PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22312298-6	2012	We also determined whether isoflurane modulates the expression and activity of sphingosine kinase-1 (SK1) and induces the phosphorylation of extracellular signal regulated kinase (ERK MAPK) as both enzymes are known to protect against cell death.	Isoflurane	27-37	mitogen-activated protein kinase 1	Homo sapiens	180-183	
22312298-8	2012	Mechanistically, isoflurane induces the phosphorylation of ERK MAPK and increased SK1 expression and activity in EA.hy926 cells.	Isoflurane	17-27	mitogen-activated protein kinase 1	Homo sapiens	59-62	
22312298-10	2012	Taken together, we demonstrate that isoflurane, in addition to its potent analgesic and anesthetic properties, protects against endothelial apoptosis most likely via SK1 and ERK MAPK activation.	Isoflurane	36-46	mitogen-activated protein kinase 1	Homo sapiens	174-177	
22312298-10	2012	Taken together, we demonstrate that isoflurane, in addition to its potent analgesic and anesthetic properties, protects against endothelial apoptosis most likely via SK1 and ERK MAPK activation.	Isoflurane	36-46	mitogen-activated protein kinase 1	Homo sapiens	178-182	
20234131-3	2010	METHODS AND RESULTS: Isoflurane-mediated phosphorylation of extracellular signal-regulated kinase (ERK) and Akt and induction of HSP70 in human kidney proximal tubule (HK-2) cells were inhibited by dimethylsphingosine (DMS), an SK inhibitor, and VPC23019, an S1P(1/3) receptor selective antagonist, in HK-2 cells.	Isoflurane	21-31	mitogen-activated protein kinase 1	Homo sapiens	60-97	
20234131-3	2010	METHODS AND RESULTS: Isoflurane-mediated phosphorylation of extracellular signal-regulated kinase (ERK) and Akt and induction of HSP70 in human kidney proximal tubule (HK-2) cells were inhibited by dimethylsphingosine (DMS), an SK inhibitor, and VPC23019, an S1P(1/3) receptor selective antagonist, in HK-2 cells.	Isoflurane	21-31	mitogen-activated protein kinase 1	Homo sapiens	99-102	
20234131-4	2010	A selective S1P(1) receptor agonist, SEW2781, mimicked isoflurane-induced phosphorylation of ERK and Akt and induction of HSP70.	Isoflurane	55-65	mitogen-activated protein kinase 1	Homo sapiens	93-96	
20234131-7	2010	CONCLUSIONS: Collectively, our study demonstrates that S1P released via isoflurane-mediated SK1 stimulation produces direct anti-necrotic effects probably via S1P(1) receptor-mediated cytoprotective signaling (ERK/Akt phosphorylation and HSP70 induction) in HK-2 cells.	Isoflurane	72-82	mitogen-activated protein kinase 1	Homo sapiens	210-213	
16806162-5	2006	Isoflurane exposure induced phosphorylation/activation of extracellular signal-regulated kinase (ERK).	Isoflurane	0-10	mitogen-activated protein kinase 1	Homo sapiens	58-95	
16806162-5	2006	Isoflurane exposure induced phosphorylation/activation of extracellular signal-regulated kinase (ERK).	Isoflurane	0-10	mitogen-activated protein kinase 1	Homo sapiens	97-100	
16806162-6	2006	Inhibition of the phospho-ERK expression abolished the isoflurane preconditioning-induced protection.	Isoflurane	55-65	mitogen-activated protein kinase 1	Homo sapiens	26-29	
16806162-7	2006	Isoflurane exposure also increased the expression of early growth response gene 1 (Egr-1) and Bcl-2, proteins downstream of ERK.	Isoflurane	0-10	mitogen-activated protein kinase 1	Homo sapiens	124-127	
16806162-10	2006	The increased expression of Egr-1 and Bcl-2 by isoflurane was inhibited by ERK inhibition.	Isoflurane	47-57	mitogen-activated protein kinase 1	Homo sapiens	75-78	
16806162-11	2006	Thus, our results suggest a role of ERK/Egr-1/Bcl-2 pathway in the isoflurane preconditioning-induced protection in the human neuroblastoma SH-SY5Y cells.	Isoflurane	67-77	mitogen-activated protein kinase 1	Homo sapiens	36-39	
28938523-5	2017	Importantly, isoflurane and propofol anesthesia reduced fibroblast growth factor (FGF2) and activity-regulated cytoskeleton-associated protein (Arc) expressions, enhanced glial fibrillary acidic protein (GFAP), Iba1 and phosphorylated-Eukaryotic elongation factor 2 (eEF2) levels as well as down-regulated mitogen-activated protein kinases (MAPKs) family members, including p38, ERK1/2 and JNK, in the hippocampus of animals.	Isoflurane	13-23	mitogen-activated protein kinase 1	Homo sapiens	374-377