PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18986596-1 2009 The aim of this study was to determine the effect of dietary quercetin supplementation on blood lipids and TNF-alpha levels according to the apoE genotype in apoE3 and apoE4 targeted gene replacement mice. Quercetin 61-70 tumor necrosis factor Mus musculus 107-116 20823570-12 2010 Quercetin treatment also markedly suppressed the histological changes such as pancreatic edema, inflammatory cell infiltration, acinar cell necrosis, and the expression of TNF-alpha. Quercetin 0-9 tumor necrosis factor Mus musculus 172-181 19949288-4 2009 The IC(50) of quercetin, b-40, and b-41 were 1.4, 0.38, and 6.21 microM, respectively, for binding of HuR protein to TNF-alpha mRNA. Quercetin 14-23 tumor necrosis factor Mus musculus 117-126 19949288-6 2009 When LPS-treated RAW264.7 cells were treated with quercetin and b-40, we observed decreased stability of TNF-alpha mRNA and decreased levels of secreted TNF-alpha. Quercetin 50-59 tumor necrosis factor Mus musculus 105-114 19949288-6 2009 When LPS-treated RAW264.7 cells were treated with quercetin and b-40, we observed decreased stability of TNF-alpha mRNA and decreased levels of secreted TNF-alpha. Quercetin 50-59 tumor necrosis factor Mus musculus 153-162 18986596-6 2009 In mice receiving the basal diet without quercetin supplementation, levels of TNF-alpha in whole blood stimulated ex vivo with lipopolysaccharide were higher in apoE3 as compared to apoE4 transgenic mice. Quercetin 41-50 tumor necrosis factor Mus musculus 78-87 18986596-7 2009 Dietary quercetin significantly lowered levels of TNF-alpha by 44 % in apoE3 mice relative to apoE3 mice receiving the unsupplemented diets. Quercetin 8-17 tumor necrosis factor Mus musculus 50-59 18986596-10 2009 Current findings indicate that apoE3 mice are more responsive to the TNF-alpha lowering properties of dietary quercetin supplementation as compared to apoE4 animals. Quercetin 110-119 tumor necrosis factor Mus musculus 69-78 16794257-4 2006 Quercetin also inhibited TNF-alpha-induced PI 3-kinase activity, Akt phosphorylation, intracellular H(2)O(2) production, NF-kappaB transactivation, IL-8 promoter activity, and steady-state mRNA levels, consistent with the notion that quercetin inhibits chemokine expression by attenuating NF-kappaB transactivation via a PI 3-kinase/Akt-dependent pathway. Quercetin 0-9 tumor necrosis factor Mus musculus 25-34 18603770-3 2008 In this study, we found evidence that the flavonol quercetin regulates the effect of MNSFbeta on TNFalpha production in LPS-stimulated Raw264.7 cells. Quercetin 51-60 tumor necrosis factor Mus musculus 97-105 18603770-4 2008 Quercetin inhibited MNSFbeta siRNA-mediated enhancement of both TNFalpha production and ERK1/2 phosphorylation in LPS-stimulated Raw264.7 cells. Quercetin 0-9 tumor necrosis factor Mus musculus 64-72 16794257-4 2006 Quercetin also inhibited TNF-alpha-induced PI 3-kinase activity, Akt phosphorylation, intracellular H(2)O(2) production, NF-kappaB transactivation, IL-8 promoter activity, and steady-state mRNA levels, consistent with the notion that quercetin inhibits chemokine expression by attenuating NF-kappaB transactivation via a PI 3-kinase/Akt-dependent pathway. Quercetin 234-243 tumor necrosis factor Mus musculus 25-34 18625009-2 2008 Quercetin and luteolin, which differ by one hydroxyl group, are known to suppress the lipopolysaccharide-induced production of TNF-alpha in vitro. Quercetin 0-9 tumor necrosis factor Mus musculus 127-136 18625009-4 2008 In a time- and dose-dependent manner, quercetin reduced the plasma levels of TNF-alpha, lowered bacterial titers in livers, prevented liver damage and prolonged survival, while luteolin had little or no effect. Quercetin 38-47 tumor necrosis factor Mus musculus 77-86 17988664-0 2008 Quercetin accelerates TNF-alpha-induced apoptosis of MC3T3-E1 osteoblastic cells through caspase-dependent and JNK-mediated pathways. Quercetin 0-9 tumor necrosis factor Mus musculus 22-31 17988664-3 2008 Therefore, this study was carried out to examine the cellular mechanisms for how quercetin accelerates TNF-alpha-mediated apoptosis, and to determine whether the accelerating effect of quercetin is a general effect in osteoblastic cells. Quercetin 81-90 tumor necrosis factor Mus musculus 103-112 17988664-4 2008 Quercetin promoted the TNF-alpha-induced apoptosis of MC3T3-E1 cells through both the mitochondrial-mediated and caspase-dependent mechanisms. Quercetin 0-9 tumor necrosis factor Mus musculus 23-32 17988664-5 2008 Quercetin also augmented the TNF-alpha-mediated apoptosis by activating c-Jun N-terminal kinase (JNK) with the attendant activation of activator protein-1, where the nuclear translocation of c-Jun protein appeared to be a critical event responsible for the accelerating action of quercetin. Quercetin 0-9 tumor necrosis factor Mus musculus 29-38 17988664-5 2008 Quercetin also augmented the TNF-alpha-mediated apoptosis by activating c-Jun N-terminal kinase (JNK) with the attendant activation of activator protein-1, where the nuclear translocation of c-Jun protein appeared to be a critical event responsible for the accelerating action of quercetin. Quercetin 280-289 tumor necrosis factor Mus musculus 29-38 17988664-6 2008 However, TNF-alpha-mediated apoptosis and its acceleration by quercetin were not observed in primary osteoblasts. Quercetin 62-71 tumor necrosis factor Mus musculus 9-18 17988664-7 2008 These results strongly suggest that quercetin accelerates TNF-alpha-mediated apoptosis of osteoblasts through caspase-dependent and JNK-mediated pathways, and that the cellular responses of osteoblasts to TNF-alpha and/or quercetin might differ according to their origins. Quercetin 36-45 tumor necrosis factor Mus musculus 58-67 17449583-0 2007 Quercetin inhibits TNF-induced NF-kappaB transcription factor recruitment to proinflammatory gene promoters in murine intestinal epithelial cells. Quercetin 0-9 tumor necrosis factor Mus musculus 19-22 17449583-2 2007 In this study, we characterized the molecular mechanisms by which quercetin and its enteric bacterial metabolites, taxifolin, alphitonin, and 3, 4-dihydroxy-phenylacetic acid, inhibit tumor necrosis factor alpha (TNF)-induced proinflammatory gene expression in the murine small intestinal epithelial cell (IEC) line Mode-K as well as in heterozygous TNFDeltaARE/WT mice, a murine model of experimental ileitis. Quercetin 66-75 tumor necrosis factor Mus musculus 184-211 17449583-2 2007 In this study, we characterized the molecular mechanisms by which quercetin and its enteric bacterial metabolites, taxifolin, alphitonin, and 3, 4-dihydroxy-phenylacetic acid, inhibit tumor necrosis factor alpha (TNF)-induced proinflammatory gene expression in the murine small intestinal epithelial cell (IEC) line Mode-K as well as in heterozygous TNFDeltaARE/WT mice, a murine model of experimental ileitis. Quercetin 66-75 tumor necrosis factor Mus musculus 213-216 17449583-3 2007 Quercetin inhibited TNF-induced interferon-gamma-inducible protein 10 (IP-10) and macrophage inflammatory protein 2 (MIP-2) gene expression in Mode-K cells with effective inhibitory concentration of 40 and 44 micromol/L, respectively. Quercetin 0-9 tumor necrosis factor Mus musculus 20-23 16794257-5 2006 Quercetin also reduced TNF-alpha-induced chemokine secretion in the presence of the transcriptional inhibitor actinomycin D, while inducing phosphorylation of eukaryotic translation initiation factor (eIF)-2alpha, suggesting that quercetin attenuates chemokine expression by post-transcriptional as well as transcriptional mechanisms. Quercetin 0-9 tumor necrosis factor Mus musculus 23-32 16794257-5 2006 Quercetin also reduced TNF-alpha-induced chemokine secretion in the presence of the transcriptional inhibitor actinomycin D, while inducing phosphorylation of eukaryotic translation initiation factor (eIF)-2alpha, suggesting that quercetin attenuates chemokine expression by post-transcriptional as well as transcriptional mechanisms. Quercetin 230-239 tumor necrosis factor Mus musculus 23-32 16316652-7 2006 Collectively, this study showed that quercetin accelerates the TNF-alpha-induced growth inhibition and apoptosis in MC3T3-E1 osteoblastic cells. Quercetin 37-46 tumor necrosis factor Mus musculus 63-72 16316652-0 2006 Quercetin, a bioflavonoid, accelerates TNF-alpha-induced growth inhibition and apoptosis in MC3T3-E1 osteoblastic cells. Quercetin 0-9 tumor necrosis factor Mus musculus 39-48 14745173-3 2004 Lipopolysaccharide (LPS)-induced TNF-alpha production from macrophages was inhibited by treatment with flavone (luteolin, apigenin, and chrysin), flavonol (quercetin and myricetin), flavanonol (taxifolin), and anthocyanidin (cyanidin chloride) in vitro. Quercetin 156-165 tumor necrosis factor Mus musculus 33-42 16316652-2 2006 This study examined how quercetin acts on tumor necrosis factor-alpha (TNF-alpha)-mediated growth inhibition and apoptosis in MC3T3-E1 osteoblastic cells. Quercetin 24-33 tumor necrosis factor Mus musculus 42-69 16316652-2 2006 This study examined how quercetin acts on tumor necrosis factor-alpha (TNF-alpha)-mediated growth inhibition and apoptosis in MC3T3-E1 osteoblastic cells. Quercetin 24-33 tumor necrosis factor Mus musculus 71-80 16316652-3 2006 Tritium uptake assay showed that a quercetin treatment accelerated TNF-alpha-induced inhibition of DNA synthesis in the cells in a dose-dependent manner. Quercetin 35-44 tumor necrosis factor Mus musculus 67-76 16316652-4 2006 Both the 3-(4,5-dimethylthiazol-2yl-)-2,5-diphenyl tetrazolium bromide and trypan blue staining assays also showed the quercetin-mediated facilitation of TNF-alpha-induced cytotoxicity in the cells. Quercetin 119-128 tumor necrosis factor Mus musculus 154-163 16316652-5 2006 Apoptosis assays revealed an accelerating effect of quercetin on TNF-alpha-induced apoptosis in MC3T3-E1 cells. Quercetin 52-61 tumor necrosis factor Mus musculus 65-74 16316652-6 2006 In addition, Fas activation and poly (ADP ribose) polymerase cleavage are thought to be closely associated with the TNF-alpha-induced apoptosis and its acceleration by the quercetin treatment in the cells. Quercetin 172-181 tumor necrosis factor Mus musculus 116-125 15630180-6 2004 Results indicate that TNF-alpha and IL-6 accumulations were significantly reduced by 5 to 20 microM quercetin treatment, and 20 microM of alpha-tocopherol treatment. Quercetin 100-109 tumor necrosis factor Mus musculus 22-31 17100629-4 2006 Treatment with flavonoids such as luteolin, apigenin, quercetin, genistein, (-)-epigallocatechin gallate, and anthocyanidin resulted in significant downregulation of LPS-elicited TNF-alpha and nitric oxide (NO) production and diminished lethal shock. Quercetin 54-63 tumor necrosis factor Mus musculus 179-188 7870067-3 1995 Both the flavonoid quercetin and phloretin inhibited the expression of IL-1 alpha/beta as well as TNF-alpha mRNA, with quercetin being more potent than phloretin and TNF-alpha expression somewhat more sensitive than that of IL-1 alpha/beta. Quercetin 19-28 tumor necrosis factor Mus musculus 98-107 11123379-3 2001 Pretreatment of RAW 264.7 with luteolin, luteolin-7-glucoside, quercetin, and the isoflavonoid genistein inhibited both the LPS-stimulated TNF-alpha and interleukin-6 release, whereas eriodictyol and hesperetin only inhibited TNF-alpha release. Quercetin 63-72 tumor necrosis factor Mus musculus 139-148 11123379-3 2001 Pretreatment of RAW 264.7 with luteolin, luteolin-7-glucoside, quercetin, and the isoflavonoid genistein inhibited both the LPS-stimulated TNF-alpha and interleukin-6 release, whereas eriodictyol and hesperetin only inhibited TNF-alpha release. Quercetin 63-72 tumor necrosis factor Mus musculus 226-235 11123379-4 2001 From the compounds tested luteolin and quercetin were the most potent in inhibiting cytokine production with an IC(50) of less than 1 and 5 microM for TNF-alpha release, respectively. Quercetin 39-48 tumor necrosis factor Mus musculus 151-160 11140816-0 2000 Induction of apoptosis and NF-kappaB by quercetin in growing murine L1210 lymphocytic leukaemic cells potentiated by TNF-alpha. Quercetin 40-49 tumor necrosis factor Mus musculus 117-126 11140816-3 2000 The above mentioned death promoting activity of quercetin was enhanced by physiological concentrations of TNF-alpha. Quercetin 48-57 tumor necrosis factor Mus musculus 106-115 11140816-9 2000 We conclude that quercetin unmasked cell death, promoting the activity of TNF-alpha. Quercetin 17-26 tumor necrosis factor Mus musculus 74-83 10454017-3 1999 In this report we provide evidence that the overproduction of TNF-alpha and NO by LPS stimulated macrophages can be markedly inhibited by quercetin, a major active component of plant Rhododendron cinnabarium. Quercetin 138-147 tumor necrosis factor Mus musculus 62-71 9292787-3 1997 Based on our recent finding that reactive oxygen intermediates play important roles in mediating TNF-alpha action, we examined the effect of an antioxidant bioflavonoid, quercetin, on TNF-alpha induced expression of interleukin 8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) in cultured human synovial cells. Quercetin 170-179 tumor necrosis factor Mus musculus 184-193 7870067-3 1995 Both the flavonoid quercetin and phloretin inhibited the expression of IL-1 alpha/beta as well as TNF-alpha mRNA, with quercetin being more potent than phloretin and TNF-alpha expression somewhat more sensitive than that of IL-1 alpha/beta. Quercetin 19-28 tumor necrosis factor Mus musculus 166-175 8352018-2 1993 The results showed that TPA (1-100 ng.ml-1) and lipopolysaccharides (LPS) (1-100 ng.ml-1) induced the release of TNF from PA-primed mouse peritoneal macrophages in dose- and time-dependent manners in vitro, and the effects of TPA and LPS were inhibited by H-7 (12.5-100 mumol.L-1) or quercetin (6.25-25 mumol.L-1) in a dose-dependent manner. Quercetin 284-293 tumor necrosis factor Mus musculus 113-116 34773179-6 2022 SiRNA knockdown experiments showed that quercetin inhibited the MNSFbeta and HSC70 siRNA-mediated enhancement of TNFalpha and the production of RANTES, a member of C-C chemokine superfamily, in LPS-stimulated Raw264.7 cells. Quercetin 40-49 tumor necrosis factor Mus musculus 113-121 34595237-7 2021 The results of molecular docking showed that AKT has the most binding activity, exhibiting certain binding activity with 10 compounds, including vanillic acid, protocatechuic acid, secologanic acid, quercetin, and luteolin; the results of qRT-PCR and WB confirmed that two key compounds, secologanic acid and luteolin, could significantly decrease the secretion of TNF-alpha and the AKT expression of RAW264.7 murine macrophages stimulated by LPS (lipopolysaccharide). Quercetin 199-208 tumor necrosis factor Mus musculus 365-374 35122975-12 2022 The levels of inflammatory factors, including tumor necrosis factor-alpha, interleukin-1beta and interleukin-6 were significantly reduced after quercetin administration. Quercetin 144-153 tumor necrosis factor Mus musculus 46-73 34303829-7 2021 Inhibition of TNF production could be mimicked by zinc ionophore quercetin, but not by primaquine, a chloroquine analog with low affinity for heme. Quercetin 65-74 tumor necrosis factor Mus musculus 14-17 34023442-14 2021 RESULTS: Que treatment decreased the clinical score and left ankle thickness of CIA mice, attenuated the synovial inflammation and hyperplasia and bone/cartilage destruction in ankle joints, and decreased the secretion of IL-6, TNF-alpha, IL-1beta, IL-8, IL-13, and IL-17. Quercetin 9-12 tumor necrosis factor Mus musculus 228-237 35186104-13 2022 Molecular docking analysis showed that quercetin combined well with TNF, CXCL8, and TLR4. Quercetin 39-48 tumor necrosis factor Mus musculus 68-71 35295707-8 2022 Moreover, the study examined the effect of quercetin on astrocytes activation and neuroinflammation, and the results indicated that it significantly attenuated the activation of astrocytes and reduced the levels of IL-1beta, TNFalpha but not IL-6. Quercetin 43-52 tumor necrosis factor Mus musculus 225-233 35186104-15 2022 Conclusions: Danlong Dingchuan Decoction may act on key targets (such as IL-6, TNF, CXCL8, VEGFA, and MAPK3) with key active ingredients (such as quercetin, xanthine, lysine, kaempferol, and ss-sitosterol) to reduce the expression levels of IL-4, IL-6, IL-8, and other Th2 cytokines. Quercetin 146-155 tumor necrosis factor Mus musculus 79-82 33550031-9 2021 Moreover, quercetin attenuated the expression of inflammatory mediators including toll-like receptor-4 (TLR-4), TLR-2, interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) and high mobility group box 1 (HMGB1) in vitro and in vivo. Quercetin 10-19 tumor necrosis factor Mus musculus 178-187 33550031-10 2021 CONCLUSIONS: Our study demonstrated that quercetin treatment can ameliorate A. fumigatus keratitis by inhibiting the growth of A. fumigatus, decreasing neutrophil recruitment and infiltration, and downregulating the productions of TLR-4, TLR-2, TNF-alpha, IL-1beta and HMGB1, indicating quercetin is likely to become a potential therapeutic agent in FK treatment. Quercetin 41-50 tumor necrosis factor Mus musculus 245-254 32932805-5 2020 Quercetin significantly decreased the hepatic and plasmatic levels of inflammatory cytokines IL-1beta, IL-6, TNF-alpha, inducible nitric oxide synthase, cyclooxygenase-2 and intercellular adhesion molecule-1-provoked by over-exercise. Quercetin 0-9 tumor necrosis factor Mus musculus 109-118 33490128-8 2020 Furthermore, quercetin supplementation markedly activated the expression of Nrf2 and HO-1 mRNAs, but inhibited the expression of NF-kappaB, IL-1beta, IL-6, and TNF-alpha mRNAs. Quercetin 13-22 tumor necrosis factor Mus musculus 160-169 32966478-10 2020 Biological pathway analysis showed that tumor necrosis factor (TNF), cytokine, and NF-kappaB signaling pathways were involved in the anti-inflammatory mechanisms of quercetin. Quercetin 165-174 tumor necrosis factor Mus musculus 40-61 32966478-10 2020 Biological pathway analysis showed that tumor necrosis factor (TNF), cytokine, and NF-kappaB signaling pathways were involved in the anti-inflammatory mechanisms of quercetin. Quercetin 165-174 tumor necrosis factor Mus musculus 63-66 32966478-11 2020 Immunohistochemical staining further showed that quercetin reduced the activation of NF-kappaB, the expression of interleukin-1beta and TNF-alpha, and the infiltration of granulocytes in retinal tissues. Quercetin 49-58 tumor necrosis factor Mus musculus 136-145 31144159-9 2020 After quercetin intervention, the areas of AS plaques and the expressions of PCSK9, TNF-alpha and IL-6 were significantly reduced (all P<0.01), while the expressions of ABCA1 and LXR-alpha were increased significantly (all P<0.01). Quercetin 6-15 tumor necrosis factor Mus musculus 84-93 32742328-6 2020 It was noted that quercetin attenuated the KA-induced seizure score and proinflammatory cytokine production, including tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), and activation of nuclear factor kappaB (NF-kappaB) in mice. Quercetin 18-27 tumor necrosis factor Mus musculus 119-146 32742328-6 2020 It was noted that quercetin attenuated the KA-induced seizure score and proinflammatory cytokine production, including tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), and activation of nuclear factor kappaB (NF-kappaB) in mice. Quercetin 18-27 tumor necrosis factor Mus musculus 148-157 32742328-7 2020 Quercetin attenuated KA-induced proinflammatory cytokine (TNF-alpha and IL-1beta) release from microglia cells, as well as activation of NF-kappaB and ionized calcium binding adapter molecule 1 in microglia cells. Quercetin 0-9 tumor necrosis factor Mus musculus 58-67 32742328-8 2020 Therefore, quercetin inhibited KA-induced epilepsy by microglia cell inactivation and the production of NF-kappaB, TNF-alpha and IL-1beta. Quercetin 11-20 tumor necrosis factor Mus musculus 115-124 31672514-4 2020 KEY RESULTS: Quercetin inhibited the ovalbumin (OVA) induced expression of IgE, HA, IL-4, TNF-alpha and substance-P in the peripheral blood of AC mouse models. Quercetin 13-22 tumor necrosis factor Mus musculus 90-99 31452288-7 2019 Not only that, quercetin markedly attenuated T2DM-induced production of interleukin 1 beta, interleukin 6, and TNF-alpha. Quercetin 15-24 tumor necrosis factor Mus musculus 111-120 32038944-14 2019 Results: Quercetin treatment for 12 weeks significantly reduced the levels of TC (P<0.001), TG (P<0.05), HDL (P<0.001), LDL (P<0.001), TNF-alpha (P<0.001) and IL-6 (P<0.001) compared with the model group. Quercetin 9-18 tumor necrosis factor Mus musculus 135-144 31140426-5 2019 RESULTS: Quercetin significantly lessened renal pathologies, lowered BUN and creatinine levels (P &lt; 0.05) and inhibited TNF-alpha, IL-1beta, and IL-6 production in mice with LPS-induced AKI (P &lt; 0.05). Quercetin 9-18 tumor necrosis factor Mus musculus 127-136 31781635-14 2019 Besides, the ELISA results showed that TNF-alpha, IL-1beta, and IL-6 were reduced in LPS-stimulated RAW264.7 cells after interfering with quercetin and quercitrin. Quercetin 138-147 tumor necrosis factor Mus musculus 39-48 31660141-6 2019 Alternating the consumption of beta-glucan and quercetin significantly decreased the TNF-alpha level, increased the relative abundance of Parabacteroides, and downregulated three genes (Hmgcs2, Fabp2, and Gpt) that are associated with inflammation and cancer. Quercetin 47-56 tumor necrosis factor Mus musculus 85-94 29197723-10 2018 The protective analgesic and anti-inflammatory mechanisms of quercetin included the inhibition of TiO2-induced neutrophil and macrophage recruitment, proteoglycan degradation, oxidative stress, cytokine production (TNF-alpha, IL-1beta, IL-6, and IL-10), COX-2 mRNA expression, and bone resorption as well as activation of Nrf2/HO-1 signaling pathway. Quercetin 61-70 tumor necrosis factor Mus musculus 215-224 30637814-2 2019 Results showed that the combined treatment of quercetin with catechin synergistically attenuated LPS-stimulated increase of some proinflammatory molecules, including nitric oxide, tumor necrosis factor alpha, interleukin-1beta, nitric oxide synthase, and cyclooxygenase-2. Quercetin 46-55 tumor necrosis factor Mus musculus 180-207 29322353-8 2018 Our observation from the present research work reveals that Quercetin suppressed the production of proinflammatory cytokines at different levels, such as TNF-alpha and IL-1beta, and inhibits the activation of I-kappaB phosphorylation, whereas the total content was not affected. Quercetin 60-69 tumor necrosis factor Mus musculus 154-163 29554596-6 2018 The treatment with quercetin also inhibited zymosan-induced depletion of reduced glutathione (GSH) levels, TNFalpha and IL-1beta production, and gp91phox, prepro-endothelin-1 (preproET-1), and cyclooxygenase-2 mRNA expression. Quercetin 19-28 tumor necrosis factor Mus musculus 107-115 29569982-0 2018 Quercetin Reduces Tumor Necrosis Factor Alpha-Induced Muscle Atrophy by Upregulation of Heme Oxygenase-1. Quercetin 0-9 tumor necrosis factor Mus musculus 18-45 29569982-3 2018 In this study, we investigated the effect of quercetin on TNFalpha-induced skeletal muscle atrophy as well as its potential mechanism of action. Quercetin 45-54 tumor necrosis factor Mus musculus 58-66 29569982-4 2018 In this study, we observed that quercetin suppressed expression of TNFalpha-induced atrophic factors such as MAFbx/atrogin-1 and MuRF1 in myotubes, and it enhanced heme oxygenase-1 (HO-1) protein level accompanied by increased nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) in myotubes. Quercetin 32-41 tumor necrosis factor Mus musculus 67-75 29480020-7 2018 Treatment with quercetin in the pristane-induced LN mice model was nephroprotective, decreasing proteinuria levels and significantly lowering tissue expression of IL-6, TNF-alpha, TGF-beta1, Bax and TBARS. Quercetin 15-24 tumor necrosis factor Mus musculus 169-178 30795510-6 2019 Results showed that low concentrations of quercetin (2.5 microM), in combination with DHA (10 microM), could more effectively enhance the expression of Nrf2 and heme oxygenase 1 (HO-1), and suppress LPS-induced nitric oxide, tumor necrosis factor-alpha, phospho-cytosolic phospholipase A2, reactive oxygen species, and 4-hydroxynonenal, as compared to the same levels of DHA or quercetin alone. Quercetin 42-51 tumor necrosis factor Mus musculus 225-252 29569982-5 2018 The HO-1 inhibitor ZnPP suppressed the inhibitory actions of quercetin on TNFalpha-induced atrophic responses and degradation of IkappaB-alpha in myotubes. Quercetin 61-70 tumor necrosis factor Mus musculus 74-82 29569982-7 2018 These findings suggest that quercetin protects against TNFalpha-induced muscle atrophy under obese conditions through Nrf2-mediated HO-1 induction accompanied by inactivation of NF-kappaB. Quercetin 28-37 tumor necrosis factor Mus musculus 55-63 29611586-6 2018 Among the compounds identified in the hydrolyzed ULCE, quercetin exhibited the strongest inhibitory effect against TNF-alpha-induced cell adhesion capacity. Quercetin 55-64 tumor necrosis factor Mus musculus 115-124 28342364-9 2017 The reduced severity of the disease in animals treated with quercetin was associated with decreased levels of TNF-alpha, IL-1beta, IL-17, and MCP-1. Quercetin 60-69 tumor necrosis factor Mus musculus 110-119 29497376-10 2018 In vitro, studies further revealed that quercetin efficiently inhibited macrophages activation and M1 polarization, as well as decreased the mRNA expression of M1 macrophage markers such as TNF-alpha, IL-1beta, IL-6, and nitric oxide synthase 2. Quercetin 40-49 tumor necrosis factor Mus musculus 190-199 28545670-11 2017 The mRNA levels of IFN-alpha, IFN-lambda, TNF-alpha, Mx, and ZAP were upregulated in RAW 264.7 cells pre-treated with fisetin, quercetin, and daidzein, but not in those pre-treated with EGCG or ECG. Quercetin 127-136 tumor necrosis factor Mus musculus 42-51 28508104-5 2017 Quercetin inhibited MSU-induced mechanical hyperalgesia, leukocyte recruitment, TNFalpha and IL-1beta production, superoxide anion production, inflammasome activation, decrease of antioxidants levels, NFkappaB activation, and inflammasome components mRNA expression. Quercetin 0-9 tumor necrosis factor Mus musculus 80-88 28615097-8 2017 Results Quercetin significantly reduced the pathological changes of lung tissues, lowered PaCO2 while increased PaO2 and D/W ratio, down-regulated the expressions of iNOS, TNF-alpha, IL-1beta while up-regulated the expressions of IL-4 and IL-10 in SW-ALI mice. Quercetin 8-17 tumor necrosis factor Mus musculus 172-181 27909560-7 2016 RESULTS: Quercetin supplementation decreased levels of inflammatory cytokines (TNFalpha, IL-6) and increased that of the anti-inflammatory cytokine (IL-10) in the livers of HFD-fed mice. Quercetin 9-18 tumor necrosis factor Mus musculus 79-87 28539723-10 2017 Flavonoids in the ECCF were found to contain bergenin, quercitrin, and quercetin with reported anti-inflammatory activity via suppressing tumor necrosis factor-alpha production. Quercetin 71-80 tumor necrosis factor Mus musculus 138-165 27615118-8 2017 This was further corroborated by the significantly low circulating TNF-alpha in the quercetin-loaded nanoparticles treated mice. Quercetin 84-93 tumor necrosis factor Mus musculus 67-76 26499876-3 2016 Supplementation with quercetin suppressed the increase in the number of macrophages, the decrease in the ratio of CD4(+) to CD8(+) T cells in EAT, and the elevation of plasma leptin and tumor necrosis factor alpha levels in mice fed the Western diet. Quercetin 21-30 tumor necrosis factor Mus musculus 186-213 27419199-1 2016 The data presented in this article describe an effect of N-acetylneuraminic acid and/or quercetin on the inflammatory proteins expressions (TNF-alpha, ICAM-1, VCAM-1 and MOMA-2) and the N-acetylneuraminic acid (NANA) levels of apolipoprotein E-deficient mice that are given a high-fat diet. Quercetin 88-97 tumor necrosis factor Mus musculus 140-149 26457790-11 2016 Quercetin at 10, 25, 50 and 100 microg/mL inhibited TNF-alpha, but at 500 and 1,000 microg/mL stimulated cell growth. Quercetin 0-9 tumor necrosis factor Mus musculus 52-61 27095146-8 2016 Results indicated that hypaconitine, mesaconitine, higenamine and quercetin in SND can directly bind to TNF-alpha, reduce the TNF-alpha-mediated cytotoxicity on L929 cells and exert anti-myocardial cell apoptosis effects. Quercetin 66-75 tumor necrosis factor Mus musculus 104-113 27095146-8 2016 Results indicated that hypaconitine, mesaconitine, higenamine and quercetin in SND can directly bind to TNF-alpha, reduce the TNF-alpha-mediated cytotoxicity on L929 cells and exert anti-myocardial cell apoptosis effects. Quercetin 66-75 tumor necrosis factor Mus musculus 126-135 26267064-5 2016 Quercetin pretreatment significantly reduced the ConA-induced elevations in plasma aminotransferase concentrations and liver necrosis, as well as reducing serum concentrations of the pro-inflammatory cytokines tumor necrosis factor (TNF)-alpha, interferon-gamma, and interleukin-4. Quercetin 0-9 tumor necrosis factor Mus musculus 210-243 25739980-9 2015 Furthermore, quercetin treatment downregulated cytoplasmic HMGB1, RAGE, nuclear p-NFkappaB, p-ERK1/2, COX2, TNFalpha, IL-1beta, IL-2Ralpha, IFNgamma and IL-4 and upregulated nuclear Nrf2. Quercetin 13-22 tumor necrosis factor Mus musculus 108-116 26277481-8 2015 Our data showed that quercetin inhibited the MAPK signaling factors ERK1/2, JNK and p38MAPK and MCP-1 and TNF-alpha in adipocytes and macrophages. Quercetin 21-30 tumor necrosis factor Mus musculus 106-115 27504150-5 2016 Intense exercise and thapsigargin- (Tg-) induced ERS (glucose-regulated protein 78, GRP78) and inflammatory cytokines levels (IL-6 and TNF-alpha) were decreased with quercetin. Quercetin 166-175 tumor necrosis factor Mus musculus 135-144 26546527-12 2015 Gene expression of Cox2, Tnfalpha and Nos2 stimulated by exposure to Pg-fimbriae was markedly suppressed by quercetin, but was not modulated by its combination with epicatechin. Quercetin 108-117 tumor necrosis factor Mus musculus 25-33 25957741-8 2015 Moreover, quercetin decreased production of pro-inflammatory markers including TNF-alpha, IL-1beta and iNOS. Quercetin 10-19 tumor necrosis factor Mus musculus 79-88 26329008-5 2015 In both a mouse AM cell line (AMJ2-C11 cells) and mouse bronchoalveolar fluid cells, we demonstrated that quercetin attenuated TLR7-induced the expression of TNF-alpha and IL-6. Quercetin 106-115 tumor necrosis factor Mus musculus 158-167 26351625-7 2015 Regarding the analgesic mechanisms of quercetin, it inhibited the production of hyperalgesic cytokines IL-1beta and TNFalpha and decreased neutrophil recruitment (myeloperoxidase activity) and oxidative stress. Quercetin 38-47 tumor necrosis factor Mus musculus 116-124 26329008-7 2015 Notably, tin protoporphyrin IX (SnPP), an inhibitor of HO-1, also attenuated TLR7-induced transcription of the TNF-alpha and IL-6 genes, suggesting that the effect of quercetin is mediated by HO-1. Quercetin 167-176 tumor necrosis factor Mus musculus 111-120 25004880-13 2014 Besides, the mRNAs and levels of IL-6 and TNF-alpha also decreased by quercetin and catechin treatment in LPS-induced RAW264.7 cells. Quercetin 70-79 tumor necrosis factor Mus musculus 42-51 23735482-6 2013 Quercetin inhibited LPS-induced NO, PGE2, iNOS, COX-2, TNF-alpha, IL-1beta, IL-6 and GM-CSF mRNA and protein expressions while it promoted HO-1 induction in a dose- and time-dependent manner. Quercetin 0-9 tumor necrosis factor Mus musculus 55-64 24137346-5 2013 Quercetin liposome administration significantly reduced the MDA content and increased SOD and GSH-PX activities in the lung tissues, and reduced the total cell counts and inflammatory cell proportions in the BALF, plasma TNF-alpha and TGF-beta1 concentrations and the HP content in the lung tissues. Quercetin 0-9 tumor necrosis factor Mus musculus 221-230 24260470-5 2013 Our results show that quercetin significantly attenuates LPS-induced production of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in RAW264.7 macrophages. Quercetin 22-31 tumor necrosis factor Mus musculus 83-110 24260470-5 2013 Our results show that quercetin significantly attenuates LPS-induced production of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in RAW264.7 macrophages. Quercetin 22-31 tumor necrosis factor Mus musculus 112-121 24260470-8 2013 Most importantly, acute administration of quercetin reduces the lethality rate and circulating levels of TNF-alpha and IL-1beta in C57BL/6J mice with endotoxemia induced by LPS, whereas chronic dietary supplementation with quercetin shows no inhibitory effect on serum TNF-alpha and IL-1beta levels. Quercetin 42-51 tumor necrosis factor Mus musculus 105-114 24260470-8 2013 Most importantly, acute administration of quercetin reduces the lethality rate and circulating levels of TNF-alpha and IL-1beta in C57BL/6J mice with endotoxemia induced by LPS, whereas chronic dietary supplementation with quercetin shows no inhibitory effect on serum TNF-alpha and IL-1beta levels. Quercetin 42-51 tumor necrosis factor Mus musculus 269-278 24260470-8 2013 Most importantly, acute administration of quercetin reduces the lethality rate and circulating levels of TNF-alpha and IL-1beta in C57BL/6J mice with endotoxemia induced by LPS, whereas chronic dietary supplementation with quercetin shows no inhibitory effect on serum TNF-alpha and IL-1beta levels. Quercetin 223-232 tumor necrosis factor Mus musculus 269-278 25788280-6 2013 Furthermore, Q-NPs showed marked reduction (compared to quercetin alone) in production of nitric oxide and cytokine (interleukin-6 and tumor necrosis factor alpha) from lipopolysaccharide-activated macrophages. Quercetin 56-65 tumor necrosis factor Mus musculus 135-162 22713545-7 2012 Quercetin treatment improved whole body insulin sensitivity by increasing GLUT4 expression and decreasing JNK phosphorylation, and TNFalpha and iNOS expression in skeletal muscle. Quercetin 0-9 tumor necrosis factor Mus musculus 131-139 23439570-3 2013 We aimed to investigate the role of quercetin and its glycoside, quercitrin in tumor necrosis factor-alpha (TNF-alpha) induced C2C12 skeletal muscle cell impairment. Quercetin 36-45 tumor necrosis factor Mus musculus 108-117 23439570-4 2013 Quercetin, but not quercitrin moderately attenuated the effects of TNF-alpha and enhanced the basal and insulin stimulated uptake of glucose in a dose-dependent manner via the activation of the protein kinase B (Akt) and AMP-activated protein kinase (AMPK) pathways. Quercetin 0-9 tumor necrosis factor Mus musculus 67-76 23393906-9 2012 Quercetin also exhibited the highest inhibitory effect on TNF-alpha production (IC50 = 1.25 microg/ml or 4.14 microM), but engeletin and astilbin had no activity. Quercetin 0-9 tumor necrosis factor Mus musculus 58-67 23454558-13 2013 Quercetin also abrogated glutamine"s beneficial effects on renal TNF-alpha, chemokines, and neutrophil infiltration. Quercetin 0-9 tumor necrosis factor Mus musculus 65-74 23439570-0 2013 Quercetin but not quercitrin ameliorates tumor necrosis factor-alpha-induced insulin resistance in C2C12 skeletal muscle cells. Quercetin 0-9 tumor necrosis factor Mus musculus 41-68 23439570-3 2013 We aimed to investigate the role of quercetin and its glycoside, quercitrin in tumor necrosis factor-alpha (TNF-alpha) induced C2C12 skeletal muscle cell impairment. Quercetin 36-45 tumor necrosis factor Mus musculus 79-106 22902988-9 2012 Quercetin and, to a lesser extent, rutin attenuated the inflammation in the liver by down-regulating the CCl(4)-induced activation of nuclear factor-kappa B (NF-kappaB), tumor necrosis factor-alpha (TNF-alpha) and cyclooxygenase (COX-2). Quercetin 0-9 tumor necrosis factor Mus musculus 170-197 22902988-9 2012 Quercetin and, to a lesser extent, rutin attenuated the inflammation in the liver by down-regulating the CCl(4)-induced activation of nuclear factor-kappa B (NF-kappaB), tumor necrosis factor-alpha (TNF-alpha) and cyclooxygenase (COX-2). Quercetin 0-9 tumor necrosis factor Mus musculus 199-228 22713545-8 2012 Quercetin suppressed palmitate-induced upregulation of TNFalpha and iNOS and restored normal levels of GLUT4 in myotubes. Quercetin 0-9 tumor necrosis factor Mus musculus 55-63 22713545-9 2012 In parallel, quercetin suppressed TNFalpha-induced reduction of glucose uptake in myotubes. Quercetin 13-22 tumor necrosis factor Mus musculus 34-42 20579867-2 2011 Quercetin and isorhamnetin but not Q3G significantly decreased mRNA and protein levels of tumor necrosis factor alpha. Quercetin 0-9 tumor necrosis factor Mus musculus 90-117 22698256-6 2012 Furthermore, resveratrol, pterostilbene, morin hydrate, and quercetin suppressed secretion of TNF-alpha (>40%; P < 0.05) in LPS-stimulated RAW 264.7 cells, and suppressed NF-kappaB activation (22% to 45%; P < 0.05) in LPS-stimulated HEK293T cells. Quercetin 60-69 tumor necrosis factor Mus musculus 94-103 22185406-13 2011 The microarray DNA analyses, followed by pathway analyses indicated that quercetin or delta-tocotrienol inhibit several LPS-induced expression of several ageing and pro-inflammatory genes (IL-1beta, IL-1alpha, IL-6, TNF-alpha, IL-12, iNOS, VCAM1, ICAM1, COX2, IL-1RA, TRAF1 and CD40). Quercetin 73-82 tumor necrosis factor Mus musculus 216-225 21992595-15 2011 CONCLUSIONS: Results of the current study demonstrate that delta-tocotrienol, riboflavin, and quercetin inhibit NO production by LPS-stimulated macrophages of all four strains of mice, and TNF-alpha, secretion only by LPS-stimulated macrophages of C57BL/6 and BALB/c mice. Quercetin 94-103 tumor necrosis factor Mus musculus 189-198 21462320-4 2011 After 20 wk, further reductions of visceral and liver fat accumulation and improved hyperglycemia, hyperinsulinemia, dyslipidemia and plasma adiponectin and TNFalpha levels in these mice fed with quercetin were observed. Quercetin 196-205 tumor necrosis factor Mus musculus 157-165 21462320-6 2011 In mice fed with the control diet, quercetin did not affect body weight but reduces the plasma TNFalpha and hepatic thiobarbituric acid-reactive substance levels. Quercetin 35-44 tumor necrosis factor Mus musculus 95-103 20690163-7 2010 Furthermore, quercetin also significantly activated the AMP-activated protein kinase (AMPK) via down-regulation of protein phosphatase 2C (PP2C), which reduced the integral optical density (IOD) of activated microglia cells and CD11b expression, down-regulated iNOS and cyclooxygenase-2 (COX-2) expression, and decreased IL-1beta, IL-6, and TNF-alpha expression in the brains of high-cholesterol-fed old mice through the suppression of NF-kappaB p65 nuclear translocation. Quercetin 13-22 tumor necrosis factor Mus musculus 341-350