PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24902966-8 2014 The quercetin-mediated protection against doxorubicin toxicity was characterized by decreased expression of Bid, p53 and oxidase (p47 and Nox1) and by increased expression of Bcl-2 and Bmi-1. Quercetin 4-13 BCL2, apoptosis regulator Rattus norvegicus 175-180 31665932-9 2022 Furthermore, the lowered mRNA expression of liver IL-4, P53 and Bcl-2 in of DEN/2AAF-administered rats were significantly counteracted by treatment with quercetin and naringenin. Quercetin 153-162 BCL2, apoptosis regulator Rattus norvegicus 64-69 24530315-0 2014 Quercetin mitigates lead acetate-induced behavioral and histological alterations via suppression of oxidative stress, Hsp-70, Bak and upregulation of Bcl-2. Quercetin 0-9 BCL2, apoptosis regulator Rattus norvegicus 150-155 24530315-9 2014 Quercetin however, restored the normal morphology of brain and the expressions of Bak, Bcl-2 and Hsp-70. Quercetin 0-9 BCL2, apoptosis regulator Rattus norvegicus 87-92 22524206-9 2012 DNA fragmentation, Bax/Bcl-2 ratio, nuclear translocation of apoptosis-inducing factor, as well as poly(adenosine diphosphate [ADP]-ribose) polymerase cleavage were significantly reduced by quercetin and sesamin administration, affirming their antiapoptotic features. Quercetin 190-199 BCL2, apoptosis regulator Rattus norvegicus 23-28 21885874-8 2011 Quercetin also inhibited the change of the p-ERK1/2 by TAA and significantly prevented the increase in Bax/Bcl-2 ratio, thus preventing apoptosis. Quercetin 0-9 BCL2, apoptosis regulator Rattus norvegicus 107-112 35313329-9 2022 In silico molecular mechanism prediction suggested that quercetin has a high affinity for cell signaling pathway proteins BCL-2, JAK2 and Cytochrome P450 Cyp2E1, which all play a significant role in CCl4 induced hepatotoxicity. Quercetin 56-65 BCL2, apoptosis regulator Rattus norvegicus 122-127 35313329-11 2022 MMGBSA studies have revealed high binding of quercetin (DeltaG) -41.48+-11.02, -43.53+-6.55 and -39.89+-5.78 kcal/mol, with BCL-2, JAK2 and Cyp2E1, respectively which led to better stability of the quercetin bound protein complexes. Quercetin 45-54 BCL2, apoptosis regulator Rattus norvegicus 124-129 35313329-11 2022 MMGBSA studies have revealed high binding of quercetin (DeltaG) -41.48+-11.02, -43.53+-6.55 and -39.89+-5.78 kcal/mol, with BCL-2, JAK2 and Cyp2E1, respectively which led to better stability of the quercetin bound protein complexes. Quercetin 198-207 BCL2, apoptosis regulator Rattus norvegicus 124-129 35313329-12 2022 Therefore, quercetin can act as potent inhibitor against CCl4 induced hepatic injury by regulating BCL-2, JAK2 and Cyp2E1. Quercetin 11-20 BCL2, apoptosis regulator Rattus norvegicus 99-104 24769323-12 2014 Our results still showed that quercetin pretreatment significantly inhibited the apoptosis by decreasing the number of apoptotic cells, decreasing the level of cleaved Bax, and increasing the level of Bcl-2 in rats subjected to I/R injury. Quercetin 30-39 BCL2, apoptosis regulator Rattus norvegicus 201-206 23281070-5 2012 Whereas simultaneous treatment with quercetin normalized all the biochemical parameters, consequently it inhibited apoptosis mediated by Aroclor-1254 by downregulating aryl hydrocarbon receptor, p53 and apoptotic protein (Bax, caspase-9, caspase-3) and upregulating the antiapoptotic protein (Bcl-2) expression patterns; thereby, quercetin reduces alteration in hepatocellular morphology. Quercetin 36-45 BCL2, apoptosis regulator Rattus norvegicus 293-298 21787598-5 2010 Western blot analysis showed that quercetin significantly inhibited apoptosis by modulating the ratio of Bax to Bcl-2 expression and suppressing the expression of phosphorylated JNK1/2 and cleaved caspase-3 in the liver of lead-treated rat. Quercetin 34-43 BCL2, apoptosis regulator Rattus norvegicus 112-117 34538551-9 2022 RESULTS: The results showed that quercetin could significantly reduce the expression of Testosterone (T) , Estradiol (E2) , LH, Bax, IL-1beta, IL-6 and TNF-alpha, increase the expression of FSH and Bcl-2, inhibit the expression of AR, regulate the expression of CNP / NPR2 gene and protein by affecting the combination of AR with the specific sequence of CNP and NPR2 gene promoters, restore the maturation of oocyte and ovulation. Quercetin 33-42 BCL2, apoptosis regulator Rattus norvegicus 198-203 35331526-10 2022 Beta-catenin and Bcl-2 proteins expression was decreased and caspase 3 expression was significantly increased in the quercetin group versus to control group. Quercetin 117-126 BCL2, apoptosis regulator Rattus norvegicus 17-22 35331526-12 2022 The quercetin supplementation lead to increase in apoptotic proteins gene expression including caspase 3 and decrease in anti-apoptotic gene expression including Bcl-2. Quercetin 4-13 BCL2, apoptosis regulator Rattus norvegicus 162-167 34984688-10 2022 Pretreatment with quercetin was effective at attenuating histopathologic changes in hepatic and renal tissues by regulating the immunoexpression of caspase-3 and Bcl-2 to return them to more normal values. Quercetin 18-27 BCL2, apoptosis regulator Rattus norvegicus 162-167 32492628-8 2020 Meanwhile, Que significantly inhibited the level of tumor suppressor P53, Bax, cleaved-cas3 expressionl and increased Bcl-2 expression to reduce apoptosis in vivo and in vitro. Quercetin 11-14 BCL2, apoptosis regulator Rattus norvegicus 118-123 30990955-13 2019 Interestingly, when chlorpyrifos-treated animals were supplemented with quercetin, a significant increase in the expression of Bcl-2 and an appreciable decline in the expression levels of Bax, cytochrome c, caspase-8, and caspase-9 was observed. Quercetin 72-81 BCL2, apoptosis regulator Rattus norvegicus 127-132 28855811-10 2017 Furthermore, the level of an anti-apoptotic protein Bcl-2 was augmented in quercetin treated diabetic retina. Quercetin 75-84 BCL2, apoptosis regulator Rattus norvegicus 52-57 29855745-8 2018 TUNEL assay showed an increase in apoptotic index (0.14 +- 0.03; 0.15 +- 0.01) in vanadium-quercetin treated groups as compared to the carcinogen control (0.02 +- 0.01) along with upregulation of Bcl-2 and downregulation of Bax and p53. Quercetin 91-100 BCL2, apoptosis regulator Rattus norvegicus 196-201 30656723-5 2019 The silent information regulatory factor 1 (SIRT1), peroxisome proliferators-activated receptor-gamma coactivator-1alpha (PGC-1alpha), and Bcl-2 proteins expression of quercetin treated were significantly upregulation compared with MC group (P < 0.05, respectively), and Bax protein expression of quercetin treated group was significantly downregulation compared with MC group ( P < 0.05, respectively). Quercetin 168-177 BCL2, apoptosis regulator Rattus norvegicus 139-144 30656723-8 2019 SIRT1, PGC-1a, Bcl-2, and Bax proteins expressions of quercetin treated groups were significant differences compared with MC group in myocardial tissue ( P < 0.05, respectively). Quercetin 54-63 BCL2, apoptosis regulator Rattus norvegicus 15-20 28391159-0 2017 Inhibitory effects of quercetin on the progression of liver fibrosis through the regulation of NF-kB/IkBalpha, p38 MAPK, and Bcl-2/Bax signaling. Quercetin 22-31 BCL2, apoptosis regulator Rattus norvegicus 125-130 28391159-7 2017 Additionally, in a dose-dependent manner, quercetin down-regulated Bax, up-regulated Bcl-2, and subsequently inhibited caspase-3 activation. Quercetin 42-51 BCL2, apoptosis regulator Rattus norvegicus 85-90 28391159-10 2017 The anti-fibrotic mechanisms of quercetin might be associated with its ability to regulate NF-kB/IkBalpha, p38 MAPK anti-inflammation signaling pathways to inhibit inflammation, and regulate Bcl-2/Bax anti-apoptosis signaling pathway to prevent liver cell apoptosis. Quercetin 32-41 BCL2, apoptosis regulator Rattus norvegicus 191-196 28684704-9 2017 In addition, quercetin pretreatment significantly increased Bcl-2 expression, and reduced Bax, cleaved caspase-3 and p53 expressions. Quercetin 13-22 BCL2, apoptosis regulator Rattus norvegicus 60-65 27572285-9 2016 Quercetin induced downregulation of Bcl-2 and upregulation of Bax, and increased cytochrome C in the cytoplasm in HSCs. Quercetin 0-9 BCL2, apoptosis regulator Rattus norvegicus 36-41 28804614-7 2017 In addition, pre-treatment with QUE and OST decreased CIS-induced apoptosis through up-regulation of Bcl-2, inhibition of caspase-3 activity, and mitochondrial membrane potential (MMP) increase. Quercetin 32-35 BCL2, apoptosis regulator Rattus norvegicus 101-106 27572285-5 2016 Quercetin (10-40 muM) effects on the expression of Bcl-2, caspase-9, caspase-3, PARP-1, PERK, IRE1, ATF6, calnexin and CHOP for 24 h were analyzed by Western blot. Quercetin 0-9 BCL2, apoptosis regulator Rattus norvegicus 51-56 26476374-7 2015 Additionally, quercetin altered the Bax/Bcl-2 ratio and reduced MMP2, MMP9, CXCR4, integrin beta1, and integrin alpha5 expression. Quercetin 14-23 BCL2, apoptosis regulator Rattus norvegicus 40-45 27690831-11 2016 Furthermore, quercetin treatment reduced the expression of LC3 caspase-3 and Bax levels induced following TBI (p < 0.05), and increased the expression of p-Akt and Bcl-2 at 48 h (p < 0.05). Quercetin 13-22 BCL2, apoptosis regulator Rattus norvegicus 167-172 26944603-8 2016 In addition, quercetin also prevents aluminum-induced translocation of cyt-c, and up-regulates Bcl-2, down-regulates Bax, p53, caspase-3 activation and reduces DNA fragmentation. Quercetin 13-22 BCL2, apoptosis regulator Rattus norvegicus 95-100 26414235-7 2016 The data showed that LY294002 almost had the same effects with H(2)O(2), which was also significantly reversed by quercetin could enhance Bax/Bcl-2 ratio and adjust the p-Akt expression, which indicated quercetin might protect PC12 cells against the negative effect of H(2)O(2) via activating the PI3K/Akt signal pathway. Quercetin 114-123 BCL2, apoptosis regulator Rattus norvegicus 142-147