PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34161119-3 2021 METHODS: The effect of quercetin (75microM) and vitamin C (100 microM) on CXCR4, CXCR7 chemokine receptors, alpha4, alpha5 and beta1 integrins, ki-67 proliferation marker and Vascular endothelial growth factor, VEGF was evaluated using Quantitative Reverse Transcription PCR (RT-qPCR). Quercetin 23-32 atypical chemokine receptor 3 Homo sapiens 81-86 34161119-4 2021 RESULTS: The effect of quercetin and vitamin C alone was different on PC3 and DU145 prostate cancer cell lines, but sequential combination reduced significantly the expression of CXCR and CXCR7 chemokine receptors, alpha4, alpha5 and beta1 integrin subunits, VEGF and Ki-67 proliferation markers in PC3 and DU145 cell lines. Quercetin 23-32 atypical chemokine receptor 3 Homo sapiens 188-193 35120520-11 2022 The docking scores toward proteins 3ODU of CXCR4 and 6K3F of CXCR7 were - 7.71 and - 7.17 for curcumin, - 5.97 and - 6.03 for quercetin, - 5.68 and - 5.49 for trans-resveratrol, and - 4.88 and - 4.70 for (1 s,4 s)-eucalyptol respectively indicating that all compounds, except quercetin, have more interactions with CXCR4 than with CXCR7. Quercetin 126-135 atypical chemokine receptor 3 Homo sapiens 61-66 35120520-11 2022 The docking scores toward proteins 3ODU of CXCR4 and 6K3F of CXCR7 were - 7.71 and - 7.17 for curcumin, - 5.97 and - 6.03 for quercetin, - 5.68 and - 5.49 for trans-resveratrol, and - 4.88 and - 4.70 for (1 s,4 s)-eucalyptol respectively indicating that all compounds, except quercetin, have more interactions with CXCR4 than with CXCR7. Quercetin 276-285 atypical chemokine receptor 3 Homo sapiens 61-66 35120520-16 2022 CONCLUSIONS: Curcumin showed the top binding interaction against active sites of CXCR4 and CXCR7 receptors, with the best safety profile, followed by quercetin, resveratrol, and eucalyptol. Quercetin 150-159 atypical chemokine receptor 3 Homo sapiens 91-96