PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18784475-2 2008 RECENT FINDINGS: In regional cerebral blood flow (rCBF) studies with isoflurane and sevoflurane, there is a consistent pattern of rise in rCBF in the anterior cingulate cortex and insula while the thalamus, lingual cortex and cerebellum show a decrease in rCBF, in a dose range of 0.2-1 minimum alveolar concentration. Isoflurane 69-79 CCAAT/enhancer binding protein zeta Rattus norvegicus 50-54 20505374-7 2010 In 12 cases of the isoflurane group, no apparent rCBF and ECoG changes were seen, except a case with decreased rCBF and slow waves. Isoflurane 19-29 CCAAT/enhancer binding protein zeta Rattus norvegicus 111-115 20505374-9 2010 During sevoflurane and isoflurane anesthesia <2.5 minimum alveolar anesthetic concentration, rCBF is affected by ECoG activities rather than pharmacologic action of inhalational anesthetics. Isoflurane 23-33 CCAAT/enhancer binding protein zeta Rattus norvegicus 96-100 20304986-13 2010 With iNOS inhibition, the increase of rCBF in the IC with isoflurane pretreatment became insignificant. Isoflurane 58-68 CCAAT/enhancer binding protein zeta Rattus norvegicus 38-42 20304986-14 2010 CONCLUSIONS: Our data demonstrate that isoflurane pretreatment improved rCBF and increased the regional O(2) supply and consumption in the focal ischemic area but did not affect capillary permeability during the early stage of focal cerebral ischemia. Isoflurane 39-49 CCAAT/enhancer binding protein zeta Rattus norvegicus 72-76 20304986-15 2010 The isoflurane-induced increase in rCBF in the ischemic area became insignificant with inhibition of iNOS. Isoflurane 4-14 CCAAT/enhancer binding protein zeta Rattus norvegicus 35-39 18784475-2 2008 RECENT FINDINGS: In regional cerebral blood flow (rCBF) studies with isoflurane and sevoflurane, there is a consistent pattern of rise in rCBF in the anterior cingulate cortex and insula while the thalamus, lingual cortex and cerebellum show a decrease in rCBF, in a dose range of 0.2-1 minimum alveolar concentration. Isoflurane 69-79 CCAAT/enhancer binding protein zeta Rattus norvegicus 138-142 18784475-2 2008 RECENT FINDINGS: In regional cerebral blood flow (rCBF) studies with isoflurane and sevoflurane, there is a consistent pattern of rise in rCBF in the anterior cingulate cortex and insula while the thalamus, lingual cortex and cerebellum show a decrease in rCBF, in a dose range of 0.2-1 minimum alveolar concentration. Isoflurane 69-79 CCAAT/enhancer binding protein zeta Rattus norvegicus 138-142 9105232-4 1997 The present study was designed to examine the role of the two constitutive NOS isoforms in cerebral blood flow (CBF) response to isoflurane using this nNOS knockout mouse. Isoflurane 129-139 CCAAT/enhancer binding protein zeta Rattus norvegicus 112-115 16480463-1 2006 BACKGROUND: In this study, we tested the hypothesis that escalating drug concentrations of isoflurane are associated with a significant decline in cerebral blood flow (CBF) in regions sub-serving conscious brain activity, including specifically the thalamus. Isoflurane 91-101 CCAAT/enhancer binding protein zeta Rattus norvegicus 168-171 16480463-7 2006 Throughout all three MAC levels of sedation, isoflurane caused an increased regional cerebral blood flow (rCBF) in the anterior cingulate and decreased rCBF in the cerebellum. Isoflurane 45-55 CCAAT/enhancer binding protein zeta Rattus norvegicus 106-110 16480463-7 2006 Throughout all three MAC levels of sedation, isoflurane caused an increased regional cerebral blood flow (rCBF) in the anterior cingulate and decreased rCBF in the cerebellum. Isoflurane 45-55 CCAAT/enhancer binding protein zeta Rattus norvegicus 152-156 16480463-8 2006 Initially, isoflurane (0 vs. 0.2 MAC) significantly increased relative rCBF in the medial frontal gyrus and in the nucleus accumbens. Isoflurane 11-21 CCAAT/enhancer binding protein zeta Rattus norvegicus 71-75 16480463-14 2006 At 1 MAC of isoflurane, rCBF decreased in the thalamus. Isoflurane 12-22 CCAAT/enhancer binding protein zeta Rattus norvegicus 24-28 9105232-6 1997 Subsequently, a NOS inhibitor, N omega-nitro-L-arginine (L-NNA), was administered intravenously (20 mg/kg), and 45 min later, the rCBF response to isoflurane was tested again. Isoflurane 147-157 CCAAT/enhancer binding protein zeta Rattus norvegicus 130-134 9105232-9 1997 RESULTS: Isoflurane produced dose-dependent increases in rCBF by 25 +/- 3%, 74 +/- 10%, and 108 +/- 14% (SEM) in 129/SV mice and by 32 +/- 2%, 71 +/- 3%, and 96 +/- 7% in C57BL/6 mice at 1.2, 1.8, and 2.4 vol%, respectively. Isoflurane 9-19 CCAAT/enhancer binding protein zeta Rattus norvegicus 57-61 9105232-12 1997 In nNOS knockout mice, isoflurane increased rCBF by 67 +/- 8%, 88 +/- 12%, and 112 +/- 18% at 1.2, 1.8, and 2.4 vol%, respectively. Isoflurane 23-33 CCAAT/enhancer binding protein zeta Rattus norvegicus 44-48 9105232-14 1997 Administration of L-NNA in the knockout mice attenuated the rCBF response to isoflurane at 1.2 and 1.8 vol% but had no effect on the response at 2.4 vol%. Isoflurane 77-87 CCAAT/enhancer binding protein zeta Rattus norvegicus 60-64 9105232-16 1997 It is suggested that in wild-type mice, eNOS and nNOS contribute to isoflurane-induced increase in rCBF. Isoflurane 68-78 CCAAT/enhancer binding protein zeta Rattus norvegicus 99-103 8342841-7 1993 RESULTS: The rCBF of the ischemic cortex (IC) and the non-ischemic contralateral cortex (CC) of the isoflurane group were significantly higher than those of the pentobarbital group. Isoflurane 100-110 CCAAT/enhancer binding protein zeta Rattus norvegicus 13-17 7856894-2 1995 In humans, various methods for measuring cerebral blood flow (CBF) have produced results compatible with a redistribution of CBF toward deep brain structures during isoflurane anesthesia in humans. Isoflurane 165-175 CCAAT/enhancer binding protein zeta Rattus norvegicus 62-65 7856894-2 1995 In humans, various methods for measuring cerebral blood flow (CBF) have produced results compatible with a redistribution of CBF toward deep brain structures during isoflurane anesthesia in humans. Isoflurane 165-175 CCAAT/enhancer binding protein zeta Rattus norvegicus 125-128 7856894-16 1995 CONCLUSIONS: There is a difference in the human rCBF distribution between halothane and isoflurane with higher relative flows in subcortical regions during isoflurane anesthesia. Isoflurane 88-98 CCAAT/enhancer binding protein zeta Rattus norvegicus 48-52 7856894-16 1995 CONCLUSIONS: There is a difference in the human rCBF distribution between halothane and isoflurane with higher relative flows in subcortical regions during isoflurane anesthesia. Isoflurane 156-166 CCAAT/enhancer binding protein zeta Rattus norvegicus 48-52 15815236-8 1989 Regional values of the ratio of rCBF/rCMRglc indicated that during hypocapnia and hypotension induced by isoflurane in nitrous oxide/oxygen, the individual brain areas were perfused according to their metabolic needs. Isoflurane 105-115 CCAAT/enhancer binding protein zeta Rattus norvegicus 32-36 1874810-8 1991 In isoflurane-anesthetized sham rats (n = 5; no ischemia), CBF was approximately three times greater than in methohexital-treated (n = 5) sham rats. Isoflurane 3-13 CCAAT/enhancer binding protein zeta Rattus norvegicus 59-62