PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34040433-14 2021 Quercetin alleviates neuralgia in CCI rats by activating AMPK pathway and inhibiting MAPK pathway and its downstream targets, p-38, p-ERK, and p-JNK. Quercetin 0-9 mitogen-activated protein kinase 8 Rattus norvegicus 145-148 34708631-6 2021 CONCLUSION: Under the condition of high glucose, the quercetin, oleanolic acid and icariin can alleviate the apoptosis of hippocampus neurons, reduce the phosphorylation of p38 and JNK in p38 mitogen-activated protein kinases and JNK signaling pathway. Quercetin 53-62 mitogen-activated protein kinase 8 Rattus norvegicus 181-184 34708631-6 2021 CONCLUSION: Under the condition of high glucose, the quercetin, oleanolic acid and icariin can alleviate the apoptosis of hippocampus neurons, reduce the phosphorylation of p38 and JNK in p38 mitogen-activated protein kinases and JNK signaling pathway. Quercetin 53-62 mitogen-activated protein kinase 8 Rattus norvegicus 230-233 33276066-0 2021 Pretreatment of IEC-6 cells with quercetin and myricetin resists the indomethacin-induced barrier dysfunction via attenuating the calcium-mediated JNK/Src activation. Quercetin 33-42 mitogen-activated protein kinase 8 Rattus norvegicus 147-150 27665434-10 2016 In addition to NF-kappaB signaling pathway, inflammation induced by oxLDL was also related to the activation of p38MAPK, ERK1/2 and JNK, and Akt pathways, and the protective effect of quercetin may be also related to the inhibition of activation of these pathways. Quercetin 184-193 mitogen-activated protein kinase 8 Rattus norvegicus 132-135 30076503-7 2018 Quercetin also inhibited TLR4 expression, NF-kappaB p65, ERK, JNK and STAT phosphorylation and decreased IkappaB-alpha degradation. Quercetin 0-9 mitogen-activated protein kinase 8 Rattus norvegicus 62-65 30076503-9 2018 CONCLUSIONS: These results indicate that quercetin may have an anti-inflammatory effect by inhibiting expression of ICAM-1 and VCAM-1 in RIMVECs by suppressing TLR4, NF-kappaB, ERK, JNK and STAT but not the p38 signaling pathway. Quercetin 41-50 mitogen-activated protein kinase 8 Rattus norvegicus 182-185 26680104-0 2016 Quercetin attenuates cardiomyocyte apoptosis via inhibition of JNK and p38 mitogen-activated protein kinase signaling pathways. Quercetin 0-9 mitogen-activated protein kinase 8 Rattus norvegicus 63-66 23679081-7 2013 The inhibition of HSP70 using quercetin resulted in an elevation of JNK activity by decreasing the cytoplasmic solubility of M3/6. Quercetin 30-39 mitogen-activated protein kinase 8 Rattus norvegicus 68-71 25203460-8 2015 Quercetin attenuated H2 O2 -induced activation of ERK1/2, PKB, p38 MAPK and JNK, but inhibitors of these kinases did not modulate quercetin-induced protection or H2 O2 -induced cell death. Quercetin 0-9 mitogen-activated protein kinase 8 Rattus norvegicus 76-79 24702479-5 2014 As quercetin may interfere with other stress-activated protein kinases (JNK and p38 MAPK), we further explored MAPK cross talks and their relationships with the mechanism of the protective effect of quercetin against oxidative stress. Quercetin 3-12 mitogen-activated protein kinase 8 Rattus norvegicus 72-75 26136938-8 2015 Furthermore, the mRNA expression levels of TGF-beta1, BMP-2 and CBFalpha1 decreased in the quercetin + SP600125 (inhibitor of JNK) and quercetin + PD98059 (inhibitor of ERK1/2) groups. Quercetin 91-100 mitogen-activated protein kinase 8 Rattus norvegicus 126-129 26136938-11 2015 Thus, activation of the ERK1/2 and JNK signaling pathways may play a leading role in the quercetin-promoted osteogenic proliferation and differentiation of MSCs. Quercetin 89-98 mitogen-activated protein kinase 8 Rattus norvegicus 35-38 20685402-4 2010 Pretreatment with four flavonoids, including quercetin, genistein, quercetagetin, and luteolin diminished LTA-induced ERK1/2, JNK, p38, and AKT phosphorylation and IL-1 beta gene expression. Quercetin 45-54 mitogen-activated protein kinase 8 Rattus norvegicus 126-129 23249147-0 2013 Protective effect of quercetin on lead-induced oxidative stress and endoplasmic reticulum stress in rat liver via the IRE1/JNK and PI3K/Akt pathway. Quercetin 21-30 mitogen-activated protein kinase 8 Rattus norvegicus 123-126 23249147-12 2013 In the examined unfolded protein response (UPR) pathways, quercetin markedly inhibited the Pb-induced increase of the phosphorylated inositol-requiring enzyme 1 (IRE1) and c-jun N-terminal kinase (JNK) in rat liver. Quercetin 58-67 mitogen-activated protein kinase 8 Rattus norvegicus 172-195 23249147-12 2013 In the examined unfolded protein response (UPR) pathways, quercetin markedly inhibited the Pb-induced increase of the phosphorylated inositol-requiring enzyme 1 (IRE1) and c-jun N-terminal kinase (JNK) in rat liver. Quercetin 58-67 mitogen-activated protein kinase 8 Rattus norvegicus 197-200 23249147-13 2013 Taken together, these results suggested that the inhibition of Pb-induced ER stress by quercetin is due at least in part to its anti-oxidant stress activity and its ability to modulate the PI3K/Akt and IRE1/JNK signaling pathway. Quercetin 87-96 mitogen-activated protein kinase 8 Rattus norvegicus 207-210 16776966-7 2006 AngII significantly activated ERK1/2, JNK and P38 expressions and only JNK activation could be inhibited by Que and DPI. Quercetin 108-111 mitogen-activated protein kinase 8 Rattus norvegicus 71-74 21179752-10 2007 CONCLUSION: EGb and Que could inhibit AngII-induced cardiomyocyte hypertrophy through a ROS-dependent pathway, the effect of Que might be related to the JNK and c-fos cascade. Quercetin 20-23 mitogen-activated protein kinase 8 Rattus norvegicus 153-156 16777073-0 2006 The flavonoid quercetin induces apoptosis and inhibits JNK activation in intimal vascular smooth muscle cells. Quercetin 14-23 mitogen-activated protein kinase 8 Rattus norvegicus 55-58 16777073-10 2006 Quercetin reduced JNK phosphorylation but had no consistent effect on ERK phosphorylation. Quercetin 0-9 mitogen-activated protein kinase 8 Rattus norvegicus 18-21 15288573-6 2004 Additionally, the phosphorylation of c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (p38MAPK) substantially increased in rat aortic smooth muscle cells exposed to 100 microM quercetin, results which differ from observations by others and ourselves of cells exposed to < or =50 microM quercetin. Quercetin 198-207 mitogen-activated protein kinase 8 Rattus norvegicus 37-60 15288573-6 2004 Additionally, the phosphorylation of c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (p38MAPK) substantially increased in rat aortic smooth muscle cells exposed to 100 microM quercetin, results which differ from observations by others and ourselves of cells exposed to < or =50 microM quercetin. Quercetin 198-207 mitogen-activated protein kinase 8 Rattus norvegicus 62-65 15288573-6 2004 Additionally, the phosphorylation of c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (p38MAPK) substantially increased in rat aortic smooth muscle cells exposed to 100 microM quercetin, results which differ from observations by others and ourselves of cells exposed to < or =50 microM quercetin. Quercetin 311-320 mitogen-activated protein kinase 8 Rattus norvegicus 37-60 15288573-6 2004 Additionally, the phosphorylation of c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (p38MAPK) substantially increased in rat aortic smooth muscle cells exposed to 100 microM quercetin, results which differ from observations by others and ourselves of cells exposed to < or =50 microM quercetin. Quercetin 311-320 mitogen-activated protein kinase 8 Rattus norvegicus 62-65 11562426-0 2001 Quercetin inhibits Shc- and phosphatidylinositol 3-kinase-mediated c-Jun N-terminal kinase activation by angiotensin II in cultured rat aortic smooth muscle cells. Quercetin 0-9 mitogen-activated protein kinase 8 Rattus norvegicus 67-90 12054679-1 2002 We previously reported that quercetin, a bioflavonoid belonging to polyphenols, inhibited Angiotensin II (Ang II)-induced vascular smooth muscle cell (VSMC) hypertrophy through the inhibition of c-Jun N-terminal kinase (JNK) activation. Quercetin 28-37 mitogen-activated protein kinase 8 Rattus norvegicus 195-218 12054679-1 2002 We previously reported that quercetin, a bioflavonoid belonging to polyphenols, inhibited Angiotensin II (Ang II)-induced vascular smooth muscle cell (VSMC) hypertrophy through the inhibition of c-Jun N-terminal kinase (JNK) activation. Quercetin 28-37 mitogen-activated protein kinase 8 Rattus norvegicus 220-223 12021531-9 2002 Quercetin treatment suppressed the JNK activity and ameliorated apoptosis induced by H2O2. Quercetin 0-9 mitogen-activated protein kinase 8 Rattus norvegicus 35-38 12021531-11 2002 Quercetin treatment could decrease JNK activity and ameliorate H2O2-induced apoptosis. Quercetin 0-9 mitogen-activated protein kinase 8 Rattus norvegicus 35-38 11562426-9 2001 Furthermore, LY294002, a PI3-K inhibitor and a quercetin derivative, inhibited Ang II-induced JNK activation as well as Akt phosphorylation. Quercetin 47-56 mitogen-activated protein kinase 8 Rattus norvegicus 94-97 11562426-11 2001 These findings suggest that the preventing effect of quercetin on Ang II-induced VSMC hypertrophy are attributable, in part, to its inhibitory effect on Shc- and PI3-K-dependent JNK activation in VSMC. Quercetin 53-62 mitogen-activated protein kinase 8 Rattus norvegicus 178-181 11562426-12 2001 Thus, inhibition of JNK by quercetin may imply its usefulness for the treatment of cardiovascular diseases relevant to VSMC growth. Quercetin 27-36 mitogen-activated protein kinase 8 Rattus norvegicus 20-23 11562426-6 2001 Ang II-induced JNK activation was inhibited by 3,3",4",5,7-pentahydroxyflavone (quercetin), a major bioflavonoid in foods of plant origin, whereas ERK1/2 and p38 activation by Ang II were not affected by quercetin. Quercetin 47-78 mitogen-activated protein kinase 8 Rattus norvegicus 15-18 11562426-6 2001 Ang II-induced JNK activation was inhibited by 3,3",4",5,7-pentahydroxyflavone (quercetin), a major bioflavonoid in foods of plant origin, whereas ERK1/2 and p38 activation by Ang II were not affected by quercetin. Quercetin 80-89 mitogen-activated protein kinase 8 Rattus norvegicus 15-18 11562426-6 2001 Ang II-induced JNK activation was inhibited by 3,3",4",5,7-pentahydroxyflavone (quercetin), a major bioflavonoid in foods of plant origin, whereas ERK1/2 and p38 activation by Ang II were not affected by quercetin. Quercetin 204-213 mitogen-activated protein kinase 8 Rattus norvegicus 15-18 9890986-11 1999 In addition, we found that, among the inhibitors of tyrosine kinases, cyclooxygenase, and Ca2+ influx, only quercetin exerted a significant inhibitory effect on HNE-induced JNK activation. Quercetin 108-117 mitogen-activated protein kinase 8 Rattus norvegicus 173-176