PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24491314-0	2014	Quercetin inhibits AMPK/TXNIP activation and reduces inflammatory lesions to improve insulin signaling defect in the hypothalamus of high fructose-fed rats.	Quercetin	0-9	thioredoxin interacting protein	Rattus norvegicus	24-29	
24491314-9	2014	Furthermore, quercetin was found to reduce metabolic nutrient sensors adenosine monophosphate-activated protein kinase (AMPK) activation and thioredoxin-interacting protein (TXNIP) overexpression, as well as the glutamine-glutamate cycle dysfunction in the hypothalamus of high fructose-fed rats.	Quercetin	13-22	thioredoxin interacting protein	Rattus norvegicus	141-172	
24491314-9	2014	Furthermore, quercetin was found to reduce metabolic nutrient sensors adenosine monophosphate-activated protein kinase (AMPK) activation and thioredoxin-interacting protein (TXNIP) overexpression, as well as the glutamine-glutamate cycle dysfunction in the hypothalamus of high fructose-fed rats.	Quercetin	13-22	thioredoxin interacting protein	Rattus norvegicus	174-179	
24491314-12	2014	These results provide in vivo evidence that quercetin-mediated down-regulation of AMPK/TXNIP and subsequent inhibition of NF-kappaB pathway/NLRP3 inflammasome activation in the hypothalamus of rats may be associated with the reduction of hypothalamic inflammatory lesions, contributing to the improvement of hypothalamic insulin signaling defect in this model.	Quercetin	44-53	thioredoxin interacting protein	Rattus norvegicus	87-92	
23647015-0	2013	Quercetin and allopurinol reduce liver thioredoxin-interacting protein to alleviate inflammation and lipid accumulation in diabetic rats.	Quercetin	0-9	thioredoxin interacting protein	Rattus norvegicus	39-70	
23647015-2	2013	In this study we investigated whether TXNIP is involved in type 1 diabetes-associated NAFLD and whether antioxidants, quercetin and allopurinol, alleviate NAFLD by targeting TXNIP.	Quercetin	118-127	thioredoxin interacting protein	Rattus norvegicus	174-179	
23647015-9	2013	KEY RESULTS: Quercetin and allopurinol significantly inhibited the TXNIP overexpression, activation of NLRP3 inflammasome, down-regulation of PPARalpha and up-regulation of sterol regulatory element binding protein-1c (SREBP-1c), SREBP-2, fatty acid synthase and liver X receptor alpha, as well as elevation of ROS and IL-1beta in diabetic rat liver.	Quercetin	13-22	thioredoxin interacting protein	Rattus norvegicus	67-72	
23647015-11	2013	CONCLUSIONS AND IMPLICATIONS: Inhibition of hepatic TXNIP by quercetin and allopurinol contributes to the reduction in liver inflammation and lipid accumulation under hyperglycaemic conditions.	Quercetin	61-70	thioredoxin interacting protein	Rattus norvegicus	52-57	
23647015-12	2013	The targeting of hepatic TXNIP by quercetin and allopurinol may have therapeutic implications for prevention of type 1 diabetes-associated NAFLD.	Quercetin	34-43	thioredoxin interacting protein	Rattus norvegicus	25-30	
34855213-0	2022	Antidiabetic effects of quercetin and liraglutide combination through modulation of TXNIP/IRS-1/PI3K pathway.	Quercetin	24-33	thioredoxin interacting protein	Rattus norvegicus	84-89	
34855213-13	2022	Quercetin and/or liraglutide significantly decreased TXNIP levels and serine phosphorylation of IRS-1 and increased PI3K levels compared to the diabetic untreated group.	Quercetin	0-9	thioredoxin interacting protein	Rattus norvegicus	53-58	
34855213-15	2022	The combination of quercetin and liraglutide showed enhanced antidiabetic effects, possibly through lowering hepatic TXNIP levels, with the resultant up-regulation of the IRS-1/PI3K pathway.	Quercetin	19-28	thioredoxin interacting protein	Rattus norvegicus	117-122