PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29371942-0 2017 Dietary quercetin potentiates the antiproliferative effect of interferon-alpha in hepatocellular carcinoma cells through activation of JAK/STAT pathway signaling by inhibition of SHP2 phosphatase. Quercetin 8-17 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 179-183 29371942-7 2017 The overexpression of SHP2 attenuated the effect of quercetin on IFN-alpha-stimulated STAT1 phosphorylation and antiproliferative effect, whereas the inhibition of SHP2 promoted the effect of quercetin on IFN-alpha-induced STAT1 phosphorylation and antiproliferative effect. Quercetin 192-201 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 22-26 29371942-7 2017 The overexpression of SHP2 attenuated the effect of quercetin on IFN-alpha-stimulated STAT1 phosphorylation and antiproliferative effect, whereas the inhibition of SHP2 promoted the effect of quercetin on IFN-alpha-induced STAT1 phosphorylation and antiproliferative effect. Quercetin 192-201 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 164-168 29371942-8 2017 The results suggested that quercetin potentiated the inhibitory effect of IFN-alpha on cancer cell proliferation through activation of JAK/STAT pathway signaling by inhibiting SHP2. Quercetin 27-36 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 176-180 29371942-3 2017 Using an in vitro screening assay for new inhibitors of SHP2 phosphatase, we found that quercetin was a potent inhibitor of SHP2. Quercetin 88-97 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 56-60 29371942-3 2017 Using an in vitro screening assay for new inhibitors of SHP2 phosphatase, we found that quercetin was a potent inhibitor of SHP2. Quercetin 88-97 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 124-128 29371942-4 2017 Computational modeling showed that quercetin exhibited an orientation favorable to nucleophilic attack in the phosphatase domain of SHP2. Quercetin 35-44 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 132-136 29371942-7 2017 The overexpression of SHP2 attenuated the effect of quercetin on IFN-alpha-stimulated STAT1 phosphorylation and antiproliferative effect, whereas the inhibition of SHP2 promoted the effect of quercetin on IFN-alpha-induced STAT1 phosphorylation and antiproliferative effect. Quercetin 52-61 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 22-26 26718867-0 2016 Experimental evidence and molecular modeling of the interaction between hRSV-NS1 and quercetin. Quercetin 85-94 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 77-80 26718867-5 2016 The aims of this study include the expression and purification of the NS1 protein besides experimental and computational assays of the NS1-quercetin interaction. Quercetin 139-148 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 135-138 26718867-7 2016 The melting temperature obtained through DSC analysis was around 56 C. FRET analysis showed a distance of approximately 19A between the NS1 and quercetin. Quercetin 144-153 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 136-139 26718867-8 2016 Fluorescence titration results showed that the dissociation constant of the NS1-quercetin interaction was around 10(-6)M. In thermodynamic analysis, the enthalpy and entropy balanced forces indicated that the NS1-quercetin interaction presented both hydrophobic and electrostatic contributions. Quercetin 80-89 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 76-79 26718867-8 2016 Fluorescence titration results showed that the dissociation constant of the NS1-quercetin interaction was around 10(-6)M. In thermodynamic analysis, the enthalpy and entropy balanced forces indicated that the NS1-quercetin interaction presented both hydrophobic and electrostatic contributions. Quercetin 80-89 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 209-212 26718867-8 2016 Fluorescence titration results showed that the dissociation constant of the NS1-quercetin interaction was around 10(-6)M. In thermodynamic analysis, the enthalpy and entropy balanced forces indicated that the NS1-quercetin interaction presented both hydrophobic and electrostatic contributions. Quercetin 213-222 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 76-79 26718867-8 2016 Fluorescence titration results showed that the dissociation constant of the NS1-quercetin interaction was around 10(-6)M. In thermodynamic analysis, the enthalpy and entropy balanced forces indicated that the NS1-quercetin interaction presented both hydrophobic and electrostatic contributions. Quercetin 213-222 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 209-212 26718867-9 2016 The computational results from the molecular modeling for NS1 structure and molecular docking regarding its interaction with quercetin corroborate the experimental data. Quercetin 125-134 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 58-61 20082303-6 2010 Furthermore, quercetin sustained epidermal growth factor receptor (EGFR) activation by suppressing the phosphatases, PP2a and SHP-2. Quercetin 13-22 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 126-131