PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31614146-13 2019 Quercetin also suppressed caspase-3 expression but not caspase-8. Quercetin 0-9 caspase 3 Rattus norvegicus 26-35 31982469-15 2020 Quercetin treatment attenuated the increase of caspase-3. Quercetin 0-9 caspase 3 Rattus norvegicus 47-56 31550528-7 2019 In addition, quercetin exhibited anti-apoptotic effects by decreasing intracellular reactive oxygen species (ROS), restoring mitochondrial membrane potential (MMP) and inhibiting the Caspase-3 pathway in apoptotic rat chondrocytes. Quercetin 13-22 caspase 3 Rattus norvegicus 183-192 30878575-6 2019 Quercetin significantly decreased caspase 3/8/9 levels. Quercetin 0-9 caspase 3 Rattus norvegicus 34-47 31800737-0 2019 QUERCETIN SUPPLEMENTATION PREVENTS CHANGES IN THE SEROTONIN AND CASPASE-3 IMMUNOREACTIVE CELLS OF THE JEJUNUM OF DIABETIC RATS. Quercetin 0-9 caspase 3 Rattus norvegicus 64-73 29749525-7 2018 Finally, quercetin significantly suppressed caspase-3 activity and activated Bmi-1 protein expression in the rat model of CPR. Quercetin 9-18 caspase 3 Rattus norvegicus 44-53 30584425-8 2018 The treatment with Quercetin showed nonsignificant differences as compared to treatment with DFO that chelated the serum and tissue iron and improved the oxidative stress and reduced tissue IL6 and increased IL10 and decreased caspase 3 and iNOs expressing cells in small intestinal tissues. Quercetin 19-28 caspase 3 Rattus norvegicus 227-236 30112361-9 2018 Inhibition of HSP70 by quercetin did not change intestinal permeability compared with the HS group but aggravated intestinal injury and affected the activation of MAPKs and caspase-3. Quercetin 23-32 caspase 3 Rattus norvegicus 173-182 28040552-7 2017 Furthermore, quercetin mediated suppression of inflammatory indices and caspase-3 activity was accompanied by preservation of histo-architectures of the brain, testes and epididymis in manganese-treated rats. Quercetin 13-22 caspase 3 Rattus norvegicus 72-81 29563391-12 2018 This study reveals the neuroprotective effect of quercetin in an MCAO-induced animal model and demonstrates the regulation of caspase-3 and PARP expression by quercetin treatment. Quercetin 159-168 caspase 3 Rattus norvegicus 126-135 29563391-13 2018 These results suggest that quercetin exerts a neuroprotective effect through preventing the MCAO-induced activation of apoptotic pathways affecting caspase-3 and PARP expression. Quercetin 27-36 caspase 3 Rattus norvegicus 148-157 28804614-7 2017 In addition, pre-treatment with QUE and OST decreased CIS-induced apoptosis through up-regulation of Bcl-2, inhibition of caspase-3 activity, and mitochondrial membrane potential (MMP) increase. Quercetin 32-35 caspase 3 Rattus norvegicus 122-131 28855811-9 2017 Our results indicate that quercetin treatment to diabetic rats caused a significant increase in the level of neurotrophic factors and inhibited the level of cytochrome c and caspase-3 activity in the diabetic retina. Quercetin 26-35 caspase 3 Rattus norvegicus 174-183 28391159-7 2017 Additionally, in a dose-dependent manner, quercetin down-regulated Bax, up-regulated Bcl-2, and subsequently inhibited caspase-3 activation. Quercetin 42-51 caspase 3 Rattus norvegicus 119-128 27572285-5 2016 Quercetin (10-40 muM) effects on the expression of Bcl-2, caspase-9, caspase-3, PARP-1, PERK, IRE1, ATF6, calnexin and CHOP for 24 h were analyzed by Western blot. Quercetin 0-9 caspase 3 Rattus norvegicus 69-78 27005763-8 2017 Mtx + quercetin group revealed significantly lower histopathological damage and APOI and caspase-3 expression decreased when compared to Mtx group. Quercetin 6-15 caspase 3 Rattus norvegicus 89-98 27572285-10 2016 The cleaved forms of caspase-9, caspase-3 and PARP-1 were also increased by quercetin. Quercetin 76-85 caspase 3 Rattus norvegicus 32-41 27008429-2 2016 Combining quercetin treatment with delayed transplantation of HUMSCs after local cerebral ischemia significantly (i) improved neurological functional recovery; (ii) reduced proinflammatory cytokines (interleukin(IL)-1beta and IL-6), increased anti-inflammatory cytokines (IL-4, IL-10, and transforming growth factor-beta1), and reduced ED-1 positive areas; (iii) inhibited cell apoptosis (caspase-3 expression); and (iv) improved the survival rate of HUMSCs in the injury site. Quercetin 10-19 caspase 3 Rattus norvegicus 389-398 27690831-11 2016 Furthermore, quercetin treatment reduced the expression of LC3 caspase-3 and Bax levels induced following TBI (p < 0.05), and increased the expression of p-Akt and Bcl-2 at 48 h (p < 0.05). Quercetin 13-22 caspase 3 Rattus norvegicus 63-72 23490140-8 2013 On the other hand, increase in nitric oxide, malondialdehyde, luminol chemiluminescence levels, and myeloperoxidase and caspase 3 activities of tissues in the SCI group were significantly reversed by quercetin treatment. Quercetin 200-209 caspase 3 Rattus norvegicus 120-129 26944603-8 2016 In addition, quercetin also prevents aluminum-induced translocation of cyt-c, and up-regulates Bcl-2, down-regulates Bax, p53, caspase-3 activation and reduces DNA fragmentation. Quercetin 13-22 caspase 3 Rattus norvegicus 127-136 26434546-9 2015 The number of TUNEL positive cells in the inner and outer hair cells in the Corti organ was found to be fewer, and Caspase 3 and 9 expressions were found to be weaker in the group receiving gentamicin plus quercetin than in the group receiving gentamicin plus ethanol. Quercetin 206-215 caspase 3 Rattus norvegicus 115-124 25945531-10 2015 The antiapoptotic effect of quercetin in terms of reducing the numbers of both TUNEL (+) cells and caspase-3 (+) cells was significant in INL. Quercetin 28-37 caspase 3 Rattus norvegicus 99-108 25945531-12 2015 The mean number of caspase-3 (+) cells in INL of ischemic and quercetin groups was 633.6 +- 38.7/mm2 and 342.4 +- 36.1/mm2, respectively (P<0.001). Quercetin 62-71 caspase 3 Rattus norvegicus 19-28 25203460-4 2015 Quercetin-induced cardiotoxicity was assessed by monitoring MTT reduction, lactate dehydrogenase (LDH) release, caspase 3 activity and reactive oxygen species production after prolonged flavonoid exposure (72 hr). Quercetin 0-9 caspase 3 Rattus norvegicus 112-121 24516353-8 2014 Caspase-3 and brain edema was ameliorated and neurobehavioral deficits improved in rats that received the high dose of quercetin. Quercetin 119-128 caspase 3 Rattus norvegicus 0-9 23770986-7 2013 Co-treatment with quercetin (2.5, 5, and 10 mmol/L) dose-dependently decreased HG-induced caspase-3 activation and apoptosis. Quercetin 18-27 caspase 3 Rattus norvegicus 90-99 23758074-8 2013 On the other hand, increase in lucigenin CL, NO, MDA levels and MPO and caspase-3 activities and decrease in GSH levels and SOD activity in the cavernosal tissues of the I/R group were also significantly reversed by quercetin treatment. Quercetin 216-225 caspase 3 Rattus norvegicus 72-81 24793929-11 2014 Treatment with quercetin decreased the number of caspase-3 and TUNEL positive cells. Quercetin 15-24 caspase 3 Rattus norvegicus 49-58 23620721-10 2013 However, it was observed that oral treatment of nanoencapsulated quercetin (2.7 mg/kg b wt) resulted in downregulation of iNOS and caspase-3 activities and improved neuronal count in the hippocampal subfields even 3 days after reperfusion. Quercetin 65-74 caspase 3 Rattus norvegicus 131-140 35187760-12 2022 Thymoquinone and quercetin not only reduced acrylamide-induced apoptosis in annexin V and caspase 3/7 assays but also morphological deformations in microscopic examinations. Quercetin 17-26 caspase 3 Rattus norvegicus 90-101 23281070-5 2012 Whereas simultaneous treatment with quercetin normalized all the biochemical parameters, consequently it inhibited apoptosis mediated by Aroclor-1254 by downregulating aryl hydrocarbon receptor, p53 and apoptotic protein (Bax, caspase-9, caspase-3) and upregulating the antiapoptotic protein (Bcl-2) expression patterns; thereby, quercetin reduces alteration in hepatocellular morphology. Quercetin 36-45 caspase 3 Rattus norvegicus 238-247 22141284-8 2011 Furthermore, quercetin treatment in rats undergoing status epilepticus led to an interventional effect on expression of X-linked inhibitor of apoptosis protein and the caspase-3 protein, with a corresponding positive change on the number of hippocampal apoptotic and surviving neurons. Quercetin 13-22 caspase 3 Rattus norvegicus 168-177 22141284-9 2011 Together, the study suggests neuroprotective effects of quercetin on hippocampal injury post status epilepticus and the effects may be associated with regulation of the X-linked inhibitor of apoptosis protein and the caspase-3 protein, which can be a decisive factor for apoptosis and survival of neurons in hippocampus. Quercetin 56-65 caspase 3 Rattus norvegicus 217-226 19496785-4 2009 Low doses of resveratrol (10 microM) or quercetin (25 microM) separately had no effect on apoptosis induction, but had a strong effect on caspase 3/7 activation when administered together. Quercetin 40-49 caspase 3 Rattus norvegicus 138-147 17045724-4 2007 Quercetin and its two O-methylated metabolites were able to reduce intracellular ROS production but only quercetin was able to counteract H(2)O(2) cell damage, as measured by MTT reduction assay, caspase-3 activity and DNA fragmentation assays. Quercetin 0-9 caspase 3 Rattus norvegicus 196-205 17045724-4 2007 Quercetin and its two O-methylated metabolites were able to reduce intracellular ROS production but only quercetin was able to counteract H(2)O(2) cell damage, as measured by MTT reduction assay, caspase-3 activity and DNA fragmentation assays. Quercetin 105-114 caspase 3 Rattus norvegicus 196-205 14505808-7 2003 Furthermore, pretreatment of quercetin inhibited the activation of caspase-3, thereby both cleavage of poly(ADP-ribose) polymerase and degradation of inhibitor of caspase-activated DNase/DNA fragmentation factor by H(2)O(2) were completely abolished. Quercetin 29-38 caspase 3 Rattus norvegicus 67-76 34295174-7 2021 Results: Our data showed that quercetin attenuated the degeneration and erosion of articular cartilage, suppressed inflammation and apoptosis, and downregulated the levels of IRAK1, NLRP3, and caspase-3 expression. Quercetin 30-39 caspase 3 Rattus norvegicus 193-202 35331526-10 2022 Beta-catenin and Bcl-2 proteins expression was decreased and caspase 3 expression was significantly increased in the quercetin group versus to control group. Quercetin 117-126 caspase 3 Rattus norvegicus 61-70 35331526-12 2022 The quercetin supplementation lead to increase in apoptotic proteins gene expression including caspase 3 and decrease in anti-apoptotic gene expression including Bcl-2. Quercetin 4-13 caspase 3 Rattus norvegicus 95-104 32599520-4 2020 Oral pretreatment using quercetin has alleviated cerebral I/R-induced neurological deficits, brain infarction, blood-brain barrier disruption, oxidative stress, TNF-alpha and IL-1beta mRNA expression, along with apoptotic caspase 3 activity. Quercetin 24-33 caspase 3 Rattus norvegicus 222-231 33507682-10 2021 In addition, the testicular levels of testosterone and SOD increased in parallel with depletion of MDA, IL-6, AFP and caspase-3 levels in MNU and/or cisplatin-treatment after -quercetin-treatment. Quercetin 176-185 caspase 3 Rattus norvegicus 118-127 33038355-0 2020 Quercetin provides protection against the peripheral nerve damage caused by vincristine in rats by suppressing caspase 3, NF-kappaB, ATF-6 pathways and activating Nrf2, Akt pathways. Quercetin 0-9 caspase 3 Rattus norvegicus 111-120 34984688-10 2022 Pretreatment with quercetin was effective at attenuating histopathologic changes in hepatic and renal tissues by regulating the immunoexpression of caspase-3 and Bcl-2 to return them to more normal values. Quercetin 18-27 caspase 3 Rattus norvegicus 148-157