PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30217191-0	2018	NLRP3 inflammasome-dependent pyroptosis is proposed to be involved in the mechanism of age-dependent isoflurane-induced cognitive impairment.	Isoflurane	101-111	NLR family pyrin domain containing 3	Homo sapiens	0-5	
30217191-2	2018	recently published a paper, titled "Critical role of NLRP3-caspase-1 pathway in age-dependent isoflurane-induced microglial inflammatory response and cognitive impairment".	Isoflurane	94-104	NLR family pyrin domain containing 3	Homo sapiens	53-58	
30217191-4	2018	Here, we propose that NLRP3 inflammasome-dependent pyroptosis may be involved in the mechanism of age-dependent isoflurane-induced cognitive impairment and discuss that inhibiting NLRP3 inflammasome activation with a novel inhibitor MCC950 may ameliorate age-dependent isoflurane-induced neuro-inflammation.	Isoflurane	112-122	NLR family pyrin domain containing 3	Homo sapiens	22-27	
30217191-4	2018	Here, we propose that NLRP3 inflammasome-dependent pyroptosis may be involved in the mechanism of age-dependent isoflurane-induced cognitive impairment and discuss that inhibiting NLRP3 inflammasome activation with a novel inhibitor MCC950 may ameliorate age-dependent isoflurane-induced neuro-inflammation.	Isoflurane	112-122	NLR family pyrin domain containing 3	Homo sapiens	180-185	
30217191-4	2018	Here, we propose that NLRP3 inflammasome-dependent pyroptosis may be involved in the mechanism of age-dependent isoflurane-induced cognitive impairment and discuss that inhibiting NLRP3 inflammasome activation with a novel inhibitor MCC950 may ameliorate age-dependent isoflurane-induced neuro-inflammation.	Isoflurane	269-279	NLR family pyrin domain containing 3	Homo sapiens	22-27	
30217191-4	2018	Here, we propose that NLRP3 inflammasome-dependent pyroptosis may be involved in the mechanism of age-dependent isoflurane-induced cognitive impairment and discuss that inhibiting NLRP3 inflammasome activation with a novel inhibitor MCC950 may ameliorate age-dependent isoflurane-induced neuro-inflammation.	Isoflurane	269-279	NLR family pyrin domain containing 3	Homo sapiens	180-185	
34305534-0	2021	NLRP3 Inflammasome: A Potential Target in Isoflurane Pretreatment Alleviates Stroke-Induced Retinal Injury in Diabetes.	Isoflurane	42-52	NLR family pyrin domain containing 3	Homo sapiens	0-5	
34305534-7	2021	Isoflurane has been demonstrated to inhibit the activation of the NLRP3 inflammasome and show neuroprotective effects.	Isoflurane	0-10	NLR family pyrin domain containing 3	Homo sapiens	66-71	
34305534-11	2021	Of note, isoflurane pretreatment inhibited the NLRP3 inflammasome activation in the retina, indicating that isoflurane pretreatment may provide substantial retinal protection in stroke-induced retinal injury in diabetes.	Isoflurane	9-19	NLR family pyrin domain containing 3	Homo sapiens	47-52	
34305534-11	2021	Of note, isoflurane pretreatment inhibited the NLRP3 inflammasome activation in the retina, indicating that isoflurane pretreatment may provide substantial retinal protection in stroke-induced retinal injury in diabetes.	Isoflurane	108-118	NLR family pyrin domain containing 3	Homo sapiens	47-52	
34964706-4	2022	Mirtazapine prevented isoflurane-induced production of the pro-inflammatory factors interleukin (IL)-1beta and IL-18 by inhibiting the activation of the nod-like receptor family protein 3 (NLRP3) inflammasome in BV2 microglia.	Isoflurane	22-32	NLR family pyrin domain containing 3	Homo sapiens	189-194