PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35586682-11	2022	This regulatory effect was related to the expression regulation of HSP90AA1, CDK2, STAT3, and phosphor-STAT3 (p-STAT3) by YQYJ, kaempferol, and quercetin.	Quercetin	144-153	cyclin dependent kinase 2	Homo sapiens	77-81	
32787531-5	2021	From the experiment, Epigallocatechin gallate was found to be the best ligand to inhibit CDK-2, Daidzein showed the best inhibitory activities towards the Human topoisomerase IIalpha, and Quercetin was predicted to be the best agent against VEGFR-2.	Quercetin	188-197	cyclin dependent kinase 2	Homo sapiens	89-94	
15689157-8	2005	However, CDK2 and HCK kinase in complex with other flavone inhibitors such as quercetin and flavopiridol showed a different binding mode with the inhibitor rotated by about 180 degrees.	Quercetin	78-87	cyclin dependent kinase 2	Homo sapiens	9-13	
25293876-6	2014	Quercetin treatment resulted in an increased cell arrest in G1 phase of the cell cycle, with pronounced decrease in CDK2, CDK6, cyclin D, cyclin E, and cyclin A proteins, decreased Rb phosphorylation and increased p21 and p27 expression.	Quercetin	0-9	cyclin dependent kinase 2	Homo sapiens	116-120	
20803121-8	2010	Quercetin caused S phase arrest by decreasing the protein expression of CDK2, cyclins A and B while increasing the p53 and p57 proteins.	Quercetin	0-9	cyclin dependent kinase 2	Homo sapiens	72-76	
28251795-4	2017	Quercetin-induced G0 /G1 -phase arrest occurred when expressions of cyclin-dependent kinase (CDK)2/4 were inhibited and the CDK inhibitors, p16 and p21, were induced.	Quercetin	0-9	cyclin dependent kinase 2	Homo sapiens	93-98	
24760952-5	2014	Quercetin-induced cell apoptosis was shown to involve p53 and p21 up-regulation, Cyclin D1, Cdk2, and Cdk7 down-regulation.	Quercetin	0-9	cyclin dependent kinase 2	Homo sapiens	92-96	
24760952-6	2014	These results suggested that the induction of G2/M arrest, apoptosis, and cell death by quercetin may associate with increased expression of p53 and p21, decrease of Cyclin D1, Cdk2, and Cdk7 levels, and generation of reactive oxygen species in cells.	Quercetin	88-97	cyclin dependent kinase 2	Homo sapiens	177-181	
22431435-8	2014	Western blotting analysis indicated that quercetin induces the G0/G1 phase arrest via decreasing the levels of CDK2, cyclins E, and D proteins.	Quercetin	41-50	cyclin dependent kinase 2	Homo sapiens	111-115	
34942456-12	2022	CONCLUSIONS: In summary, combined network pharmacology and biological experiments proved that the main ingredients of ZJC such as quercetin, (R)-Canadine, palmatine, rutaecarpine, evodiamine, beta-sitosterol and berberine can target CDKN1A, Bcl2, E2F1, PRKCB, MYC, CDK2 and MMP9 to combat colorectal cancer.	Quercetin	130-139	cyclin dependent kinase 2	Homo sapiens	265-269