PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23339682-2 2014 METHODS: Cocktail approach was used to evaluate the influence of IR and IPC on the activities of CYP1A2, CYP2C9, CYP2E1, CYP2D6 and CYP3A4, which were reflected by the changes of pharmacokinetic parameters of five specific probe drugs: caffeine, chlorzoxazone, tolbutamide, metoprolol and midazolam, respectively. Metoprolol 274-284 cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus 113-119 23235327-2 2012 Phenacetin, dapsone, chlorzoxazone, omeprazole and metoprolol were selected as probe substrates for CYP1A2, CYP3A1/2, CYP2E1, CYP2C19 and CYP2D6 respectively. Metoprolol 51-61 cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus 118-124