PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34529966-0 2021 Quercetin reverses chronic unpredictable mild stress-induced depression-like behavior in vivo by involving nuclear factor-E2-related factor 2. Quercetin 0-9 nuclear factor, erythroid derived 2, like 2 Mus musculus 107-141 34529966-9 2021 Collectively, the present study confirmed for the first time that quercetin weakened CUMS-induced depression in vivo, and its mechanism was at least partially attributable to the upregulation of hippocampal Nrf2 and the inhibition of iNOS, thereby correcting the central inflammatory response, and the imbalance between oxidation and antioxidant. Quercetin 66-75 nuclear factor, erythroid derived 2, like 2 Mus musculus 207-211 34408403-10 2021 Results: Quercetin at 5 muM strongly activated NF-E2-related factor 2 (NRF2) signaling, alleviated oxidative damage and enhanced the antioxidant capacity of hPDLCs. Quercetin 9-18 nuclear factor, erythroid derived 2, like 2 Mus musculus 47-69 34408403-10 2021 Results: Quercetin at 5 muM strongly activated NF-E2-related factor 2 (NRF2) signaling, alleviated oxidative damage and enhanced the antioxidant capacity of hPDLCs. Quercetin 9-18 nuclear factor, erythroid derived 2, like 2 Mus musculus 71-75 34408403-12 2021 Finally, quercetin activated NRF2 signaling in the periodontal ligaments, reduced the OS level of mice with periodontitis, and slowed the absorption of alveolar bone in vivo. Quercetin 9-18 nuclear factor, erythroid derived 2, like 2 Mus musculus 29-33 34408403-13 2021 Conclusion: Quercetin can increase the antioxidant capacity of PDLCs and reduce OS damage by activating the NRF2 signaling pathway, which alleviates alveolar bone loss in periodontitis. Quercetin 12-21 nuclear factor, erythroid derived 2, like 2 Mus musculus 108-112 34356358-7 2021 Our findings indicated that the effects of quercetin on regulating the generation of mtROS were dependent on increased levels of deacetyl-SOD2 through the Nrf2-PGC-1alpha-Sirt1 signaling pathway. Quercetin 43-52 nuclear factor, erythroid derived 2, like 2 Mus musculus 155-159 34356358-0 2021 Quercetin Alleviates the Accumulation of Superoxide in Sodium Iodate-Induced Retinal Autophagy by Regulating Mitochondrial Reactive Oxygen Species Homeostasis through Enhanced Deacetyl-SOD2 via the Nrf2-PGC-1alpha-Sirt1 Pathway. Quercetin 0-9 nuclear factor, erythroid derived 2, like 2 Mus musculus 198-202 33918248-0 2021 Synergistic Protection by Isoquercitrin and Quercetin against Glutamate-Induced Oxidative Cell Death in HT22 Cells via Activating Nrf2 and HO-1 Signaling Pathway: Neuroprotective Principles and Mechanisms of Dendropanax morbifera Leaves. Quercetin 44-53 nuclear factor, erythroid derived 2, like 2 Mus musculus 130-134 34214359-3 2021 Quercetin, known as an antioxidant, binds free radicals and modulates endogenous antioxidants through Nrf2 activations is expected as a potential agent to reduce the risk of nicotine dependence. Quercetin 0-9 nuclear factor, erythroid derived 2, like 2 Mus musculus 102-106 33918248-8 2021 These findings suggest that isoquercitrin and quercetin are the active principles representing the protective effects of DMLE, and these effects were mediated by the Nrf2/HO-1 pathway. Quercetin 46-55 nuclear factor, erythroid derived 2, like 2 Mus musculus 166-170 33530513-0 2021 Quercetin Alleviates Oxidative Damage by Activating Nuclear Factor Erythroid 2-Related Factor 2 Signaling in Porcine Enterocytes. Quercetin 0-9 nuclear factor, erythroid derived 2, like 2 Mus musculus 52-95 32920133-13 2021 We found that Nrf2 promotes a cell antioxidant response and is a key common target in the response to treatment with isoliquiritigenin (ISL), pterostilbene (PTE) and quercetin (QUE), the highly absorbed active ingredients in the formula. Quercetin 166-175 nuclear factor, erythroid derived 2, like 2 Mus musculus 14-18 32920133-13 2021 We found that Nrf2 promotes a cell antioxidant response and is a key common target in the response to treatment with isoliquiritigenin (ISL), pterostilbene (PTE) and quercetin (QUE), the highly absorbed active ingredients in the formula. Quercetin 177-180 nuclear factor, erythroid derived 2, like 2 Mus musculus 14-18 33530513-5 2021 Further study indicated that the protective effect of quercetin was associated with elevated protein abundance of nuclear factor erythroid 2-related factor 2 (Nrf2) and increased intracellular glutathione (GSH) content. Quercetin 54-63 nuclear factor, erythroid derived 2, like 2 Mus musculus 114-157 33530513-5 2021 Further study indicated that the protective effect of quercetin was associated with elevated protein abundance of nuclear factor erythroid 2-related factor 2 (Nrf2) and increased intracellular glutathione (GSH) content. Quercetin 54-63 nuclear factor, erythroid derived 2, like 2 Mus musculus 159-163 33530513-6 2021 Interestingly, the beneficial effects of quercetin on diquat-induced oxidative damage were abolished by all-trans-retinoic acid (Atra), a specific inhibitor of Nrf2, indicating a Nrf2-dependent regulation manner. Quercetin 41-50 nuclear factor, erythroid derived 2, like 2 Mus musculus 160-164 33530513-6 2021 Interestingly, the beneficial effects of quercetin on diquat-induced oxidative damage were abolished by all-trans-retinoic acid (Atra), a specific inhibitor of Nrf2, indicating a Nrf2-dependent regulation manner. Quercetin 41-50 nuclear factor, erythroid derived 2, like 2 Mus musculus 179-183 33530513-7 2021 The results show that quercetin attenuates diquat-induced cell injury by promoting protein abundance of Nrf2 and regulating GSH-related redox homeostasis in enterocytes. Quercetin 22-31 nuclear factor, erythroid derived 2, like 2 Mus musculus 104-108 32456069-8 2020 As rutin (quercetin-3-O-rutinose) was abundantly present in EAE and free quercetin was able to induce defensive antioxidant enzymes in an Nrf2-dependent manner, our findings suggested that quercetin derived from rutin via the intestinal microflora played a significant role in the protection of the mouse hippocampus from scopolamine-induced damage through BDNF-mediated Nrf2 activation, thereby dampening cognitive decline. Quercetin 73-82 nuclear factor, erythroid derived 2, like 2 Mus musculus 138-142 33490128-8 2020 Furthermore, quercetin supplementation markedly activated the expression of Nrf2 and HO-1 mRNAs, but inhibited the expression of NF-kappaB, IL-1beta, IL-6, and TNF-alpha mRNAs. Quercetin 13-22 nuclear factor, erythroid derived 2, like 2 Mus musculus 76-80 33490128-9 2020 In conclusion, our results revealed that quercetin supplementation could inhibit CuSO4-induced nephrotoxicity in mice via the inhibition of mitochondrial apoptotic and NF-kappaB pathways and the activation of Nrf2/HO-1 pathway. Quercetin 41-50 nuclear factor, erythroid derived 2, like 2 Mus musculus 209-213 32142880-5 2020 In this study, we investigated the cytotoxicity and prooxidant profile of synthetic conjugate of two electrophilic compounds, quercetin and 1,4-naphthoquinone, 4"-O-(2-chloro-1,4-naphthoquinone-3-yloxy) quercetin (CHNQ), and its attenuation of inflammatory responses and modulation of Nrf2 pathway in BV-2 microglial cells. Quercetin 126-135 nuclear factor, erythroid derived 2, like 2 Mus musculus 285-289 32456069-8 2020 As rutin (quercetin-3-O-rutinose) was abundantly present in EAE and free quercetin was able to induce defensive antioxidant enzymes in an Nrf2-dependent manner, our findings suggested that quercetin derived from rutin via the intestinal microflora played a significant role in the protection of the mouse hippocampus from scopolamine-induced damage through BDNF-mediated Nrf2 activation, thereby dampening cognitive decline. Quercetin 73-82 nuclear factor, erythroid derived 2, like 2 Mus musculus 371-375 32349726-12 2020 CONCLUSION: Quercetin exerts anti-fibrogenic and anti-inflammatory effects on bleomycin-induced pulmonary damage in mice possibly through modulation of the redox balance by inducing Nrf2. Quercetin 12-21 nuclear factor, erythroid derived 2, like 2 Mus musculus 182-186 32454852-6 2020 HPLC analysis revealed AVEE contained quercetin, a possible activator of the Nrf2/HO-1 pathway. Quercetin 38-47 nuclear factor, erythroid derived 2, like 2 Mus musculus 77-81 32349726-4 2020 Quercetin is a dietary antioxidant with strong redox modulating capacities that is suggested to exert part of its antioxidative effects via activation of the redox-sensitive transcription factor Nrf2 that regulates endogenous antioxidant levels. Quercetin 0-9 nuclear factor, erythroid derived 2, like 2 Mus musculus 195-199 32349726-5 2020 Therefore, the aim of the present study was to investigate if the dietary antioxidant quercetin can exert anti-fibrotic effects in a mouse model of bleomycin-induced pulmonary fibrogenesis through Nrf2-dependent restoration of redox imbalance. Quercetin 86-95 nuclear factor, erythroid derived 2, like 2 Mus musculus 197-201 31114202-0 2019 Gold-quercetin nanoparticles prevent metabolic endotoxemia-induced kidney injury by regulating TLR4/NF-kappaB signaling and Nrf2 pathway in high fat diet fed mice [Retraction]. Quercetin 5-14 nuclear factor, erythroid derived 2, like 2 Mus musculus 124-128 31863770-5 2020 LF, CR, Que and Ex significantly ameliorated HF-induced hepatic steatosis to varying degrees, inhibited T4 production via differentially elevating miR-339, miR-383 and miR-146b to decrease NIS expression and regulating miR-200a/Nrf2 to maintain redox status in the thyroid. Quercetin 8-11 nuclear factor, erythroid derived 2, like 2 Mus musculus 228-232 31781321-0 2019 A Solid Dispersion of Quercetin Shows Enhanced Nrf2 Activation and Protective Effects against Oxidative Injury in a Mouse Model of Dry Age-Related Macular Degeneration. Quercetin 22-31 nuclear factor, erythroid derived 2, like 2 Mus musculus 47-51 31251921-7 2019 The induction of HO-1 by quercetin was associated with the nuclear accumulation of Nrf2 and downregulation of Keap1, a negative regulator of Nrf2. Quercetin 25-34 nuclear factor, erythroid derived 2, like 2 Mus musculus 83-87 31251921-7 2019 The induction of HO-1 by quercetin was associated with the nuclear accumulation of Nrf2 and downregulation of Keap1, a negative regulator of Nrf2. Quercetin 25-34 nuclear factor, erythroid derived 2, like 2 Mus musculus 141-145 30795510-3 2019 DHA and quercetin can individually suppress lipopolysaccharide (LPS)-induced oxidative/inflammatory responses and enhance the antioxidative stress pathway involving nuclear factor erythroid-2 related factor 2 (Nrf2). Quercetin 8-17 nuclear factor, erythroid derived 2, like 2 Mus musculus 165-208 30795510-3 2019 DHA and quercetin can individually suppress lipopolysaccharide (LPS)-induced oxidative/inflammatory responses and enhance the antioxidative stress pathway involving nuclear factor erythroid-2 related factor 2 (Nrf2). Quercetin 8-17 nuclear factor, erythroid derived 2, like 2 Mus musculus 210-214 30795510-6 2019 Results showed that low concentrations of quercetin (2.5 microM), in combination with DHA (10 microM), could more effectively enhance the expression of Nrf2 and heme oxygenase 1 (HO-1), and suppress LPS-induced nitric oxide, tumor necrosis factor-alpha, phospho-cytosolic phospholipase A2, reactive oxygen species, and 4-hydroxynonenal, as compared to the same levels of DHA or quercetin alone. Quercetin 42-51 nuclear factor, erythroid derived 2, like 2 Mus musculus 152-156 29921882-9 2019 In addition, the quercetin-provided protection against TSN-induced hepatotoxicity was diminished in Nrf2 knock-out mice. Quercetin 17-26 nuclear factor, erythroid derived 2, like 2 Mus musculus 100-104 28115850-0 2017 Gold-quercetin nanoparticles prevent metabolic endotoxemia-induced kidney injury by regulating TLR4/NF-kappaB signaling and Nrf2 pathway in high fat diet fed mice. Quercetin 5-14 nuclear factor, erythroid derived 2, like 2 Mus musculus 124-128 29554596-7 2018 These molecular effects of quercetin were related to the inhibition of the nuclear factor kappa-B and induction of Nuclear factor erythroid 2- related factor (Nrf2)/home oxygenase (HO-1) pathway. Quercetin 27-36 nuclear factor, erythroid derived 2, like 2 Mus musculus 159-163 29569982-4 2018 In this study, we observed that quercetin suppressed expression of TNFalpha-induced atrophic factors such as MAFbx/atrogin-1 and MuRF1 in myotubes, and it enhanced heme oxygenase-1 (HO-1) protein level accompanied by increased nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) in myotubes. Quercetin 32-41 nuclear factor, erythroid derived 2, like 2 Mus musculus 252-295 29569982-4 2018 In this study, we observed that quercetin suppressed expression of TNFalpha-induced atrophic factors such as MAFbx/atrogin-1 and MuRF1 in myotubes, and it enhanced heme oxygenase-1 (HO-1) protein level accompanied by increased nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) in myotubes. Quercetin 32-41 nuclear factor, erythroid derived 2, like 2 Mus musculus 297-301 29569982-6 2018 Moreover, quercetin supplementation to high-fat diet-fed obese mice inhibited obesity-induced atrophic responses in skeletal muscle, accompanied by upregulation of HO-1 and inactivation of nuclear factor-kappa B (NF-kappaB), and the quercetin actions were attenuated in Nrf2-deficient mice. Quercetin 10-19 nuclear factor, erythroid derived 2, like 2 Mus musculus 270-274 29569982-7 2018 These findings suggest that quercetin protects against TNFalpha-induced muscle atrophy under obese conditions through Nrf2-mediated HO-1 induction accompanied by inactivation of NF-kappaB. Quercetin 28-37 nuclear factor, erythroid derived 2, like 2 Mus musculus 118-122 28277184-9 2018 Moreover, quercetin activated nuclear factorerythroid-2-related factor-2 (Nrf2)-mediated phase II enzymes and decreased reactive oxygen species and protein carbonylation. Quercetin 10-19 nuclear factor, erythroid derived 2, like 2 Mus musculus 30-72 28277184-9 2018 Moreover, quercetin activated nuclear factorerythroid-2-related factor-2 (Nrf2)-mediated phase II enzymes and decreased reactive oxygen species and protein carbonylation. Quercetin 10-19 nuclear factor, erythroid derived 2, like 2 Mus musculus 74-78 28277184-11 2018 Taken together, these findings suggest that a reduction in mitochondrial dysfunction through the increase of AMPK activity, coupled with an increase in Nrf2 pathway mediated oxidative defence, may be one of the mechanisms by which quercetin improves cognitive impairment induced by DA in mice. Quercetin 231-240 nuclear factor, erythroid derived 2, like 2 Mus musculus 152-156 29197723-10 2018 The protective analgesic and anti-inflammatory mechanisms of quercetin included the inhibition of TiO2-induced neutrophil and macrophage recruitment, proteoglycan degradation, oxidative stress, cytokine production (TNF-alpha, IL-1beta, IL-6, and IL-10), COX-2 mRNA expression, and bone resorption as well as activation of Nrf2/HO-1 signaling pathway. Quercetin 61-70 nuclear factor, erythroid derived 2, like 2 Mus musculus 322-326 28757412-0 2017 Quercetin ameliorates learning and memory via the Nrf2-ARE signaling pathway in d-galactose-induced neurotoxicity in mice. Quercetin 0-9 nuclear factor, erythroid derived 2, like 2 Mus musculus 50-54 28757412-6 2017 Quercetin also prevented changes in the neuronal cell morphology and apoptosis in the hippocampus as well as increased the expression of Nrf2, HO-1 and SOD in d-galactose-treated mice. Quercetin 0-9 nuclear factor, erythroid derived 2, like 2 Mus musculus 137-141 28757412-7 2017 Treatment with the Nrf2 inhibitor Brusatol reversed the effects of quercetin on HO-1 and SOD expression as well as neuronal cell protection. Quercetin 67-76 nuclear factor, erythroid derived 2, like 2 Mus musculus 19-23 28757412-8 2017 In conclusion, quercetin protected mice from d-galactose-induced cognitive functional impairment and neuronal cell apoptosis via activation of the Nrf2-ARE signaling pathway. Quercetin 15-24 nuclear factor, erythroid derived 2, like 2 Mus musculus 147-151 28274305-0 2017 [Protective effect of quercetin against immunological liver injury through activating Nrf2/ARE signaling pathway]. Quercetin 22-31 nuclear factor, erythroid derived 2, like 2 Mus musculus 86-90 28274305-10 2017 Results Compared with the model group, the serum activities of ALT and AST as well as MDA content remarkably decreased by the administration of quercetin (80 mg/kg), while GSH, SOD contents were elevated in liver tissues; pathologic changes of the liver was ameliorated evidently by quercetin; Nrf2 protein expression in the nucleus as well as mRNA expressions of HO-1, NQO1, GCLC increased. Quercetin 144-153 nuclear factor, erythroid derived 2, like 2 Mus musculus 294-298 28274305-12 2017 Conclusion High-dose quercetin can inhibit immunological liver injury induced by triptolide, and the mechanism may be associated with the activation of Nrf2/ARE signaling pathway. Quercetin 21-30 nuclear factor, erythroid derived 2, like 2 Mus musculus 152-156 26931552-0 2016 3,4-Dihydroxyphenylacetic acid, a microbiota-derived metabolite of quercetin, attenuates acetaminophen (APAP)-induced liver injury through activation of Nrf-2. Quercetin 67-76 nuclear factor, erythroid derived 2, like 2 Mus musculus 153-158 27777014-1 2016 The natural flavonoid quercetin is known to activate the transcription factor Nrf2, which regulates the expression of cytoprotective enzymes such as heme oxygenase-1 (HO-1) and NAD(P)H:quinone oxidoreductase 1 (NQO1). Quercetin 22-31 nuclear factor, erythroid derived 2, like 2 Mus musculus 78-82 27777014-2 2016 In this study, a novel semisynthetic flavonoid 7-O-galloylquercetin (or quercetin-7-gallate, 3) was prepared by direct galloylation of quercetin, and its effect on the Nrf2 pathway was examined. Quercetin 58-67 nuclear factor, erythroid derived 2, like 2 Mus musculus 168-172 27909560-10 2016 Moreover, these effects of quercetin were blunted by an HO-1 inhibitor and deficiency of nuclear factor E2-related factor 2 (Nrf2) in macrophages. Quercetin 27-36 nuclear factor, erythroid derived 2, like 2 Mus musculus 125-129 27909560-12 2016 The beneficial effect of quercetin is associated with Nrf2-mediated HO-1 induction. Quercetin 25-34 nuclear factor, erythroid derived 2, like 2 Mus musculus 54-58 27780244-0 2016 Protective Effects of Quercetin on Mitochondrial Biogenesis in Experimental Traumatic Brain Injury via the Nrf2 Signaling Pathway. Quercetin 22-31 nuclear factor, erythroid derived 2, like 2 Mus musculus 107-111 27780244-1 2016 The present investigation was carried out to elucidate a possible molecular mechanism related to the protective effect of quercetin administration against oxidative stress on various mitochondrial respiratory complex subunits with special emphasis on the role of nuclear factor erythroid 2-related factor 2 (Nrf2) in mitochondrial biogenesis. Quercetin 122-131 nuclear factor, erythroid derived 2, like 2 Mus musculus 263-306 27780244-1 2016 The present investigation was carried out to elucidate a possible molecular mechanism related to the protective effect of quercetin administration against oxidative stress on various mitochondrial respiratory complex subunits with special emphasis on the role of nuclear factor erythroid 2-related factor 2 (Nrf2) in mitochondrial biogenesis. Quercetin 122-131 nuclear factor, erythroid derived 2, like 2 Mus musculus 308-312 27780244-7 2016 Quercetin treatment resulted in an upregulation of Nrf2 expression and cytochrome c, malondialdehyde (MDA) and superoxide dismutase (SOD) levels were restored by quercetin treatment. Quercetin 0-9 nuclear factor, erythroid derived 2, like 2 Mus musculus 51-55 27780244-7 2016 Quercetin treatment resulted in an upregulation of Nrf2 expression and cytochrome c, malondialdehyde (MDA) and superoxide dismutase (SOD) levels were restored by quercetin treatment. Quercetin 162-171 nuclear factor, erythroid derived 2, like 2 Mus musculus 51-55 27780244-8 2016 Quercetin markedly promoted the translocation of Nrf2 protein from the cytoplasm to the nucleus. Quercetin 0-9 nuclear factor, erythroid derived 2, like 2 Mus musculus 49-53 27780244-9 2016 These observations suggest that quercetin improves mitochondrial function in TBI models, possibly by activating the Nrf2 pathway. Quercetin 32-41 nuclear factor, erythroid derived 2, like 2 Mus musculus 116-120 26505893-0 2015 Quercetin Attenuates Inflammatory Responses in BV-2 Microglial Cells: Role of MAPKs on the Nrf2 Pathway and Induction of Heme Oxygenase-1. Quercetin 0-9 nuclear factor, erythroid derived 2, like 2 Mus musculus 91-95 27583449-4 2016 Quercetin inhibited myeloperoxidase (MPO) and N-acetyl-beta-D- glucosaminidase (NAG) activities, cytokine production, oxidative stress, cyclooxygenase-2 (COX-2) and gp91phox mRNA expression and muscle injury (creatinine kinase [CK] blood levels and myoblast determination protein [MyoD] mRNA expression) as well as inhibited NFkappaB activation and induced Nrf2 and HO-1 mRNA expression in the soleus muscle. Quercetin 0-9 nuclear factor, erythroid derived 2, like 2 Mus musculus 357-361 26505893-4 2015 Quercetin was 10 folds more potent than cyanidin in inhibition of lipopolysaccharide (LPS)-induced NO production as well as stimulation of Nrf2-induced heme-oxygenase-1 (HO-1) protein expression. Quercetin 0-9 nuclear factor, erythroid derived 2, like 2 Mus musculus 139-143 26505893-6 2015 In an attempt to unveil mechanism(s) for quercetin to enhance Nrf2/HO-1 activity under endotoxic stress, results pointed to an increase in phospho-p38MAPK expression upon addition of quercetin to LPS. Quercetin 41-50 nuclear factor, erythroid derived 2, like 2 Mus musculus 62-66 26505893-6 2015 In an attempt to unveil mechanism(s) for quercetin to enhance Nrf2/HO-1 activity under endotoxic stress, results pointed to an increase in phospho-p38MAPK expression upon addition of quercetin to LPS. Quercetin 183-192 nuclear factor, erythroid derived 2, like 2 Mus musculus 62-66 26445592-7 2015 RESULTS: Quercetin upregulated genes involved in mitochondrial biogenesis and oxidative metabolism in lipid-laden hepatocytes and the livers of HFD-fed obese mice, and this was accompanied by increased levels of the transcription factor, nuclear erythroid 2-related factor 2 (Nrf-2), and HO-1 protein. Quercetin 9-18 nuclear factor, erythroid derived 2, like 2 Mus musculus 238-274 26445592-9 2015 Moreover, the metabolic changes and the lipid-lowering effects of quercetin were completely blocked by the HO-1 inhibitor ZnPP and by deficiency of Nrf-2. Quercetin 66-75 nuclear factor, erythroid derived 2, like 2 Mus musculus 148-153 26445592-10 2015 CONCLUSION: These findings suggest that quercetin stimulates hepatic mitochondrial oxidative metabolism by inducing HO-1 via the Nrf-2 pathway. Quercetin 40-49 nuclear factor, erythroid derived 2, like 2 Mus musculus 129-134 26445592-7 2015 RESULTS: Quercetin upregulated genes involved in mitochondrial biogenesis and oxidative metabolism in lipid-laden hepatocytes and the livers of HFD-fed obese mice, and this was accompanied by increased levels of the transcription factor, nuclear erythroid 2-related factor 2 (Nrf-2), and HO-1 protein. Quercetin 9-18 nuclear factor, erythroid derived 2, like 2 Mus musculus 276-281 25957741-0 2015 Quercetin protects mouse liver against nickel-induced DNA methylation and inflammation associated with the Nrf2/HO-1 and p38/STAT1/NF-kappaB pathway. Quercetin 0-9 nuclear factor, erythroid derived 2, like 2 Mus musculus 107-111 25957741-6 2015 In exploring the underlying mechanisms of quercetin action, we found that quercetin decreased total DNA methyltransferases (DNMTs) activity and DNA methylation level of the NF-E2 related factor 2 (Nrf2) DNA in livers of nickel-treated mice. Quercetin 42-51 nuclear factor, erythroid derived 2, like 2 Mus musculus 173-195 25957741-6 2015 In exploring the underlying mechanisms of quercetin action, we found that quercetin decreased total DNA methyltransferases (DNMTs) activity and DNA methylation level of the NF-E2 related factor 2 (Nrf2) DNA in livers of nickel-treated mice. Quercetin 42-51 nuclear factor, erythroid derived 2, like 2 Mus musculus 197-201 25957741-6 2015 In exploring the underlying mechanisms of quercetin action, we found that quercetin decreased total DNA methyltransferases (DNMTs) activity and DNA methylation level of the NF-E2 related factor 2 (Nrf2) DNA in livers of nickel-treated mice. Quercetin 74-83 nuclear factor, erythroid derived 2, like 2 Mus musculus 173-195 25957741-6 2015 In exploring the underlying mechanisms of quercetin action, we found that quercetin decreased total DNA methyltransferases (DNMTs) activity and DNA methylation level of the NF-E2 related factor 2 (Nrf2) DNA in livers of nickel-treated mice. Quercetin 74-83 nuclear factor, erythroid derived 2, like 2 Mus musculus 197-201 25957741-7 2015 Quercetin also induced Nrf2 nuclear translocation and heme oxygenase-1 (HO-1) activity. Quercetin 0-9 nuclear factor, erythroid derived 2, like 2 Mus musculus 23-27 25957741-10 2015 In conclusion, these results suggested that the inhibition of nickel-induced inflammation by quercetin is associated with its ability to modulate Nrf2/HO-1 and p38/STAT1/NF-kappaB signaling pathway. Quercetin 93-102 nuclear factor, erythroid derived 2, like 2 Mus musculus 146-150 24559113-2 2014 Dietary components such as sulforaphane in broccoli and quercetin in onions have been shown to be inducers of Nrf2. Quercetin 56-65 nuclear factor, erythroid derived 2, like 2 Mus musculus 110-114 25739980-9 2015 Furthermore, quercetin treatment downregulated cytoplasmic HMGB1, RAGE, nuclear p-NFkappaB, p-ERK1/2, COX2, TNFalpha, IL-1beta, IL-2Ralpha, IFNgamma and IL-4 and upregulated nuclear Nrf2. Quercetin 13-22 nuclear factor, erythroid derived 2, like 2 Mus musculus 182-186 25739980-10 2015 Our data demonstrated that the HMGB1/RAGE/NFkappaB signalling might play an important role in skin inflammation, and quercetin treatment could be a promising agent for AD by modulating the HMGB1/RAGE/NFkappaB signalling and induction of Nrf2 protein. Quercetin 117-126 nuclear factor, erythroid derived 2, like 2 Mus musculus 237-241 26329008-6 2015 In AMJ2-C11 cells, quercetin also attenuated the TLR7-induced CD40 expression; attenuated the translocation of p65; induced translocation of Nrf2 from cytosol to nucleus; and induced heme oxygenase (HO)-1 expression. Quercetin 19-28 nuclear factor, erythroid derived 2, like 2 Mus musculus 141-145 23295412-3 2013 Maternal intake of quercetin increased the expression of Nrf2 and Sod2 in fetal liver at gestational day 14.5. Quercetin 19-28 nuclear factor, erythroid derived 2, like 2 Mus musculus 57-61 24076371-0 2013 Quercetin inhibits lipopolysaccharide-induced nitric oxide production in BV2 microglial cells by suppressing the NF-kappaB pathway and activating the Nrf2-dependent HO-1 pathway. Quercetin 0-9 nuclear factor, erythroid derived 2, like 2 Mus musculus 150-154 24076371-9 2013 Additionally, quercetin induced the specific DNA-binding activity of nuclear factor-2-erythroid 2-related factor 2 (Nrf2), and siRNA-mediated knockdown of Nrf2 expression reduced the inhibitory effect of quercetin on LPS-stimulated NO production by inhibiting HO-1 expression, indicating that quercetin regulated NO production by inducing Nrf2-mediated HO-1 expression. Quercetin 14-23 nuclear factor, erythroid derived 2, like 2 Mus musculus 116-120 24076371-9 2013 Additionally, quercetin induced the specific DNA-binding activity of nuclear factor-2-erythroid 2-related factor 2 (Nrf2), and siRNA-mediated knockdown of Nrf2 expression reduced the inhibitory effect of quercetin on LPS-stimulated NO production by inhibiting HO-1 expression, indicating that quercetin regulated NO production by inducing Nrf2-mediated HO-1 expression. Quercetin 204-213 nuclear factor, erythroid derived 2, like 2 Mus musculus 116-120 24076371-9 2013 Additionally, quercetin induced the specific DNA-binding activity of nuclear factor-2-erythroid 2-related factor 2 (Nrf2), and siRNA-mediated knockdown of Nrf2 expression reduced the inhibitory effect of quercetin on LPS-stimulated NO production by inhibiting HO-1 expression, indicating that quercetin regulated NO production by inducing Nrf2-mediated HO-1 expression. Quercetin 204-213 nuclear factor, erythroid derived 2, like 2 Mus musculus 155-159 24076371-9 2013 Additionally, quercetin induced the specific DNA-binding activity of nuclear factor-2-erythroid 2-related factor 2 (Nrf2), and siRNA-mediated knockdown of Nrf2 expression reduced the inhibitory effect of quercetin on LPS-stimulated NO production by inhibiting HO-1 expression, indicating that quercetin regulated NO production by inducing Nrf2-mediated HO-1 expression. Quercetin 204-213 nuclear factor, erythroid derived 2, like 2 Mus musculus 155-159 24076371-9 2013 Additionally, quercetin induced the specific DNA-binding activity of nuclear factor-2-erythroid 2-related factor 2 (Nrf2), and siRNA-mediated knockdown of Nrf2 expression reduced the inhibitory effect of quercetin on LPS-stimulated NO production by inhibiting HO-1 expression, indicating that quercetin regulated NO production by inducing Nrf2-mediated HO-1 expression. Quercetin 204-213 nuclear factor, erythroid derived 2, like 2 Mus musculus 116-120 24076371-9 2013 Additionally, quercetin induced the specific DNA-binding activity of nuclear factor-2-erythroid 2-related factor 2 (Nrf2), and siRNA-mediated knockdown of Nrf2 expression reduced the inhibitory effect of quercetin on LPS-stimulated NO production by inhibiting HO-1 expression, indicating that quercetin regulated NO production by inducing Nrf2-mediated HO-1 expression. Quercetin 204-213 nuclear factor, erythroid derived 2, like 2 Mus musculus 155-159 24076371-9 2013 Additionally, quercetin induced the specific DNA-binding activity of nuclear factor-2-erythroid 2-related factor 2 (Nrf2), and siRNA-mediated knockdown of Nrf2 expression reduced the inhibitory effect of quercetin on LPS-stimulated NO production by inhibiting HO-1 expression, indicating that quercetin regulated NO production by inducing Nrf2-mediated HO-1 expression. Quercetin 204-213 nuclear factor, erythroid derived 2, like 2 Mus musculus 155-159 24076371-10 2013 Therefore, quercetin has the potential to decrease nitrosative stress by suppressing NF-kappaB activation and inducing Nrf2-mediated HO-1 expression. Quercetin 11-20 nuclear factor, erythroid derived 2, like 2 Mus musculus 119-123 23294286-1 2013 Quercetin and gallic acid are natural activators of the transcription factor Nrf2, which regulates the expression of many cytoprotective enzymes including heme oxygenase-1 (HO-1). Quercetin 0-9 nuclear factor, erythroid derived 2, like 2 Mus musculus 77-81 21216973-9 2011 Furthermore, the translocation of the nuclear factor E2-related factor-2 (Nrf2), an important transcription factor that regulates the expression of HO-1 from the cytoplasm to the nuclei, was demonstrated in NIH3T3 cells by exposure to quercetin. Quercetin 235-244 nuclear factor, erythroid derived 2, like 2 Mus musculus 74-78 20579867-5 2011 Anti-inflammatory properties of quercetin and isorhamnetin were accompanied by an increase in heme oxygenase 1 protein levels, a downstream target of the transcription factor Nrf2, known to antagonize chronic inflammation. Quercetin 32-41 nuclear factor, erythroid derived 2, like 2 Mus musculus 175-179