PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25896587-0 2015 The p53/miR-34a/SIRT1 Positive Feedback Loop in Quercetin-Induced Apoptosis. Quercetin 48-57 sirtuin 1 Homo sapiens 16-21 26904161-7 2016 In addition, quercetin has been shown to activate sirtuins (SIRT1), to induce autophagy, and to act as a phytoestrogen, all mechanisms by which quercetin may provide its neuroprotection. Quercetin 13-22 sirtuin 1 Homo sapiens 60-65 26202455-0 2015 Quercetin is a potent anti-atherosclerotic compound by activation of SIRT1 signaling under oxLDL stimulation. Quercetin 0-9 sirtuin 1 Homo sapiens 69-74 26202455-4 2015 This study was designed to confirm the hypothesis that quercetin inhibits oxidized LDL (oxLDL) induced endothelial oxidative damage by activating sirtuin 1 (SIRT1) and to explore the role of adenosine monophosphate activated protein kinase (AMPK), which is a negative regulator of Nicotinamide adenine dinucleotide phosphate-oxidase (NADPH oxidase) and free radicals. Quercetin 55-64 sirtuin 1 Homo sapiens 146-155 26202455-4 2015 This study was designed to confirm the hypothesis that quercetin inhibits oxidized LDL (oxLDL) induced endothelial oxidative damage by activating sirtuin 1 (SIRT1) and to explore the role of adenosine monophosphate activated protein kinase (AMPK), which is a negative regulator of Nicotinamide adenine dinucleotide phosphate-oxidase (NADPH oxidase) and free radicals. Quercetin 55-64 sirtuin 1 Homo sapiens 157-162 26202455-6 2015 We found that quercetin pretreatment increased SIRT1 mRNA expression. Quercetin 14-23 sirtuin 1 Homo sapiens 47-52 26202455-7 2015 In fact, quercetin protected against oxLDL-impaired SIRT1 and AMPK activities and reduced oxLDL-activated NOX2 and NOX4. Quercetin 9-18 sirtuin 1 Homo sapiens 52-57 26202455-8 2015 However, silencing SIRT1 and AMPK diminished the protective function of quercetin against oxidative injuries. Quercetin 72-81 sirtuin 1 Homo sapiens 19-24 26202455-11 2015 Quercetin suppresses oxLDL-induced endothelial oxidative injuries by activating SIRT1 and modulating the AMPK/NADPH oxidase/AKT/endothelial NO synthase signaling pathway. Quercetin 0-9 sirtuin 1 Homo sapiens 80-85 25057854-0 2014 Quercetin, luteolin, and epigallocatechin gallate promote glucose disposal in adipocytes with regulation of AMP-activated kinase and/or sirtuin 1 activity. Quercetin 0-9 sirtuin 1 Homo sapiens 136-145 25197782-7 2014 Quercetin also increased Sirt1 expression in EPCs. Quercetin 0-9 sirtuin 1 Homo sapiens 25-30 25197782-8 2014 Inhibition of Sirt1 by a chemical antagonist sirtinol abolished the protective effect of quercetin on eNOS phosphorylation, NO production and cGMP levels following high glucose stress. Quercetin 89-98 sirtuin 1 Homo sapiens 14-19 25197782-9 2014 To the best of our knowledge, the results provide the first evidence that quercetin protects against high glucose-induced damage by inducing Sirt1-dependent eNOS upregulation in EPCs, and suggest that quercetin is a promising therapeutic agent for diabetic patients undergoing surgery or other invasive procedures. Quercetin 74-83 sirtuin 1 Homo sapiens 141-146 25197782-9 2014 To the best of our knowledge, the results provide the first evidence that quercetin protects against high glucose-induced damage by inducing Sirt1-dependent eNOS upregulation in EPCs, and suggest that quercetin is a promising therapeutic agent for diabetic patients undergoing surgery or other invasive procedures. Quercetin 201-210 sirtuin 1 Homo sapiens 141-146 25057854-5 2014 Quercetin, luteolin, and epigallocatechin gallate suppressed nuclear factor-kappaB activation by inhibition of p65 phosphorylation with beneficial regulation of adipokine expression, whereas these actions were diminished by coincubation with compound C. The sirtuin 1 inhibitor nicotinamide attenuated the effects of luteolin and EGCG on p65 phosphorylation and adipokine expression without any influence on the activity of quercetin. Quercetin 0-9 sirtuin 1 Homo sapiens 258-267 25057854-5 2014 Quercetin, luteolin, and epigallocatechin gallate suppressed nuclear factor-kappaB activation by inhibition of p65 phosphorylation with beneficial regulation of adipokine expression, whereas these actions were diminished by coincubation with compound C. The sirtuin 1 inhibitor nicotinamide attenuated the effects of luteolin and EGCG on p65 phosphorylation and adipokine expression without any influence on the activity of quercetin. Quercetin 424-433 sirtuin 1 Homo sapiens 258-267 25057854-7 2014 These findings suggested that quercetin, luteolin, and epigallocatechin gallate inhibited inflammation and promoted glucose disposal in adipocytes with the regulation of AMP-activated kinase and/or sirtuin 1. Quercetin 30-39 sirtuin 1 Homo sapiens 198-207 33785094-12 2021 Therefore, these sequels indicate that quercetin protects against sepsis-associated AKI by upregulation Sirt1 expression through quenching NF-kappaB activation and may be an encouraging therapeutic agent for patients with sepsis-associated AKI. Quercetin 39-48 sirtuin 1 Homo sapiens 104-109 24606795-21 2014 Several pharmacological strategies to trigger these signaling cascades, according to these authors, are the use of bezafibrate to activate the PPAR-PGC-1alpha axis, the activation of AMPK by resveratrol and the use of Sirt1 agonists such as quercetin or resveratrol. Quercetin 241-250 sirtuin 1 Homo sapiens 218-223 22245592-2 2012 In this study, we investigated the role of SIRT1 signaling in the hypoxic down-regulations of c-Myc and beta-catenin and hypoxic preconditioning effect of the red wine polyphenols such as piceatannol, myricetin, quercetin and resveratrol. Quercetin 212-221 sirtuin 1 Homo sapiens 43-48 22245592-6 2012 We also found that myricetin, quercetin, piceatannol and resveratrol up-regulated HIF-1alpha and down-regulated c-Myc, PHD2 and beta-catenin expressions via SIRT1 activation, in a manner that mimics hypoxic preconditioning. Quercetin 30-39 sirtuin 1 Homo sapiens 157-162 21253976-8 2011 Quercetin, a natural polyphenolic flavonoid that has been widely investigated for its other health benefits, may act as an inducer of SirT1. Quercetin 0-9 sirtuin 1 Homo sapiens 134-139 19071085-4 2009 The putative SIRT1 activators resveratrol and quercetin also increased AMPK phosphorylation. Quercetin 46-55 sirtuin 1 Homo sapiens 13-18 34314805-10 2021 Furthermore, EAS, quercetin, 6-methoxykaempferol and kaempferol increase significantly (p < 0.05) SIRT1 (3.43, 1.18, 2.62 and 1.72 expression quantity, respectively) and SIRT3 (16.27, 5.01, 3.01 and 6.18 expression quantity, respectively) in HaCaT cell. Quercetin 18-27 sirtuin 1 Homo sapiens 98-103 33859776-0 2021 Quercetin Improves Cardiomyocyte Vulnerability to Hypoxia by Regulating SIRT1/TMBIM6-Related Mitophagy and Endoplasmic Reticulum Stress. Quercetin 0-9 sirtuin 1 Homo sapiens 72-77 33859776-9 2021 Furthermore, transfection with short interfering RNA against silent information regulator protein 1 (SIRT1) counteracted the protective effects of quercetin on cardiomyocytes. Quercetin 147-156 sirtuin 1 Homo sapiens 61-99 33859776-9 2021 Furthermore, transfection with short interfering RNA against silent information regulator protein 1 (SIRT1) counteracted the protective effects of quercetin on cardiomyocytes. Quercetin 147-156 sirtuin 1 Homo sapiens 101-106 33859776-10 2021 Thus, quercetin was predicted to regulate mitophagy and endoplasmic reticulum stress through SIRT1/TMBIM6 and inhibit H/R-induced oxidative stress damage. Quercetin 6-15 sirtuin 1 Homo sapiens 93-98 16603228-6 2006 Using metabolically active HT29 cells we were able to show that quercetin (a stimulator of recombinant SIRT1) could not stimulate intracellular SIRT1. Quercetin 64-73 sirtuin 1 Homo sapiens 103-108 16603228-7 2006 The major quercetin metabolite in humans, quercetin 3-O-glucuronide, slightly inhibited the recombinant SIRT1 activity which explains the lack of stimulatory action of quercetin in HT29 cells. Quercetin 10-19 sirtuin 1 Homo sapiens 104-109 16603228-7 2006 The major quercetin metabolite in humans, quercetin 3-O-glucuronide, slightly inhibited the recombinant SIRT1 activity which explains the lack of stimulatory action of quercetin in HT29 cells. Quercetin 42-51 sirtuin 1 Homo sapiens 104-109 34853352-6 2021 Besides, quercetin treatment decreased miR-155-5p expression in both models, with down-regulation of p65 and a trend toward an up-regulation of SIRT-1 in complete cell extracts. Quercetin 9-18 sirtuin 1 Homo sapiens 144-150 34853352-8 2021 The downregulation of miRNA-155-5p, possibly through the modulation of NF-kappaB and SIRT-1, could have a key role in the effects of quercetin on both pre-adipocytes and adipocytes. Quercetin 133-142 sirtuin 1 Homo sapiens 85-91 34335587-12 2021 In the mechanistic study, we found that the induction of p53 deacetylation, due to either the resveratrol/quercetin -induced activation of the deacetylase Sirtuin 1 (Sirt1) or the mutation of the acetylated lysine site in p53, promoted RTEC autophagy and alleviated SAKI. Quercetin 106-115 sirtuin 1 Homo sapiens 155-164 34335587-12 2021 In the mechanistic study, we found that the induction of p53 deacetylation, due to either the resveratrol/quercetin -induced activation of the deacetylase Sirtuin 1 (Sirt1) or the mutation of the acetylated lysine site in p53, promoted RTEC autophagy and alleviated SAKI. Quercetin 106-115 sirtuin 1 Homo sapiens 166-171 35325306-11 2022 Compared with control group, quercetin group had a higher weight retention rate, a higher gene/protein expression of SIRT1, HSP60, UCP1, PPAR-gamma and VEGF-A, and a higher occurrence of peripheral adipose browning. Quercetin 29-38 sirtuin 1 Homo sapiens 117-122 35277012-3 2022 Nevertheless, in vitro and in vivo studies and clinical trials with humans show that the SIRT1-activating compounds derived from natural sources, such as polyphenols found in fruits, vegetables, and plants, including resveratrol, quercetin, and isoflavones, can prevent disease and be part of treatments for a wide variety of diseases. Quercetin 230-239 sirtuin 1 Homo sapiens 89-94 33709560-0 2021 Quercetin induces pro-apoptotic autophagy via SIRT1/AMPK signaling pathway in human lung cancer cell lines A549 and H1299 in vitro. Quercetin 0-9 sirtuin 1 Homo sapiens 46-51 33709560-12 2021 In addition, quercetin dose-dependently elevated the levels of SIRT1 protein and the pAMPK-AMPK ratio. Quercetin 13-22 sirtuin 1 Homo sapiens 63-68 33709560-13 2021 Quercetin-induced autophagy was attenuated by SIRT1 inhibitor EX527 and SirT1 knockdown by small interfering RNA (siRNA). Quercetin 0-9 sirtuin 1 Homo sapiens 46-51 33709560-13 2021 Quercetin-induced autophagy was attenuated by SIRT1 inhibitor EX527 and SirT1 knockdown by small interfering RNA (siRNA). Quercetin 0-9 sirtuin 1 Homo sapiens 72-77 33709560-14 2021 CONCLUSIONS: Quercetin-induced autophagy contributes to apoptosis in A549 and H1299 lung cancer cells, which involved the SIRT1/AMPK signaling pathway. Quercetin 13-22 sirtuin 1 Homo sapiens 122-127 33066597-10 2020 Furthermore, downregulation of SIRT1 and SIRT6 by BLU9931 contributed to senescence induction, priming these cells for quercetin-induced death, a process termed senolysis. Quercetin 119-128 sirtuin 1 Homo sapiens 31-36 32702447-0 2020 Quercetin alleviates kidney fibrosis by reducing renal tubular epithelial cell senescence through the SIRT1/PINK1/mitophagy axis. Quercetin 0-9 sirtuin 1 Homo sapiens 102-107 32702447-9 2020 Sirtuin-1 (SIRT1) was involved in quercetin-mediated PTEN-induced kinase 1 (PINK1)/Parkin-associated mitophagy activation. Quercetin 34-43 sirtuin 1 Homo sapiens 0-9 32702447-9 2020 Sirtuin-1 (SIRT1) was involved in quercetin-mediated PTEN-induced kinase 1 (PINK1)/Parkin-associated mitophagy activation. Quercetin 34-43 sirtuin 1 Homo sapiens 11-16 32702447-10 2020 Pharmacological antagonism of SIRT1 in AngII-treated RTECs blocked the effects of quercetin on mitophagy and cellular senescence. Quercetin 82-91 sirtuin 1 Homo sapiens 30-35 32702447-12 2020 Collectively, the antifibrotic effect of quercetin involved inhibition of RTEC senescence, possibly through activation of SIRT1/PINK1/Parkin-mediated mitophagy. Quercetin 41-50 sirtuin 1 Homo sapiens 122-127 31548332-9 2019 Pretreatment with quercetin, which increases SIRT-1 expression, normalized RV-induced IFN levels in COPD airway epithelial cells. Quercetin 18-27 sirtuin 1 Homo sapiens 45-51 32848804-8 2020 This review will examine compounds of natural origin recently found to upregulate SIRT1 activity, such as polyphenolic products in fruits, vegetables, and plants including resveratrol, fisetin, quercetin, and curcumin. Quercetin 194-203 sirtuin 1 Homo sapiens 82-87 31773385-6 2020 Quercetin and caffeic acid in old fibroblast cells showed higher clock gene expression than resveratrol, quercetin increased Sirt1 expression, and caffeic acid increased Sirt6 expression indicating the possibility of an anti-aging effect. Quercetin 105-114 sirtuin 1 Homo sapiens 125-130 31773385-7 2020 Also, quercetin and caffeic acid showed higher clock-controlled gene (Sirt1 and NR1D1) expression than resveratrol in young fibroblast cells. Quercetin 6-15 sirtuin 1 Homo sapiens 70-75 31548332-10 2019 Inhibition of SIRT-1 in quercetin-pretreated COPD cells abolished the normalizing effects of quercetin on RV-induced IFN expression in these cells, confirming that quercetin exerts its effect via SIRT-1. Quercetin 24-33 sirtuin 1 Homo sapiens 14-20 31548332-10 2019 Inhibition of SIRT-1 in quercetin-pretreated COPD cells abolished the normalizing effects of quercetin on RV-induced IFN expression in these cells, confirming that quercetin exerts its effect via SIRT-1. Quercetin 24-33 sirtuin 1 Homo sapiens 196-202 31548332-10 2019 Inhibition of SIRT-1 in quercetin-pretreated COPD cells abolished the normalizing effects of quercetin on RV-induced IFN expression in these cells, confirming that quercetin exerts its effect via SIRT-1. Quercetin 93-102 sirtuin 1 Homo sapiens 14-20 31548332-10 2019 Inhibition of SIRT-1 in quercetin-pretreated COPD cells abolished the normalizing effects of quercetin on RV-induced IFN expression in these cells, confirming that quercetin exerts its effect via SIRT-1. Quercetin 93-102 sirtuin 1 Homo sapiens 14-20 31295065-3 2019 As quercetin activates PGC-1alpha through Sirtuin-1, an NAD+-dependent deacetylase, the depleted NAD+ in dystrophic skeletal muscle may limit quercetin efficacy, hence, supplementation with the NAD+ donor, nicotinamide riboside (NR), may facilitate quercetin efficacy. Quercetin 3-12 sirtuin 1 Homo sapiens 42-51 31332904-0 2019 Quercetin protected against isoniazide-induced HepG2 cell apoptosis by activating the SIRT1/ERK pathway. Quercetin 0-9 sirtuin 1 Homo sapiens 86-91 27334466-6 2018 Some polyphenolic natural products such as Resveratrol, Fisetin, and Quercetin have demonstrated health benefits due to their SIRT1 activation effects. Quercetin 69-78 sirtuin 1 Homo sapiens 126-131 30026749-9 2018 No effect of resveratrol was found on both WM-sirtuin and hSIRT1 activities, while only a slight increase, up to about 20%, of hSIRT1 activity by quercetin was observed. Quercetin 146-155 sirtuin 1 Homo sapiens 127-133