PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35162967-6 2022 Quercetin (Que), a flavonoid with strong antioxidant properties, and noticeably reduced the lipid accumulation and the expression of SREBP-1 and XBP-1, as well as of their lipogenic gene targets in steatotic cells. Quercetin 0-9 X-box binding protein 1 Homo sapiens 145-150 35162967-6 2022 Quercetin (Que), a flavonoid with strong antioxidant properties, and noticeably reduced the lipid accumulation and the expression of SREBP-1 and XBP-1, as well as of their lipogenic gene targets in steatotic cells. Quercetin 11-14 X-box binding protein 1 Homo sapiens 145-150 29438776-0 2018 Quercetin ameliorates HFD-induced NAFLD by promoting hepatic VLDL assembly and lipophagy via the IRE1a/XBP1s pathway. Quercetin 0-9 X-box binding protein 1 Homo sapiens 103-107 29438776-3 2018 Quercetin intake decreased hepatic TG content by 39%, with a 1.5-fold increase in VLDL, and up-regulated spliced X-box binding protein 1 (XBP1s) expression compared with the HFD group. Quercetin 0-9 X-box binding protein 1 Homo sapiens 113-136 29438776-8 2018 Collectively, these findings demonstrate that hepatic VLDL assembly and lipophagy are the main targets of quercetin against NAFLD via the IRE1a/XBP1s pathway. Quercetin 106-115 X-box binding protein 1 Homo sapiens 144-148 19017364-6 2009 Moreover, our studies reveal that HSP70 knockdown or quercetin induces other typical components of the UPR, including CHOP expression, eIF2alpha and JNK phosphorylation, caspases activation and XBP-1 splicing. Quercetin 53-62 X-box binding protein 1 Homo sapiens 194-199