PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25108166-6 2014 However, Quercetin decreased cell contents of HIF-1alpha, Foxo-3a and NICD as well as pro-apoptotic factors including p53 and Bax compared to H2O2-treated cells. Quercetin 9-18 tumor protein p53 Homo sapiens 118-121 25896587-0 2015 The p53/miR-34a/SIRT1 Positive Feedback Loop in Quercetin-Induced Apoptosis. Quercetin 48-57 tumor protein p53 Homo sapiens 4-7 25896587-5 2015 RESULTS: miR-34a was up-regulated in HepG2 cells treated by quercetin exhibiting wild-type p53. Quercetin 60-69 tumor protein p53 Homo sapiens 91-94 24928376-9 2014 Quercetin also could increase p53 and Caspase-3 expression. Quercetin 0-9 tumor protein p53 Homo sapiens 30-33 25947292-0 2015 PLGA-Loaded Gold-Nanoparticles Precipitated with Quercetin Downregulate HDAC-Akt Activities Controlling Proliferation and Activate p53-ROS Crosstalk to Induce Apoptosis in Hepatocarcinoma Cells. Quercetin 49-58 tumor protein p53 Homo sapiens 131-134 25896587-6 2015 When inhibiting the miR-34a, the sensitivity of the cells to quercetin decreased and the expression of the SIRT1 was up-regulated, but the acetylation of p53 and the expression of some genes related to p53 down-regulated. Quercetin 61-70 tumor protein p53 Homo sapiens 202-205 24849437-0 2014 [Effect of quercetin on glioma cell U87 apoptosis and feedback regulation of MDM2-p53]. Quercetin 11-20 tumor protein p53 Homo sapiens 82-85 24760952-5 2014 Quercetin-induced cell apoptosis was shown to involve p53 and p21 up-regulation, Cyclin D1, Cdk2, and Cdk7 down-regulation. Quercetin 0-9 tumor protein p53 Homo sapiens 54-57 24760952-6 2014 These results suggested that the induction of G2/M arrest, apoptosis, and cell death by quercetin may associate with increased expression of p53 and p21, decrease of Cyclin D1, Cdk2, and Cdk7 levels, and generation of reactive oxygen species in cells. Quercetin 88-97 tumor protein p53 Homo sapiens 141-144 24849437-1 2014 OBJECTIVE: To investigate the effect of quercetin on apoptosis and feedback regulation of MDM2-p53 in multiform glioblastoma U87 cells in vitro. Quercetin 40-49 tumor protein p53 Homo sapiens 95-98 24849437-2 2014 METHODS: U87 cells exposed to different concentrations of quercetin (50, 100, and 150 micromol/L) were examined with flow cytometry, RT-PCR and Western blotting for detecting the cell apoptosis, MDM2 mRNA expression, and p53 and caspase-3 expressions. Quercetin 58-67 tumor protein p53 Homo sapiens 221-224 24849437-4 2014 Quercetin significantly increased the expressions of MDM2 mRNA and active caspase-3 protein but decreased the expression of p53 in the cells. Quercetin 0-9 tumor protein p53 Homo sapiens 124-127 24849437-5 2014 CONCLUSION: Quercetin promotes the apoptosis of multiform glioblastoma U87 cells mediated by caspase-3 and influences the feedback balance of MDM2-p53. Quercetin 12-21 tumor protein p53 Homo sapiens 147-150 24535669-0 2014 Quercetin regulates the sestrin 2-AMPK-p38 MAPK signaling pathway and induces apoptosis by increasing the generation of intracellular ROS in a p53-independent manner. Quercetin 0-9 tumor protein p53 Homo sapiens 143-146 24535669-7 2014 We demonstrate that the increase in the expression of sestrin 2 by quercetin-generated intracellular ROS is p53-independent. Quercetin 67-76 tumor protein p53 Homo sapiens 108-111 22070678-4 2011 Quercetin can also upregulate proteins that abrogate free radical damage, such as p53. Quercetin 0-9 tumor protein p53 Homo sapiens 82-85 22983795-0 2013 p53 contributes to quercetin-induced apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes. Quercetin 19-28 tumor protein p53 Homo sapiens 0-3 22983795-8 2013 Quercetin also elevated p53 phosphorylation at ser15. Quercetin 0-9 tumor protein p53 Homo sapiens 24-27 22983795-9 2013 Pretreatment with pifithrin-alpha, a p53 inhibitor, significantly diminished p53 phosphorylation at the concentration of 30 muM and abrogated quercetin-induced apoptosis in a dose-dependent manner. Quercetin 142-151 tumor protein p53 Homo sapiens 37-40 22983795-10 2013 Quercetin-induced apoptosis was also significantly blocked by p53 silencing, further suggesting the involvement of p53 in quercetin-induced apoptosis in RAFLSs. Quercetin 0-9 tumor protein p53 Homo sapiens 62-65 22983795-10 2013 Quercetin-induced apoptosis was also significantly blocked by p53 silencing, further suggesting the involvement of p53 in quercetin-induced apoptosis in RAFLSs. Quercetin 0-9 tumor protein p53 Homo sapiens 115-118 22983795-10 2013 Quercetin-induced apoptosis was also significantly blocked by p53 silencing, further suggesting the involvement of p53 in quercetin-induced apoptosis in RAFLSs. Quercetin 122-131 tumor protein p53 Homo sapiens 62-65 22983795-10 2013 Quercetin-induced apoptosis was also significantly blocked by p53 silencing, further suggesting the involvement of p53 in quercetin-induced apoptosis in RAFLSs. Quercetin 122-131 tumor protein p53 Homo sapiens 115-118 22983795-11 2013 Our study indicated that quercetin-induced apoptosis of RAFLSs is through mitochondrial pathway, in which p53 plays an important role. Quercetin 25-34 tumor protein p53 Homo sapiens 106-109 23342112-0 2013 Quercetin enhances the antitumor activity of trichostatin A through upregulation of p53 protein expression in vitro and in vivo. Quercetin 0-9 tumor protein p53 Homo sapiens 84-87 23342112-2 2013 We first showed that quercetin (5 microM) significantly increased the growth arrest and apoptosis in A549 cells (expressing wild-type p53) induced by 25 ng/mL of (82.5 nM) TSA at 48 h by about 25% and 101%, respectively. Quercetin 21-30 tumor protein p53 Homo sapiens 134-137 23342112-4 2013 In addition, quercetin significantly increased TSA-induced p53 expression in A549 cells. Quercetin 13-22 tumor protein p53 Homo sapiens 59-62 23342112-7 2013 Transfection of p53 siRNA abolished such enhancing effects of quercetin. Quercetin 62-71 tumor protein p53 Homo sapiens 16-19 23342112-8 2013 However, quercetin increased the acetylation of histones H3 and H4 induced by TSA in A549 cells, even with p53 siRNA transfection as well as in H1299 cells. Quercetin 9-18 tumor protein p53 Homo sapiens 107-110 23342112-11 2013 These data indicate that regulation of the expression of p53 by quercetin plays an important role in enhancing TSA-induced apoptosis in A549 cells. Quercetin 64-73 tumor protein p53 Homo sapiens 57-60 23342112-12 2013 However, p53-independent mechanisms may also contribute to the enhancing effect of quercetin. Quercetin 83-92 tumor protein p53 Homo sapiens 9-12 22213289-6 2012 In p53-null cells, the combination of low dose 5-FU with up to 6 muM quercetin promoted clonogenic survival. Quercetin 69-78 tumor protein p53 Homo sapiens 3-6 22213289-7 2012 Treatment of p53-wild-type cells with 50 muM quercetin reduced drug-induced up-regulation of p53, p21 and BAX. Quercetin 45-54 tumor protein p53 Homo sapiens 13-16 22213289-7 2012 Treatment of p53-wild-type cells with 50 muM quercetin reduced drug-induced up-regulation of p53, p21 and BAX. Quercetin 45-54 tumor protein p53 Homo sapiens 93-96 22213289-9 2012 CONCLUSION: While high doses of quercetin synergize with DNA-damaging agents, the effect of drug combination with quercetin is influenced by the effective doses and the p53 status of the cells. Quercetin 114-123 tumor protein p53 Homo sapiens 169-172 21479885-0 2011 Quercetin enhances 5-fluorouracil-induced apoptosis in MSI colorectal cancer cells through p53 modulation. Quercetin 0-9 tumor protein p53 Homo sapiens 91-94 21196432-5 2011 Both strategies could use tyrosinase-mediated activation of quercetin, a dietary polyphenol that induces the expression of p53 and modulates reactive oxygen species. Quercetin 60-69 tumor protein p53 Homo sapiens 123-126 21196432-6 2011 In addition to antitumor signaling properties, activation of quercetin could complement conventional cancer therapy by the induction of phase II detoxification enzymes resulting in p53 stabilization and transduction of its downstream targets. Quercetin 61-70 tumor protein p53 Homo sapiens 181-184 23918355-7 2013 We found that quercetin-induced selective cell death is caused by mitochondrial accumulation of p53 and is sufficient to prevent teratoma formation after transplantation of hESC- or hiPSC-derived cells. Quercetin 14-23 tumor protein p53 Homo sapiens 96-99 23564507-8 2013 Quercetin activated JNK and increased the expression levels of c-Jun and p53-dependent Bax. Quercetin 0-9 tumor protein p53 Homo sapiens 73-76 23564507-9 2013 Blockade of JNK activation by overexpression of dominant negative JNK1 suppressed apoptosis by quercetin via inhibition of caspase-3 activation and reduction of p53 and Bax expression. Quercetin 95-104 tumor protein p53 Homo sapiens 161-164 23564507-13 2013 Taken together, the JNK-p53 pathway is involved in quercetin-induced apoptosis, and simultaneous inactivation of GSK-3beta can attenuate apoptosis in normal bronchial epithelial cells. Quercetin 51-60 tumor protein p53 Homo sapiens 24-27 27481281-2 2013 Quercetin and taxifolin bind to p53 binding hydrophobic groove of MDM2, and alter the conformation of groove as evidenced by 65 ns molecular dynamics simulation. Quercetin 0-9 tumor protein p53 Homo sapiens 32-35 24379902-2 2013 However, U373MG malignant glioma cells expressing mutant p53 are resistant to a 24 h quercetin treatment. Quercetin 85-94 tumor protein p53 Homo sapiens 57-60 24379902-5 2013 Furthermore, quercetin activated JNK and increased the expression of p53, which translocated to the mitochondria and simultaneously led to the release of cytochrome c from mitochondria to the cytosol. Quercetin 13-22 tumor protein p53 Homo sapiens 69-72 22765290-3 2012 In this review, we focus on highlighting several representative plant natural compounds such as curcumin, resveratrol, paclitaxel, oridonin, quercetin and plant lectin - that may lead to cancer cell death - for regulation of some core autophagic pathways, involved in Ras-Raf signalling, Beclin-1 interactome, BCR-ABL, PI3KCI/Akt/mTOR, FOXO1 signalling and p53. Quercetin 141-150 tumor protein p53 Homo sapiens 357-360 22509835-0 2012 Quercetin enhancement of arsenic-induced apoptosis via stimulating ROS-dependent p53 protein ubiquitination in human HaCaT keratinocytes. Quercetin 0-9 tumor protein p53 Homo sapiens 81-84 22509835-8 2012 QUE plus As(+3) stimulation of apoptosis in human HaCaT keratinocytes via activating ROS-dependent p53 protein ubiquitination may offer a rationale for the use of QUE to improve the clinical efficacy of arsenics in treating psoriasis. Quercetin 0-3 tumor protein p53 Homo sapiens 99-102 21994207-0 2011 Enhancement of carboplatin- and quercetin-induced cell death by roscovitine is Akt dependent and p53 independent in hepatoma cells. Quercetin 32-41 tumor protein p53 Homo sapiens 97-100 21965740-9 2011 Genistein and quercetin induced extrinsic apoptosis pathway, up-regulating p53. Quercetin 14-23 tumor protein p53 Homo sapiens 75-78 20803121-8 2010 Quercetin caused S phase arrest by decreasing the protein expression of CDK2, cyclins A and B while increasing the p53 and p57 proteins. Quercetin 0-9 tumor protein p53 Homo sapiens 115-118 20681654-4 2010 Notably, quercetin increased cell cycle arrest in the G1 phase and up-regulated apoptosis-related proteins, such as AMPK, p53, and p21, within 48 h. Furthermore, in vivo experiments showed that quercetin treatment resulted in a significant reduction in tumor volume over 6 weeks, and apoptosis-related protein induction by quercetin was significantly higher in the 100 mg/kg treated group compared to the control group. Quercetin 9-18 tumor protein p53 Homo sapiens 122-125 20681654-4 2010 Notably, quercetin increased cell cycle arrest in the G1 phase and up-regulated apoptosis-related proteins, such as AMPK, p53, and p21, within 48 h. Furthermore, in vivo experiments showed that quercetin treatment resulted in a significant reduction in tumor volume over 6 weeks, and apoptosis-related protein induction by quercetin was significantly higher in the 100 mg/kg treated group compared to the control group. Quercetin 194-203 tumor protein p53 Homo sapiens 122-125 20681654-4 2010 Notably, quercetin increased cell cycle arrest in the G1 phase and up-regulated apoptosis-related proteins, such as AMPK, p53, and p21, within 48 h. Furthermore, in vivo experiments showed that quercetin treatment resulted in a significant reduction in tumor volume over 6 weeks, and apoptosis-related protein induction by quercetin was significantly higher in the 100 mg/kg treated group compared to the control group. Quercetin 194-203 tumor protein p53 Homo sapiens 122-125 20681654-5 2010 All of these results indicate that quercetin induces apoptosis via AMPK activation and p53-dependent apoptotic cell death in HT-29 colon cancer cells and that it may be a potential chemopreventive or therapeutic agent against HT-29 colon cancer. Quercetin 35-44 tumor protein p53 Homo sapiens 87-90 20858478-0 2010 The flavonoid quercetin induces cell cycle arrest and mitochondria-mediated apoptosis in human cervical cancer (HeLa) cells through p53 induction and NF-kappaB inhibition. Quercetin 14-23 tumor protein p53 Homo sapiens 132-135 20858478-4 2010 The results demonstrate that quercetin suppressed the viability of HeLa cells in a dose-dependent manner by inducing G2/M phase cell cycle arrest and mitochondrial apoptosis through a p53-dependent mechanism. Quercetin 29-38 tumor protein p53 Homo sapiens 184-187 18813348-6 2008 Suppression of Hsf1 in A1-5 cells with quercetin or an Hsf1 siRNA reduced p53 nuclear importation and inhibited p53-mediated activation of a p21 reporter. Quercetin 39-48 tumor protein p53 Homo sapiens 74-77 20540768-4 2010 We have previously demonstrated that the bioflavonoid quercetin (Qct) promoted a p53-mediated response and sensitized melanoma to DTIC. Quercetin 54-63 tumor protein p53 Homo sapiens 81-84 19623560-6 2009 We also demonstrate that the levels of survivin and Bcl-2 protein expression in HepG2 cells decreased concurrently, and the levels of p53 protein increased significantly after treatment with quercetin by immunocytochemistry analysis. Quercetin 191-200 tumor protein p53 Homo sapiens 134-137 19424582-5 2009 From 117 kinds of chemicals (34 kinds of natural compounds that are obtained from herbal plants, 53 kinds of flavonoid, and 31 kinds of phenolic compounds), we find that quercetin works as an activator of p53 in K-Ras mutated cells but not in wild-type cells. Quercetin 170-179 tumor protein p53 Homo sapiens 205-208 19424582-6 2009 Treatment with quercetin can induce p53 target genes such as PUMA and p21. Quercetin 15-24 tumor protein p53 Homo sapiens 36-39 19424582-7 2009 These results suggest that although quercetin has limitations for use as a therapeutic drug due to its broad effects, specific function of it on K-Ras-p53 may be useful for K-Ras-induced cancer prevention and therapy through further development. Quercetin 36-45 tumor protein p53 Homo sapiens 151-154 18791269-0 2008 Tyrosinase overexpression promotes ATM-dependent p53 phosphorylation by quercetin and sensitizes melanoma cells to dacarbazine. Quercetin 72-81 tumor protein p53 Homo sapiens 49-52 18608579-1 2008 PURPOSE: Quercetin (QCT), an important flavonol, is known to sensitize tumour cells to hyperthermia by suppressing heat shock protein 72 (Hsp72) induction, and is also reported to inhibit p53 accumulation. Quercetin 9-18 tumor protein p53 Homo sapiens 188-191 18323654-0 2008 Stabilization of p53 is involved in quercetin-induced cell cycle arrest and apoptosis in HepG2 cells. Quercetin 36-45 tumor protein p53 Homo sapiens 17-20 18323654-3 2008 In the present study, we attempted to reactivate p53 in HepG2 retaining wild-type p53 by quercetin, an ubiquitous bioactive plant flavonoid. Quercetin 89-98 tumor protein p53 Homo sapiens 49-52 18323654-3 2008 In the present study, we attempted to reactivate p53 in HepG2 retaining wild-type p53 by quercetin, an ubiquitous bioactive plant flavonoid. Quercetin 89-98 tumor protein p53 Homo sapiens 82-85 18323654-5 2008 Molecular data revealed that quercetin induced p53 phosphorylation and total p53 protein, but that it did not up-regulate p53 mRNA at the transcription level. Quercetin 29-38 tumor protein p53 Homo sapiens 47-50 18323654-5 2008 Molecular data revealed that quercetin induced p53 phosphorylation and total p53 protein, but that it did not up-regulate p53 mRNA at the transcription level. Quercetin 29-38 tumor protein p53 Homo sapiens 77-80 18323654-5 2008 Molecular data revealed that quercetin induced p53 phosphorylation and total p53 protein, but that it did not up-regulate p53 mRNA at the transcription level. Quercetin 29-38 tumor protein p53 Homo sapiens 77-80 18323654-8 2008 Interestingly, quercetin inhibited p53 ubiquitination and extended the half-life (t(1/2)) of p53 from 74 to 184 min. Quercetin 15-24 tumor protein p53 Homo sapiens 35-38 18323654-8 2008 Interestingly, quercetin inhibited p53 ubiquitination and extended the half-life (t(1/2)) of p53 from 74 to 184 min. Quercetin 15-24 tumor protein p53 Homo sapiens 93-96 18323654-9 2008 Quercetin also inhibited p53 mRNA degradation at the post-transcription stage. Quercetin 0-9 tumor protein p53 Homo sapiens 25-28 18323654-11 2008 Taken together, our data demonstrate that quercetin stabilized p53 at both the mRNA and protein levels to reactivate p53-dependent cell cycle arrest and apoptosis in HepG2 cells. Quercetin 42-51 tumor protein p53 Homo sapiens 63-66 18323654-11 2008 Taken together, our data demonstrate that quercetin stabilized p53 at both the mRNA and protein levels to reactivate p53-dependent cell cycle arrest and apoptosis in HepG2 cells. Quercetin 42-51 tumor protein p53 Homo sapiens 117-120 17520098-6 2007 Furthermore, the results indicate that quercetin increased the content of Cdk inhibitor p21 protein, which was correlated with the elevation in p53 levels during 12 h of incubation. Quercetin 39-48 tumor protein p53 Homo sapiens 144-147 17520098-8 2007 From our results it can be concluded that quercetin blocks cell cycle progression at G(1) phase and exerts its growth-inhibitory effect through the increase of Cdk inhibitors p21 and p27 and tumor suppressor p53 in HepG2. Quercetin 42-51 tumor protein p53 Homo sapiens 208-211 16720314-7 2006 In all cell lines, quercetin decreased the expression of mutant P53 and Survivin proteins. Quercetin 19-28 tumor protein p53 Homo sapiens 64-67 17191121-4 2007 Reporter assays using the luciferase constructs containing NAG-1 promoter region demonstrate that early growth response-1 (EGR-1) and p53 are required for quercetin-mediated activation of the NAG-1 promoter. Quercetin 155-164 tumor protein p53 Homo sapiens 134-137 17191121-0 2007 NAG-1 up-regulation mediated by EGR-1 and p53 is critical for quercetin-induced apoptosis in HCT116 colon carcinoma cells. Quercetin 62-71 tumor protein p53 Homo sapiens 42-45 18001220-7 2007 The increase in apoptosis following quercetin exposure was p53/Bax mediated and correlated with a decrease in GST-driven bioreduction capacity and an increase in ROS. Quercetin 36-45 tumor protein p53 Homo sapiens 59-62 16720314-11 2006 Quercetin-induced apoptosis might be associated with a decrease in mutant P53 and Survivin proteins. Quercetin 0-9 tumor protein p53 Homo sapiens 74-77 16211300-0 2005 Quercetin induces gadd45 expression through a p53-independent pathway. Quercetin 0-9 tumor protein p53 Homo sapiens 46-49 16948901-6 2006 Expression of P53 and C-myc protein decreased following quercetin induction in a dose-dependent manner, whereas P16 expression increased significantly compared with that of the control group (P<0.01). Quercetin 56-65 tumor protein p53 Homo sapiens 14-17 16898267-0 2006 Quercetin induces p53-independent apoptosis in human prostate cancer cells by modulating Bcl-2-related proteins: a possible mediation by IGFBP-3. Quercetin 0-9 tumor protein p53 Homo sapiens 18-21 16898267-2 2006 We report insulin-like growth factor-binding protein-3 (IGFBP-3) as an effector of quercetin-induced apoptosis in human prostate cancer cell lines in a p53-independent manner. Quercetin 83-92 tumor protein p53 Homo sapiens 152-155 16211300-7 2005 Quercetin did not activate transcription through p53-binding sites in HeLa cells, although it up-regulated gadd45 in p53-inactivated tumor cells. Quercetin 0-9 tumor protein p53 Homo sapiens 117-120 16211300-8 2005 These results indicate that quercetin induces gadd45 expression in a p53-independent manner. Quercetin 28-37 tumor protein p53 Homo sapiens 69-72 15456784-0 2004 Survivin and p53 modulate quercetin-induced cell growth inhibition and apoptosis in human lung carcinoma cells. Quercetin 26-35 tumor protein p53 Homo sapiens 13-16 15795422-6 2005 Micromolar (-)epigallocatechin gallate and quercetin partially eliminated the dichlorodihydrofluorescein (DCF) and phospho-p53 staining, suggesting that these flavonoids inhibited the accumulation of intracellular oxidants and nuclear transactivation of p53 in H2O2-exposed cells. Quercetin 43-52 tumor protein p53 Homo sapiens 123-126 15795422-6 2005 Micromolar (-)epigallocatechin gallate and quercetin partially eliminated the dichlorodihydrofluorescein (DCF) and phospho-p53 staining, suggesting that these flavonoids inhibited the accumulation of intracellular oxidants and nuclear transactivation of p53 in H2O2-exposed cells. Quercetin 43-52 tumor protein p53 Homo sapiens 254-257 15735102-0 2005 Ellagic acid potentiates the effect of quercetin on p21waf1/cip1, p53, and MAP-kinases without affecting intracellular generation of reactive oxygen species in vitro. Quercetin 39-48 tumor protein p53 Homo sapiens 66-69 15735102-4 2005 We found that quercetin and combinations of quercetin and ellagic acid nonsynergistically increased p53 protein levels. Quercetin 14-23 tumor protein p53 Homo sapiens 100-103 15735102-4 2005 We found that quercetin and combinations of quercetin and ellagic acid nonsynergistically increased p53 protein levels. Quercetin 44-53 tumor protein p53 Homo sapiens 100-103 15735102-10 2005 In summary, quercetin and ellagic acid combined increase the activation of p53 and p21(cip1/waf1) and the MAP kinases, JNK1,2 and p38, in a more than additive manner, suggesting a mechanism by which quercetin and ellagic acid synergistically induce apoptosis in cancer cells. Quercetin 12-21 tumor protein p53 Homo sapiens 75-78 15456784-2 2004 However, the regulation of survivin and p53 on the quercetin-induced cell growth inhibition and apoptosis in cancer cells remains unclear. Quercetin 51-60 tumor protein p53 Homo sapiens 40-43 15456784-3 2004 In this study, we investigated the roles of survivin and p53 in the quercetin-treated human lung carcinoma cells. Quercetin 68-77 tumor protein p53 Homo sapiens 57-60 15456784-9 2004 Subsequently, quercetin increased the levels of total p53 (DO-1), phospho-p53 (serine 15), and p21 proteins, which were translocated to the nuclei in A549 cells. Quercetin 14-23 tumor protein p53 Homo sapiens 54-57 15456784-9 2004 Subsequently, quercetin increased the levels of total p53 (DO-1), phospho-p53 (serine 15), and p21 proteins, which were translocated to the nuclei in A549 cells. Quercetin 14-23 tumor protein p53 Homo sapiens 74-77 15456784-10 2004 Treatment with a specific p53 inhibitor, pifithrin-alpha, or transfection of a p53 antisense oligodeoxynucleotide enhanced the cytotoxicity of the quercetin-treated cells. Quercetin 147-156 tumor protein p53 Homo sapiens 26-29 15456784-10 2004 Treatment with a specific p53 inhibitor, pifithrin-alpha, or transfection of a p53 antisense oligodeoxynucleotide enhanced the cytotoxicity of the quercetin-treated cells. Quercetin 147-156 tumor protein p53 Homo sapiens 79-82 15456784-12 2004 Together, our results suggest that survivin can reduce the cell growth inhibition and apoptosis, and p53 elevates the p21 level, which may attenuate the cell death in the quercetin-treated human lung carcinoma cells. Quercetin 171-180 tumor protein p53 Homo sapiens 101-104 15177039-0 2004 The isoflavonoids genistein and quercetin activate different stress signaling pathways as shown by analysis of site-specific phosphorylation of ATM, p53 and histone H2AX. Quercetin 32-41 tumor protein p53 Homo sapiens 149-152 15177039-7 2004 Like genistein, quercetin induced phosphorylation of ATM on serine 1981, and ATM-dependent phosphorylation of histone H2AX on serine 139; however, p53 accumulation and phosphorylation on serines 6, 9, 15, 20, 46, and 392 occurred in ATM-deficient cells, indicating that ATM is not required for quercetin-induced phosphorylation of p53. Quercetin 16-25 tumor protein p53 Homo sapiens 331-334 14767529-2 2004 In this report, we investigate the effects of quercetin on the growth of wild-type and mutant p53 nasopharyngeal carcinoma cell lines, HK1 and CNE2 respectively. Quercetin 46-55 tumor protein p53 Homo sapiens 94-97 14767529-3 2004 The wild-type p53 HK1 was more susceptible to growth inhibition by quercetin than the mutant p53 CNE2. Quercetin 67-76 tumor protein p53 Homo sapiens 14-17 11562764-8 2001 We also found that quercetin markedly increased Cdk-inhibitor p21CIP1/WAF1 protein level after treatment for 48 h or longer, and the induction of p21CIP1/WAF1 increased its association with Cdc2-cyclin B1 complex, however, up-regulation of p53 by quercetin was not observed. Quercetin 19-28 tumor protein p53 Homo sapiens 240-243 12589822-7 2003 Treatment of quercetin, which induced a cell-cycle block in G1-phase, induced down-regulation of cyclins and CDKs and up-regulation of the CDK inhibitor p21 expression, whereas up-regulation of p27 or p53 by quercetin was not observed. Quercetin 13-22 tumor protein p53 Homo sapiens 201-204 12589822-7 2003 Treatment of quercetin, which induced a cell-cycle block in G1-phase, induced down-regulation of cyclins and CDKs and up-regulation of the CDK inhibitor p21 expression, whereas up-regulation of p27 or p53 by quercetin was not observed. Quercetin 208-217 tumor protein p53 Homo sapiens 201-204 11408351-4 2001 However, in cells transformed but non-tumorigenic, p53 protein is elevated and transcriptionally activated in response to quercetin or other DNA damaging stimuli, but the cells bypass quercetin-induced G1 arrest likely due to E7 expression. Quercetin 122-131 tumor protein p53 Homo sapiens 51-54 11408351-4 2001 However, in cells transformed but non-tumorigenic, p53 protein is elevated and transcriptionally activated in response to quercetin or other DNA damaging stimuli, but the cells bypass quercetin-induced G1 arrest likely due to E7 expression. Quercetin 184-193 tumor protein p53 Homo sapiens 51-54 11408351-5 2001 In transformed tumorigenic cells, p53 is elevated in response to quercetin but its transcriptional activity is inhibited due to mutation, and the cells fail to stop in G1 in the presence of quercetin. Quercetin 65-74 tumor protein p53 Homo sapiens 34-37 11408351-5 2001 In transformed tumorigenic cells, p53 is elevated in response to quercetin but its transcriptional activity is inhibited due to mutation, and the cells fail to stop in G1 in the presence of quercetin. Quercetin 190-199 tumor protein p53 Homo sapiens 34-37 34986125-9 2021 Finally, the binding modes of EGFR, IL1B, NOS3 and TP53 with quercetin were visualized. Quercetin 61-70 tumor protein p53 Homo sapiens 51-55 8895505-4 1996 To further elucidate this dual role, we investigated the influence of apigenin, luteolin and quercetin on the tumour suppressor protein p53, regarding p53 accumulation, cell cycle arrest, apoptosis, and biological activity. Quercetin 93-102 tumor protein p53 Homo sapiens 136-139 10082992-4 1999 Northern blot analysis revealed that quercetin induced the increases in c-fos and p21WAF1CIP1 mRNA levels within 2 h. The expression of p21 protein was also enhanced, while p53 mRNA and protein levels were not affected by quercetin. Quercetin 37-46 tumor protein p53 Homo sapiens 173-176 10082992-5 1999 These results suggest that quercetin-induced apoptosis is associated with the increase in c-fos mRNA level and the upregulation of p21 mRNA and protein expression, probably in a p53-independent pathway. Quercetin 27-36 tumor protein p53 Homo sapiens 178-181 10408175-3 1999 Quercetin, an inhibitor of heat-shock response, dose dependently suppressed the p53 accumulation induced by X-rays at more than 100 microM. Quercetin 0-9 tumor protein p53 Homo sapiens 80-83 8162591-0 1994 Quercetin mediates the down-regulation of mutant p53 in the human breast cancer cell line MDA-MB468. Quercetin 0-9 tumor protein p53 Homo sapiens 49-52 8162591-4 1994 We have correlated these effects on cell proliferation with the observation that quercetin strongly inhibited, in a time- and dose-dependent fashion, the expression of the mutated p53 protein, which is the only form present at high levels in this cell line. Quercetin 81-90 tumor protein p53 Homo sapiens 180-183 8162591-6 1994 Quercetin did not affect the steady-state mRNA levels of p53, but prevented the accumulation of newly synthesized p53 protein. Quercetin 0-9 tumor protein p53 Homo sapiens 114-117 8162591-7 1994 This quercetin action appeared to be somewhat specific for p53 because the drug did not alter the amount of other proteins present in MDA-MB468 cells such as P-glycoprotein and did not prevent the induction of the synthesis of epidermal growth factor receptor in response to epidermal growth factor. Quercetin 5-14 tumor protein p53 Homo sapiens 59-62 34986125-10 2021 DISCUSSION AND CONCLUSION: Quercetin of Baiying Qinghou decoction showed therapeutic effect against laryngeal squamous cell carcinoma by regulating TP53, EGFR, NOS3 and IL1B involved with drug resistance and PI3K-AKT signaling pathway. Quercetin 27-36 tumor protein p53 Homo sapiens 148-152 34335587-12 2021 In the mechanistic study, we found that the induction of p53 deacetylation, due to either the resveratrol/quercetin -induced activation of the deacetylase Sirtuin 1 (Sirt1) or the mutation of the acetylated lysine site in p53, promoted RTEC autophagy and alleviated SAKI. Quercetin 106-115 tumor protein p53 Homo sapiens 57-60 34660782-11 2021 This study revealed that SZRD has the characteristics and advantages of "multicomponent, multitarget, and multipathway" in the treatment of PDSD; among these, the combination of the main active components of quercetin and kaempferol with the key targets of AKT1, IL6, MAPK1, TP53, and VEGFA may be one of the important mechanisms. Quercetin 208-217 tumor protein p53 Homo sapiens 275-279 35600955-8 2022 Results: The network pharmacology analysis showed that quercetin, luteolin, and kaempferol are the most significant active components in BHHD; STAT3, Jun, AKT1, MAPK3, MAPK1, and TP53 are the most critical drug targets; regulating hormones, reversing insulin (INS) resistance, exerting anti-inflammatory effects, and improving fertility might be the most important mechanisms of BHHD in the treatment of PCOS. Quercetin 55-64 tumor protein p53 Homo sapiens 179-183 34306252-10 2021 The main compounds of XYS include Quercetin, Naringenin, Isorhamnetin, and Stigmasterol, which mainly regulate the targets such as TP53, Akt1, and MYC and PI3K/Akt, p53, and cell cycle signal pathways. Quercetin 34-43 tumor protein p53 Homo sapiens 131-135 34306252-10 2021 The main compounds of XYS include Quercetin, Naringenin, Isorhamnetin, and Stigmasterol, which mainly regulate the targets such as TP53, Akt1, and MYC and PI3K/Akt, p53, and cell cycle signal pathways. Quercetin 34-43 tumor protein p53 Homo sapiens 165-168 34257824-6 2021 For example, quercetin arrests human cervical cancer cell growth by blocking the G2/M phase cell cycle and inducing mitochondrial apoptosis through a p53-dependent mechanism. Quercetin 13-22 tumor protein p53 Homo sapiens 150-153 34208730-8 2021 Examination of the NAG-1 promoter activity showed that p53, C/EBPalpha, or C/EBPdelta played a role in quercetin-induced NAG-1 expression. Quercetin 103-112 tumor protein p53 Homo sapiens 55-58 35510223-13 2022 The molecular docking results showed that there was a certain affinity between the main compounds (kaempferol, quercetin, beta-sitosterol, naringenin) and core target genes (PTGS2, CASP3, MAPK1, MAPK3, TP53). Quercetin 111-120 tumor protein p53 Homo sapiens 202-206 35532255-7 2022 By constructing the disease-common target-compound network, five ingredients (quercetin, arachidonate, beta-sitosterol, beta-carotene, and cholesterol) were selected out as the key ingredients of YJD, which can interact with the 10 hub genes (VEGFA, AKT1, TP53, ALB, TNF, PIK3CA, IGF1, INS, IL1B, PTEN) against PCOS. Quercetin 78-87 tumor protein p53 Homo sapiens 256-260 34035828-9 2021 Further analysis showed that the HGD activity of quercetin, formononetin, kaempferol, isorhamnetin, and beta-sitosterol ingredients is possible through VEGFA, IL6, TNF, AKT1, and TP53 targets involved in TNF, toll-like receptors, and MAPK-related pathways, which have anti-inflammatory, antiapoptosis, antioxidation, and autophagy effects, relieve renal fibrosis and renal cortex injury, and improve renal function, thus delaying the development of DN. Quercetin 49-58 tumor protein p53 Homo sapiens 179-183 35070983-13 2021 The KEGG pathway analysis revealed that quercetin and cisplatin may affect cervical cancer through platinum drug resistance and the p53 and HIF-1 pathways. Quercetin 40-49 tumor protein p53 Homo sapiens 132-135 34035828-10 2021 The molecular docking results showed that quercetin, formononetin, kaempferol, isorhamnetin, beta-sitosterol had a good binding activity with VEGFA, IL6, TNF, AKT1, and TP53. Quercetin 42-51 tumor protein p53 Homo sapiens 169-173 33628636-15 2021 In addition, quercetin, which has the most targets, can act on the main targets (BAX, CDK1, CCNB1, SERPINE1, CHEK2, and IGFBP3) of the P53 pathway to treat HCC. Quercetin 13-22 tumor protein p53 Homo sapiens 135-138 33347603-0 2021 Quercetin Induces p53-independent Cancer Cell Death via TFEB-mediated Lysosome Activation and ROS-dependent Ferroptosis. Quercetin 0-9 tumor protein p53 Homo sapiens 18-21 33347603-5 2021 KEY RESULTS: Quercetin is able to promote p53-independent cell death in various cancer cell lines. Quercetin 13-22 tumor protein p53 Homo sapiens 42-45 32530119-3 2020 As results, quercetin showed contrasting dose-response to cellular behaviors dependent on the ROS-regulated p53 signaling pathways. Quercetin 12-21 tumor protein p53 Homo sapiens 108-111 32420759-11 2021 Combination of quercetin and curcumin was effective on genes that were particularly related to p53, NF-kappaB and TGF-alpha pathways. Quercetin 15-24 tumor protein p53 Homo sapiens 95-98 33052979-9 2020 In addition, our results indicated that the combination of anti-cancer drugs and quercetin down-regulated the expression of HIF-1alpha and increased the expression levels of the regulator of apoptosis p53. Quercetin 81-90 tumor protein p53 Homo sapiens 201-204 31960917-7 2020 Quercetin down-regulated p53, Bax and cleaved-caspase-3 expression, while up-regulated CyclinD1, CDK4 and Bcl-2. Quercetin 0-9 tumor protein p53 Homo sapiens 25-28 32733640-5 2020 Western blot analysis revealed that quercetin reduced copper-induced increase in p53 upregulated modulator of apoptosis (PUMA) expression and promoted upregulation of nucleoside diphosphate kinase NME1. Quercetin 36-45 tumor protein p53 Homo sapiens 81-84 31827702-1 2019 A flavonoid antioxidant quercetin promotes dose-dependent activation of the ATM-CHK-p53 pathway, downregulation of antiapoptotic survivin, and upregulation of proapoptotic NOXA in human T cell acute lymphoblastic leukemia Jurkat clones (J/Neo and J/BCL-XL). Quercetin 24-33 tumor protein p53 Homo sapiens 84-87 30303965-4 2018 Biological methods demonstrated the oxidative damage of P19 neurons and showed that quercetin improved neuronal survival by preventing H2O2-induced p53 and Bcl-2 down-regulation and modulated Akt and ERK1/2 signalling pathways. Quercetin 84-93 tumor protein p53 Homo sapiens 148-151 30958996-0 2019 Quercetin enhances the antitumor activity of trichostatin A through up-regulation of p300 protein expression in p53 null cancer cells. Quercetin 0-9 tumor protein p53 Homo sapiens 112-115 30958996-1 2019 In the present study, we investigated the p53-independent mechanism by which quercetin (Q) increased apoptosis in human lung cancer H1299 cells exposed to trichostatin A (TSA), a histone deacetylase inhibitor. Quercetin 77-86 tumor protein p53 Homo sapiens 42-45 31223026-8 2019 The expression levels of BAD and p53 genes decreased by combined treatment with quercetin and selenium while showing synergistic effects in terms of gene expression. Quercetin 80-89 tumor protein p53 Homo sapiens 33-36 30664221-0 2019 Quercetin induces G2 phase arrest and apoptosis with the activation of p53 in an E6 expression-independent manner in HPV-positive human cervical cancer-derived cells. Quercetin 0-9 tumor protein p53 Homo sapiens 71-74 30664221-7 2019 In the present study, it was demonstrated that quercetin induced G2 phase cell cycle arrest and apoptosis in both HeLa and SiHa cells, accompanied by an increase of p53 and its nuclear signal. Quercetin 47-56 tumor protein p53 Homo sapiens 165-168 30664221-8 2019 It was also observed that quercetin increased the level of the p21 transcript and the pro-apoptotic Bax protein, which are two p53-downstream effectors. Quercetin 26-35 tumor protein p53 Homo sapiens 127-130 30664221-9 2019 However, quercetin did not alter the expression of the HPV E6 protein in cervical cancer cells; therefore, the increase in p53 occurred in an E6 expression-independent manner. Quercetin 9-18 tumor protein p53 Homo sapiens 123-126 30664221-11 2019 These data suggest that quercetin increases the nuclear localization of p53 by interrupting E6/E6AP complex formation in cervical cancer cells. Quercetin 24-33 tumor protein p53 Homo sapiens 72-75 30947605-6 2019 Quercetin did not have any influence on the number of granulosa cells containing caspase 3, but at the concentration 10 mumol L-1 it inhibited p53 occurrence. Quercetin 0-9 tumor protein p53 Homo sapiens 143-146 30947605-7 2019 Results confirm the safety of quercetin in porcine ovarian granulosa cell model and further suggest its possible concentration-dependent influence on ovarian functions through pathway that may involve progesterone, cyclin B1 and p53. Quercetin 30-39 tumor protein p53 Homo sapiens 229-232 30661409-1 2019 Quercetin, an antioxidant flavonoid, has been known that it can induce the cell cycle arrest and apoptosis of hepatocellular carcinoma (HCC) cells by the stabilization or induction of p53. Quercetin 0-9 tumor protein p53 Homo sapiens 184-187 30661409-6 2019 This study demonstrates that the antiproliferative effect of quercetin on HCC cells can be mediated by reducing intracellular ROS, which is independent of p53 expression. Quercetin 61-70 tumor protein p53 Homo sapiens 155-158 29737207-6 2018 Silencing LPL increased the expression levels of senescence proteins such as p16INK4A and p53 and silencing KCNE2 reversed gene expressions of EGR1 and p-ERK in quercetin-treated aged HDFs. Quercetin 161-170 tumor protein p53 Homo sapiens 90-93 29935106-7 2018 Specifically, frataxin was lowered in the liver of HFD-fed mice or HepG2 cell incubated with oleate/palmitate but restored by quercetin, and quercetin"s regulation of frataxin may depend on p53. Quercetin 141-150 tumor protein p53 Homo sapiens 190-193 29898731-12 2018 PCa cells with mutated p53 (DU-145) and increased ROS showed significant reduction in the activation of pro-survival Akt pathway while Raf/MEK were activated in response to quercetin. Quercetin 173-182 tumor protein p53 Homo sapiens 23-26 29317830-0 2018 Quercetin suppresses DNA double-strand break repair and enhances the radiosensitivity of human ovarian cancer cells via p53-dependent endoplasmic reticulum stress pathway. Quercetin 0-9 tumor protein p53 Homo sapiens 120-123 29317830-2 2018 However, the role of tumor suppressor p53 on quercetin"s radiosensitization and regulation of endoplasmic reticulum (ER) stress response in this process remains obscure. Quercetin 45-54 tumor protein p53 Homo sapiens 38-41 29317830-3 2018 Here, quercetin exposure resulted in ER stress, prolonged DNA repair, and the expression of p53 protein; phosphorylation on serine 15 and 20 increased in combination with X-irradiation. Quercetin 6-15 tumor protein p53 Homo sapiens 92-95 29317830-6 2018 Knocking down of p53 could reverse all the above effects under quercetin in combination with radiation. Quercetin 63-72 tumor protein p53 Homo sapiens 17-20 29317830-8 2018 In human ovarian cancer xenograft model, combined treatment of quercetin and radiation significantly restrained the growth of tumors, accompanied with the activation of p53, CCAAT/enhancer-binding protein homologous protein, and gamma-H2AX. Quercetin 63-72 tumor protein p53 Homo sapiens 169-172 29317830-9 2018 Overall, these results indicated that quercetin acted as a promising radiosensitizer through p53-dependent ER stress signals. Quercetin 38-47 tumor protein p53 Homo sapiens 93-96 27621033-14 2016 The expression level of LC3 and ERK as well as cytoplasm p53, cleaved Caspase-3 and PARP was positively correlated with the concentration of quercetin nanoparticle. Quercetin 141-150 tumor protein p53 Homo sapiens 57-60 28280414-9 2017 Knockdown of Foxo3a and inhibition of JNK activity reduced the signaling activities of p53, p21 and GADD45, triggered by quercetin. Quercetin 121-130 tumor protein p53 Homo sapiens 87-90 27748879-8 2016 Western blot analysis revealed that quercetin reduced the protein expression levels of phosphorylated-Akt and increased CSN6 protein degradation; therefore, affecting the expression levels of Myc, p53, B-cell lymphoma 2 (Bcl-2) and Bcl-2 associated X protein. Quercetin 36-45 tumor protein p53 Homo sapiens 197-200 27681719-10 2016 Quercetin more effectively induced p53-dependent apoptosis than isoliquiritigenin in EBV(+) human gastric carcinoma, and this induction was correlated with increased expressions of the cleaved forms of caspase-3, -9, and Parp. Quercetin 0-9 tumor protein p53 Homo sapiens 35-38 27681719-11 2016 In EBV(-)human gastric carcinoma (MKN74), both quercetin and isoliquiritigenin induced the expressions of p53, Bax, and Puma and the cleaved forms of caspase-3 and -9 and Parp at similar levels. Quercetin 47-56 tumor protein p53 Homo sapiens 106-109 26311153-0 2015 Anticarcinogenic action of quercetin by downregulation of phosphatidylinositol 3-kinase (PI3K) and protein kinase C (PKC) via induction of p53 in hepatocellular carcinoma (HepG2) cell line. Quercetin 27-36 tumor protein p53 Homo sapiens 139-142 29029404-2 2017 In this context, we have reported that Quercetin (QC) induces cell death selectively in hESCs via p53 mitochondrial localization. Quercetin 39-48 tumor protein p53 Homo sapiens 98-101 26311153-12 2015 Additionally, QUE enhanced the expression of p53 and BAX in HepG2 cells. Quercetin 14-17 tumor protein p53 Homo sapiens 45-48