PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32104488-0 2019 Evaluation of the Mrp2-mediated flavonoid-drug interaction potential of quercetin in rats and in vitro models. Quercetin 72-81 ATP binding cassette subfamily C member 2 Rattus norvegicus 18-22 32104488-3 2019 In this study, we comprehensively evaluated the potential of the pharmacokinetic interaction of quercetin mediated by multidrug resistance-associated protein 2 (MRP2), another major efflux transporter. Quercetin 96-105 ATP binding cassette subfamily C member 2 Rattus norvegicus 118-159 32104488-3 2019 In this study, we comprehensively evaluated the potential of the pharmacokinetic interaction of quercetin mediated by multidrug resistance-associated protein 2 (MRP2), another major efflux transporter. Quercetin 96-105 ATP binding cassette subfamily C member 2 Rattus norvegicus 161-165 32104488-6 2019 Mrp2-mediated interaction potential was also evaluated by the pharmacokinetic study of phenolsulfonphthalein in rats after single or multiple doses of quercetin. Quercetin 151-160 ATP binding cassette subfamily C member 2 Rattus norvegicus 0-4 32104488-8 2019 Quercetin inhibited the function of MRP2 at 10 microM and induced the mRNA expression of MRP2 at 50 microM in vitro. Quercetin 0-9 ATP binding cassette subfamily C member 2 Rattus norvegicus 36-40 32104488-8 2019 Quercetin inhibited the function of MRP2 at 10 microM and induced the mRNA expression of MRP2 at 50 microM in vitro. Quercetin 0-9 ATP binding cassette subfamily C member 2 Rattus norvegicus 89-93 32104488-9 2019 Additionally, at 100 mg/kg, quercetin markedly increased Mrp2 expression in the small intestine of rats. Quercetin 28-37 ATP binding cassette subfamily C member 2 Rattus norvegicus 57-61 32104488-12 2019 The results suggested that although quercetin modulates the function and expression of MRP2 in vitro, it may have a low potential of Mrp2-mediated interaction and present negligible safety concerns related to the interaction. Quercetin 36-45 ATP binding cassette subfamily C member 2 Rattus norvegicus 87-91 32104488-12 2019 The results suggested that although quercetin modulates the function and expression of MRP2 in vitro, it may have a low potential of Mrp2-mediated interaction and present negligible safety concerns related to the interaction. Quercetin 36-45 ATP binding cassette subfamily C member 2 Rattus norvegicus 133-137 11408547-7 2001 Quercetin, a flavonoid compound known to block As(III)-related induction of P-glycoprotein, was also found to prevent up-regulation of MRP2 gene expression in rat hepatocytes exposed to As(III). Quercetin 0-9 ATP binding cassette subfamily C member 2 Rattus norvegicus 135-139