PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32658336-0	2020	Modulation of Bleomycin-induced oxidative stress and pulmonary fibrosis by N-acetylcysteine in Ratsvia AMPK/SIRT1/ NF-Kbeta.	Acetylcysteine	75-91	sirtuin 1	Rattus norvegicus	108-113	
32658336-11	2020	NAC markedly attenuated the lung histopathological changes and reduced collagen deposition.These results suggested that NAC exerted anameliorative effect against BLM-induced oxidative damage and pulmonary fibrosisvia SIRT1/ AMPK/ NF-Kbeta pathways.	Acetylcysteine	0-3	sirtuin 1	Rattus norvegicus	217-222	
32658336-11	2020	NAC markedly attenuated the lung histopathological changes and reduced collagen deposition.These results suggested that NAC exerted anameliorative effect against BLM-induced oxidative damage and pulmonary fibrosisvia SIRT1/ AMPK/ NF-Kbeta pathways.	Acetylcysteine	120-123	sirtuin 1	Rattus norvegicus	217-222	
29223039-0	2018	N-acetyl-l-cysteine ameliorates the PM2.5-induced oxidative stress by regulating SIRT-1 in rats.	Acetylcysteine	0-19	sirtuin 1	Rattus norvegicus	81-87	
31223283-10	2019	Furthermore, treatment with antioxidant, N-acetyl-cysteine (NAC) in offspring reversed GDM-mediated DNA hypermethylation, Sirt1 repression and autophagy-related gene protein overexpression in the hearts, and rescued GDM-induced deterioration in heart ischemic injury and LV dysfunction.	Acetylcysteine	41-58	sirtuin 1	Rattus norvegicus	122-127	
31223283-10	2019	Furthermore, treatment with antioxidant, N-acetyl-cysteine (NAC) in offspring reversed GDM-mediated DNA hypermethylation, Sirt1 repression and autophagy-related gene protein overexpression in the hearts, and rescued GDM-induced deterioration in heart ischemic injury and LV dysfunction.	Acetylcysteine	60-63	sirtuin 1	Rattus norvegicus	122-127	
30107137-9	2018	NAC supplementation also downregulated the expression of inflammatory markers (TNF-alpha, IL-1beta, IL-6) and upregulated the expression of marker genes associated with aging (sirtuin-1) and neurodegeneration (neuron-specific enolase, neuroglobin, synapsin-I, myelin basic protein 2) in old rats.	Acetylcysteine	0-3	sirtuin 1	Rattus norvegicus	176-185	
30948926-5	2019	Secondly, the influence of ROS content on the activity of the JNK1/Sirt1/FoxO3a signaling pathway was explored through the application of NAC, sp600125 (a JNK1 inhibitor), and nicotinamide (a Sirt1 inhibitor).	Acetylcysteine	138-141	sirtuin 1	Rattus norvegicus	67-72	
29223039-8	2018	NAC can activate SIRT1 and exert an anti-oxidative role in PM2.5-induced oxidative injury.	Acetylcysteine	0-3	sirtuin 1	Rattus norvegicus	17-22	
33772418-0	2021	The effect of N-Acetyl cysteine on the expression of Fxr (Nr1h4), LXRalpha (Nr1h3) and Sirt1 genes, oxidative stress, and apoptosis in the liver of rats exposed to different doses of cadmium.	Acetylcysteine	14-31	sirtuin 1	Rattus norvegicus	87-92	
33772418-9	2021	NAC increased Fxr, LXRalpha, and Sirt1 expression (P < 0.01) and decreased Cd concentrations in both serum and tissue samples in G4 and G5 groups.	Acetylcysteine	0-3	sirtuin 1	Rattus norvegicus	33-38	
33772418-10	2021	Our results suggested that NAC protects liver tissue against Cd toxicity by elevating antioxidant capacity, mitigating oxidative stress, inflammation, apoptosis and up-regulation of FXR, LXR, and SIRT1 genes.	Acetylcysteine	27-30	sirtuin 1	Rattus norvegicus	196-201