus 31-40 24241058-2 2014 Adenosine 5"-monophosphate-activated protein kinase (AMPK) is crucial for GTPCH-1 preservation, and tumor suppressor kinase liver kinase B1 (LKB1), an upstream kinase of AMPK, is activated by NAD-dependent class III histone deacetylase sirtuin 1 (SIRT1)-mediated deacetylation. NAD 192-195 sirtuin 1 Rattus norvegicus 236-245 24241058-2 2014 Adenosine 5"-monophosphate-activated protein kinase (AMPK) is crucial for GTPCH-1 preservation, and tumor suppressor kinase liver kinase B1 (LKB1), an upstream kinase of AMPK, is activated by NAD-dependent class III histone deacetylase sirtuin 1 (SIRT1)-mediated deacetylation. NAD 192-195 sirtuin 1 Rattus norvegicus 247-252 24183892-2 2013 Recent evidence suggests that the NAD(+)-dependent histone deacetylase sirtuin 1 (SIRT1) plays a prominent role in linking changes in nutritional availability with cellular fate regulation. NAD 34-40 sirtuin 1 Rattus norvegicus 71-80 24183892-2 2013 Recent evidence suggests that the NAD(+)-dependent histone deacetylase sirtuin 1 (SIRT1) plays a prominent role in linking changes in nutritional availability with cellular fate regulation. NAD 34-40 sirtuin 1 Rattus norvegicus 82-87 23422569-2 2013 Previous studies demonstrate that the activity of the evolutionarily conserved NAD(+)-dependent deacetylase SIRT1 declines with age and that pharmacological activators of SIRT1 confer significant anti-aging cardiovascular effects. NAD 79-85 sirtuin 1 Rattus norvegicus 108-113 23422569-2 2013 Previous studies demonstrate that the activity of the evolutionarily conserved NAD(+)-dependent deacetylase SIRT1 declines with age and that pharmacological activators of SIRT1 confer significant anti-aging cardiovascular effects. NAD 79-85 sirtuin 1 Rattus norvegicus 171-176 20362304-2 2011 Nicotinamide adenine dinucleotide-dependent histone deacetylase sirtuin 1 (SIRT1) is also thought to play a pivotal role for such metabolic adaptations. NAD 0-33 sirtuin 1 Rattus norvegicus 64-73 20362304-2 2011 Nicotinamide adenine dinucleotide-dependent histone deacetylase sirtuin 1 (SIRT1) is also thought to play a pivotal role for such metabolic adaptations. NAD 0-33 sirtuin 1 Rattus norvegicus 75-80 22113495-3 2012 Activators of Sirt1 are known to improve mitochondrial function and the naturally occurring polyphenol resveratrol (RSV) has been shown to significantly increase Sirt1 activity by increasing its affinity to both NAD+ and the acetylated substrate. NAD 212-216 sirtuin 1 Rattus norvegicus 14-19 22113495-3 2012 Activators of Sirt1 are known to improve mitochondrial function and the naturally occurring polyphenol resveratrol (RSV) has been shown to significantly increase Sirt1 activity by increasing its affinity to both NAD+ and the acetylated substrate. NAD 212-216 sirtuin 1 Rattus norvegicus 162-167 21541336-9 2011 The strong positive correlation observed between DNA damage associated NAD+ depletion and Sirt1 activity suggests that adequate NAD+ concentrations may be an important longevity assurance factor. NAD 71-75 sirtuin 1 Rattus norvegicus 90-95 21541336-9 2011 The strong positive correlation observed between DNA damage associated NAD+ depletion and Sirt1 activity suggests that adequate NAD+ concentrations may be an important longevity assurance factor. NAD 128-132 sirtuin 1 Rattus norvegicus 90-95