PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34549711-4 2021 CONCLUSION: Quercetin improves the pathological changes in HF possibly by regulating the AKT1-eNOS-MMP9 pathway to inhibit cell apoptosis. Quercetin 12-21 nitric oxide synthase 3 Homo sapiens 94-98 34549711-2 2021 METHODS: Quercetin and HF-related targets were obtained using TCMSP, PharmMapper, CTD and GeneCards databases, and quercetin-HF intersection targets were obtained through the online website Venn; the protein interaction network was constructed and imported into Cytoscape 3.7.2 to identify the core targets of quercetin in the treatment of HF.GO and KEGG pathway enrichment analyses were performed using R package, and molecular docking was performed using Auto Dock Vina.The protein levels of AKT1, phospho-AKT(Ser473), eNOS, MMP9, and caspase-3 in quercetin-treated HF cell models were detected using protein immunoblotting. Quercetin 310-319 nitric oxide synthase 3 Homo sapiens 521-525 34986125-9 2021 Finally, the binding modes of EGFR, IL1B, NOS3 and TP53 with quercetin were visualized. Quercetin 61-70 nitric oxide synthase 3 Homo sapiens 42-46 34986125-10 2021 DISCUSSION AND CONCLUSION: Quercetin of Baiying Qinghou decoction showed therapeutic effect against laryngeal squamous cell carcinoma by regulating TP53, EGFR, NOS3 and IL1B involved with drug resistance and PI3K-AKT signaling pathway. Quercetin 27-36 nitric oxide synthase 3 Homo sapiens 160-164 34549711-3 2021 RESULTS: We identified 80 quercetin-HF intersectional targets (AKT1, CASP3, MAPK1, MMP9, and MAPK8) and 5 core targets of quercetin for treatment of HF.GO analysis suggested that the therapeutic effect of quercetin for HF was mediated mainly by such biological processes as responses to peptide hormones, phosphatidylinositol-mediated signalling, responses to lipopolysaccharides, responses to molecules of bacterial origin and regulation of inflammatory responses.KEGG pathway enrichment analysis identified lipid and atherosclerosis pathway, proteoglycans in cancer, PI3K-AKT signaling pathway, diabetic cardiomyopathy and MAPK signaling pathway as the most significantly enriched signaling pathways.Molecular docking showed a good binding activity of quercetin to the 5 core targets.The results of protein immunoblotting showed that 100 mumol/L quercetin significantly reduced AKT1, phospho-AKT (Ser473), eNOS, MMP9 and caspase-3 levels in the cell models of HF (P < 0.01). Quercetin 205-214 nitric oxide synthase 3 Homo sapiens 908-912 20021702-4 2010 Resveratrol and quercetin (0.1-1 microm) increased eNOS and VEGF mRNA expression particularly in the absence of H2O2 (50 microm) and decreased H2O2-induced ET-1 mRNA expression (P < 0.001 for polyphenol x H2O2 interactions). Quercetin 16-25 nitric oxide synthase 3 Homo sapiens 51-55 33557218-11 2021 Quercetin, a component of honey, can improve vasodilation by enhancing nitric oxide production via endothelial nitric oxide synthase and stimulate calcium-activated potassium channels. Quercetin 0-9 nitric oxide synthase 3 Homo sapiens 99-132 22902249-8 2012 The protein expression of superoxide dismutase (Cu/Zn-SOD, Mn-SOD), glutathione peroxidase (GPx) and endothelial nitric oxide synthase (eNOS) increased in the cells treated with CQE, quercetin or resveratrol prior to H(2)O(2) exposure, as compared with control. Quercetin 183-192 nitric oxide synthase 3 Homo sapiens 101-134 23947593-0 2013 Human metabolic transformation of quercetin blocks its capacity to decrease endothelial nitric oxide synthase (eNOS) expression and endothelin-1 secretion by human endothelial cells. Quercetin 34-43 nitric oxide synthase 3 Homo sapiens 76-109 23947593-0 2013 Human metabolic transformation of quercetin blocks its capacity to decrease endothelial nitric oxide synthase (eNOS) expression and endothelin-1 secretion by human endothelial cells. Quercetin 34-43 nitric oxide synthase 3 Homo sapiens 111-115 23947593-2 2013 This study examined the relative abilities of quercetin and its human metabolites to modulate the expression of eNOS and ET-1, which are involved in regulating endothelial homeostasis. Quercetin 46-55 nitric oxide synthase 3 Homo sapiens 112-116 23947593-7 2013 These results suggest that metabolic transformation of quercetin prevents it from causing a potentially deleterious decrease in eNOS in endothelial cells. Quercetin 55-64 nitric oxide synthase 3 Homo sapiens 128-132 15740983-6 2005 The flavonol quercetin inhibited eNOS expression (with no effect on eNOS promoter activity). Quercetin 13-22 nitric oxide synthase 3 Homo sapiens 33-37