PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32922227-0 2020 Manipulation of Quercetin and Melatonin in the Down-Regulation of HIF-1alpha, HSP-70 and VEGF Pathways in Rat"s Kidneys Induced by Hypoxic Stress. Quercetin 16-25 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 78-84 32308802-10 2020 Moreover, inhibition of Hsp70 by quercetin enhanced I/R-induced myocardial injury, while SB203580 pretreatment reversed the harmful effects caused by quercetin. Quercetin 33-42 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 24-29 31377559-9 2019 A similar abolition of nicotine effects was seen after HSP70 inhibition by quercetin. Quercetin 75-84 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 55-60 30934771-5 2019 8-OHdG and Hsp70 protein expressions were up-regulated markedly by light exposure and suppressed by quercetin pretreatment. Quercetin 100-109 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 11-16 30171731-0 2018 Quercetin attenuates hypertension induced by sodium fluoride via reduction in oxidative stress and modulation of HSP 70/ERK/PPARgamma signaling pathways. Quercetin 0-9 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 113-119 24530315-0 2014 Quercetin mitigates lead acetate-induced behavioral and histological alterations via suppression of oxidative stress, Hsp-70, Bak and upregulation of Bcl-2. Quercetin 0-9 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 118-124 30112361-1 2018 Aim: To evaluate the role of heat shock protein 70 (HSP70) on the MAPK pathway activation with quercetin treatment and its protection against small intestine impairments of heat stressed rats. Quercetin 95-104 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 29-50 30112361-1 2018 Aim: To evaluate the role of heat shock protein 70 (HSP70) on the MAPK pathway activation with quercetin treatment and its protection against small intestine impairments of heat stressed rats. Quercetin 95-104 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 52-57 30112361-9 2018 Inhibition of HSP70 by quercetin did not change intestinal permeability compared with the HS group but aggravated intestinal injury and affected the activation of MAPKs and caspase-3. Quercetin 23-32 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 14-19 27896629-7 2017 Furthermore, the administration of YC-1 (HIF-1 inhibitor), 8-bAMP (AMPK inhibitor), and Quercetin (HSP70 inhibitor) to MCAO+RIPC rats demonstrated that HIF-1alpha/AMPK/HSP70 was involved in RIPC-mediated protection against cerebral ischemia. Quercetin 88-97 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 99-104 27244466-7 2016 Quercetin (100 mg/kg), an inhibitor of heat shock protein 70 (HSP70), was injected into the peritoneum 2 hours before SAH induction. Quercetin 0-9 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 39-60 27244466-7 2016 Quercetin (100 mg/kg), an inhibitor of heat shock protein 70 (HSP70), was injected into the peritoneum 2 hours before SAH induction. Quercetin 0-9 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 62-67 27354628-9 2016 Expression of HSP70 and HSF1 was suppressed in the group treated with GGA and quercetin, and this group had severe liver damage. Quercetin 78-87 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 14-19 30192489-5 2016 It was shown for the first time that quercetin pretreatment inhibited the LC-induced expression of Hsp70 in the SNpc neurons and increased in 1.5 times the dopamine (DA)-ergic neurons death and in 2.7 times the striatal DA-ergic axons degeneration. Quercetin 37-46 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 99-104 29763367-11 2018 Nitric oxide, nitric oxide synthase, and inducible nitric oxide synthase levels in the hippocampus were significantly increased after hyperbaric oxygen exposure, but reversed by geranylgeranylacetone, while heat shock protein 70 inhibitor quercetin could inhibit this effect of geranylgeranylacetone. Quercetin 239-248 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 207-228 28350760-10 2017 Pretreatment with quercetin, an inhibitor of HSP70, or SnPP, an inhibitor of HO-1, reversed the protective effects of raloxifene in septic OVX rats and LPS-activated macrophages. Quercetin 18-27 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 45-50 27241357-9 2016 Treatment with quercetin significantly suppressed Hsp70 and pAMPK levels and reduced the protective effects of 17-DMAG in HS rats. Quercetin 15-24 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 50-55 24530315-9 2014 Quercetin however, restored the normal morphology of brain and the expressions of Bak, Bcl-2 and Hsp-70. Quercetin 0-9 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 97-103 22690838-10 2012 Hsp70 inhibitor quercetin reduced Hsp70, while aggravating the WBH-induced hepatic changes. Quercetin 16-25 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 0-5 23679081-7 2013 The inhibition of HSP70 using quercetin resulted in an elevation of JNK activity by decreasing the cytoplasmic solubility of M3/6. Quercetin 30-39 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 18-23 23922702-10 2013 The neuroprotective effect of YC-1 was significantly attenuated by an Hsp70 inhibitor (quercetin, 50 microM) or in PC12 cells transfected with an Hsp70 small interfering RNA. Quercetin 87-96 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 70-75 23219797-5 2013 Male Sprague-Dawley rats untreated or treated with either YC-1 or quercetin (heat shock protein (Hsp) 70 inhibitor) were exposures to heat as a model of heat stroke. Quercetin 66-75 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 77-104 23479759-11 2013 l-NAME or quercetin eliminated most of the beneficial effects of HBO on DCS, and counteracted the stimulation of HSP70 by HBO. Quercetin 10-19 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 113-118 22690838-10 2012 Hsp70 inhibitor quercetin reduced Hsp70, while aggravating the WBH-induced hepatic changes. Quercetin 16-25 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 34-39 21080136-7 2011 To further investigate whether increase of HSP70 might be responsible for protection of the myocardium against I/R injury, we co-administered the HSP70 inhibitor, quercetin, with LPS before I/R injury. Quercetin 163-172 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 43-48 21080136-7 2011 To further investigate whether increase of HSP70 might be responsible for protection of the myocardium against I/R injury, we co-administered the HSP70 inhibitor, quercetin, with LPS before I/R injury. Quercetin 163-172 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 146-151 20535998-3 2010 Blockade of the expression of Hsp70 by quercetin increased the duration of clonic and tonic seizures and did not affect severity of seizures and ataxia symptoms, induced by intraperitoneal injection of pentylenetetrazole. Quercetin 39-48 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 30-35 21846189-9 2011 Combination quercetin-RF decreased Hsp70 expression compared with RF alone at both 4 h (percentage of stained cells/hpf 22.4+-13.9% vs. 38.8+-16.1%, P<0.03) and 24 h (45.2+-10.5% vs. 81.1+-3.6%, P<0.001). Quercetin 12-21 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 35-40 20535998-0 2010 [EFfect of quercetin on the severity of chemically induced seizures and the content of heat shock protein 70 in the rat brain structures]. Quercetin 11-20 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 87-108 20535998-4 2010 Immunoblotting showed that injection of quercetin resulted in reduced content of the inducible form of Hsp70 in the hippocampus, thalamus and corpus callosum. Quercetin 40-49 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 103-108 20535998-5 2010 The obtained results indicate proconvulsant effect of quercetin associated with the inhibition of Hsp70 expression. Quercetin 54-63 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 98-103 21784011-10 2009 In addition, results from Western blot showed that GGA-induced Hsp70 expression of neurons both in normal and heat-treatment conditions (P<0.01, P<0.05) and quercetin inhibited GGA-induced Hsp70 expression (P<0.05). Quercetin 163-172 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 195-200 21784011-12 2009 Quercetin inhibited GGA-induced Hsp70 expression and prevented GGA-protective effects, which indicated that this protection was dependent on the Hsp70 synthesis. Quercetin 0-9 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 32-37 21784011-12 2009 Quercetin inhibited GGA-induced Hsp70 expression and prevented GGA-protective effects, which indicated that this protection was dependent on the Hsp70 synthesis. Quercetin 0-9 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 145-150 17804168-8 2008 Co-administration of quercetin with SA abolished the SA-induced HSP70 over-expression and the beneficial effects of SA. Quercetin 21-30 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 64-69 19462895-5 2009 HSP70 and VEGF were both significantly reduced by quercetin or combination treatment, but no significant difference was seen between quercetin and combination treatment groups. Quercetin 50-59 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 0-5 19462895-6 2009 CONCLUSION: Quercetin inhibits surgically induced endometriosis in rats, and the possible mechanism is to inhibit the expression of HSP70 and VEGF. Quercetin 12-21 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 132-137 17588336-8 2007 Moreover, quercetin, an inhibitor of HSP70 expression, aggravated the infiltration of inflammatory cells and glandular loss in the antrum. Quercetin 10-19 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 37-42 17543279-6 2007 Quercetin, an inhibitor of HSP70, blocked the effects of ghrelin on ASK1 activity. Quercetin 0-9 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 27-32 17375204-5 2007 In contrast, treatment with quercetin, an HSP 70 inhibitor, inhibited both upregulation of endothelial HSP 70 and formation of SFs in response to tensile stress. Quercetin 28-37 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 42-48 17375204-5 2007 In contrast, treatment with quercetin, an HSP 70 inhibitor, inhibited both upregulation of endothelial HSP 70 and formation of SFs in response to tensile stress. Quercetin 28-37 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 103-109 15882264-13 2005 The induction of Hsp70 was blocked by quercetin. Quercetin 38-47 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 17-22 16247336-9 2005 Furthermore, the protective effect of GGA on mortality in LPS-treated rats was inhibited with quercetin, known as an HSP70 inhibitor. Quercetin 94-103 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 117-122 17021270-8 2006 Inhibition of HSP-70 by quercetin almost completely reversed the functional protection that was provided by heat preconditioning. Quercetin 24-33 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 14-20 16710168-0 2006 Expression of Hsp70 and Hsp27 in lens epithelial cells in contused eye of rat modulated by thermotolerance or quercetin. Quercetin 110-119 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 14-19 16710168-11 2006 However, Hsp70 levels in the 1-6 h subgroup in the quercetin group was significantly lower. Quercetin 51-60 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 9-14 16710168-14 2006 Immunostaining of Hsp70 was faint in LECs of quercetin eyes. Quercetin 45-54 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 18-23 16497619-6 2006 Furthermore, quercetin, an inhibitor of HSP70 synthesis, diminished the protective effects of GGA in IEC-18 cells upon NH(2)Cl-caused injury. Quercetin 13-22 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 40-45 15882264-18 2005 Quercetin, an inhibitor of Hsp70 induction, eliminated these renoprotective effects of GGA. Quercetin 0-9 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 27-32 12958199-5 2003 rHuEPO treatment increased HSP70 expression in a dose-dependent manner in normal rat kidneys, and inhibition of HSP70 expression by quercetin eliminated the renoprotective effect of rHuEPO in ischemic kidneys. Quercetin 132-141 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 112-117 15723751-9 2005 The next two groups of rats were treated with quercetin (HSP-70 inhibitor; 400 mg/kg intraperitoneally) 6 h before LPS administration. Quercetin 46-55 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 57-63 15723751-16 2005 Quercetin inhibited a GLN-mediated increase in lung HSP-70 and blocked a beneficial effect of GLN on the ratio of adenosine triphosphate to adenosine diphosphate after LPS. Quercetin 0-9 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 52-58 14605528-6 2003 To evaluate dose-dependent inhibition of GGA-induced HSP70 expression by quercetin, rats were pretreated with progressive doses of quercetin before GGA administration. Quercetin 73-82 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 53-58 14605528-10 2003 MEASUREMENTS AND MAIN RESULTS: Western blot analysis using diaphragm homogenates obtained from normal rats showed that HSP70 expression peaked at 24 or 36 hrs after GGA administration and that pretreatment with >10 mg/kg of quercetin blocked the induction of HSP70 expression by GGA. Quercetin 227-236 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 119-124 11920758-5 2002 Quercetin, an inhibitor for biosynthesis of heat shock protein 70 (HSP70), masked only the protective effect of L-Gln in both rat large intestine and Caco-2 cells. Quercetin 0-9 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 44-65 11920758-5 2002 Quercetin, an inhibitor for biosynthesis of heat shock protein 70 (HSP70), masked only the protective effect of L-Gln in both rat large intestine and Caco-2 cells. Quercetin 0-9 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 67-72 11318950-6 2001 The induction of HSP84 and HSP70 was blocked by pretreatment with quercetin. Quercetin 66-75 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 27-32 11731719-4 2002 Upon treatment of cells with heat shock in the presence of quercetin, cell viability was significantly decreased 24 h after heat shock, with strong inhibition of HSP70 expression. Quercetin 59-68 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 162-167 11731719-5 2002 Rebamipide suppressed both cell death and a reduction in HSP70 induced by the combined treatment of heat shock and quercetin. Quercetin 115-124 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 57-62 11041272-6 2000 In HSP synthesis inhibitor quercetin-treated cells, HSP-70 expression was not enhanced after heat stress, and Ca2+ rise in response to 5-HT did not return to the control level. Quercetin 27-36 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 52-58 10880051-7 2000 The culture-induced enhanced HSP70 expression can be prevented by addition of either the flavonoid antioxidant quercetin or an antisense oligonucleotide to HSP70. Quercetin 111-120 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 29-34 10880051-7 2000 The culture-induced enhanced HSP70 expression can be prevented by addition of either the flavonoid antioxidant quercetin or an antisense oligonucleotide to HSP70. Quercetin 111-120 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 156-161 10805410-6 2000 Both the antihypotensive effects of adaptation and HSP70 accumulation were completely prevented by L-NNA, an inhibitor of NO synthesis, or quercetin, an inhibitor of HSP70 synthesis. Quercetin 139-148 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 51-56 10805410-6 2000 Both the antihypotensive effects of adaptation and HSP70 accumulation were completely prevented by L-NNA, an inhibitor of NO synthesis, or quercetin, an inhibitor of HSP70 synthesis. Quercetin 139-148 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 166-171 9142921-9 1997 Quercetin blocked HSP70 induction and the protective effect of Gln and DON. Quercetin 0-9 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 18-23