PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29371942-0	2017	Dietary quercetin potentiates the antiproliferative effect of interferon-alpha in hepatocellular carcinoma cells through activation of JAK/STAT pathway signaling by inhibition of SHP2 phosphatase.	Quercetin	8-17	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	179-183	
29371942-7	2017	The overexpression of SHP2 attenuated the effect of quercetin on IFN-alpha-stimulated STAT1 phosphorylation and antiproliferative effect, whereas the inhibition of SHP2 promoted the effect of quercetin on IFN-alpha-induced STAT1 phosphorylation and antiproliferative effect.	Quercetin	192-201	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	22-26	
29371942-7	2017	The overexpression of SHP2 attenuated the effect of quercetin on IFN-alpha-stimulated STAT1 phosphorylation and antiproliferative effect, whereas the inhibition of SHP2 promoted the effect of quercetin on IFN-alpha-induced STAT1 phosphorylation and antiproliferative effect.	Quercetin	192-201	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	164-168	
29371942-8	2017	The results suggested that quercetin potentiated the inhibitory effect of IFN-alpha on cancer cell proliferation through activation of JAK/STAT pathway signaling by inhibiting SHP2.	Quercetin	27-36	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	176-180	
29371942-3	2017	Using an in vitro screening assay for new inhibitors of SHP2 phosphatase, we found that quercetin was a potent inhibitor of SHP2.	Quercetin	88-97	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	56-60	
29371942-3	2017	Using an in vitro screening assay for new inhibitors of SHP2 phosphatase, we found that quercetin was a potent inhibitor of SHP2.	Quercetin	88-97	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	124-128	
29371942-4	2017	Computational modeling showed that quercetin exhibited an orientation favorable to nucleophilic attack in the phosphatase domain of SHP2.	Quercetin	35-44	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	132-136	
29371942-7	2017	The overexpression of SHP2 attenuated the effect of quercetin on IFN-alpha-stimulated STAT1 phosphorylation and antiproliferative effect, whereas the inhibition of SHP2 promoted the effect of quercetin on IFN-alpha-induced STAT1 phosphorylation and antiproliferative effect.	Quercetin	52-61	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	22-26	
26718867-0	2016	Experimental evidence and molecular modeling of the interaction between hRSV-NS1 and quercetin.	Quercetin	85-94	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	77-80	
26718867-5	2016	The aims of this study include the expression and purification of the NS1 protein besides experimental and computational assays of the NS1-quercetin interaction.	Quercetin	139-148	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	135-138	
26718867-7	2016	The melting temperature obtained through DSC analysis was around 56 C. FRET analysis showed a distance of approximately 19A between the NS1 and quercetin.	Quercetin	144-153	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	136-139	
26718867-8	2016	Fluorescence titration results showed that the dissociation constant of the NS1-quercetin interaction was around 10(-6)M. In thermodynamic analysis, the enthalpy and entropy balanced forces indicated that the NS1-quercetin interaction presented both hydrophobic and electrostatic contributions.	Quercetin	80-89	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	76-79	
26718867-8	2016	Fluorescence titration results showed that the dissociation constant of the NS1-quercetin interaction was around 10(-6)M. In thermodynamic analysis, the enthalpy and entropy balanced forces indicated that the NS1-quercetin interaction presented both hydrophobic and electrostatic contributions.	Quercetin	80-89	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	209-212	
26718867-8	2016	Fluorescence titration results showed that the dissociation constant of the NS1-quercetin interaction was around 10(-6)M. In thermodynamic analysis, the enthalpy and entropy balanced forces indicated that the NS1-quercetin interaction presented both hydrophobic and electrostatic contributions.	Quercetin	213-222	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	76-79	
26718867-8	2016	Fluorescence titration results showed that the dissociation constant of the NS1-quercetin interaction was around 10(-6)M. In thermodynamic analysis, the enthalpy and entropy balanced forces indicated that the NS1-quercetin interaction presented both hydrophobic and electrostatic contributions.	Quercetin	213-222	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	209-212	
26718867-9	2016	The computational results from the molecular modeling for NS1 structure and molecular docking regarding its interaction with quercetin corroborate the experimental data.	Quercetin	125-134	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	58-61	
20082303-6	2010	Furthermore, quercetin sustained epidermal growth factor receptor (EGFR) activation by suppressing the phosphatases, PP2a and SHP-2.	Quercetin	13-22	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	126-131