PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33968984-9 2021 Molecular docking results suggest that each bioactive compounds (quercetin, wogonin, luteolin, naringenin, and kaempferol) is capable to bind with STAT3, PTGS2, JUN, VEGFA, EGFR, and ALOX5. Quercetin 65-74 epidermal growth factor receptor Homo sapiens 173-177 33204288-12 2020 Molecular docking showed that quercetin, kaempferol, baicalein, and wogonin have good binding activity with IL6, VEGFA, EGFR, and NFKBIA targets. Quercetin 30-39 epidermal growth factor receptor Homo sapiens 120-124 33577840-4 2021 Quercetin treatment at 50 muM and 75 muM concentration inhibit human metastatic ovarian cancer PA-1 cell survival and proliferation via inactivating PI3k/Akt, Ras/Raf pathways and EGFR expression. Quercetin 0-9 epidermal growth factor receptor Homo sapiens 180-184 33426081-7 2020 Molecular docking and SPR analyses suggested direct binding of berberine with AKT1 and TP53; quercetin with EGFR and VEGF165; and ginkgetin, isoginkgetin, and daucosterol with VEGF165 with weak affinities. Quercetin 93-102 epidermal growth factor receptor Homo sapiens 108-112 31545905-10 2020 In MCF-7 cells, separate or combined incubations with somatostatin and quercetin, significantly decreased EGFR and incubation with curcumin decreased MAPK signaling. Quercetin 71-80 epidermal growth factor receptor Homo sapiens 106-110 31545905-12 2020 Incubation with curcumin and quercetin decreased the EGFR levels. Quercetin 29-38 epidermal growth factor receptor Homo sapiens 53-57 30810849-10 2019 Quercetin was used as positive control, and strong binding energy of -7.54 kcal/mol with EGFR is in accordance with experimental evidence. Quercetin 0-9 epidermal growth factor receptor Homo sapiens 89-93 30200670-4 2018 Notably, 50 micromolar resveratrol and quercetin fully suppressed the low constitutive levels of type I interferon signaling and prevented its activation by the anti-EGFR cetuximab or gefitinib in cultured keratinocytes. Quercetin 39-48 epidermal growth factor receptor Homo sapiens 166-170 30200670-6 2018 Overall, these data suggest that topical application of resveratrol or quercetin could be potentially effective in preventing pathological conditions due to overactivation of type I IFN (interferon)-driven circuits in the skin, including the inflammatory manifestations of anti-EGFR drug-induced skin-targeted toxicity. Quercetin 71-80 epidermal growth factor receptor Homo sapiens 278-282 28498520-0 2017 Gold nanoparticles-conjugated quercetin induces apoptosis via inhibition of EGFR/PI3K/Akt-mediated pathway in breast cancer cell lines (MCF-7 and MDA-MB-231). Quercetin 30-39 epidermal growth factor receptor Homo sapiens 76-80 28958213-0 2017 Ligand-based virtual screening, molecular docking, QSAR and pharmacophore analysis of quercetin-associated potential novel analogs against epidermal growth factor receptor. Quercetin 86-95 epidermal growth factor receptor Homo sapiens 139-171 28958213-1 2017 The present study was to explore expectation and examination of therapeutic potential quercetin analogs as efficient anticancer agents against human epidermal growth factor receptor (EGFR), which is a consistent hallmark for moderating the non-small-cell lung carcinoma (NSCLC). Quercetin 86-95 epidermal growth factor receptor Homo sapiens 149-181 28958213-1 2017 The present study was to explore expectation and examination of therapeutic potential quercetin analogs as efficient anticancer agents against human epidermal growth factor receptor (EGFR), which is a consistent hallmark for moderating the non-small-cell lung carcinoma (NSCLC). Quercetin 86-95 epidermal growth factor receptor Homo sapiens 183-187 27641938-0 2016 Gold nanoparticle-conjugated quercetin inhibits epithelial-mesenchymal transition, angiogenesis and invasiveness via EGFR/VEGFR-2-mediated pathway in breast cancer. Quercetin 29-38 epidermal growth factor receptor Homo sapiens 117-121 21756928-6 2011 Verbascoside and quercetin invariably impaired EGFR phosphorylation and UV-associated aryl hydrocarbon receptor (AhR)-mediated signaling, while rutin, polydatin and resveratrol did not affect EGFR phosphorylation and further activated AhR machinery in UV-exposed keratinocytes. Quercetin 17-26 epidermal growth factor receptor Homo sapiens 47-51 27510965-9 2016 Taken together, our data indicate that quercetin is an effective anti-cancer agent against MMP-2- and MMP-9-mediated metastasis in EGFR-overexpressing HNSCC. Quercetin 39-48 epidermal growth factor receptor Homo sapiens 131-135 25150162-9 2014 The protein expressions of epidermal growth factor receptor (EGFR)/phosphatidylinositide 3-kinases (PI3K)/Akt/extracellular signal-regulated kinase (ERK)1/2 pathway showed that quercetin prevents EGF-induced EMT via EGFR/PI3k/Akt/ERK1/2 pathway and by suppressing transcriptional repressors Snail, Slug and Twist in PC-3 cells. Quercetin 177-186 epidermal growth factor receptor Homo sapiens 27-59 25150162-9 2014 The protein expressions of epidermal growth factor receptor (EGFR)/phosphatidylinositide 3-kinases (PI3K)/Akt/extracellular signal-regulated kinase (ERK)1/2 pathway showed that quercetin prevents EGF-induced EMT via EGFR/PI3k/Akt/ERK1/2 pathway and by suppressing transcriptional repressors Snail, Slug and Twist in PC-3 cells. Quercetin 177-186 epidermal growth factor receptor Homo sapiens 61-65 25150162-9 2014 The protein expressions of epidermal growth factor receptor (EGFR)/phosphatidylinositide 3-kinases (PI3K)/Akt/extracellular signal-regulated kinase (ERK)1/2 pathway showed that quercetin prevents EGF-induced EMT via EGFR/PI3k/Akt/ERK1/2 pathway and by suppressing transcriptional repressors Snail, Slug and Twist in PC-3 cells. Quercetin 177-186 epidermal growth factor receptor Homo sapiens 216-220 27510965-3 2016 In a previous study, we demonstrated that quercetin appears to be a potent anti-tumorigenic agent through its inhibition of the EGFR/Akt pathway in oral cancer, but its anti-metastatic potential in HNSCC remains unclear [1]. Quercetin 42-51 epidermal growth factor receptor Homo sapiens 128-132 27510965-4 2016 Here, we have hypothesized that quercetin might be effective in metastatic inhibition in EGFR-overexpressing HNSCC cells. Quercetin 32-41 epidermal growth factor receptor Homo sapiens 89-93 27510965-5 2016 Quercetin treatment with 10 muM (half concentration of IC50) suppressed cell migration and invasion in EGFR-overexpressing HSC-3 and FaDu HNSCC cells. Quercetin 0-9 epidermal growth factor receptor Homo sapiens 103-107 25596948-6 2015 All the results demonstrated that quercetin exhibited excellent effect on inhibiting cell proliferation in human breast cancer cells, which was performed by up-regulating miR-146a expression, then via inducing apoptosis through caspase-3 activation and mitochondrial-dependent pathways, and inhibiting invasion through down-regulating the expression of EGFR. Quercetin 34-43 epidermal growth factor receptor Homo sapiens 353-357 25150162-0 2014 Quercetin reverses EGF-induced epithelial to mesenchymal transition and invasiveness in prostate cancer (PC-3) cell line via EGFR/PI3K/Akt pathway. Quercetin 0-9 epidermal growth factor receptor Homo sapiens 125-129 22824072-7 2012 mRNA and protein expressions of EGFR decreased markedly when pretreated with quercetin. Quercetin 77-86 epidermal growth factor receptor Homo sapiens 32-36 22824072-10 2012 These results suggest that quercetin can inhibit HNE-induced MUC5AC expression in human airway epithelial cells through PKC/EGFR/ERK signal transduction pathway. Quercetin 27-36 epidermal growth factor receptor Homo sapiens 124-128 21756928-6 2011 Verbascoside and quercetin invariably impaired EGFR phosphorylation and UV-associated aryl hydrocarbon receptor (AhR)-mediated signaling, while rutin, polydatin and resveratrol did not affect EGFR phosphorylation and further activated AhR machinery in UV-exposed keratinocytes. Quercetin 17-26 epidermal growth factor receptor Homo sapiens 192-196 19251944-8 2009 These observations indicate that quercetin stimulates Cl(-) secretion by activating NKCC1 via translocation of an NKCC1-activating factor through an EGFR kinase-dependent pathway. Quercetin 33-42 epidermal growth factor receptor Homo sapiens 149-153 21499124-1 2011 As quercetin, which can inhibit phosphatidylinositol 3-kinase, nuclear factor-kappa B, and protein kinase C (PKC) pathways, induced expression of natural killer group 2, member D (NKG2D) ligands on cancer cells and made the cells sensitive to NK -cell-mediated killing; inhibition of epidermal growth factor receptor (EGFR) pathway might lead to induction of NKG2D ligands. Quercetin 3-12 epidermal growth factor receptor Homo sapiens 284-316 21499124-1 2011 As quercetin, which can inhibit phosphatidylinositol 3-kinase, nuclear factor-kappa B, and protein kinase C (PKC) pathways, induced expression of natural killer group 2, member D (NKG2D) ligands on cancer cells and made the cells sensitive to NK -cell-mediated killing; inhibition of epidermal growth factor receptor (EGFR) pathway might lead to induction of NKG2D ligands. Quercetin 3-12 epidermal growth factor receptor Homo sapiens 318-322 21308698-5 2011 Quercetin downregulates uPA, uPAR and EGF, EGF-R mRNA expressions. Quercetin 0-9 epidermal growth factor receptor Homo sapiens 43-48 21308698-6 2011 Quercetin inhibits cell survival factor beta-catenin, NF-kappaB and also proliferative signalling molecules such as p-EGF-R, N-Ras, Raf-1, c.Fos c.Jun and p-c.Jun protein expressions. Quercetin 0-9 epidermal growth factor receptor Homo sapiens 118-123 20082303-0 2010 Quercetin suppresses HeLa cell viability via AMPK-induced HSP70 and EGFR down-regulation. Quercetin 0-9 epidermal growth factor receptor Homo sapiens 68-72 20082303-6 2010 Furthermore, quercetin sustained epidermal growth factor receptor (EGFR) activation by suppressing the phosphatases, PP2a and SHP-2. Quercetin 13-22 epidermal growth factor receptor Homo sapiens 33-65 20082303-6 2010 Furthermore, quercetin sustained epidermal growth factor receptor (EGFR) activation by suppressing the phosphatases, PP2a and SHP-2. Quercetin 13-22 epidermal growth factor receptor Homo sapiens 67-71 20082303-7 2010 Finally, quercetin increased the interaction between EGFR and Cbl, and also induced the tyrosine phosphorylation of Cbl. Quercetin 9-18 epidermal growth factor receptor Homo sapiens 53-57 20082303-8 2010 Together, these results suggest that quercetin may have anti-tumor effects on HeLa cells via AMPK-induced HSP70 and down-regulation of EGFR. Quercetin 37-46 epidermal growth factor receptor Homo sapiens 135-139 12168845-0 2002 Blockade of the epidermal growth factor receptor tyrosine kinase activity by quercetin and luteolin leads to growth inhibition and apoptosis of pancreatic tumor cells. Quercetin 77-86 epidermal growth factor receptor Homo sapiens 16-48 18618485-0 2008 Comparison of delphinidin, quercetin and (-)-epigallocatechin-3-gallate as inhibitors of the EGFR and the ErbB2 receptor phosphorylation. Quercetin 27-36 epidermal growth factor receptor Homo sapiens 93-97 18618485-1 2008 In the present study, delphinidin was found to suppress the phosphorylation of the epidermal growth factor receptor (EGFR) within human tumour cells (human colon carcinoma cell line (HT29), human vulva carcinoma cell line (A431)), albeit less effective than the flavonol quercetin. Quercetin 271-280 epidermal growth factor receptor Homo sapiens 83-115 18618485-1 2008 In the present study, delphinidin was found to suppress the phosphorylation of the epidermal growth factor receptor (EGFR) within human tumour cells (human colon carcinoma cell line (HT29), human vulva carcinoma cell line (A431)), albeit less effective than the flavonol quercetin. Quercetin 271-280 epidermal growth factor receptor Homo sapiens 117-121 12888923-9 2003 Since ErbB receptor is important for growth, metastasis and drug resistance, inhibition of ErbB-2 and ErbB-3 by pharmacological doses of quercetin may provide a new approach for treatment of prostate cancers. Quercetin 137-146 epidermal growth factor receptor Homo sapiens 6-10 14649542-11 2003 We conclude that the capacity of Q and TAM to increase apoptosis in EGFR-activated cells makes these compounds possible chemopreventive drugs in subjects at risk of developing laryngeal cancer. Quercetin 33-34 epidermal growth factor receptor Homo sapiens 68-72 12168845-1 2002 To glean insights into the mechanism of their action, we assessed the effects of two flavonoids, quercetin (Qu) and luteolin (Lu), on the growth and epidermal growth factor receptor (EGFR) tyrosine kinase activity of MiaPaCa-2 cancer cells. Quercetin 97-106 epidermal growth factor receptor Homo sapiens 149-181 10556937-14 1999 The addition of EGF only marginally diminished the inhibitory effect of luteolin and quercetin on the growth rate of A431 cells, treatment of cellular proteins with EGF and luteolin or quercetin greatly reduced protein phosphorylation, indicating Lu and Qu may act effectively to inhibit a wide range of protein kinases, including EGFR tyrosine kinase. Quercetin 185-194 epidermal growth factor receptor Homo sapiens 331-335 34231170-9 2022 The ten hub targets for quercetin in preventing preterm birth were AKT serine/threonine kinase 1, mitogen-activated protein kinase 3, epidermal growth factor receptor, prostaglandin-endoperoxide synthase 2, mitogen-activated protein kinase 1, estrogen receptor 1, heat shock protein 90 alpha family class A member 1, mitogen-activated protein kinase 8, androgen receptor, and matrix metallopeptidase 9. Quercetin 24-33 epidermal growth factor receptor Homo sapiens 134-166 10090785-1 1999 Using a pharmacophore model for ATP-competitive inhibitors interacting with the active site of the EGFR protein tyrosine kinase together with published X-ray crystal data of quercetin (2) in complex with the Hck tyrosine kinase and of deschloroflavopiridol (3b) in complex with CDK2, a putative binding mode of the isoflavone genistein (1) was proposed. Quercetin 174-183 epidermal growth factor receptor Homo sapiens 99-103 10453447-7 1999 On the cellular level, quercetin sensitivity was correlated with epidermal growth factor (EGF) receptor levels, rapid growth, and poor differentiation, indicating the possibility of targeting those cells most harmful for the organism. Quercetin 23-32 epidermal growth factor receptor Homo sapiens 65-103 34986125-9 2021 Finally, the binding modes of EGFR, IL1B, NOS3 and TP53 with quercetin were visualized. Quercetin 61-70 epidermal growth factor receptor Homo sapiens 30-34 34986125-10 2021 DISCUSSION AND CONCLUSION: Quercetin of Baiying Qinghou decoction showed therapeutic effect against laryngeal squamous cell carcinoma by regulating TP53, EGFR, NOS3 and IL1B involved with drug resistance and PI3K-AKT signaling pathway. Quercetin 27-36 epidermal growth factor receptor Homo sapiens 154-158 34824300-5 2021 A protein functional module with best score was obtained from the PPI network using CytoHubba, and 6 high-probability quercetin targets (AKT1, JUN, MAPK, TNF, VEGFA, and EGFR) were confirmed by docking simulations. Quercetin 118-127 epidermal growth factor receptor Homo sapiens 170-174 34998178-0 2022 Co-encapsulated nanoparticles of Erlotinib and Quercetin for targeting lung cancer through nuclear EGFR and PI3K/AKT inhibition. Quercetin 47-56 epidermal growth factor receptor Homo sapiens 99-103 35070983-14 2021 Furthermore, quercetin combined with cisplatin downregulated the expression of EGFR, MYC, CCND1, and ERBB2 proteins and upregulated CASP8 expression in HeLa and SiHa cells. Quercetin 13-22 epidermal growth factor receptor Homo sapiens 79-83 34539858-0 2021 EGFR and ERK activation resists flavonoid quercetin-induced anticancer activities in human cervical cancer cells in vitro. Quercetin 42-51 epidermal growth factor receptor Homo sapiens 0-4 34539858-2 2021 The results suggested that the natural flavonoid quercetin (Que), the effective antitumor ingredient in SH, which is widely present in a variety of plants, may depend on the target, EGFR. Quercetin 49-58 epidermal growth factor receptor Homo sapiens 182-186 34539858-2 2021 The results suggested that the natural flavonoid quercetin (Que), the effective antitumor ingredient in SH, which is widely present in a variety of plants, may depend on the target, EGFR. Quercetin 60-63 epidermal growth factor receptor Homo sapiens 182-186 34539858-8 2021 Therefore, to the best of our knowledge, the current results provided the first evidence that EGFR and ERK activation induced by Que could resist Que-induced anticancer activities. Quercetin 129-132 epidermal growth factor receptor Homo sapiens 94-98 34539858-8 2021 Therefore, to the best of our knowledge, the current results provided the first evidence that EGFR and ERK activation induced by Que could resist Que-induced anticancer activities. Quercetin 146-149 epidermal growth factor receptor Homo sapiens 94-98 34539858-9 2021 On this basis, the present study determined the role of EGFR and the underlying signaling pathways involved in the anti-cervical cancer malignant behavior induced by Que and identified the negative regulatory association. Quercetin 166-169 epidermal growth factor receptor Homo sapiens 56-60 34572484-0 2021 Growth Suppression in Lung Cancer Cells Harboring EGFR-C797S Mutation by Quercetin. Quercetin 73-82 epidermal growth factor receptor Homo sapiens 50-54 34572484-5 2021 As quercetin was recently shown to inhibit AXL, quercetin may be effective in treating NSCLC cells harboring the EGFR C797S mutation. Quercetin 48-57 epidermal growth factor receptor Homo sapiens 113-117 34572484-6 2021 In this work, the cytotoxic effects of quercetin and its ability to inhibit tumor growth were examined in TKI-resistant NSCLC cells harboring the EGFR C797S mutation. Quercetin 39-48 epidermal growth factor receptor Homo sapiens 146-150 34572484-7 2021 We demonstrated that quercetin exhibited potent cytotoxic effects on NSCLC cells harboring the EGFR C797S mutation by inhibiting AXL and inducing apoptosis. Quercetin 21-30 epidermal growth factor receptor Homo sapiens 95-99 34572484-8 2021 Quercetin inhibited the tumor growth of xenografted NSCLC cells harboring the EGFR C797S mutation and appeared to act synergistically with brigatinib to inhibit of tumor growth in vivo. Quercetin 0-9 epidermal growth factor receptor Homo sapiens 78-82 34572484-9 2021 In summary, herein, we revealed that quercetin is an effective inhibitor for the treatment of non-small-cell lung cancer harboring the EGFR C797S mutation. Quercetin 37-46 epidermal growth factor receptor Homo sapiens 135-139 35442463-17 2022 CONCLUSIONS: (1) Icariin, quercetin and luteolin may act on target proteins, including IL-6, ESR1, EGFR, MAPK8, VEGFA and CASP8, to participate in the regulation of the human cytomegalovirus infection pathway, the PI3K-Akt signaling pathway, the TNF signaling pathway and other signaling pathways in order to effectively treat CAD. Quercetin 26-35 epidermal growth factor receptor Homo sapiens 99-103 35024051-13 2022 The docking results indicated that five main compounds (arachidonic acid, isorhamnetin, quercetin, kaempferol, and (2R)-5,7-dihydroxy-2-(4-hydroxyphenyl)chroman-4-one) had good binding activity with EGFR and AKT1 targets. Quercetin 88-97 epidermal growth factor receptor Homo sapiens 199-203