PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24410488-9	2014	propose a model linking decreased NAD+ to loss of nuclear SIRT1 activity to stabilization of the hypoxia-associated transcription factor hypoxia-inducible factor 1-alpha (HIF-1a).	NAD	34-38	hypoxia inducible factor 1, alpha subunit	Mus musculus	137-169	
33528041-8	2021	Nmnat3 gene expression is suppressed by HIF1alpha, a transcription factor that is stabilized by mitochondrial translation dysfunction, suggesting that HIF1alpha-Nmnat3-mediated NAD+ production is important for lysosomal function.	NAD	177-181	hypoxia inducible factor 1, alpha subunit	Mus musculus	40-49	
33528041-8	2021	Nmnat3 gene expression is suppressed by HIF1alpha, a transcription factor that is stabilized by mitochondrial translation dysfunction, suggesting that HIF1alpha-Nmnat3-mediated NAD+ production is important for lysosomal function.	NAD	177-181	hypoxia inducible factor 1, alpha subunit	Mus musculus	151-160	
24410488-9	2014	propose a model linking decreased NAD+ to loss of nuclear SIRT1 activity to stabilization of the hypoxia-associated transcription factor hypoxia-inducible factor 1-alpha (HIF-1a).	NAD	34-38	hypoxia inducible factor 1, alpha subunit	Mus musculus	171-177	
20620956-5	2010	During hypoxia, SIRT1 was downregulated due to decreased NAD(+) levels, which allowed the acetylation and activation of HIF-1alpha.	NAD	57-63	hypoxia inducible factor 1, alpha subunit	Mus musculus	120-130	
24280190-12	2013	Such trigger was mediated by HIF-1alpha, whose stabilization was regulated after recovery of the balance between alpha-ketoglutarate and succinate due to a recuperation of NADH consumption that followed complex I rescue.	NAD	172-176	hypoxia inducible factor 1, alpha subunit	Mus musculus	29-39	
19276158-6	2009	Because lactate dehydrogenase-A (LDH-A), also a HIF-1alpha target, promotes fermentative glycolysis (conversion of pyruvate to lactate), a step essential for regenerating NAD+, we asked whether FH-deficient cells would be exquisitely sensitive to LDH-A blockade.	NAD	171-175	hypoxia inducible factor 1, alpha subunit	Mus musculus	48-58