PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33612499-0 2021 Protective effects of quercetin on traumatic brain injury induced inflammation and oxidative stress in cortex through activating Nrf2/HO-1 pathway. Quercetin 22-31 heme oxygenase 1 Rattus norvegicus 134-138 33951501-7 2021 Quercetin administration also reduced increased level of HO-1 mRNA in asphyctic piglets. Quercetin 0-9 heme oxygenase 1 Rattus norvegicus 57-61 33951501-8 2021 These results suggest that quercetin neuroprotection might be involved in the regulation of HIF-1alpha, HO-1 and their targets. Quercetin 27-36 heme oxygenase 1 Rattus norvegicus 104-108 34052411-6 2021 Quercetin and salbutamol pretreatment considerably restored the expressions of Nrf-2, HO-1, and surfactant proteins to normal by attenuating the increase in oxidative stress, inflammation, and extravasations of plasma proteins in the animals under hypoxia. Quercetin 0-9 heme oxygenase 1 Rattus norvegicus 86-90 33612499-17 2021 Quercetin treatment activated the cortical Nrf2/HO-1 pathway in TBI rats. Quercetin 0-9 heme oxygenase 1 Rattus norvegicus 48-52 33612499-18 2021 CONCLUSIONS: Quercetin ameliorated the TBI-induced neuroinflammation and oxidative stress in the cortex through activating the Nrf2/HO-1 pathway. Quercetin 13-22 heme oxygenase 1 Rattus norvegicus 132-136 32420373-0 2020 Effect of Quercetin on PC12 Alzheimer"s Disease Cell Model Induced by Abeta 25-35 and Its Mechanism Based on Sirtuin1/Nrf2/HO-1 Pathway. Quercetin 10-19 heme oxygenase 1 Rattus norvegicus 123-127 32660180-13 2020 Conclusion: CO/HO-1 metabolite mediates the protective effect of quercetin on alcoholic oxidative damage of hepatocytes, which may be related to the inhibition of CYP2E1 activity. Quercetin 65-74 heme oxygenase 1 Rattus norvegicus 15-19 32660180-0 2020 [Study on the role and possible mechanism of hemeoxygenase-1/carbon monoxide system in protection of quercetin against ethanol-induced hepatocytes oxidative injury]. Quercetin 101-110 heme oxygenase 1 Rattus norvegicus 45-60 32660180-1 2020 Objective: To study the protective effect and potential mechanism of heme oxygenase (HO-1)/carbon monoxide (CO)-mediated quercetin on alcoholic oxidative damage of primary rat hepatocytes. Quercetin 121-130 heme oxygenase 1 Rattus norvegicus 85-89 32420373-11 2020 Quercetin could increase the survival rate and proliferation rate of PC12 cells; reduce the levels of LDH, AChE, MDA, and HO-1 protein; and increase the levels of SOD, GSH-Px, CAT, T-AOC, sirtuin1, and Nrf2 protein. Quercetin 0-9 heme oxygenase 1 Rattus norvegicus 122-126 23537890-0 2013 The involvement of heme oxygenase 1 but not nitric oxide synthase 2 in a hepatoprotective action of quercetin in lipopolysaccharide-induced hepatotoxicity of D-galactosamine sensitized rats. Quercetin 100-109 heme oxygenase 1 Rattus norvegicus 19-35 29800788-9 2018 In conclusion, the natural antioxidants oleuropein and quercetin counteract the Cyclo induced hepatotoxicity through activation of Nrf2/HO-1 signaling pathway with subsequent suppression of oxidative stress and inflammation. Quercetin 55-64 heme oxygenase 1 Rattus norvegicus 136-140 28248534-9 2017 Pretreatment of D-GalN/LPS rats with either quercetin or SRT1720 returned SIRT1 expression, HO-1 expression and all the aforementioned markers towards normal. Quercetin 44-53 heme oxygenase 1 Rattus norvegicus 92-96 28347707-0 2017 The involvement of sirtuin 1 and heme oxygenase 1 in the hepatoprotective effects of quercetin against carbon tetrachloride-induced sub-chronic liver toxicity in rats. Quercetin 85-94 heme oxygenase 1 Rattus norvegicus 33-49 28347707-10 2017 Collectively, these results suggest that the antioxidant and cytoprotective effects of quercetin in CTC treated rats were SIRT1 mediated and less dependent on HO-1. Quercetin 87-96 heme oxygenase 1 Rattus norvegicus 159-163 26297952-8 2015 In addition, quercetin inhibited the enzymatic activity of pro-inflammatory 12/15-lipoxygenase in lung and liver and increased the expression of heme oxygenase-1 in joint and lung of arthritic rats. Quercetin 13-22 heme oxygenase 1 Rattus norvegicus 145-161 24331699-6 2013 CONCLUSION: Quercetin may induce HO-1 expression via the ERK/Nrf2 signaling transduction pathway. Quercetin 12-21 heme oxygenase 1 Rattus norvegicus 33-37 29993075-6 2018 Quercetin could elevate the expression of nuclear factor E2-related factor 2(Nrf2)/HO-1 and ameliorate ethanol-induced acute liver injury in rats. Quercetin 0-9 heme oxygenase 1 Rattus norvegicus 83-87 29800788-2 2018 This study was designed to investigate the possible cytoprotective effect of natural antioxidants as oleuropein and quercetin against Cyclo induced hepatotoxicity via the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling pathway. Quercetin 116-125 heme oxygenase 1 Rattus norvegicus 222-238 29800788-2 2018 This study was designed to investigate the possible cytoprotective effect of natural antioxidants as oleuropein and quercetin against Cyclo induced hepatotoxicity via the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling pathway. Quercetin 116-125 heme oxygenase 1 Rattus norvegicus 240-244 29149703-0 2018 Quercetin attenuates collagen-induced arthritis by restoration of Th17/Treg balance and activation of Heme Oxygenase 1-mediated anti-inflammatory effect. Quercetin 0-9 heme oxygenase 1 Rattus norvegicus 102-118 28914791-0 2017 Quercetin Attenuates Manganese-Induced Neuroinflammation by Alleviating Oxidative Stress through Regulation of Apoptosis, iNOS/NF-kappaB and HO-1/Nrf2 Pathways. Quercetin 0-9 heme oxygenase 1 Rattus norvegicus 141-145 28589248-4 2017 Quercetin, a plant pigment (flavonoid), is an antioxidant and HO-1 inducer. Quercetin 0-9 heme oxygenase 1 Rattus norvegicus 62-66 28589248-12 2017 These findings suggest that quercetin has a hepatoprotective effect against I/R injury via HO-1 induction and unexpectedly, SnPP showed the similar effect. Quercetin 28-37 heme oxygenase 1 Rattus norvegicus 91-95 28589248-13 2017 Quercetin has more prominent protective effect than SnPP because of its superior ability to induce HO-1. Quercetin 0-9 heme oxygenase 1 Rattus norvegicus 99-103 23024111-11 2014 Accordingly, this study suggests that the reduction in oxidative stress and modulation of HO-1 mRNA expression and TNF-alpha release by curcumin and quercetin may contribute to the synergistic anti-inflammatory effects of these two flavonoids upon combination. Quercetin 149-158 heme oxygenase 1 Rattus norvegicus 90-94 24331699-0 2013 [Potential molecular mechanisms of quercetin-induced heme oxygenase-1 in rat primary hepatocytes]. Quercetin 35-44 heme oxygenase 1 Rattus norvegicus 53-69 24331699-1 2013 OBJECTIVE: To investigate the possible molecular mechanisms of heme oxygenase-1 (HO-1) induction by quercetin using rat primary hepatocytes. Quercetin 100-109 heme oxygenase 1 Rattus norvegicus 63-79 24331699-1 2013 OBJECTIVE: To investigate the possible molecular mechanisms of heme oxygenase-1 (HO-1) induction by quercetin using rat primary hepatocytes. Quercetin 100-109 heme oxygenase 1 Rattus norvegicus 81-85 24331699-4 2013 RESULTS: After 4 - 12 h of treatment with quercetin at all concentrations, the HO-1 mRNA level in hepatocytes had increased significantly (vs. untreated control cells; all P less than 0.01). Quercetin 42-51 heme oxygenase 1 Rattus norvegicus 79-83 24331699-5 2013 The quercetin-induced HO-1 expression and Nrf2 translocation into the nucleolus was inhibited by PD98059. Quercetin 4-13 heme oxygenase 1 Rattus norvegicus 22-26 23537890-1 2013 The objective of this study was to evaluate potential hepatoprotective capabilities of quercetin in relation to its modulation of the HO-1 and NOS-2 activities in an experimental model of fulminant liver failure. Quercetin 87-96 heme oxygenase 1 Rattus norvegicus 134-138 23537890-7 2013 Additionally, quercetin treatment in D-GalN/LPS treated rats significantly increased HO-1 mRNA and its protein expressions. Quercetin 14-23 heme oxygenase 1 Rattus norvegicus 85-89 23537890-10 2013 It can be concluded that the quercetin"s induction of HO-1 and its byproducts, without concomitant NOS-2 activity reduction, is among mechanisms contributing to the hepatoprotective effect in D-GalN/LPS hepatotoxicity. Quercetin 29-38 heme oxygenase 1 Rattus norvegicus 54-58 23265624-0 2013 Bilirubin participates in protecting of heme oxygenase-1 induction by quercetin against ethanol hepatotoxicity in cultured rat hepatocytes. Quercetin 70-79 heme oxygenase 1 Rattus norvegicus 40-56 15118350-0 2004 Mechanism of heme oxygenase-1 gene induction by quercetin in rat aortic smooth muscle cells. Quercetin 48-57 heme oxygenase 1 Rattus norvegicus 13-29 19494027-8 2009 Quercetin also ameliorated liver injury and reduced the expression of hepatic endothelin-1 and HO-1 in untreated cirrhotic rats. Quercetin 0-9 heme oxygenase 1 Rattus norvegicus 95-99 22056766-0 2012 Heme oxygenase-1 mediates the protective role of quercetin against ethanol-induced rat hepatocytes oxidative damage. Quercetin 49-58 heme oxygenase 1 Rattus norvegicus 0-16 19390785-0 2009 Heme oxygenase-1 mediates the anti-allergic actions of quercetin in rodent mast cells. Quercetin 55-64 heme oxygenase 1 Rattus norvegicus 0-16 19390785-1 2009 OBJECTIVE AND DESIGN: We investigated the involvement of heme oxygenase (HO)-1 in the anti-allergic action of quercetin against degranulation of rat basophilic leukemia (RBL-2H3) cells, rat peritoneal mast cells, and mouse bone marrow-derived mast cells. Quercetin 110-119 heme oxygenase 1 Rattus norvegicus 57-78 18602965-12 2008 Treatment with quercetin dose-dependently upregulated the expression of HO-1 mRNA in the bone marrow cells. Quercetin 15-24 heme oxygenase 1 Rattus norvegicus 72-76 16647178-2 2006 Induction of HO-1 protein expression was detected in QUE- but not RUT- or QUI-treated C6 cells, and this was prevented by cycloheximide and actinomycin D. Quercetin 53-56 heme oxygenase 1 Rattus norvegicus 13-17 16647178-9 2006 Adding the HO-1 inhibitors, SnPP, CoPP, and ZnPP, reversed the protective effect of QUE against H(2)O(2)- and chemical anoxia-induced cell death according to the MTT assay and morphological observations. Quercetin 84-87 heme oxygenase 1 Rattus norvegicus 11-15 15118350-4 2004 This study was aimed at examining the potency of quercetin as a HO-1 inducer and its regulation in rat aortic smooth muscle cells (RASMCs). Quercetin 49-58 heme oxygenase 1 Rattus norvegicus 64-68 15118350-5 2004 We showed that quercetin-induced HO-1 production was in time- and dose-dependent fashions, and that this regulation occurred at both transcription and translation levels. Quercetin 15-24 heme oxygenase 1 Rattus norvegicus 33-37 15118350-7 2004 The level of quercetin-induced HO-1 expression was attenuated by SB202190 (a p38MAPK inhibitor). Quercetin 13-22 heme oxygenase 1 Rattus norvegicus 31-35 15118350-8 2004 Taken together from the data in this study, we suggest that quercetin induced HO-1 expression, at least in part, through p38MAPK. Quercetin 60-69 heme oxygenase 1 Rattus norvegicus 78-82 33811899-0 2021 Chlorogenic acid, quercetin, coenzyme Q10 and silymarin modulate Keap1-Nrf2/heme oxygenase-1 signaling in thioacetamide-induced acute liver toxicity. Quercetin 18-27 heme oxygenase 1 Rattus norvegicus 76-92 33811899-2 2021 We investigated the effect of chlorogenic acid (CGA), quercetin (Qt), coenzyme Q10 (Q10) and silymarin on the expression of Keap1/Nrf2 complex and its downstream target; heme oxygenase 1 (HO-1) as well as inflammation and apoptosis in an acute liver toxicity model induced by thioacetamide (TAA). Quercetin 54-63 heme oxygenase 1 Rattus norvegicus 170-186 34554409-0 2021 Quercetin Exhibits alpha7nAChR/Nrf2/HO-1-Mediated Neuroprotection Against STZ-Induced Mitochondrial Toxicity and Cognitive Impairments in Experimental Rodents. Quercetin 0-9 heme oxygenase 1 Rattus norvegicus 36-40 34554409-6 2021 Further, Quercetin significantly attenuated STZ-induced reduction in the alpha7nAChRs and HO-1 expression levels in the selected rat brain regions. Quercetin 9-18 heme oxygenase 1 Rattus norvegicus 90-94 34554409-10 2021 Hence, Quercetin exhibits alpha7nAChR/Nrf2/HO-1-mediated neuroprotection against STZ-challenged AD-like animals. Quercetin 7-16 heme oxygenase 1 Rattus norvegicus 43-47 34754366-0 2021 Quercetin Alleviates Red Bull Energy Drink-Induced Cerebral Cortex Neurotoxicity via Modulation of Nrf2 and HO-1. Quercetin 0-9 heme oxygenase 1 Rattus norvegicus 108-112 33318415-0 2021 Quercetin protects against diabetic retinopathy in rats by inducing heme oxygenase-1 expression. Quercetin 0-9 heme oxygenase 1 Rattus norvegicus 68-84 33318415-7 2021 Intraperitoneal injection of the heme oxygenase-1 inhibitor zinc protoporphyrin blocked the protective effect of quercetin. Quercetin 113-122 heme oxygenase 1 Rattus norvegicus 33-49 33318415-8 2021 These findings suggest that quercetin exerts therapeutic effects in diabetic retinopathy possibly by inducing heme oxygenase-1 expression. Quercetin 28-37 heme oxygenase 1 Rattus norvegicus 110-126 34829572-8 2021 Further biochemical assessment of the hind limb tissue showed decreased oxidative stress, increased levels of nitric oxide and endothelial nitric oxide synthase (eNOS), and enhancement of the levels of heme oxygenase-1 (HO-1) and vascular endothelial growth factor (VEGF) in the groups treated with methyl gallate and quercetin. Quercetin 318-327 heme oxygenase 1 Rattus norvegicus 202-218 34829572-8 2021 Further biochemical assessment of the hind limb tissue showed decreased oxidative stress, increased levels of nitric oxide and endothelial nitric oxide synthase (eNOS), and enhancement of the levels of heme oxygenase-1 (HO-1) and vascular endothelial growth factor (VEGF) in the groups treated with methyl gallate and quercetin. Quercetin 318-327 heme oxygenase 1 Rattus norvegicus 220-224 34292112-3 2022 The results showed that quercetin significantly reduced cerebral infarct volume, neurological deficit, BBB permeability and ROS generation via Sirt1/Nrf2/HO-1 signaling pathway. Quercetin 24-33 heme oxygenase 1 Rattus norvegicus 154-158