PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32536965-14 2020 Second, the molecular docking results showed that there was a certain affinity between the core compounds (kaempferol, quercetin, 7-Methoxy-2-methyl isoflavone, naringenin, formononetin) and core target genes (IL6, IL1B, CCL2). Quercetin 119-128 C-C motif chemokine ligand 2 Homo sapiens 221-225 22469745-0 2012 Quercetin suppresses NF-kappaB and MCP-1 expression in a high glucose-induced human mesangial cell proliferation model. Quercetin 0-9 C-C motif chemokine ligand 2 Homo sapiens 35-40 31212975-5 2019 The results showed that quercetin could dose-dependently decrease the mRNA and protein levels of ICAM-1, IL-6, IL-8 and monocyte chemoattractant protein-1 (MCP-1). Quercetin 24-33 C-C motif chemokine ligand 2 Homo sapiens 120-154 31212975-5 2019 The results showed that quercetin could dose-dependently decrease the mRNA and protein levels of ICAM-1, IL-6, IL-8 and monocyte chemoattractant protein-1 (MCP-1). Quercetin 24-33 C-C motif chemokine ligand 2 Homo sapiens 156-161 30471617-14 2019 In Mrgprx2 knockdown LAD2 cells, the effect of Quercetin (200 muM) reduced C48/80 induced calcium flux and the release of beta-hexosaminidase, histamine, MCP-1 and IL-8 compared with non-atopic control (NC) transfected LAD2 human mast cells, suggesting that Quercetin anti-pseudo-allergic effect was related to Mrgprx2. Quercetin 47-56 C-C motif chemokine ligand 2 Homo sapiens 154-159 27295129-8 2016 We also identified 3 drugs, methotrexate, quercetin, and mimosine, which repressed the activated cell cycle genes, ARID5B, STK17B, and CCL2, in HeLa cells with minimal side-effects. Quercetin 42-51 C-C motif chemokine ligand 2 Homo sapiens 135-139 31960917-6 2020 Pre-treating ARPE-19 cells with quercetin clearly attenuated high glucose-induced viability loss, apoptosis, MCP-1 and IL-6 overproduction, and ROS generation. Quercetin 32-41 C-C motif chemokine ligand 2 Homo sapiens 109-114 31212975-11 2019 Taken together, these results provide evidence that quercetin protects ARPE-19 cells from the IL-1beta-stimulated increase in ICAM-1, sICAM-1, IL-6, IL-8 and MCP-1 production by blocking the activation of MAPK and NF-kappaB signaling pathways to ameliorate the inflammatory response. Quercetin 52-61 C-C motif chemokine ligand 2 Homo sapiens 158-163 21186817-5 2011 p-Coumaric acid, quercetin, and resveratrol demonstrated inhibitions of TNF-alpha-induced changes in levels of monocyte chemoattractant protein-1 (MCP-1), plasminogen activator inhibitor-1 (PAI-1), and intracellular reactive oxygen species (ROS) in 3T3-L1 adipocytes. Quercetin 17-26 C-C motif chemokine ligand 2 Homo sapiens 111-145 21186817-5 2011 p-Coumaric acid, quercetin, and resveratrol demonstrated inhibitions of TNF-alpha-induced changes in levels of monocyte chemoattractant protein-1 (MCP-1), plasminogen activator inhibitor-1 (PAI-1), and intracellular reactive oxygen species (ROS) in 3T3-L1 adipocytes. Quercetin 17-26 C-C motif chemokine ligand 2 Homo sapiens 147-152 20943792-7 2010 RESULTS: Quercetin, and to a lesser extent trans-RSV, attenuated the TNF-alpha-induced expression of inflammatory genes such as interleukin (IL)-6, IL-1beta, IL-8, and monocyte chemoattractant protein-1 (MCP-1) and the secretion of IL-6, IL-8, and MCP-1. Quercetin 9-18 C-C motif chemokine ligand 2 Homo sapiens 168-202 20943792-7 2010 RESULTS: Quercetin, and to a lesser extent trans-RSV, attenuated the TNF-alpha-induced expression of inflammatory genes such as interleukin (IL)-6, IL-1beta, IL-8, and monocyte chemoattractant protein-1 (MCP-1) and the secretion of IL-6, IL-8, and MCP-1. Quercetin 9-18 C-C motif chemokine ligand 2 Homo sapiens 204-209 20943792-7 2010 RESULTS: Quercetin, and to a lesser extent trans-RSV, attenuated the TNF-alpha-induced expression of inflammatory genes such as interleukin (IL)-6, IL-1beta, IL-8, and monocyte chemoattractant protein-1 (MCP-1) and the secretion of IL-6, IL-8, and MCP-1. Quercetin 9-18 C-C motif chemokine ligand 2 Homo sapiens 248-253 9292787-6 1997 RESULTS: Addition of quercetin suppressed TNF-alpha induced increase in the mRNA for IL-8 and MCP-1 in a dose dependent manner. Quercetin 21-30 C-C motif chemokine ligand 2 Homo sapiens 94-99 9292787-0 1997 Quercetin, a bioflavonoid, inhibits the induction of interleukin 8 and monocyte chemoattractant protein-1 expression by tumor necrosis factor-alpha in cultured human synovial cells. Quercetin 0-9 C-C motif chemokine ligand 2 Homo sapiens 71-105 18489909-5 2009 Quercetin was able to reduce TNFalpha-induced upregulation of VCAM-1, ICAM-1 and MCP-1 at both the protein and transcript (mRNA) level in HUASMC. Quercetin 0-9 C-C motif chemokine ligand 2 Homo sapiens 81-86 17880982-7 2008 Quercetin also inhibited MCP-1 gene expression. Quercetin 0-9 C-C motif chemokine ligand 2 Homo sapiens 25-30 16794257-3 2006 Pretreatment with quercetin and the PI 3-kinase inhibitor LY294002 each reduced TNF-alpha-induced IL-8 and monocyte chemoattractant protein (MCP)-1 (also called CCL2) expression in cultured human airway epithelial cells. Quercetin 18-27 C-C motif chemokine ligand 2 Homo sapiens 107-147 16794257-3 2006 Pretreatment with quercetin and the PI 3-kinase inhibitor LY294002 each reduced TNF-alpha-induced IL-8 and monocyte chemoattractant protein (MCP)-1 (also called CCL2) expression in cultured human airway epithelial cells. Quercetin 18-27 C-C motif chemokine ligand 2 Homo sapiens 161-165 17191019-0 2006 Inhibitory effect of quercetin on tryptase and MCP-1 chemokine release, and histidine decarboxylase mRNA transcription by human mast cell-1 cell line. Quercetin 21-30 C-C motif chemokine ligand 2 Homo sapiens 47-52 17191019-5 2006 In this study quercetin inhibits, in a dose-response manner, tryptase and MCP-1. Quercetin 14-23 C-C motif chemokine ligand 2 Homo sapiens 74-79 17191019-6 2006 Moreover, using RT-PCR quercetin inhibited the transcription of histidine decarboxylase, the rate-limiting enzyme responsible for the generation of histamine from histidine, and MCP-1. Quercetin 23-32 C-C motif chemokine ligand 2 Homo sapiens 178-183 9292787-8 1997 H2O2 mediated induction of IL-8 and MCP-1 genes was also inhibited by quercetin. Quercetin 70-79 C-C motif chemokine ligand 2 Homo sapiens 36-41 9292787-10 1997 CONCLUSION: Quercetin suppresses TNF-alpha mediated stimulation of IL-8 and MCP-1 expression, at least in part, by inhibiting the activation of NF-kappa B. Quercetin 12-21 C-C motif chemokine ligand 2 Homo sapiens 76-81 34493195-7 2022 RESULTS: We filtered out 6 pivotal ingredients from QFPDD by using the bioinformatics method, namely quercetin, luteolin, berberine, hederagenin, shionone and kaempferol, which can inhibit the highly expressed genes (i.e. CXCR4, ICAM1, CXCL8, CXCL10, IL6, IL2, CCL2, IL1B, IL4, IFNG) in severe COVID-19 patients. Quercetin 101-110 C-C motif chemokine ligand 2 Homo sapiens 261-265 34385920-5 2021 Real-time gene expression assay for intercellular adhesion molecule-1 (ICAM-1) and monocyte chemoattractant protein-1 (MCP-1) was carried out following treatment with quercetin at 15 and 30 muM for 24 h either in the absence or presence of interferon (IFN-gamma) for 3 h to induce inflammation. Quercetin 167-176 C-C motif chemokine ligand 2 Homo sapiens 83-117 34385920-5 2021 Real-time gene expression assay for intercellular adhesion molecule-1 (ICAM-1) and monocyte chemoattractant protein-1 (MCP-1) was carried out following treatment with quercetin at 15 and 30 muM for 24 h either in the absence or presence of interferon (IFN-gamma) for 3 h to induce inflammation. Quercetin 167-176 C-C motif chemokine ligand 2 Homo sapiens 119-124 34385920-13 2021 Conclusion: Our results from both in vitro and in silico studies identified that quercetin inhibited the THP-1 monocyte migration, MCP-1, and ICAM-1 and increased cholesterol efflux probably mediated via the LXR/RXR signaling pathway. Quercetin 81-90 C-C motif chemokine ligand 2 Homo sapiens 131-136 33520015-11 2020 Finally, 6 key proteins of TNF, IL-10, IL-2, IL-6, STAT1 and CCL2 were selected and successfully docked with 4 active ingredients of quercetin, luteolin, wogonin and kaempferol. Quercetin 133-142 C-C motif chemokine ligand 2 Homo sapiens 61-65 35593365-12 2022 The results indicated that quercetin and wogonin had better affinity with CXCL8, CCL2 or IL1B. Quercetin 27-36 C-C motif chemokine ligand 2 Homo sapiens 81-85 35593365-14 2022 The expression CXCL8, CCL2 or IL1B were down-regulated after quercetin or wogonin treating, compared with LPS-induced A549 cells (P < 0.01). Quercetin 61-70 C-C motif chemokine ligand 2 Homo sapiens 22-26 35372072-11 2022 Network pharmacological results showed that the active ingredient luteolin, quercetin, licochalcone a, and kaempferol and the effective targets prostaglandin-endoperoxide synthase 2 (PTGS2), matrix metallopeptidase 9 (MMP9), and C-C motif chemokine ligand 2 (CCL2) were related to the interleukin-17 (IL-17) and tumor necrosis factor (TNF) pathway. Quercetin 76-85 C-C motif chemokine ligand 2 Homo sapiens 229-257 33278444-9 2021 Moreover, quercetin-glycyrrhizin nanogels were more effective in down-regulating the inflammation-related gene expression of tumor necrosis factor-alpha, interleukin-6, inducible nitric oxide synthase and monocyte chemotactic protein-1. Quercetin 10-19 C-C motif chemokine ligand 2 Homo sapiens 205-235 35372072-13 2022 The results showed that luteolin and quercetin increased the expression of PTGS2 and MMP9 and reduced the expression of CCL2 in HaCaT cells treated with gefitinib. Quercetin 37-46 C-C motif chemokine ligand 2 Homo sapiens 120-124 35372072-15 2022 Luteolin and quercetin may be the core active ingredients of QYSLS in the treatment of EGFRI-related adverse skin reactions, and their therapeutic effects are potentially mediated through PTGS2, CCL2, and MMP9 in the IL-17 and TNF signaling pathway. Quercetin 13-22 C-C motif chemokine ligand 2 Homo sapiens 195-199 35135448-9 2022 Molecular docking and dynamics simulations were performed to study the interaction between selected target genes (Chemokine ligand 2 (CCL2) and matrix metalloproteinase 1 (MMP1)) and active ingredients (quercetin and wogonin) of Ermiao San. Quercetin 203-212 C-C motif chemokine ligand 2 Homo sapiens 134-138 35135448-11 2022 CCL2 and MMP1 were identified and verified to be the targets of both quercetin and wogonin, the two active ingredients of Ermiao San, by molecular docking and molecular dynamics. Quercetin 69-78 C-C motif chemokine ligand 2 Homo sapiens 0-4