PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29566331-11 2018 Strikingly, 2-guanidino-quinolines and -pyridines showed a concentration-dependent biphasic effect that resulted at higher concentrations in ASIC1a and ASIC3 inhibition (IC50 > 100 muM), while causing at lower concentration a potentiation of ASIC1a, but not ASIC3 currents (EC50 10 muM). Pyridines 39-49 acid sensing ion channel subunit 3 Homo sapiens 152-157 29566331-11 2018 Strikingly, 2-guanidino-quinolines and -pyridines showed a concentration-dependent biphasic effect that resulted at higher concentrations in ASIC1a and ASIC3 inhibition (IC50 > 100 muM), while causing at lower concentration a potentiation of ASIC1a, but not ASIC3 currents (EC50 10 muM). Pyridines 39-49 acid sensing ion channel subunit 3 Homo sapiens 261-266