PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20148354-0 2010 Suppression of the androgen receptor function by quercetin through protein-protein interactions of Sp1, c-Jun, and the androgen receptor in human prostate cancer cells. Quercetin 49-58 androgen receptor Homo sapiens 19-36 20148354-0 2010 Suppression of the androgen receptor function by quercetin through protein-protein interactions of Sp1, c-Jun, and the androgen receptor in human prostate cancer cells. Quercetin 49-58 androgen receptor Homo sapiens 119-136 20148354-1 2010 We have previously reported that the increase in c-Jun expression induced by quercetin inhibited androgen receptor (AR) transactivation, and Sp1 was involved in quercetin-mediated downregulation of AR activity. Quercetin 77-86 androgen receptor Homo sapiens 97-114 20148354-1 2010 We have previously reported that the increase in c-Jun expression induced by quercetin inhibited androgen receptor (AR) transactivation, and Sp1 was involved in quercetin-mediated downregulation of AR activity. Quercetin 77-86 androgen receptor Homo sapiens 116-118 20148354-1 2010 We have previously reported that the increase in c-Jun expression induced by quercetin inhibited androgen receptor (AR) transactivation, and Sp1 was involved in quercetin-mediated downregulation of AR activity. Quercetin 161-170 androgen receptor Homo sapiens 198-200 20148354-4 2010 The physical associations of c-Jun, Sp1, and AR induced by quercetin were further demonstrated by co-immunoprecipitation experiments. Quercetin 59-68 androgen receptor Homo sapiens 45-47 20148354-5 2010 In addition, quercetin-mediated repression of AR expression and activity was partially reversed by blocking of JNK signaling pathway. Quercetin 13-22 androgen receptor Homo sapiens 46-48 20148354-6 2010 These results suggested that c-Jun might play an important role in the suppression of AR expression and activity in the presence of quercetin, and association of a c-Jun/Sp1/AR protein complex induced by quercetin represented a novel mechanism that was involved in down-regulation of the AR function in prostate cancer cells. Quercetin 132-141 androgen receptor Homo sapiens 86-88 20148354-6 2010 These results suggested that c-Jun might play an important role in the suppression of AR expression and activity in the presence of quercetin, and association of a c-Jun/Sp1/AR protein complex induced by quercetin represented a novel mechanism that was involved in down-regulation of the AR function in prostate cancer cells. Quercetin 204-213 androgen receptor Homo sapiens 86-88 20148354-6 2010 These results suggested that c-Jun might play an important role in the suppression of AR expression and activity in the presence of quercetin, and association of a c-Jun/Sp1/AR protein complex induced by quercetin represented a novel mechanism that was involved in down-regulation of the AR function in prostate cancer cells. Quercetin 204-213 androgen receptor Homo sapiens 174-176 20148354-6 2010 These results suggested that c-Jun might play an important role in the suppression of AR expression and activity in the presence of quercetin, and association of a c-Jun/Sp1/AR protein complex induced by quercetin represented a novel mechanism that was involved in down-regulation of the AR function in prostate cancer cells. Quercetin 204-213 androgen receptor Homo sapiens 174-176 16239064-0 2006 Selenium- or quercetin-induced retardation of DNA synthesis in primary prostate cells occurs in the presence of a concomitant reduction in androgen-receptor activity. Quercetin 13-22 androgen receptor Homo sapiens 139-156 17111826-5 2006 RESULTS: Quercetin dramatically induced the protein expression of c-Jun which in turn inhibited the AR function. Quercetin 9-18 androgen receptor Homo sapiens 100-102 17111826-8 2006 CONCLUSION: Overexpression of c-Jun induced by quercetin had inhibitory effect on the function of AR protein, and increased CBP expression did not reverse the inhibition by quercetin. Quercetin 47-56 androgen receptor Homo sapiens 98-100 17111826-9 2006 Together, quercetin-mediated inhibition on the AR function might be not by competition with limited amount of CBP in the cell, but through a direct association of c-Jun and the AR. Quercetin 10-19 androgen receptor Homo sapiens 47-49 17111826-9 2006 Together, quercetin-mediated inhibition on the AR function might be not by competition with limited amount of CBP in the cell, but through a direct association of c-Jun and the AR. Quercetin 10-19 androgen receptor Homo sapiens 177-179 16239064-9 2006 In LNCaP cells transfected with an androgen-receptor (AR)-reporter gene coupled to luciferase, selenomethionine or quercetin reduced AR activity. Quercetin 115-124 androgen receptor Homo sapiens 35-52 16239064-9 2006 In LNCaP cells transfected with an androgen-receptor (AR)-reporter gene coupled to luciferase, selenomethionine or quercetin reduced AR activity. Quercetin 115-124 androgen receptor Homo sapiens 54-56 32174789-0 2020 Quercetin reverses docetaxel resistance in prostate cancer via androgen receptor and PI3K/Akt signaling pathways. Quercetin 0-9 androgen receptor Homo sapiens 63-80 11238180-0 2001 Quercetin inhibits the expression and function of the androgen receptor in LNCaP prostate cancer cells. Quercetin 0-9 androgen receptor Homo sapiens 54-71 11238180-3 2001 Western blot analysis showed that AR protein expression was inhibited by quercetin in a dose-dependent manner. Quercetin 73-82 androgen receptor Homo sapiens 34-36 11238180-4 2001 To demonstrate that the repression effects on AR expression can actually reduce its function, we found that quercetin inhibited the secretion of the prostate-specific, androgen-regulated tumor markers, PSA and hK2. Quercetin 108-117 androgen receptor Homo sapiens 46-48 15661808-0 2005 Involvement of transcription factor Sp1 in quercetin-mediated inhibitory effect on the androgen receptor in human prostate cancer cells. Quercetin 43-52 androgen receptor Homo sapiens 87-104 15661808-3 2005 Our previous study has shown that quercetin, one of the main polyphenols, can effectively inhibit the expression and function of the AR. Quercetin 34-43 androgen receptor Homo sapiens 133-135 15661808-4 2005 The present study is to address if quercetin may affect Sp1"s action on AR transactivation activity in human prostate adenocarcinoma cell lines, LNCaP and PC-3. Quercetin 35-44 androgen receptor Homo sapiens 72-74 15661808-8 2005 However, the state of interaction of Sp1 with the AR treated by quercetin plus androgen was different from that by androgen treatment or none as demonstrated by coimmunoprecipitation experiments and glutathione S-transferase (GST) pull-down assays. Quercetin 64-73 androgen receptor Homo sapiens 50-52 15661808-9 2005 Moreover, we showed that quercetin caused changes in post-translational modification of AR protein. Quercetin 25-34 androgen receptor Homo sapiens 88-90 15661808-10 2005 The above findings strongly suggest that changes induced by quercetin in post-translational modification of the AR and in states of physical interaction of Sp1 with the AR may be critical for the attenuation of AR"s function. Quercetin 60-69 androgen receptor Homo sapiens 112-114 15661808-10 2005 The above findings strongly suggest that changes induced by quercetin in post-translational modification of the AR and in states of physical interaction of Sp1 with the AR may be critical for the attenuation of AR"s function. Quercetin 60-69 androgen receptor Homo sapiens 169-171 15661808-10 2005 The above findings strongly suggest that changes induced by quercetin in post-translational modification of the AR and in states of physical interaction of Sp1 with the AR may be critical for the attenuation of AR"s function. Quercetin 60-69 androgen receptor Homo sapiens 169-171 15327830-0 2004 Overexpression of c-Jun induced by quercetin and resverol inhibits the expression and function of the androgen receptor in human prostate cancer cells. Quercetin 35-44 androgen receptor Homo sapiens 102-119 15327830-1 2004 Previously, we reported that quercetin and resveratrol inhibit the function of androgen receptor (AR). Quercetin 29-38 androgen receptor Homo sapiens 79-96 15327830-1 2004 Previously, we reported that quercetin and resveratrol inhibit the function of androgen receptor (AR). Quercetin 29-38 androgen receptor Homo sapiens 98-100 12391264-0 2002 The mutant androgen receptor T877A mediates the proliferative but not the cytotoxic dose-dependent effects of genistein and quercetin on human LNCaP prostate cancer cells. Quercetin 124-133 androgen receptor Homo sapiens 11-28 12237244-6 2002 Inhibition of AR expression could be achieved by potential chemopreventive agents flufenamic acid, resveratrol, quercetin, polyunsaturated fatty acids and interleukin-1beta, and by the application of AR antisense oligonucleotides. Quercetin 112-121 androgen receptor Homo sapiens 14-16 11238180-6 2001 Transient transfections further showed that quercetin inhibited AR-mediated PSA expression at the transcription level. Quercetin 44-53 androgen receptor Homo sapiens 64-66 11238180-7 2001 Finally, it was demonstrated that quercetin could repress the expression of the AR gene at the transcription level. Quercetin 34-43 androgen receptor Homo sapiens 80-82 11238180-8 2001 Our result suggests that quercetin can attenuate the function of AR by repressing its expression and has the potential to become a chemopreventive and/or chemotherapeutic agent for prostate cancer. Quercetin 25-34 androgen receptor Homo sapiens 65-67 34231170-9 2022 The ten hub targets for quercetin in preventing preterm birth were AKT serine/threonine kinase 1, mitogen-activated protein kinase 3, epidermal growth factor receptor, prostaglandin-endoperoxide synthase 2, mitogen-activated protein kinase 1, estrogen receptor 1, heat shock protein 90 alpha family class A member 1, mitogen-activated protein kinase 8, androgen receptor, and matrix metallopeptidase 9. Quercetin 24-33 androgen receptor Homo sapiens 353-370 27132804-0 2016 Sensitization of androgen refractory prostate cancer cells to anti-androgens through re-expression of epigenetically repressed androgen receptor - Synergistic action of quercetin and curcumin. Quercetin 169-178 androgen receptor Homo sapiens 127-144 27132804-2 2016 Some dietary phytocompounds like quercetin (Q) and curcumin (C) with reported DNMT-inhibitory activity were tested for their ability to re-express the AR in AR-negative CaP cell lines PC3 and DU145. Quercetin 33-42 androgen receptor Homo sapiens 151-153 24726691-10 2014 Resveratrol, quercetin and morin were the only nutrients that significantly inhibited AR mRNA expression. Quercetin 13-22 androgen receptor Homo sapiens 86-88 24726691-13 2014 We confirm that resveratrol, morin and quercetin may achieve such effect through reduced expression of AR. Quercetin 39-48 androgen receptor Homo sapiens 103-105