PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28691026-8 2017 Western blot analysis showed that iNOS/p38MAPK pathway was normalized by the quercetin supplementation. Quercetin 77-86 nitric oxide synthase 2 Rattus norvegicus 34-38 30584425-8 2018 The treatment with Quercetin showed nonsignificant differences as compared to treatment with DFO that chelated the serum and tissue iron and improved the oxidative stress and reduced tissue IL6 and increased IL10 and decreased caspase 3 and iNOs expressing cells in small intestinal tissues. Quercetin 19-28 nitric oxide synthase 2 Rattus norvegicus 241-245 30197123-8 2018 Our results showed that quercetin regulated iron absorption, despite SLC40 down-expression, indicating possible alternate route of iron transport, and that quercetin modulated iNOS production in splenic macrophages. Quercetin 156-165 nitric oxide synthase 2 Rattus norvegicus 176-180 31065489-8 2019 Quercetin considerably reduced the protein expression of iNOS. Quercetin 0-9 nitric oxide synthase 2 Rattus norvegicus 57-61 28914791-0 2017 Quercetin Attenuates Manganese-Induced Neuroinflammation by Alleviating Oxidative Stress through Regulation of Apoptosis, iNOS/NF-kappaB and HO-1/Nrf2 Pathways. Quercetin 0-9 nitric oxide synthase 2 Rattus norvegicus 122-126 28149015-3 2017 Oral treatment of quercetin (50 mg/kg b.w) to hyperammonemic rats (1) increased the expression of urea cycle enzymes (CPS-1, OTC, ASS and ARG), neuronal and astrocytic markers (GS and PAG) (2) decreased the expression of IL6, iNOS and NF-kappaB and (3) upregulated mRNA expression of SGC, GFAP and ASS. Quercetin 18-27 nitric oxide synthase 2 Rattus norvegicus 226-230 28691026-9 2017 CONCLUSIONS: Quercetin exerted a protective effect on vascular calcification in adenine-induced chronic renal failure rats, possibly through the modulation of oxidative stress and iNOs/p38MAPK pathway. Quercetin 13-22 nitric oxide synthase 2 Rattus norvegicus 180-184 26690102-9 2015 A decrease in the levels of oxidative stress markers, NOx production and iNOS expression associated with elevated activity of antioxidant enzymes in the aortic tissue were observed in quercetin-treated diabetic trained rats. Quercetin 184-193 nitric oxide synthase 2 Rattus norvegicus 73-77 26221305-13 2015 iNOS expression have a certain degree of increased after quercetin treatment. Quercetin 57-66 nitric oxide synthase 2 Rattus norvegicus 0-4 23770986-9 2013 Quercetin also dose-dependently inhibited the NF-kappaB signaling pathway and suppressed the expression of iNOS, COX-2, and proinflammatory cytokines IL-6 and TNF-alpha. Quercetin 0-9 nitric oxide synthase 2 Rattus norvegicus 107-111 24337631-1 2014 Previously, we reported that isorhamnentin, a 3"-O-methylated metabolite of quercetin, reduced inducible nitric oxide synthase (iNOS) expression and NO production. Quercetin 76-85 nitric oxide synthase 2 Rattus norvegicus 95-126 24337631-1 2014 Previously, we reported that isorhamnentin, a 3"-O-methylated metabolite of quercetin, reduced inducible nitric oxide synthase (iNOS) expression and NO production. Quercetin 76-85 nitric oxide synthase 2 Rattus norvegicus 128-132 22221676-8 2012 Quercetin significantly reduced IL-1beta-induced nitrite production, iNOS protein and its mRNA expression levels, and it also inhibited IL-1beta-induced IkappaBalpha phosphorylation, NF-kappaB activation and iNOS promoter activity. Quercetin 0-9 nitric oxide synthase 2 Rattus norvegicus 69-73 23620721-10 2013 However, it was observed that oral treatment of nanoencapsulated quercetin (2.7 mg/kg b wt) resulted in downregulation of iNOS and caspase-3 activities and improved neuronal count in the hippocampal subfields even 3 days after reperfusion. Quercetin 65-74 nitric oxide synthase 2 Rattus norvegicus 122-126 23688865-0 2013 Antioxidant effect of quercetin against acute spinal cord injury in rats and its correlation with the p38MAPK/iNOS signaling pathway. Quercetin 22-31 nitric oxide synthase 2 Rattus norvegicus 110-114 23688865-1 2013 AIMS: The present study aimed to investigate the correlation between quercetin (Que) and the p38 mitogen-activated protein kinase (p38MAPK)/inducible nitric oxide synthase (iNOS) signaling pathway and to explore its regulating effect on secondary oxidative stress following acute spinal cord injury (SCI), so as to elucidate the protective effects and mechanism associated with Que treatment during acute SCI. Quercetin 69-78 nitric oxide synthase 2 Rattus norvegicus 140-171 23688865-1 2013 AIMS: The present study aimed to investigate the correlation between quercetin (Que) and the p38 mitogen-activated protein kinase (p38MAPK)/inducible nitric oxide synthase (iNOS) signaling pathway and to explore its regulating effect on secondary oxidative stress following acute spinal cord injury (SCI), so as to elucidate the protective effects and mechanism associated with Que treatment during acute SCI. Quercetin 69-78 nitric oxide synthase 2 Rattus norvegicus 173-177 23688865-1 2013 AIMS: The present study aimed to investigate the correlation between quercetin (Que) and the p38 mitogen-activated protein kinase (p38MAPK)/inducible nitric oxide synthase (iNOS) signaling pathway and to explore its regulating effect on secondary oxidative stress following acute spinal cord injury (SCI), so as to elucidate the protective effects and mechanism associated with Que treatment during acute SCI. Quercetin 80-83 nitric oxide synthase 2 Rattus norvegicus 140-171 23688865-1 2013 AIMS: The present study aimed to investigate the correlation between quercetin (Que) and the p38 mitogen-activated protein kinase (p38MAPK)/inducible nitric oxide synthase (iNOS) signaling pathway and to explore its regulating effect on secondary oxidative stress following acute spinal cord injury (SCI), so as to elucidate the protective effects and mechanism associated with Que treatment during acute SCI. Quercetin 80-83 nitric oxide synthase 2 Rattus norvegicus 173-177 23688865-6 2013 Que significantly inhibited increases in phosphorylated-p38MAPK (p-p38MAPK) and iNOS expression and reduced the rate of iNOS-positive cells in rats with SCI, similar to the effects of SB203580. Quercetin 0-3 nitric oxide synthase 2 Rattus norvegicus 80-84 23688865-6 2013 Que significantly inhibited increases in phosphorylated-p38MAPK (p-p38MAPK) and iNOS expression and reduced the rate of iNOS-positive cells in rats with SCI, similar to the effects of SB203580. Quercetin 0-3 nitric oxide synthase 2 Rattus norvegicus 120-124 23537890-1 2013 The objective of this study was to evaluate potential hepatoprotective capabilities of quercetin in relation to its modulation of the HO-1 and NOS-2 activities in an experimental model of fulminant liver failure. Quercetin 87-96 nitric oxide synthase 2 Rattus norvegicus 143-148 23537890-10 2013 It can be concluded that the quercetin"s induction of HO-1 and its byproducts, without concomitant NOS-2 activity reduction, is among mechanisms contributing to the hepatoprotective effect in D-GalN/LPS hepatotoxicity. Quercetin 29-38 nitric oxide synthase 2 Rattus norvegicus 99-104 22221676-8 2012 Quercetin significantly reduced IL-1beta-induced nitrite production, iNOS protein and its mRNA expression levels, and it also inhibited IL-1beta-induced IkappaBalpha phosphorylation, NF-kappaB activation and iNOS promoter activity. Quercetin 0-9 nitric oxide synthase 2 Rattus norvegicus 208-212 18590707-6 2008 Inducible nitric oxide synthase expression was also blocked largely by some flavonoids, especially quercetin, luteolin and apigenin, while cyclooxygenase 2 was downregulated only by apigenin, diosmetin and quercetin. Quercetin 99-108 nitric oxide synthase 2 Rattus norvegicus 0-31 21132259-0 2011 Quercetin exerts a neuroprotective effect through inhibition of the iNOS/NO system and pro-inflammation gene expression in PC12 cells and in zebrafish. Quercetin 0-9 nitric oxide synthase 2 Rattus norvegicus 68-72 21132259-8 2011 A mechanistic study showed that quercetin could inhibit NO over-production and iNOS over-expression in PC12 cells and could down-regulate the over-expression of pro-inflammatory genes (e.g. IL-1ss, TNF-alpha and COX-2) in zebrafish, suggesting that these genes play a role in the neuroprotective effect of quercetin. Quercetin 32-41 nitric oxide synthase 2 Rattus norvegicus 79-83 19056647-2 2009 In this study, we determined whether quercetin protects against colon cancer by regulating the protein level of phosphatidylinositol 3-kinase (PI 3-kinase) and Akt or by suppressing the expression of proinflammatory mediators [cyclooxygenase (COX)-1, COX-2, inducible nitric oxide synthase (iNOS)] during the aberrant crypt (AC) stage. Quercetin 37-46 nitric oxide synthase 2 Rattus norvegicus 258-289 19056647-2 2009 In this study, we determined whether quercetin protects against colon cancer by regulating the protein level of phosphatidylinositol 3-kinase (PI 3-kinase) and Akt or by suppressing the expression of proinflammatory mediators [cyclooxygenase (COX)-1, COX-2, inducible nitric oxide synthase (iNOS)] during the aberrant crypt (AC) stage. Quercetin 37-46 nitric oxide synthase 2 Rattus norvegicus 291-295 18551111-9 2008 Furthermore, chronic intake of the higher dose of quercetin enhanced VAT eNOS expression among obese Zucker rats, whereas it downregulated VAT iNOS expression. Quercetin 50-59 nitric oxide synthase 2 Rattus norvegicus 143-147 18590707-6 2008 Inducible nitric oxide synthase expression was also blocked largely by some flavonoids, especially quercetin, luteolin and apigenin, while cyclooxygenase 2 was downregulated only by apigenin, diosmetin and quercetin. Quercetin 206-215 nitric oxide synthase 2 Rattus norvegicus 0-31 16226777-14 2006 Our results demonstrate that quercetin treatment prevents Cd-induced overexpression of iNOS and COX-2, and increases MT expression. Quercetin 29-38 nitric oxide synthase 2 Rattus norvegicus 87-91 18090225-7 2007 The molecular mechanism by which quercetin, apigenin, and luteolin inhibited inducible NO synthase gene expression appeared to involve the inhibition of nuclear factor kappaB (NF-kappaB) activation. Quercetin 33-42 nitric oxide synthase 2 Rattus norvegicus 77-98 17012770-11 2006 At week 33, the expression of iNOS was reduced by quercetin without a statistical significance, and COX-2 expression was slightly reduced in rats on beta-carotene supplementation. Quercetin 50-59 nitric oxide synthase 2 Rattus norvegicus 30-34 16177186-0 2005 Quercetin decreases oxidative stress, NF-kappaB activation, and iNOS overexpression in liver of streptozotocin-induced diabetic rats. Quercetin 0-9 nitric oxide synthase 2 Rattus norvegicus 64-68 16177186-2 2005 This study investigated the protective effects of quercetin treatment on oxidative stress, nuclear factor (NF)-kappaB activation and expression of inducible nitric oxide synthase (iNOS) in streptozotocin-induced diabetic rats. Quercetin 50-59 nitric oxide synthase 2 Rattus norvegicus 180-184 15476665-9 2004 IkappaB decrease and induction of iNOS protein were partially prevented by quercetin. Quercetin 75-84 nitric oxide synthase 2 Rattus norvegicus 34-38 15930438-5 2005 Western blot and reverse transcription-PCR analyses demonstrated that increased levels of inducible nitric oxide synthase (iNOS) protein and mRNA in hepatocytes stimulated by IL-1beta were prevented by 50 micromol/L and 100 micromol/L of quercetin. Quercetin 238-247 nitric oxide synthase 2 Rattus norvegicus 90-121 15930438-5 2005 Western blot and reverse transcription-PCR analyses demonstrated that increased levels of inducible nitric oxide synthase (iNOS) protein and mRNA in hepatocytes stimulated by IL-1beta were prevented by 50 micromol/L and 100 micromol/L of quercetin. Quercetin 238-247 nitric oxide synthase 2 Rattus norvegicus 123-127 14700523-11 2004 Wogonin and quercetin but not rutin, inhibitors of iNOS gene expression and NO production induced by LPS, showed the significant inhibition on LPS/TPA-induced transformation foci formation, accompanied by inhibiting iNOS gene expression, NO production and MMP9 activity. Quercetin 12-21 nitric oxide synthase 2 Rattus norvegicus 51-55 14700523-11 2004 Wogonin and quercetin but not rutin, inhibitors of iNOS gene expression and NO production induced by LPS, showed the significant inhibition on LPS/TPA-induced transformation foci formation, accompanied by inhibiting iNOS gene expression, NO production and MMP9 activity. Quercetin 12-21 nitric oxide synthase 2 Rattus norvegicus 216-220 12741479-7 2003 Treatment with quercetin during 3 weeks improved liver histology and reduced collagen content, iNOS expression, and lipid peroxidation. Quercetin 15-24 nitric oxide synthase 2 Rattus norvegicus 95-99