PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8043030-4	1994	The accumulation of 24,25-epoxycholesterol in relationship to the decrease of C27-sterol biosynthesis and of HMG-CoA reductase activity showed only a partial correlation: e.g. at [1] = 100 x IC50 only a 50% reduction in enzyme activity could be attained.	24,25-epoxycholesterol	20-42	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	109-126	
8043030-5	1994	In contrast, when HepG2 cells were treated with 2,3:22,23-dioxidosqualene or 24,25-epoxycholesterol, excellent correlations were found between the inhibition of C27-sterol biosynthesis and the repression of HMG-CoA reductase activity, which was almost complete at the highest concentrations of these epoxides (10(-5) M).	24,25-epoxycholesterol	77-99	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	207-224