PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26995374-3	2016	Metoprolol is a beta-adrenergic receptor antagonist that is ineffective in younger patients, but may benefit older (>=40 years) VVS patients.	Metoprolol	0-10	VVS	Homo sapiens	131-134	
26995374-4	2016	Given the limited therapeutic options, a placebo-controlled clinical trial of metoprolol for the prevention of VVS in older patients is needed.	Metoprolol	78-88	VVS	Homo sapiens	111-114	
26995374-5	2016	STRUCTURE OF STUDY: The POST5 is a multicenter, international, randomized, placebo-controlled study of metoprolol in the prevention of VVS in patients >=40 years old.	Metoprolol	103-113	VVS	Homo sapiens	135-138	
26995374-12	2016	IMPLICATIONS: This study will be the first adequately powered trial to determine whether metoprolol is effective in preventing VVS in patients >=40 years.	Metoprolol	89-99	VVS	Homo sapiens	127-130