PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22075574-5 2011 In the LPS-stimulated inducible nitric oxide synthase (iNOS) activation analysis, two known compounds, quercetin (1) and ethyl caffeate (6), were found to markedly suppress nitric oxide (NO) production (IC50 value, 27.6 and 42.9 muM, respectively) in RAW264.7 cells. Quercetin 103-112 nitric oxide synthase 2, inducible Mus musculus 22-53 22713545-8 2012 Quercetin suppressed palmitate-induced upregulation of TNFalpha and iNOS and restored normal levels of GLUT4 in myotubes. Quercetin 0-9 nitric oxide synthase 2, inducible Mus musculus 68-72 22185406-13 2011 The microarray DNA analyses, followed by pathway analyses indicated that quercetin or delta-tocotrienol inhibit several LPS-induced expression of several ageing and pro-inflammatory genes (IL-1beta, IL-1alpha, IL-6, TNF-alpha, IL-12, iNOS, VCAM1, ICAM1, COX2, IL-1RA, TRAF1 and CD40). Quercetin 73-82 nitric oxide synthase 2, inducible Mus musculus 234-238 22075574-5 2011 In the LPS-stimulated inducible nitric oxide synthase (iNOS) activation analysis, two known compounds, quercetin (1) and ethyl caffeate (6), were found to markedly suppress nitric oxide (NO) production (IC50 value, 27.6 and 42.9 muM, respectively) in RAW264.7 cells. Quercetin 103-112 nitric oxide synthase 2, inducible Mus musculus 55-59 21810460-9 2011 We evaluated that ETL and the reference compound of quercetin decreased the LPS-induced NO production and expressions of iNOS and COX-2 in RAW264.7 cells. Quercetin 52-61 nitric oxide synthase 2, inducible Mus musculus 121-125 20690163-7 2010 Furthermore, quercetin also significantly activated the AMP-activated protein kinase (AMPK) via down-regulation of protein phosphatase 2C (PP2C), which reduced the integral optical density (IOD) of activated microglia cells and CD11b expression, down-regulated iNOS and cyclooxygenase-2 (COX-2) expression, and decreased IL-1beta, IL-6, and TNF-alpha expression in the brains of high-cholesterol-fed old mice through the suppression of NF-kappaB p65 nuclear translocation. Quercetin 13-22 nitric oxide synthase 2, inducible Mus musculus 261-265 20361964-13 2010 Although quercetin treatment could recover systemic anti-oxidative capacity, suppress the systemic expression of NO, COX and PGE-2, and decrease ocular A2E levels, it could not effectively suppress the transcripts of the ocular inflammatory factors Tnf-alpha, Cox-2 and Inos, or the pro-apoptotic factors Fas, FasL and Caspase-3 in DKO mice. Quercetin 9-18 nitric oxide synthase 2, inducible Mus musculus 270-274 20417174-2 2010 Quercetin (Qt) has anti-inflammatory properties through its ability to inhibits nitric oxide production and iNOS expression in different cellular types. Quercetin 0-9 nitric oxide synthase 2, inducible Mus musculus 108-112 20417174-2 2010 Quercetin (Qt) has anti-inflammatory properties through its ability to inhibits nitric oxide production and iNOS expression in different cellular types. Quercetin 11-13 nitric oxide synthase 2, inducible Mus musculus 108-112 17465695-6 2008 Quercetin and resveratrol decreased the release of nitric oxide by these cells in a dose-dependent manner which corresponded to a decrease in iNOS expression in the case of quercetin. Quercetin 0-9 nitric oxide synthase 2, inducible Mus musculus 142-146 20060843-7 2010 KEY FINDINGS: Quercetin produced an inhibitory effect on inducible nitric oxide synthase (iNOS) expression and NO production. Quercetin 14-23 nitric oxide synthase 2, inducible Mus musculus 57-88 20060843-7 2010 KEY FINDINGS: Quercetin produced an inhibitory effect on inducible nitric oxide synthase (iNOS) expression and NO production. Quercetin 14-23 nitric oxide synthase 2, inducible Mus musculus 90-94 17465695-6 2008 Quercetin and resveratrol decreased the release of nitric oxide by these cells in a dose-dependent manner which corresponded to a decrease in iNOS expression in the case of quercetin. Quercetin 173-182 nitric oxide synthase 2, inducible Mus musculus 142-146 12928578-8 2003 Apigenin-7-glucoside showed more efficacy as compared with quercetin in both models that may be probably due to its greater efficacy to inhibit cyclooxygenase-2 and inducible nitric oxide synthase. Quercetin 59-68 nitric oxide synthase 2, inducible Mus musculus 165-196 15630180-9 2004 Expressions of COX-2 and iNOS were effectively reduced by 5 microM quercetin treatment. Quercetin 67-76 nitric oxide synthase 2, inducible Mus musculus 25-29 18229606-6 2007 Compared with ADR 20 mg x kg(-1) group, the quercetin decreased the levels of LDH, iNOS, NO and MDA, increased the activity of SOD, restored the amplitude of R wave, decreased the incidence of arrhythmia and p53 expression (P < 0.001 , P < 0.01 or P < 0.05), and markedly reduced the myocardial ultrastructure injury. Quercetin 44-53 nitric oxide synthase 2, inducible Mus musculus 83-87 16171798-0 2005 Inhibition of iNOS gene expression by quercetin is mediated by the inhibition of IkappaB kinase, nuclear factor-kappa B and STAT1, and depends on heme oxygenase-1 induction in mouse BV-2 microglia. Quercetin 38-47 nitric oxide synthase 2, inducible Mus musculus 14-18 16171798-2 2005 Quercetin could suppress LPS- and IFN-gamma-induced NO production and inducible nitric oxide synthase (iNOS) gene transcription, while quercetin-3"-sulfate had no effect. Quercetin 0-9 nitric oxide synthase 2, inducible Mus musculus 70-101 16171798-2 2005 Quercetin could suppress LPS- and IFN-gamma-induced NO production and inducible nitric oxide synthase (iNOS) gene transcription, while quercetin-3"-sulfate had no effect. Quercetin 0-9 nitric oxide synthase 2, inducible Mus musculus 103-107 16171798-6 2005 Quercetin-mediated inhibition of NO production and iNOS protein expression were partially reversed by heme oxygenase-1 antisense oligodeoxynucleotide, but was mimicked by hemin, a heme oxygenase-1 inducer. Quercetin 0-9 nitric oxide synthase 2, inducible Mus musculus 51-55 12098601-3 2002 In vitro results showed that wogonin and quercetin dose-dependently suppressed lipopolysaccharide-induced NO production in RAW 264.7 macrophages and primary peritoneal macrophages without a notable cytotoxic effect on either cell types associated with a decrease in inducible nitric oxide synthase (iNOS) protein expression in both cells. Quercetin 41-50 nitric oxide synthase 2, inducible Mus musculus 266-297 12098601-9 2002 A decrease in iNOS protein, but not cyclooxygenase-2 protein, was detected in liver and lung specimens of lipopolysaccharide-treated Balb/c mice in the presence of rutin, wogonin or quercetin. Quercetin 182-191 nitric oxide synthase 2, inducible Mus musculus 14-18 12098601-10 2002 In conclusion, data obtained both in vitro and in vivo suggest that wogonin and quercetin exert inhibitory activity on lipopolysaccharide-induced NO production through suppression of iNOS expression. Quercetin 80-89 nitric oxide synthase 2, inducible Mus musculus 183-187 12098601-3 2002 In vitro results showed that wogonin and quercetin dose-dependently suppressed lipopolysaccharide-induced NO production in RAW 264.7 macrophages and primary peritoneal macrophages without a notable cytotoxic effect on either cell types associated with a decrease in inducible nitric oxide synthase (iNOS) protein expression in both cells. Quercetin 41-50 nitric oxide synthase 2, inducible Mus musculus 299-303 29958399-4 2018 The results show quercetin decreases the NO production and iNOS gene expression in RAW264.7 cells, and it inhibits the production of cytokines in RAW264.7 cells and peritoneal macrophages. Quercetin 17-26 nitric oxide synthase 2, inducible Mus musculus 59-63 34529966-9 2021 Collectively, the present study confirmed for the first time that quercetin weakened CUMS-induced depression in vivo, and its mechanism was at least partially attributable to the upregulation of hippocampal Nrf2 and the inhibition of iNOS, thereby correcting the central inflammatory response, and the imbalance between oxidation and antioxidant. Quercetin 66-75 nitric oxide synthase 2, inducible Mus musculus 234-238 35627075-5 2022 Ast and Que significantly reduced LPS-induced production of NO, iNOS, and pro-inflammatory cytokines in the microglia and hippocampus of mice. Quercetin 8-11 nitric oxide synthase 2, inducible Mus musculus 64-68 11753212-5 2001 The expression of inducible-type NO synthase (iNOS) was markedly down-regulated by quercetin. Quercetin 83-92 nitric oxide synthase 2, inducible Mus musculus 18-44 11753212-5 2001 The expression of inducible-type NO synthase (iNOS) was markedly down-regulated by quercetin. Quercetin 83-92 nitric oxide synthase 2, inducible Mus musculus 46-50 11753212-9 2001 Taken together, these results indicate that the inhibitory action of quercetin on NO production in LPS- and/or IFN-gamma-stimulated macrophages might be due to abrogation of iNOS protein induction by impairment of a series of intracellular signal pathways. Quercetin 69-78 nitric oxide synthase 2, inducible Mus musculus 174-178 11020457-0 2000 Synergy between ethanol and grape polyphenols, quercetin, and resveratrol, in the inhibition of the inducible nitric oxide synthase pathway. Quercetin 47-56 nitric oxide synthase 2, inducible Mus musculus 100-131 11020457-5 2000 The polyphenols quercetin and resveratrol at a micromolar range suppressed iNOS gene expression and NO production, as determined by reverse transcription-polymerase chain reaction and nitrite assay. Quercetin 16-25 nitric oxide synthase 2, inducible Mus musculus 75-79 32932805-5 2020 Quercetin significantly decreased the hepatic and plasmatic levels of inflammatory cytokines IL-1beta, IL-6, TNF-alpha, inducible nitric oxide synthase, cyclooxygenase-2 and intercellular adhesion molecule-1-provoked by over-exercise. Quercetin 0-9 nitric oxide synthase 2, inducible Mus musculus 120-151 29945484-0 2019 Quercetin inhibits LPS-induced macrophage migration by suppressing the iNOS/FAK/paxillin pathway and modulating the cytoskeleton. Quercetin 0-9 nitric oxide synthase 2, inducible Mus musculus 71-75 29945484-3 2019 Quercetin significantly attenuated LPS-induced inducible nitric oxide synthase (iNOS)-derived nitric oxide (NO) production in RAW264.7 cells without affecting their viability. Quercetin 0-9 nitric oxide synthase 2, inducible Mus musculus 47-78 29945484-3 2019 Quercetin significantly attenuated LPS-induced inducible nitric oxide synthase (iNOS)-derived nitric oxide (NO) production in RAW264.7 cells without affecting their viability. Quercetin 0-9 nitric oxide synthase 2, inducible Mus musculus 80-84 29207037-3 2018 It was identified that quercetin and galangin markedly reduced the production of nitric oxide (NO), inducible NO synthase and interleukin-6, and the nuclear translocation of nuclear factor-kappaB (NF-kappaB). Quercetin 23-32 nitric oxide synthase 2, inducible Mus musculus 100-121 28107044-9 2017 Further, quercetin attenuated the levels of angiogenic factor VEGF-A and inflammatory enzymes COX-2 and iNOS as well as NO levels, whereas it increased the levels of phosphatase PTEN. Quercetin 9-18 nitric oxide synthase 2, inducible Mus musculus 104-108 28615097-8 2017 Results Quercetin significantly reduced the pathological changes of lung tissues, lowered PaCO2 while increased PaO2 and D/W ratio, down-regulated the expressions of iNOS, TNF-alpha, IL-1beta while up-regulated the expressions of IL-4 and IL-10 in SW-ALI mice. Quercetin 8-17 nitric oxide synthase 2, inducible Mus musculus 166-170 25957741-8 2015 Moreover, quercetin decreased production of pro-inflammatory markers including TNF-alpha, IL-1beta and iNOS. Quercetin 10-19 nitric oxide synthase 2, inducible Mus musculus 103-107 26476923-4 2016 Both dexamethasone and quercetin were found to inhibit LPS-induced NO production, iNOS expression, IkappaBalpha phosphorylation, and IKKalpha/beta phosphorylation in RAW264.7 macrophages. Quercetin 23-32 nitric oxide synthase 2, inducible Mus musculus 82-86 26887929-3 2016 The present study aimed to target nitrosative stress using a naturally occurring Nos2 inhibitor, quercetin, to prevent NTDs in the embryos of diabetic mice. Quercetin 97-106 nitric oxide synthase 2, inducible Mus musculus 81-85 26887929-7 2016 Quercetin treatment decreased the levels of Nos2 expression, protein nitrosylation, and protein nitration, alleviating nitrosative stress. Quercetin 0-9 nitric oxide synthase 2, inducible Mus musculus 44-48 26546527-12 2015 Gene expression of Cox2, Tnfalpha and Nos2 stimulated by exposure to Pg-fimbriae was markedly suppressed by quercetin, but was not modulated by its combination with epicatechin. Quercetin 108-117 nitric oxide synthase 2, inducible Mus musculus 38-42 24912504-8 2014 Additionally, quercetin significantly reduced COX-2, HMGB1, iNOS expression, and NF-kappaB p65 phosphorylation. Quercetin 14-23 nitric oxide synthase 2, inducible Mus musculus 60-64 26198964-5 2015 RESULTS: Quercetin pretreatment significantly improved the cardiac function of LPS-challenged mice (P<0.05), and attenuated LPS-induced increment in myocardial iNOS expression and decrement in eNOS level. Quercetin 9-18 nitric oxide synthase 2, inducible Mus musculus 163-167 22902988-10 2012 The expression of inducible nitric oxide synthase (iNOS) was more potently suppressed by rutin than by quercetin. Quercetin 103-112 nitric oxide synthase 2, inducible Mus musculus 18-49 24337353-6 2014 In addition, quercetin-treated mice exhibited significantly lower expression of the p47phox subunit of nicotinamide adenine dinucleotide phosphate oxidase and inducible nitric oxide synthase, as well as coordinated downregulation of manganese-superoxide dismutase activities and glutathione peroxidase (GPx)-1 and GPx-3 expression. Quercetin 13-22 nitric oxide synthase 2, inducible Mus musculus 159-190 23735482-8 2013 Quercetin attenuated p38(MAPK) and JNK1/2 but not ERK1/2 activations and this effect was further confirmed by SB203580 and SP600125-mediated suppressions of HO-1, iNOS, and COX-2 protein expressions. Quercetin 0-9 nitric oxide synthase 2, inducible Mus musculus 163-167 23735482-9 2013 Moreover, quercetin arrested Src, PI3K, PDK1 and Akt activation in a time- and dose-dependent manner, which was comparable to PP2 and LY294002 inhibition of Src, PI3K/Akt and iNOS expressions. Quercetin 10-19 nitric oxide synthase 2, inducible Mus musculus 175-179 24076371-5 2013 Here, we found that quercetin significantly suppressed LPS-induced NO production and inducible NO synthase (iNOS) expression. Quercetin 20-29 nitric oxide synthase 2, inducible Mus musculus 85-106 24076371-5 2013 Here, we found that quercetin significantly suppressed LPS-induced NO production and inducible NO synthase (iNOS) expression. Quercetin 20-29 nitric oxide synthase 2, inducible Mus musculus 108-112 23735482-6 2013 Quercetin inhibited LPS-induced NO, PGE2, iNOS, COX-2, TNF-alpha, IL-1beta, IL-6 and GM-CSF mRNA and protein expressions while it promoted HO-1 induction in a dose- and time-dependent manner. Quercetin 0-9 nitric oxide synthase 2, inducible Mus musculus 42-46 22902988-10 2012 The expression of inducible nitric oxide synthase (iNOS) was more potently suppressed by rutin than by quercetin. Quercetin 103-112 nitric oxide synthase 2, inducible Mus musculus 51-55