PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31933141-0 2020 Up-regulation of miR-106a targets LIMK1 and contributes to cognitive impairment induced by isoflurane anesthesia in mice. Isoflurane 91-101 microRNA 106a Mus musculus 17-25 31933141-2 2020 OBJECTIVE: To explore the role and potential mechanism of miR-106a in isoflurane anesthesia-induced cognitive impairment. Isoflurane 70-80 microRNA 106a Mus musculus 58-66 31933141-10 2020 Decreased expression levels of miR-106a improved the cognitive impairment of the mice treated with isoflurane. Isoflurane 99-109 microRNA 106a Mus musculus 31-39 31933141-11 2020 Intrahippocampally injected antagomir of miR-106a also increased LIMK1 and Bcl-2 levels, decreased the BAX and cleaved caspase3 expression levels in the mice treated with isoflurane. Isoflurane 171-181 microRNA 106a Mus musculus 41-49 31933141-12 2020 CONCLUSION: Decrease of LIMK1 expression by miR-106a played an important role in isoflurane anesthesia-induced cognitive impairment. Isoflurane 81-91 microRNA 106a Mus musculus 44-52