PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
1315561-7	1992	In contrast, in CAD-patients chronically treated with beta 1-adrenoceptor antagonists (atenolol, bisoprolol, metoprolol) and CEB, atrial beta-adrenoceptor density was significantly increased (108.6 +/- 10.5 fmol ICYP bound mg-1 protein, n = 21); this increase was due to a selective increase in beta 1-adrenoceptors.	Metoprolol	109-119	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	54-60	
22118662-5	2011	The beta2-adrenergic antagonist ICI118,551 significantly induced G1/S phase arrest and apoptosis compared with the beta1-adrenergic antagonist metoprolol, which was determined by the flow cytometry assay.	Metoprolol	143-153	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	115-120	
11026647-4	2000	Atenolol and metoprolol were about fivefold selective for beta1- versus beta2- and beta3-adrenoceptors.	Metoprolol	13-23	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	58-63	
11026647-7	2000	We conclude that the beta1-selectivities of atenolol, metoprolol, and bisoprolol are lower in COS cell membranes compared with previous investigations performed in native membranes.	Metoprolol	54-64	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	21-26	
10372227-7	1999	Atenolol, metoprolol, and betaxolol displayed lower, selectivity for the beta1 receptor, whereas propranolol and carvedilol displayed no significant beta-adrenergic selectivity.	Metoprolol	10-20	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	73-78	
25480109-1	2015	The beta1-adrenergic antagonist metoprolol improves cardiac function in animals and patients with chronic heart failure, isolated mitral regurgitation (MR), and ischemic heart disease, though the molecular mechanisms remain incompletely understood.	Metoprolol	32-42	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	4-9	
25480109-4	2015	We tested whether chronic beta1-adrenergic blockade with metoprolol enhances myocardial beta3AR coupling with nitric oxide-stimulated cyclic guanosine monophosphate (beta3AR/NO-cGMP) signaling in the MR-induced, volume-overloaded heart.	Metoprolol	57-67	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	26-31	
23489141-10	2013	CONCLUSIONS AND IMPLICATIONS: Metoprolol induces a control by PDE3 of ventricular effects mediated through both beta1 and beta2 adrenoceptors, thereby further reducing sympathetic cardiostimulation in patients with terminal heart failure.	Metoprolol	30-40	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	112-117