PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29436612-6	2018	Furthermore, blocking ROS with NAC inhibited SW-induced ER stress, as evidenced by the downregulation of GRP78, phosphorylated (p)-protein kinase R-like ER kinase (PERK), p-inositol-requiring kinase 1alpha (IRE1alpha), p-50 activating transcription factor 6alpha and CHOP.	Acetylcysteine	31-34	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	105-110	
31447555-5	2019	NAC can effectively mitigate iron-induced oxidative injury of cardiomyocytes, evidenced by reduced production of MDA, 8-iso-PGF2alpha, and 8-OHDG and maintained concentrations of SOD, CAT, GSH-Px, and GSH in ELISA and biochemical tests; downregulated expression of CHOP, GRP78, p62, and LC3-II proteins in Western Blot, and less cardiomyocytes apoptosis in flow cytometric analysis.	Acetylcysteine	0-3	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	271-276	
26206453-5	2015	RESULTS: Treatment with NAC inhibited apoptosis of penile tissue, the expressions of ERS-related products: BIP, CHOP, caspase12, and Bax, NO, and endothelial NOS.	Acetylcysteine	24-27	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	107-110	
26206453-7	2015	CONCLUSION: Our results show that pre-CIH NAC administration ameliorates the ED following CIH partly by alleviating CIH-induced ERS and cell apoptosis via regulating the expressions of BIP, CHOP, caspase12, and Bax.	Acetylcysteine	42-45	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	185-188	
25438539-10	2014	NAC was also found to suppress the levels of GRP78, PERK and CHOP expression in NaF-treated cells (p<0.01).	Acetylcysteine	0-3	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	45-50	
25359386-12	2014	Significantly increased expressions of GRP78 and CHOP were observed in the NRK-52E cells exposed to iopromide for 4 h; NAC attenuated iopromide-induced NRK-52E cell apoptosis by inhibiting the overproduction of intracellular ROS and subsequently suppressing the overexpression of GRP78 and CHOP.	Acetylcysteine	119-122	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	39-44	
25359386-12	2014	Significantly increased expressions of GRP78 and CHOP were observed in the NRK-52E cells exposed to iopromide for 4 h; NAC attenuated iopromide-induced NRK-52E cell apoptosis by inhibiting the overproduction of intracellular ROS and subsequently suppressing the overexpression of GRP78 and CHOP.	Acetylcysteine	119-122	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	280-285	
12681446-4	2003	The induced grp78 expression is sensitive to antioxidant N-acetylcysteine (NAC) addition, indicating the involvement of reactive oxygen species (ROS) in GA-induced ER stress.	Acetylcysteine	57-73	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	12-17	
12681446-4	2003	The induced grp78 expression is sensitive to antioxidant N-acetylcysteine (NAC) addition, indicating the involvement of reactive oxygen species (ROS) in GA-induced ER stress.	Acetylcysteine	75-78	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	12-17	
12681446-7	2003	The critical ROS-dependent elements in grp78 promoter can be confined within ER stress responsive element (ERSE) region, since reporter constructs loss of ERSE elements that lost the susceptibility to be modulated by NAC after GA treatment.	Acetylcysteine	217-220	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	39-44